U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Anaplastic cancer

MedGen UID:
231373
•Concept ID:
C1332287
•
Neoplastic Process
Synonyms: anaplastic cancer; Anaplastic Malignant Neoplasm; anaplastic malignant neoplasm
 
Monarch Initiative: MONDO:0020633

Definition

A malignant neoplasm characterized by the presence of poorly differentiated, often large neoplastic cells with bizarre morphologic characteristics, associated with high mitotic activity and necrotic changes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnaplastic cancer

Professional guidelines

PubMed

Management of acute clinical presentation of anaplastic thyroid cancer. A difficult choice.
Biffoni M, Garritano S, Scipioni P, Colangelo M, De Meo D, Monti M
Ann Ital Chir 2013 Mar-Apr;84(2):187-91. PMID: 23698085
Treatment of recurrent thyroid cancers--is there a light in the horizon?
Rovere RK, Awada A
Curr Opin Oncol 2008 May;20(3):245-8. doi: 10.1097/CCO.0b013e3282fb289a. PMID: 18391621
Prognosis and treatment of brain metastases in thyroid carcinoma.
Chiu AC, Delpassand ES, Sherman SI
J Clin Endocrinol Metab 1997 Nov;82(11):3637-42. doi: 10.1210/jcem.82.11.4386. PMID: 9360519

Recent clinical studies

Etiology

External beam radiotherapy for thyroid cancer: Patients, complications, and survival.
Goodsell K, Ermer J, Amjad W, Swisher-McClure S, Wachtel H
Am J Surg 2023 Jun;225(6):994-999. Epub 2023 Jan 11 doi: 10.1016/j.amjsurg.2023.01.009. PMID: 36707300
Five-year relative survival and determinants of excess mortality in patients with head and neck and thyroid cancers: A population-based study from Golestan province, Northern Iran.
Taziki M, Rajaei S, Firouzei G, Hashemzadeh F, Rajabalian M, Mansoury M, Sedaghat S, Ghahraman F, Ghasemi-Kebria F, Weiderpass E, Roshandel G
Cancer Epidemiol 2022 Oct;80:102247. Epub 2022 Sep 5 doi: 10.1016/j.canep.2022.102247. PMID: 36081275
Thyroid cancer in the Democratic Republic of the Congo: Frequency and risk factors.
Bukasa Kakamba J, Sabbah N, Bayauli P, Massicard M, Bidingija J, Nkodila A, Mbunga B, Ditu S, Beckers A, Potorac I
Ann Endocrinol (Paris) 2021 Dec;82(6):606-612. Epub 2021 Oct 5 doi: 10.1016/j.ando.2021.09.002. PMID: 34624256
Anaplastic cancer, lymphoma, and metastases of the thyroid gland.
Pasieka JL
Surg Oncol Clin N Am 1998 Oct;7(4):707-20. PMID: 9735130
Predictors of thyroid tumor aggressiveness.
Clark OH
West J Med 1996 Sep;165(3):131-8. PMID: 8909165Free PMC Article

Diagnosis

Early mortality critically impedes improvements in thyroid cancer survival through a half century.
Tichanek F, Försti A, Liska V, Hemminki O, Koskinen A, Hemminki A, Hemminki K
Eur J Endocrinol 2023 Sep 1;189(3):355-362. doi: 10.1093/ejendo/lvad117. PMID: 37675794
Thyroid cancer patient reported outcome measures in clinical practice: analysing acceptability and optimizing recruitment.
O'Neill CJ, Morris-Baguley H, Alam AS, Carlson MA, Blefari N, Rowe CW, Fradgley EA, Paul C
ANZ J Surg 2023 Sep;93(9):2214-2221. Epub 2023 Jun 30 doi: 10.1111/ans.18578. PMID: 37391881
Thyroid cancer in the Democratic Republic of the Congo: Frequency and risk factors.
Bukasa Kakamba J, Sabbah N, Bayauli P, Massicard M, Bidingija J, Nkodila A, Mbunga B, Ditu S, Beckers A, Potorac I
Ann Endocrinol (Paris) 2021 Dec;82(6):606-612. Epub 2021 Oct 5 doi: 10.1016/j.ando.2021.09.002. PMID: 34624256
Merkel cell carcinoma.
Swann MH, Yoon J
Semin Oncol 2007 Feb;34(1):51-6. doi: 10.1053/j.seminoncol.2006.10.021. PMID: 17270666
Predictors of thyroid tumor aggressiveness.
Clark OH
West J Med 1996 Sep;165(3):131-8. PMID: 8909165Free PMC Article

