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Nasopharyngeal Differentiated Carcinoma

MedGen UID:
313473
•Concept ID:
C1709153
•
Neoplastic Process
Synonym: Nasopharyngeal Nonkeratinizing Differentiated Carcinoma

Definition

A nonkeratinizing nasopharyngeal carcinoma characterized by the presence of cells without prominent nucleoli, cellular stratification, and a lymphoplasmacytic infiltrate. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNasopharyngeal Differentiated Carcinoma

Professional guidelines

PubMed

Differentiation therapy: a promising strategy for cancer treatment.
Yan M, Liu Q
Chin J Cancer 2016 Jan 6;35:3. doi: 10.1186/s40880-015-0059-x. PMID: 26739838Free PMC Article
The Differential Diagnosis of Sinonasal/Nasopharyngeal Neuroendocrine/Neuroectodermally Derived Tumors.
Montone KT
Arch Pathol Lab Med 2015 Dec;139(12):1498-507. doi: 10.5858/arpa.2014-0383-RA. PMID: 26619022
Evaluation and management of neck masses in children.
Meier JD, Grimmer JF
Am Fam Physician 2014 Mar 1;89(5):353-8. PMID: 24695506

Recent clinical studies

Etiology

Refining the 8th edition TNM classification for EBV related nasopharyngeal carcinoma.
Du XJ, Wang GY, Zhu XD, Han YQ, Lei F, Shen LF, Yang KY, Chen L, Mao YP, Tang LL, Li L, Wu Z, Xu GQ, Zhou Q, Huang J, Guo R, Zhang Y, Liu X, Zhou GQ, Li WF, Xu C, Lin L, Chen YP, Chen FP, Liang XY, Chen SY, Li SQ, Cui CY, Li JB, Ren J, Chen MY, Liu LZ, Sun Y, Ma J
Cancer Cell 2024 Mar 11;42(3):464-473.e3. Epub 2024 Jan 18 doi: 10.1016/j.ccell.2023.12.020. PMID: 38242125
Dysregulated Gln-Glu-α-ketoglutarate axis impairs maternal decidualization and increases the risk of recurrent spontaneous miscarriage.
Tang L, Xu XH, Xu S, Liu Z, He Q, Li W, Sun J, Shuai W, Mao J, Zhao JY, Jin L
Cell Rep Med 2023 May 16;4(5):101026. Epub 2023 May 2 doi: 10.1016/j.xcrm.2023.101026. PMID: 37137303Free PMC Article
Infectious Mononucleosis: Rapid Evidence Review.
Sylvester JE, Buchanan BK, Silva TW
Am Fam Physician 2023 Jan;107(1):71-78. PMID: 36689975
Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma.
Chen YP, Yin JH, Li WF, Li HJ, Chen DP, Zhang CJ, Lv JW, Wang YQ, Li XM, Li JY, Zhang PP, Li YQ, He QM, Yang XJ, Lei Y, Tang LL, Zhou GQ, Mao YP, Wei C, Xiong KX, Zhang HB, Zhu SD, Hou Y, Sun Y, Dean M, Amit I, Wu K, Kuang DM, Li GB, Liu N, Ma J
Cell Res 2020 Nov;30(11):1024-1042. Epub 2020 Jul 20 doi: 10.1038/s41422-020-0374-x. PMID: 32686767Free PMC Article
The human leukocyte antigen class I genes in nasopharyngeal carcinoma risk.
Hassen E, Nahla G, Bouaouina N, Chouchane L
Mol Biol Rep 2010 Jan;37(1):119-26. Epub 2009 May 17 doi: 10.1007/s11033-009-9548-9. PMID: 19449168

