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EBV-Related Malignant Neoplasm

MedGen UID:
234226
•Concept ID:
C1333432
•
Neoplastic Process
Synonyms: EBV Related Malignancy; EBV-Related Malignancy; Epstein-Barr Virus Related Malignancy; Epstein-Barr Virus-Related Malignancy; Epstein-Barr Virus-Related Malignant Neoplasm

Definition

A malignant neoplasm that develops in a patient infected with Epstein-Barr virus (EBV) and in which there is a well-documented association between the malignancy and EBV. Representative examples include EBV-related lymphomas and carcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEBV-Related Malignant Neoplasm

Professional guidelines

PubMed

Genotypes Distribution of Epstein-Barr Virus among Lymphoma Patients in Ethiopia.
Teshome S, Ahmed EH, Zealiyas K, Abubeker A, Tadesse F, Weigel C, Baiocchi RA, Abebe T
Int J Mol Sci 2023 Sep 9;24(18) doi: 10.3390/ijms241813891. PMID: 37762195Free PMC Article
Immunotherapy for the treatment of advanced nasopharyngeal carcinoma: a promising new era.
Wang S, Chen S, Zhong Q, Liu Y
J Cancer Res Clin Oncol 2023 May;149(5):2071-2079. Epub 2022 Jul 25 doi: 10.1007/s00432-022-04214-8. PMID: 35876949
The appropriate use of circulating EBV-DNA in nasopharyngeal carcinoma: Comprehensive clinical practice guidelines evaluation.
Trevisiol C, Gion M, Vaona A, Fabricio ASC, Roca E, Licitra L, Alfieri S, Bossi P
Oral Oncol 2021 Mar;114:105128. Epub 2021 Jan 11 doi: 10.1016/j.oraloncology.2020.105128. PMID: 33444925

Recent clinical studies

Etiology

Revisiting TNM staging for EBV-related nasopharyngeal carcinoma.
Dennis M, Haddad R
Cancer Cell 2024 Mar 11;42(3):333-334. Epub 2024 Feb 22 doi: 10.1016/j.ccell.2024.01.014. PMID: 38402611
Refining the 8th edition TNM classification for EBV related nasopharyngeal carcinoma.
Du XJ, Wang GY, Zhu XD, Han YQ, Lei F, Shen LF, Yang KY, Chen L, Mao YP, Tang LL, Li L, Wu Z, Xu GQ, Zhou Q, Huang J, Guo R, Zhang Y, Liu X, Zhou GQ, Li WF, Xu C, Lin L, Chen YP, Chen FP, Liang XY, Chen SY, Li SQ, Cui CY, Li JB, Ren J, Chen MY, Liu LZ, Sun Y, Ma J
Cancer Cell 2024 Mar 11;42(3):464-473.e3. Epub 2024 Jan 18 doi: 10.1016/j.ccell.2023.12.020. PMID: 38242125
Management of inflammatory bowel disease patients with a cancer history.
Beaugerie L
Curr Drug Targets 2014;15(11):1042-8. doi: 10.2174/1389450115666140821113330. PMID: 25146698
Effect of mycophenolic acid on Epstein-Barr virus infection of human B lymphocytes.
Alfieri C, Allison AC, Kieff E
Antimicrob Agents Chemother 1994 Jan;38(1):126-9. doi: 10.1128/AAC.38.1.126. PMID: 8141564Free PMC Article
Epstein-Barr virus vaccines.
Morgan AJ
Vaccine 1992;10(9):563-71. doi: 10.1016/0264-410x(92)90434-l. PMID: 1323899

Diagnosis

Refining the 8th edition TNM classification for EBV related nasopharyngeal carcinoma.
Du XJ, Wang GY, Zhu XD, Han YQ, Lei F, Shen LF, Yang KY, Chen L, Mao YP, Tang LL, Li L, Wu Z, Xu GQ, Zhou Q, Huang J, Guo R, Zhang Y, Liu X, Zhou GQ, Li WF, Xu C, Lin L, Chen YP, Chen FP, Liang XY, Chen SY, Li SQ, Cui CY, Li JB, Ren J, Chen MY, Liu LZ, Sun Y, Ma J
Cancer Cell 2024 Mar 11;42(3):464-473.e3. Epub 2024 Jan 18 doi: 10.1016/j.ccell.2023.12.020. PMID: 38242125
EBV infection-induced GPX4 promotes chemoresistance and tumor progression in nasopharyngeal carcinoma.
Yuan L, Li S, Chen Q, Xia T, Luo D, Li L, Liu S, Guo S, Liu L, Du C, Jia G, Li X, Lu Z, Yang Z, Liu H, Mai H, Tang L
Cell Death Differ 2022 Aug;29(8):1513-1527. Epub 2022 Feb 1 doi: 10.1038/s41418-022-00939-8. PMID: 35105963Free PMC Article
Haemophagocytic lymphohistiocytosis and Epstein-Barr virus: a complex relationship with diverse origins, expression and outcomes.
El-Mallawany NK, Curry CV, Allen CE
Br J Haematol 2022 Jan;196(1):31-44. Epub 2021 Jun 24 doi: 10.1111/bjh.17638. PMID: 34169507
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
Epstein-Barr virus-associated diffuse large B-cell lymphoma: diagnosis, difficulties and therapeutic options.
Battle-Lopez A, Gonzalez de Villambrosia S, Nuñez J, Cagigal ML, Montes-Moreno S, Conde E, Piris MA
Expert Rev Anticancer Ther 2016;16(4):411-21. Epub 2016 Mar 7 doi: 10.1586/14737140.2016.1149065. PMID: 26838128

