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EBV-Related Malignant Neoplasm

MedGen UID:
234226
•Concept ID:
C1333432
•
Neoplastic Process
Synonyms: EBV Related Malignancy; EBV-Related Malignancy; Epstein-Barr Virus Related Malignancy; Epstein-Barr Virus-Related Malignancy; Epstein-Barr Virus-Related Malignant Neoplasm

Definition

A malignant neoplasm that develops in a patient infected with Epstein-Barr virus (EBV) and in which there is a well-documented association between the malignancy and EBV. Representative examples include EBV-related lymphomas and carcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEBV-Related Malignant Neoplasm

Professional guidelines

PubMed

Utility of clinical metagenomics in diagnosing malignancies in a cohort of patients with Epstein-Barr virus positivity.
Song J, Zhu K, Wang X, Yang Q, Yu S, Zhang Y, Fu Z, Wang H, Zhao Y, Lin K, Yuan G, Guo J, Shi Y, Liu C, Ai J, Zhang H, Zhang W
Front Cell Infect Microbiol 2023;13:1211732. Epub 2023 Aug 22 doi: 10.3389/fcimb.2023.1211732. PMID: 37674580Free PMC Article
Immunotherapy for the treatment of advanced nasopharyngeal carcinoma: a promising new era.
Wang S, Chen S, Zhong Q, Liu Y
J Cancer Res Clin Oncol 2023 May;149(5):2071-2079. Epub 2022 Jul 25 doi: 10.1007/s00432-022-04214-8. PMID: 35876949
Current Treatment Options for Older Patients with Hodgkin Lymphoma.
Carter J, David KA, Kritharis A, Evens AM
Curr Treat Options Oncol 2020 Apr 23;21(5):42. doi: 10.1007/s11864-020-00745-9. PMID: 32328822

Recent clinical studies

Etiology

Revisiting TNM staging for EBV-related nasopharyngeal carcinoma.
Dennis M, Haddad R
Cancer Cell 2024 Mar 11;42(3):333-334. Epub 2024 Feb 22 doi: 10.1016/j.ccell.2024.01.014. PMID: 38402611
Refining the 8th edition TNM classification for EBV related nasopharyngeal carcinoma.
Du XJ, Wang GY, Zhu XD, Han YQ, Lei F, Shen LF, Yang KY, Chen L, Mao YP, Tang LL, Li L, Wu Z, Xu GQ, Zhou Q, Huang J, Guo R, Zhang Y, Liu X, Zhou GQ, Li WF, Xu C, Lin L, Chen YP, Chen FP, Liang XY, Chen SY, Li SQ, Cui CY, Li JB, Ren J, Chen MY, Liu LZ, Sun Y, Ma J
Cancer Cell 2024 Mar 11;42(3):464-473.e3. Epub 2024 Jan 18 doi: 10.1016/j.ccell.2023.12.020. PMID: 38242125
Integrated genetic analyses of immunodeficiency-associated Epstein-Barr virus- (EBV) positive primary CNS lymphomas.
Kaulen LD, Denisova E, Hinz F, Hai L, Friedel D, Henegariu O, Hoffmann DC, Ito J, Kourtesakis A, Lehnert P, Doubrovinskaia S, Karschnia P, von Baumgarten L, Kessler T, Baehring JM, Brors B, Sahm F, Wick W
Acta Neuropathol 2023 Sep;146(3):499-514. Epub 2023 Jul 26 doi: 10.1007/s00401-023-02613-w. PMID: 37495858Free PMC Article
What we should know about natural killer/T-cell lymphomas.
Xiong J, Zhao W
Hematol Oncol 2019 Jun;37 Suppl 1:75-81. doi: 10.1002/hon.2588. PMID: 31187536
EBV-Related Malignancies, Outcomes and Novel Prevention Strategies.
Ozoya OO, Sokol L, Dalia S
Infect Disord Drug Targets 2016;16(1):4-21. doi: 10.2174/1871526516666160407113536. PMID: 27052336