Diagnosis

IgG4-related disease with nasopharyngeal malignancy-like manifestations.
Lin X, Lin P, Fan J, Zhang B, Liang F, Han P, Liu X, Huang X
Front Immunol 2024;15:1322159. Epub 2024 Jun 20 doi: 10.3389/fimmu.2024.1322159. PMID: 38966645Free PMC Article
Refining the 8th edition TNM classification for EBV related nasopharyngeal carcinoma.
Du XJ, Wang GY, Zhu XD, Han YQ, Lei F, Shen LF, Yang KY, Chen L, Mao YP, Tang LL, Li L, Wu Z, Xu GQ, Zhou Q, Huang J, Guo R, Zhang Y, Liu X, Zhou GQ, Li WF, Xu C, Lin L, Chen YP, Chen FP, Liang XY, Chen SY, Li SQ, Cui CY, Li JB, Ren J, Chen MY, Liu LZ, Sun Y, Ma J
Cancer Cell 2024 Mar 11;42(3):464-473.e3. Epub 2024 Jan 18 doi: 10.1016/j.ccell.2023.12.020. PMID: 38242125
Lymphoepithelial Carcinoma of Salivary Glands.
Thompson LDR, Whaley RD
Surg Pathol Clin 2021 Mar;14(1):75-96. doi: 10.1016/j.path.2020.09.009. PMID: 33526225
Human Papillomavirus-Associated Neoplasms of the Head and Neck.
Udager AM, McHugh JB
Surg Pathol Clin 2017 Mar;10(1):35-55. Epub 2016 Dec 29 doi: 10.1016/j.path.2016.10.007. PMID: 28153135
Posttreatment imaging of the nasopharynx.
Ng SH, Liu HM, Ko SF, Hao SP, Chong VF
Eur J Radiol 2002 Nov;44(2):82-95. doi: 10.1016/s0720-048x(02)00061-x. PMID: 12413677

Therapy

Cerebral (18)F-FDG PET/CT Metabolism as Diagnostic Signature for Central Nervous System Toxicity After Immune Checkpoint Blockade Cancer Treatment.
Ma Y, Zeng J, Ding F, Xu Y, Wang Y, Zhong G, Liu N, Wang Y, Li Y, Chen S, Wei X, Zhu P, Jian G, Niu YS, Fu G, Liu C, Li G, Zhou X, Zhang A, Weng S
J Nucl Med 2024 Jul 1;65(7):1129-1136. doi: 10.2967/jnumed.123.267025. PMID: 38697671
A Rapidly Progressing Polycystic Liver Disease?
Dong ZR, Zhi XT, Li T
Gastroenterology 2020 Jan;158(1):e9-e11. Epub 2019 Jul 31 doi: 10.1053/j.gastro.2019.07.046. PMID: 31376387
Lymphoepithelioma-like carcinoma of breast: A case report and review of the literature.
Nieto-Coronel MT, Perez-Sanchez VM, Salazar-Campos JE, Diaz-Molina R, Arce-Salinas CH
Indian J Pathol Microbiol 2019 Jan-Mar;62(1):125-128. doi: 10.4103/IJPM.IJPM_761_17. PMID: 30706876
Differentiation therapy: a promising strategy for cancer treatment.
Yan M, Liu Q
Chin J Cancer 2016 Jan 6;35:3. doi: 10.1186/s40880-015-0059-x. PMID: 26739838Free PMC Article
MRI of nasopharyngeal carcinoma with emphasis on relationship to radiotherapy.
Ng SH, Wan YL, Ko SF, Chang JT
J Magn Reson Imaging 1998 Mar-Apr;8(2):327-36. doi: 10.1002/jmri.1880080212. PMID: 9562059

