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Nasopharyngeal Differentiated Carcinoma

MedGen UID:
313473
•Concept ID:
C1709153
•
Neoplastic Process
Synonym: Nasopharyngeal Nonkeratinizing Differentiated Carcinoma

Definition

A nonkeratinizing nasopharyngeal carcinoma characterized by the presence of cells without prominent nucleoli, cellular stratification, and a lymphoplasmacytic infiltrate. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNasopharyngeal Differentiated Carcinoma

Professional guidelines

PubMed

Progression of understanding for the role of Epstein-Barr virus and management of nasopharyngeal carcinoma.
Nakanishi Y, Wakisaka N, Kondo S, Endo K, Sugimoto H, Hatano M, Ueno T, Ishikawa K, Yoshizaki T
Cancer Metastasis Rev 2017 Sep;36(3):435-447. doi: 10.1007/s10555-017-9693-x. PMID: 28819752Free PMC Article
The Differential Diagnosis of Sinonasal/Nasopharyngeal Neuroendocrine/Neuroectodermally Derived Tumors.
Montone KT
Arch Pathol Lab Med 2015 Dec;139(12):1498-507. doi: 10.5858/arpa.2014-0383-RA. PMID: 26619022
Evaluation and management of neck masses in children.
Meier JD, Grimmer JF
Am Fam Physician 2014 Mar 1;89(5):353-8. PMID: 24695506

Recent clinical studies

Etiology

Refining the 8th edition TNM classification for EBV related nasopharyngeal carcinoma.
Du XJ, Wang GY, Zhu XD, Han YQ, Lei F, Shen LF, Yang KY, Chen L, Mao YP, Tang LL, Li L, Wu Z, Xu GQ, Zhou Q, Huang J, Guo R, Zhang Y, Liu X, Zhou GQ, Li WF, Xu C, Lin L, Chen YP, Chen FP, Liang XY, Chen SY, Li SQ, Cui CY, Li JB, Ren J, Chen MY, Liu LZ, Sun Y, Ma J
Cancer Cell 2024 Mar 11;42(3):464-473.e3. Epub 2024 Jan 18 doi: 10.1016/j.ccell.2023.12.020. PMID: 38242125
Hyperfractionation compared with standard fractionation in intensity-modulated radiotherapy for patients with locally advanced recurrent nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase 3 trial.
You R, Liu YP, Xie YL, Lin C, Duan CY, Chen DP, Pan Y, Qi B, Zou X, Guo L, Cao JY, Zhang YN, Wang ZQ, Liu YL, Ouyang YF, Wen K, Yang Q, Xie RQ, Li HF, Duan XT, Ding X, Peng L, Chen SY, Liang JL, Feng ZK, Xia TL, Xie RL, Jiang R, Gu CM, Liu RZ, Sun R, Yang X, Liu LZ, Ling L, Liu Q, Ng WT, Hua YJ, Huang PY, Chen MY
Lancet 2023 Mar 18;401(10380):917-927. Epub 2023 Feb 23 doi: 10.1016/S0140-6736(23)00269-6. PMID: 36842439
Infectious Mononucleosis: Rapid Evidence Review.
Sylvester JE, Buchanan BK, Silva TW
Am Fam Physician 2023 Jan;107(1):71-78. PMID: 36689975
Epigenetic analysis of cell-free DNA by fragmentomic profiling.
Zhou Q, Kang G, Jiang P, Qiao R, Lam WKJ, Yu SCY, Ma ML, Ji L, Cheng SH, Gai W, Peng W, Shang H, Chan RWY, Chan SL, Wong GLH, Hiraki LT, Volpi S, Wong VWS, Wong J, Chiu RWK, Chan KCA, Lo YMD
Proc Natl Acad Sci U S A 2022 Nov;119(44):e2209852119. Epub 2022 Oct 26 doi: 10.1073/pnas.2209852119. PMID: 36288287Free PMC Article
Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma.
Chen YP, Yin JH, Li WF, Li HJ, Chen DP, Zhang CJ, Lv JW, Wang YQ, Li XM, Li JY, Zhang PP, Li YQ, He QM, Yang XJ, Lei Y, Tang LL, Zhou GQ, Mao YP, Wei C, Xiong KX, Zhang HB, Zhu SD, Hou Y, Sun Y, Dean M, Amit I, Wu K, Kuang DM, Li GB, Liu N, Ma J
Cell Res 2020 Nov;30(11):1024-1042. Epub 2020 Jul 20 doi: 10.1038/s41422-020-0374-x. PMID: 32686767Free PMC Article