Diagnosis

Refining the 8th edition TNM classification for EBV related nasopharyngeal carcinoma.
Du XJ, Wang GY, Zhu XD, Han YQ, Lei F, Shen LF, Yang KY, Chen L, Mao YP, Tang LL, Li L, Wu Z, Xu GQ, Zhou Q, Huang J, Guo R, Zhang Y, Liu X, Zhou GQ, Li WF, Xu C, Lin L, Chen YP, Chen FP, Liang XY, Chen SY, Li SQ, Cui CY, Li JB, Ren J, Chen MY, Liu LZ, Sun Y, Ma J
Cancer Cell 2024 Mar 11;42(3):464-473.e3. Epub 2024 Jan 18 doi: 10.1016/j.ccell.2023.12.020. PMID: 38242125
EBV infection-induced GPX4 promotes chemoresistance and tumor progression in nasopharyngeal carcinoma.
Yuan L, Li S, Chen Q, Xia T, Luo D, Li L, Liu S, Guo S, Liu L, Du C, Jia G, Li X, Lu Z, Yang Z, Liu H, Mai H, Tang L
Cell Death Differ 2022 Aug;29(8):1513-1527. Epub 2022 Feb 1 doi: 10.1038/s41418-022-00939-8. PMID: 35105963Free PMC Article
Haemophagocytic lymphohistiocytosis and Epstein-Barr virus: a complex relationship with diverse origins, expression and outcomes.
El-Mallawany NK, Curry CV, Allen CE
Br J Haematol 2022 Jan;196(1):31-44. Epub 2021 Jun 24 doi: 10.1111/bjh.17638. PMID: 34169507
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
Angiocentric and intravascular lymphomas.
Tomasini D, Berti E
G Ital Dermatol Venereol 2015 Feb;150(1):95-113. Epub 2014 Dec 22 PMID: 25531150

Therapy

Clinical efficacy and biomarker analysis of dual PD-1/CTLA-4 blockade in recurrent/metastatic EBV-associated nasopharyngeal carcinoma.
Lim DW, Kao HF, Suteja L, Li CH, Quah HS, Tan DS, Tan SH, Tan EH, Tan WL, Lee JN, Wee FY, Jain A, Goh BC, Chua MLK, Liao BC, Ng QS, Hong RL, Ang MK, Yeong JP, Iyer NG
Nat Commun 2023 May 15;14(1):2781. doi: 10.1038/s41467-023-38407-7. PMID: 37188668Free PMC Article
Estimating the global burden of Epstein-Barr virus-related cancers.
Wong Y, Meehan MT, Burrows SR, Doolan DL, Miles JJ
J Cancer Res Clin Oncol 2022 Jan;148(1):31-46. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03824-y. PMID: 34705104Free PMC Article
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
NK/T-cell lymphomas.
Tse E, Kwong YL
Best Pract Res Clin Haematol 2019 Sep;32(3):253-261. Epub 2019 Jun 12 doi: 10.1016/j.beha.2019.06.005. PMID: 31585625
Novel Therapeutics for Epstein⁻Barr Virus.
Andrei G, Trompet E, Snoeck R
Molecules 2019 Mar 12;24(5) doi: 10.3390/molecules24050997. PMID: 30871092Free PMC Article