Prognosis

Refining the 8th edition TNM classification for EBV related nasopharyngeal carcinoma.
Du XJ, Wang GY, Zhu XD, Han YQ, Lei F, Shen LF, Yang KY, Chen L, Mao YP, Tang LL, Li L, Wu Z, Xu GQ, Zhou Q, Huang J, Guo R, Zhang Y, Liu X, Zhou GQ, Li WF, Xu C, Lin L, Chen YP, Chen FP, Liang XY, Chen SY, Li SQ, Cui CY, Li JB, Ren J, Chen MY, Liu LZ, Sun Y, Ma J
Cancer Cell 2024 Mar 11;42(3):464-473.e3. Epub 2024 Jan 18 doi: 10.1016/j.ccell.2023.12.020. PMID: 38242125
Lymphoepithelial Carcinoma of Salivary Glands.
Thompson LDR, Whaley RD
Surg Pathol Clin 2021 Mar;14(1):75-96. doi: 10.1016/j.path.2020.09.009. PMID: 33526225
Recurrent respiratory papillomatosis: A state-of-the-art review.
Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E
Respir Med 2017 May;126:116-121. Epub 2017 Apr 1 doi: 10.1016/j.rmed.2017.03.030. PMID: 28427542
Human Papillomavirus-Associated Neoplasms of the Head and Neck.
Udager AM, McHugh JB
Surg Pathol Clin 2017 Mar;10(1):35-55. Epub 2016 Dec 29 doi: 10.1016/j.path.2016.10.007. PMID: 28153135
Trigeminal neurinomas.
Fee WE Jr, Epsy CD, Konrad HR
Laryngoscope 1975 Feb;85(2):371-6. doi: 10.1288/00005537-197502000-00014. PMID: 1113604

Clinical prediction guides

STIM1-regulated exosomal EBV-LMP1 empowers endothelial cells with an aggressive phenotype by activating the Akt/ERK pathway in nasopharyngeal carcinoma.
Deng Y, Liu X, Huang Y, Ye J, He Q, Luo Y, Chen Y, Li Q, Lin Y, Liang R, Li Y, Wei J, Zhang J
Cell Oncol (Dordr) 2023 Aug;46(4):987-1000. Epub 2023 Mar 14 doi: 10.1007/s13402-023-00790-0. PMID: 36917356
Post-irradiation endolymphatic hydrops vs. post-irradiation sudden deafness.
Tien CT, Chen CN, Young YH
Radiother Oncol 2022 Nov;176:222-227. Epub 2022 Oct 17 doi: 10.1016/j.radonc.2022.10.010. PMID: 36265683
Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma.
Chen YP, Yin JH, Li WF, Li HJ, Chen DP, Zhang CJ, Lv JW, Wang YQ, Li XM, Li JY, Zhang PP, Li YQ, He QM, Yang XJ, Lei Y, Tang LL, Zhou GQ, Mao YP, Wei C, Xiong KX, Zhang HB, Zhu SD, Hou Y, Sun Y, Dean M, Amit I, Wu K, Kuang DM, Li GB, Liu N, Ma J
Cell Res 2020 Nov;30(11):1024-1042. Epub 2020 Jul 20 doi: 10.1038/s41422-020-0374-x. PMID: 32686767Free PMC Article
miR-185-3p regulates nasopharyngeal carcinoma radioresistance by targeting WNT2B in vitro.
Li G, Wang Y, Liu Y, Su Z, Liu C, Ren S, Deng T, Huang D, Tian Y, Qiu Y
Cancer Sci 2014 Dec;105(12):1560-8. Epub 2014 Nov 20 doi: 10.1111/cas.12555. PMID: 25297925Free PMC Article
Epstein-Barr virus-targeted immunotherapy for nasopharyngeal carcinoma.
Masmoudi A, Toumi N, Khanfir A, Kallel-Slimi L, Daoud J, Karray H, Frikha M
Cancer Treat Rev 2007 Oct;33(6):499-505. Epub 2007 Jun 4 doi: 10.1016/j.ctrv.2007.04.007. PMID: 17544585

Recent systematic reviews

Imaging features, therapies, and outcomes of fibrosing inflammatory pseudotumor of the nasopharynx: A systematic review.
Mishra S, Suh CH, Bergmark RW, Jo VY, Miyawaki EK, Schoenfeld JD, Uppaluri R, Guenette JP
J Neuroimaging 2022 Mar;32(2):223-229. Epub 2021 Dec 8 doi: 10.1111/jon.12953. PMID: 34879175

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