Diagnosis

IGF-1R mediates crosstalk between nasopharyngeal carcinoma cells and osteoclasts and promotes tumor bone metastasis.
Yang K, Hu Y, Feng Y, Li K, Zhu Z, Liu S, Lin Y, Yu B
J Exp Clin Cancer Res 2024 Feb 12;43(1):46. doi: 10.1186/s13046-024-02970-8. PMID: 38342894Free PMC Article
Refining the 8th edition TNM classification for EBV related nasopharyngeal carcinoma.
Du XJ, Wang GY, Zhu XD, Han YQ, Lei F, Shen LF, Yang KY, Chen L, Mao YP, Tang LL, Li L, Wu Z, Xu GQ, Zhou Q, Huang J, Guo R, Zhang Y, Liu X, Zhou GQ, Li WF, Xu C, Lin L, Chen YP, Chen FP, Liang XY, Chen SY, Li SQ, Cui CY, Li JB, Ren J, Chen MY, Liu LZ, Sun Y, Ma J
Cancer Cell 2024 Mar 11;42(3):464-473.e3. Epub 2024 Jan 18 doi: 10.1016/j.ccell.2023.12.020. PMID: 38242125
Undifferentiated and dedifferentiated head and neck carcinomas.
Franchi A, Skalova A
Semin Diagn Pathol 2021 Nov;38(6):127-136. Epub 2021 Sep 26 doi: 10.1053/j.semdp.2021.09.001. PMID: 34583858
Lymphoepithelial Carcinoma of Salivary Glands.
Thompson LDR, Whaley RD
Surg Pathol Clin 2021 Mar;14(1):75-96. doi: 10.1016/j.path.2020.09.009. PMID: 33526225
Calprotectin and the Initiation and Progression of Head and Neck Cancer.
Argyris PP, Slama ZM, Ross KF, Khammanivong A, Herzberg MC
J Dent Res 2018 Jun;97(6):674-682. Epub 2018 Feb 14 doi: 10.1177/0022034518756330. PMID: 29443623Free PMC Article

Therapy

IGF-1R mediates crosstalk between nasopharyngeal carcinoma cells and osteoclasts and promotes tumor bone metastasis.
Yang K, Hu Y, Feng Y, Li K, Zhu Z, Liu S, Lin Y, Yu B
J Exp Clin Cancer Res 2024 Feb 12;43(1):46. doi: 10.1186/s13046-024-02970-8. PMID: 38342894Free PMC Article
Hyperfractionation compared with standard fractionation in intensity-modulated radiotherapy for patients with locally advanced recurrent nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase 3 trial.
You R, Liu YP, Xie YL, Lin C, Duan CY, Chen DP, Pan Y, Qi B, Zou X, Guo L, Cao JY, Zhang YN, Wang ZQ, Liu YL, Ouyang YF, Wen K, Yang Q, Xie RQ, Li HF, Duan XT, Ding X, Peng L, Chen SY, Liang JL, Feng ZK, Xia TL, Xie RL, Jiang R, Gu CM, Liu RZ, Sun R, Yang X, Liu LZ, Ling L, Liu Q, Ng WT, Hua YJ, Huang PY, Chen MY
Lancet 2023 Mar 18;401(10380):917-927. Epub 2023 Feb 23 doi: 10.1016/S0140-6736(23)00269-6. PMID: 36842439
Radiomics features of ascending and descending nasopharyngeal carcinoma.
Yao J, Yang P, Zhao L, Jin H, Xie X, Yang J, Lou F, Zhang R, Xu Z, Chen C
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Jul 28;45(7):819-826. doi: 10.11817/j.issn.1672-7347.2020.190114. PMID: 32879076
CD137L-DCs, Potent Immune-Stimulators-History, Characteristics, and Perspectives.
Zeng Q, Zhou Y, Schwarz H
Front Immunol 2019;10:2216. Epub 2019 Oct 2 doi: 10.3389/fimmu.2019.02216. PMID: 31632390Free PMC Article
Immunotherapeutic approaches in nasopharyngeal carcinoma.
Chow JC, Ngan RK, Cheung KM, Cho WC
Expert Opin Biol Ther 2019 Nov;19(11):1165-1172. Epub 2019 Aug 13 doi: 10.1080/14712598.2019.1650910. PMID: 31361154