Therapy

Effects of metformin and pioglitazone combination on apoptosis and AMPK/mTOR signaling pathway in human anaplastic thyroid cancer cells.
Ozdemir Kutbay N, Biray Avci C, Sarer Yurekli B, Caliskan Kurt C, Shademan B, Gunduz C, Erdogan M
J Biochem Mol Toxicol 2020 Oct;34(10):e22547. Epub 2020 Jun 26 doi: 10.1002/jbt.22547. PMID: 32589349
Inhibition of gap junction transfer sensitizes thyroid cancer cells to anoikis.
Jensen K, Patel A, Klubo-Gwiezdzinska J, Bauer A, Vasko V
Endocr Relat Cancer 2011 Oct;18(5):613-26. Epub 2011 Sep 20 doi: 10.1530/ERC-10-0289. PMID: 21813730
Merkel cell carcinoma.
Swann MH, Yoon J
Semin Oncol 2007 Feb;34(1):51-6. doi: 10.1053/j.seminoncol.2006.10.021. PMID: 17270666
Epidemiology of thyroid diseases in iodine sufficiency.
Lind P, Langsteger W, Molnar M, Gallowitsch HJ, Mikosch P, Gomez I
Thyroid 1998 Dec;8(12):1179-83. doi: 10.1089/thy.1998.8.1179. PMID: 9920375
Thyroid cancer.
Leeper RD
Med Clin North Am 1985 Sep;69(5):1079-96. doi: 10.1016/s0025-7125(16)31007-0. PMID: 4058094

Prognosis

Early mortality critically impedes improvements in thyroid cancer survival through a half century.
Tichanek F, Försti A, Liska V, Hemminki O, Koskinen A, Hemminki A, Hemminki K
Eur J Endocrinol 2023 Sep 1;189(3):355-362. doi: 10.1093/ejendo/lvad117. PMID: 37675794
Merkel cell carcinoma.
Swann MH, Yoon J
Semin Oncol 2007 Feb;34(1):51-6. doi: 10.1053/j.seminoncol.2006.10.021. PMID: 17270666
The management of advanced thyroid cancer.
Wilson PC, Millar BM, Brierley JD
Clin Oncol (R Coll Radiol) 2004 Dec;16(8):561-8. doi: 10.1016/j.clon.2004.08.009. PMID: 15630850
Anaplastic cancer, lymphoma, and metastases of the thyroid gland.
Pasieka JL
Surg Oncol Clin N Am 1998 Oct;7(4):707-20. PMID: 9735130
Predictors of thyroid tumor aggressiveness.
Clark OH
West J Med 1996 Sep;165(3):131-8. PMID: 8909165Free PMC Article

Clinical prediction guides

Early mortality critically impedes improvements in thyroid cancer survival through a half century.
Tichanek F, Försti A, Liska V, Hemminki O, Koskinen A, Hemminki A, Hemminki K
Eur J Endocrinol 2023 Sep 1;189(3):355-362. doi: 10.1093/ejendo/lvad117. PMID: 37675794
The mutation profile of differentiated thyroid cancer coexisting with undifferentiated anaplastic cancer resembles that of anaplastic thyroid cancer but not that of archetypal differentiated thyroid cancer.
Mika J, Łabaj W, Chekan M, Abramowicz A, Pietrowska M, Polański A, Widłak P
J Appl Genet 2021 Feb;62(1):115-120. doi: 10.1007/s13353-020-00594-0. PMID: 33222100Free PMC Article
Inhibition of gap junction transfer sensitizes thyroid cancer cells to anoikis.
Jensen K, Patel A, Klubo-Gwiezdzinska J, Bauer A, Vasko V
Endocr Relat Cancer 2011 Oct;18(5):613-26. Epub 2011 Sep 20 doi: 10.1530/ERC-10-0289. PMID: 21813730
Predictors of thyroid tumor aggressiveness.
Clark OH
West J Med 1996 Sep;165(3):131-8. PMID: 8909165Free PMC Article
Thyroid cancer.
Leeper RD
Med Clin North Am 1985 Sep;69(5):1079-96. doi: 10.1016/s0025-7125(16)31007-0. PMID: 4058094

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...