Therapy

Estimating the global burden of Epstein-Barr virus-related cancers.
Wong Y, Meehan MT, Burrows SR, Doolan DL, Miles JJ
J Cancer Res Clin Oncol 2022 Jan;148(1):31-46. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03824-y. PMID: 34705104Free PMC Article
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
Novel Therapeutics for Epstein⁻Barr Virus.
Andrei G, Trompet E, Snoeck R
Molecules 2019 Mar 12;24(5) doi: 10.3390/molecules24050997. PMID: 30871092Free PMC Article
The 150 most important questions in cancer research and clinical oncology series: questions 31-39 : Edited by Chinese Journal of Cancer.
Chinese Journal of Cancer
Chin J Cancer 2017 Jun 2;36(1):48. doi: 10.1186/s40880-017-0215-6. PMID: 28571582Free PMC Article
Epstein-Barr virus-associated diffuse large B-cell lymphoma: diagnosis, difficulties and therapeutic options.
Battle-Lopez A, Gonzalez de Villambrosia S, Nuñez J, Cagigal ML, Montes-Moreno S, Conde E, Piris MA
Expert Rev Anticancer Ther 2016;16(4):411-21. Epub 2016 Mar 7 doi: 10.1586/14737140.2016.1149065. PMID: 26838128

Prognosis

Revisiting TNM staging for EBV-related nasopharyngeal carcinoma.
Dennis M, Haddad R
Cancer Cell 2024 Mar 11;42(3):333-334. Epub 2024 Feb 22 doi: 10.1016/j.ccell.2024.01.014. PMID: 38402611
Refining the 8th edition TNM classification for EBV related nasopharyngeal carcinoma.
Du XJ, Wang GY, Zhu XD, Han YQ, Lei F, Shen LF, Yang KY, Chen L, Mao YP, Tang LL, Li L, Wu Z, Xu GQ, Zhou Q, Huang J, Guo R, Zhang Y, Liu X, Zhou GQ, Li WF, Xu C, Lin L, Chen YP, Chen FP, Liang XY, Chen SY, Li SQ, Cui CY, Li JB, Ren J, Chen MY, Liu LZ, Sun Y, Ma J
Cancer Cell 2024 Mar 11;42(3):464-473.e3. Epub 2024 Jan 18 doi: 10.1016/j.ccell.2023.12.020. PMID: 38242125
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
The 150 most important questions in cancer research and clinical oncology series: questions 31-39 : Edited by Chinese Journal of Cancer.
Chinese Journal of Cancer
Chin J Cancer 2017 Jun 2;36(1):48. doi: 10.1186/s40880-017-0215-6. PMID: 28571582Free PMC Article
Epstein-Barr virus-associated diffuse large B-cell lymphoma: diagnosis, difficulties and therapeutic options.
Battle-Lopez A, Gonzalez de Villambrosia S, Nuñez J, Cagigal ML, Montes-Moreno S, Conde E, Piris MA
Expert Rev Anticancer Ther 2016;16(4):411-21. Epub 2016 Mar 7 doi: 10.1586/14737140.2016.1149065. PMID: 26838128

Clinical prediction guides

Clinical efficacy and biomarker analysis of dual PD-1/CTLA-4 blockade in recurrent/metastatic EBV-associated nasopharyngeal carcinoma.
Lim DW, Kao HF, Suteja L, Li CH, Quah HS, Tan DS, Tan SH, Tan EH, Tan WL, Lee JN, Wee FY, Jain A, Goh BC, Chua MLK, Liao BC, Ng QS, Hong RL, Ang MK, Yeong JP, Iyer NG
Nat Commun 2023 May 15;14(1):2781. doi: 10.1038/s41467-023-38407-7. PMID: 37188668Free PMC Article
Estimating the global burden of Epstein-Barr virus-related cancers.
Wong Y, Meehan MT, Burrows SR, Doolan DL, Miles JJ
J Cancer Res Clin Oncol 2022 Jan;148(1):31-46. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03824-y. PMID: 34705104Free PMC Article
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
Spontaneous Regression of Pulmonary Nodules Presenting as Epstein-Barr Virus-related Atypical Infectious Mononucleosis.
Shinozuka J, Awaguni H, Tanaka S, Makino S, Maruyama R, Inaba T, Imashuku S
J Pediatr Hematol Oncol 2016 Jul;38(5):e162-5. doi: 10.1097/MPH.0000000000000562. PMID: 27123664
Epstein-Barr virus-associated diffuse large B-cell lymphoma: diagnosis, difficulties and therapeutic options.
Battle-Lopez A, Gonzalez de Villambrosia S, Nuñez J, Cagigal ML, Montes-Moreno S, Conde E, Piris MA
Expert Rev Anticancer Ther 2016;16(4):411-21. Epub 2016 Mar 7 doi: 10.1586/14737140.2016.1149065. PMID: 26838128

Recent systematic reviews

EBV Positivity and Programmed Death-ligand 1 Expression in Diffuse Large B-cell Lymphoma: A Systematic Review.
Barzyk GA, Sheriff V
Anticancer Res 2020 Nov;40(11):5951-5968. doi: 10.21873/anticanres.14616. PMID: 33109533

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