Prognosis

Hyperfractionation compared with standard fractionation in intensity-modulated radiotherapy for patients with locally advanced recurrent nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase 3 trial.
You R, Liu YP, Xie YL, Lin C, Duan CY, Chen DP, Pan Y, Qi B, Zou X, Guo L, Cao JY, Zhang YN, Wang ZQ, Liu YL, Ouyang YF, Wen K, Yang Q, Xie RQ, Li HF, Duan XT, Ding X, Peng L, Chen SY, Liang JL, Feng ZK, Xia TL, Xie RL, Jiang R, Gu CM, Liu RZ, Sun R, Yang X, Liu LZ, Ling L, Liu Q, Ng WT, Hua YJ, Huang PY, Chen MY
Lancet 2023 Mar 18;401(10380):917-927. Epub 2023 Feb 23 doi: 10.1016/S0140-6736(23)00269-6. PMID: 36842439
Epigenetic analysis of cell-free DNA by fragmentomic profiling.
Zhou Q, Kang G, Jiang P, Qiao R, Lam WKJ, Yu SCY, Ma ML, Ji L, Cheng SH, Gai W, Peng W, Shang H, Chan RWY, Chan SL, Wong GLH, Hiraki LT, Volpi S, Wong VWS, Wong J, Chiu RWK, Chan KCA, Lo YMD
Proc Natl Acad Sci U S A 2022 Nov;119(44):e2209852119. Epub 2022 Oct 26 doi: 10.1073/pnas.2209852119. PMID: 36288287Free PMC Article
Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer.
Wang M, Chen X, Tan P, Wang Y, Pan X, Lin T, Jiang Y, Wang B, Xu H, Wang Y, Yang Y, Wang J, Zhao L, Zhang J, Zhong A, Peng Y, Du J, Zhang Q, Zheng J, Chen J, Dai S, Na F, Lu Z, Liu J, Zheng X, Yang L, Zhang P, Han P, Gong Q, Zhong Q, Xiao K, Yang H, Deng H, Zhao Y, Shi H, Man J, Gou M, Zhao C, Dai L, Xue Z, Chen L, Wang Y, Zeng M, Huang C, Wei Q, Wei Y, Liu Y, Chen C
Cancer Cell 2022 Sep 12;40(9):1044-1059.e8. doi: 10.1016/j.ccell.2022.08.010. PMID: 36099882
Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma.
Chen YP, Yin JH, Li WF, Li HJ, Chen DP, Zhang CJ, Lv JW, Wang YQ, Li XM, Li JY, Zhang PP, Li YQ, He QM, Yang XJ, Lei Y, Tang LL, Zhou GQ, Mao YP, Wei C, Xiong KX, Zhang HB, Zhu SD, Hou Y, Sun Y, Dean M, Amit I, Wu K, Kuang DM, Li GB, Liu N, Ma J
Cell Res 2020 Nov;30(11):1024-1042. Epub 2020 Jul 20 doi: 10.1038/s41422-020-0374-x. PMID: 32686767Free PMC Article
Recurrent respiratory papillomatosis: A state-of-the-art review.
Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E
Respir Med 2017 May;126:116-121. Epub 2017 Apr 1 doi: 10.1016/j.rmed.2017.03.030. PMID: 28427542

Clinical prediction guides

ACSL4 promotes ferroptosis and M1 macrophage polarization to regulate the tumorigenesis of nasopharyngeal carcinoma.
Chen P, Wang D, Xiao T, Gu W, Yang H, Yang M, Wang H
Int Immunopharmacol 2023 Sep;122:110629. Epub 2023 Jul 13 doi: 10.1016/j.intimp.2023.110629. PMID: 37451020
Epigenetic analysis of cell-free DNA by fragmentomic profiling.
Zhou Q, Kang G, Jiang P, Qiao R, Lam WKJ, Yu SCY, Ma ML, Ji L, Cheng SH, Gai W, Peng W, Shang H, Chan RWY, Chan SL, Wong GLH, Hiraki LT, Volpi S, Wong VWS, Wong J, Chiu RWK, Chan KCA, Lo YMD
Proc Natl Acad Sci U S A 2022 Nov;119(44):e2209852119. Epub 2022 Oct 26 doi: 10.1073/pnas.2209852119. PMID: 36288287Free PMC Article
PD-1(+)CXCR5(-)CD4(+) Th-CXCL13 cell subset drives B cells into tertiary lymphoid structures of nasopharyngeal carcinoma.
Li JP, Wu CY, Chen MY, Liu SX, Yan SM, Kang YF, Sun C, Grandis JR, Zeng MS, Zhong Q
J Immunother Cancer 2021 Jul;9(7) doi: 10.1136/jitc-2020-002101. PMID: 34253636Free PMC Article
MAPK1/3 kinase-dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasis.
Deng R, Zhang HL, Huang JH, Cai RZ, Wang Y, Chen YH, Hu BX, Ye ZP, Li ZL, Mai J, Huang Y, Li X, Peng XD, Feng GK, Li JD, Tang J, Zhu XF
Autophagy 2021 Oct;17(10):3011-3029. Epub 2020 Dec 7 doi: 10.1080/15548627.2020.1850609. PMID: 33213267Free PMC Article
Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma.
Chen YP, Yin JH, Li WF, Li HJ, Chen DP, Zhang CJ, Lv JW, Wang YQ, Li XM, Li JY, Zhang PP, Li YQ, He QM, Yang XJ, Lei Y, Tang LL, Zhou GQ, Mao YP, Wei C, Xiong KX, Zhang HB, Zhu SD, Hou Y, Sun Y, Dean M, Amit I, Wu K, Kuang DM, Li GB, Liu N, Ma J
Cell Res 2020 Nov;30(11):1024-1042. Epub 2020 Jul 20 doi: 10.1038/s41422-020-0374-x. PMID: 32686767Free PMC Article

Recent systematic reviews

Imaging features, therapies, and outcomes of fibrosing inflammatory pseudotumor of the nasopharynx: A systematic review.
Mishra S, Suh CH, Bergmark RW, Jo VY, Miyawaki EK, Schoenfeld JD, Uppaluri R, Guenette JP
J Neuroimaging 2022 Mar;32(2):223-229. Epub 2021 Dec 8 doi: 10.1111/jon.12953. PMID: 34879175

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