Prognosis

Single-cell and spatial transcriptome analyses reveal tertiary lymphoid structures linked to tumour progression and immunotherapy response in nasopharyngeal carcinoma.
Liu Y, Ye SY, He S, Chi DM, Wang XZ, Wen YF, Ma D, Nie RC, Xiang P, Zhou Y, Ruan ZH, Peng RJ, Luo CL, Wei PP, Lin GW, Zheng J, Cui Q, Cai MY, Yun JP, Dong J, Mai HQ, Xia X, Bei JX
Nat Commun 2024 Sep 4;15(1):7713. doi: 10.1038/s41467-024-52153-4. PMID: 39231979Free PMC Article
Refining the 8th edition TNM classification for EBV related nasopharyngeal carcinoma.
Du XJ, Wang GY, Zhu XD, Han YQ, Lei F, Shen LF, Yang KY, Chen L, Mao YP, Tang LL, Li L, Wu Z, Xu GQ, Zhou Q, Huang J, Guo R, Zhang Y, Liu X, Zhou GQ, Li WF, Xu C, Lin L, Chen YP, Chen FP, Liang XY, Chen SY, Li SQ, Cui CY, Li JB, Ren J, Chen MY, Liu LZ, Sun Y, Ma J
Cancer Cell 2024 Mar 11;42(3):464-473.e3. Epub 2024 Jan 18 doi: 10.1016/j.ccell.2023.12.020. PMID: 38242125
Clinical efficacy and biomarker analysis of dual PD-1/CTLA-4 blockade in recurrent/metastatic EBV-associated nasopharyngeal carcinoma.
Lim DW, Kao HF, Suteja L, Li CH, Quah HS, Tan DS, Tan SH, Tan EH, Tan WL, Lee JN, Wee FY, Jain A, Goh BC, Chua MLK, Liao BC, Ng QS, Hong RL, Ang MK, Yeong JP, Iyer NG
Nat Commun 2023 May 15;14(1):2781. doi: 10.1038/s41467-023-38407-7. PMID: 37188668Free PMC Article
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
EBV-Related Malignancies, Outcomes and Novel Prevention Strategies.
Ozoya OO, Sokol L, Dalia S
Infect Disord Drug Targets 2016;16(1):4-21. doi: 10.2174/1871526516666160407113536. PMID: 27052336

Clinical prediction guides

Integrated genetic analyses of immunodeficiency-associated Epstein-Barr virus- (EBV) positive primary CNS lymphomas.
Kaulen LD, Denisova E, Hinz F, Hai L, Friedel D, Henegariu O, Hoffmann DC, Ito J, Kourtesakis A, Lehnert P, Doubrovinskaia S, Karschnia P, von Baumgarten L, Kessler T, Baehring JM, Brors B, Sahm F, Wick W
Acta Neuropathol 2023 Sep;146(3):499-514. Epub 2023 Jul 26 doi: 10.1007/s00401-023-02613-w. PMID: 37495858Free PMC Article
Clinical efficacy and biomarker analysis of dual PD-1/CTLA-4 blockade in recurrent/metastatic EBV-associated nasopharyngeal carcinoma.
Lim DW, Kao HF, Suteja L, Li CH, Quah HS, Tan DS, Tan SH, Tan EH, Tan WL, Lee JN, Wee FY, Jain A, Goh BC, Chua MLK, Liao BC, Ng QS, Hong RL, Ang MK, Yeong JP, Iyer NG
Nat Commun 2023 May 15;14(1):2781. doi: 10.1038/s41467-023-38407-7. PMID: 37188668Free PMC Article
Estimating the global burden of Epstein-Barr virus-related cancers.
Wong Y, Meehan MT, Burrows SR, Doolan DL, Miles JJ
J Cancer Res Clin Oncol 2022 Jan;148(1):31-46. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03824-y. PMID: 34705104Free PMC Article
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
What we should know about natural killer/T-cell lymphomas.
Xiong J, Zhao W
Hematol Oncol 2019 Jun;37 Suppl 1:75-81. doi: 10.1002/hon.2588. PMID: 31187536

Recent systematic reviews

EBV Positivity and Programmed Death-ligand 1 Expression in Diffuse Large B-cell Lymphoma: A Systematic Review.
Barzyk GA, Sheriff V
Anticancer Res 2020 Nov;40(11):5951-5968. doi: 10.21873/anticanres.14616. PMID: 33109533

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