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Non-functioning adrenal cortex adenoma

MedGen UID:
313501
•Concept ID:
C1709240
•
Neoplastic Process
Synonyms: adrenal cortex non-functioning endocrine neoplasm; Adrenal Cortical Incidentaloma; adrenal cortical incidentaloma; Non-Functioning Adrenal Cortex Adenoma; non-functioning adrenal cortex adenoma; Non-Functioning Adrenal Cortical Adenoma; non-functioning adrenal cortical adenoma; Non-Functioning Adrenal Gland Adenoma; non-functioning endocrine neoplasm of adrenal cortex; Nonfunctional Adrenal Cortex Adenoma; nonfunctional adrenal cortex adenoma; Nonfunctioning Adrenal Cortex Adenoma
 
Monarch Initiative: MONDO:0006321

Definition

An adenoma of the adrenal cortex characterized by the absence of a hormonal syndrome or symptoms suggestive of adrenal disease. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-functioning adrenal cortex adenoma

Professional guidelines

PubMed

Mild autonomous cortisol secretion: pathophysiology, comorbidities and management approaches.
Prete A, Bancos I
Nat Rev Endocrinol 2024 Aug;20(8):460-473. Epub 2024 Apr 22 doi: 10.1038/s41574-024-00984-y. PMID: 38649778
Adrenal venous sampling for primary aldosteronism: laboratory medicine best practice.
Kline G, Holmes DT
J Clin Pathol 2017 Nov;70(11):911-916. Epub 2017 Sep 11 doi: 10.1136/jclinpath-2017-204423. PMID: 28893861
Recommendations for the management of adrenal incidentalomas: what is pertinent for radiologists?
Sahdev A
Br J Radiol 2017 Apr;90(1072):20160627. Epub 2017 Feb 9 doi: 10.1259/bjr.20160627. PMID: 28181818Free PMC Article

Recent clinical studies

Etiology

Clinical Characteristics and Long-Term Outcomes of Adrenal Tumors in Children and Adolescents.
Kim JH, Choi Y, Hwang S, Yoon JH, Kim GH, Yoo HW, Choi JH
Exp Clin Endocrinol Diabetes 2023 Oct;131(10):515-522. Epub 2023 Jul 12 doi: 10.1055/a-2127-9292. PMID: 37437600
Heterogeneous circulating miRNA profiles of PBMAH.
Hara K, Murakami M, Niitsu Y, Takeuchi A, Horino M, Shiba K, Tsujimoto K, Komiya C, Ikeda K, Tsuiki M, Tanabe A, Tanaka T, Yokoyama M, Fujii Y, Naruse M, Yamada T
Front Endocrinol (Lausanne) 2022;13:1073328. Epub 2022 Dec 13 doi: 10.3389/fendo.2022.1073328. PMID: 36583003Free PMC Article
ATP1A1 Mutant in Aldosterone-Producing Adenoma Leads to Cell Proliferation.
Kobuke K, Oki K, Gomez-Sanchez CE, Gomez-Sanchez EP, Itcho K, Ohno H, Nagano G, Yoshii Y, Baba R, Kodama T, Arihiro K, Hattori N, Yoneda M
Int J Mol Sci 2021 Oct 12;22(20) doi: 10.3390/ijms222010981. PMID: 34681640Free PMC Article
Genomic classification of benign adrenocortical lesions.
Faillot S, Foulonneau T, Néou M, Espiard S, Garinet S, Vaczlavik A, Jouinot A, Rondof W, Septier A, Drougat L, Hécale-Perlemoine K, Ragazzon B, Rizk-Rabin M, Sibony M, Bonnet-Serrano F, Guibourdenche J, Libé R, Groussin L, Dousset B, de Reyniès A, Bertherat J, Assié G
Endocr Relat Cancer 2021 Jan;28(1):79-95. doi: 10.1530/ERC-20-0128. PMID: 33151900
Adrenal incidentaloma: a diagnostic challenge.
Anagnostis P, Karagiannis A, Tziomalos K, Kakafika AI, Athyros VG, Mikhailidis DP
Hormones (Athens) 2009 Jul-Sep;8(3):163-84. doi: 10.14310/horm.2002.1233. PMID: 19671516

Diagnosis

Mild autonomous cortisol secretion: pathophysiology, comorbidities and management approaches.
Prete A, Bancos I
Nat Rev Endocrinol 2024 Aug;20(8):460-473. Epub 2024 Apr 22 doi: 10.1038/s41574-024-00984-y. PMID: 38649778
Clinical Characteristics and Long-Term Outcomes of Adrenal Tumors in Children and Adolescents.
Kim JH, Choi Y, Hwang S, Yoon JH, Kim GH, Yoo HW, Choi JH
Exp Clin Endocrinol Diabetes 2023 Oct;131(10):515-522. Epub 2023 Jul 12 doi: 10.1055/a-2127-9292. PMID: 37437600
Heterogeneous circulating miRNA profiles of PBMAH.
Hara K, Murakami M, Niitsu Y, Takeuchi A, Horino M, Shiba K, Tsujimoto K, Komiya C, Ikeda K, Tsuiki M, Tanabe A, Tanaka T, Yokoyama M, Fujii Y, Naruse M, Yamada T
Front Endocrinol (Lausanne) 2022;13:1073328. Epub 2022 Dec 13 doi: 10.3389/fendo.2022.1073328. PMID: 36583003Free PMC Article
Assessment of mild autonomous cortisol secretion among incidentally discovered adrenal masses.
Yozamp N, Vaidya A
Best Pract Res Clin Endocrinol Metab 2021 Jan;35(1):101491. Epub 2021 Feb 6 doi: 10.1016/j.beem.2021.101491. PMID: 33593680
Adrenal incidentaloma: a diagnostic challenge.
Anagnostis P, Karagiannis A, Tziomalos K, Kakafika AI, Athyros VG, Mikhailidis DP
Hormones (Athens) 2009 Jul-Sep;8(3):163-84. doi: 10.14310/horm.2002.1233. PMID: 19671516

Therapy

Using CT radiomic features based on machine learning models to subtype adrenal adenoma.
Qi S, Zuo Y, Chang R, Huang K, Liu J, Zhang Z
BMC Cancer 2023 Jan 31;23(1):111. doi: 10.1186/s12885-023-10562-6. PMID: 36721273Free PMC Article
Impact of Adrenalectomy on Morbidity in Patients with Non-Functioning Adrenal Cortical Tumours, Mild Hypercortisolism and Cushing's Syndrome as Assessed by National and Quality Registries.
Thompson LH, Ranstam J, Almquist M, Nordenström E, Bergenfelz A
World J Surg 2021 Oct;45(10):3099-3107. Epub 2021 Jun 27 doi: 10.1007/s00268-021-06214-0. PMID: 34180008Free PMC Article
Assessment of mild autonomous cortisol secretion among incidentally discovered adrenal masses.
Yozamp N, Vaidya A
Best Pract Res Clin Endocrinol Metab 2021 Jan;35(1):101491. Epub 2021 Feb 6 doi: 10.1016/j.beem.2021.101491. PMID: 33593680
Incidentaloma: from general practice to specific endocrine frame.
Gheorghisan-Galateanu AA, Carsote M, Valea A
J Pak Med Assoc 2017 Jun;67(6):917-922. PMID: 28585593
Non-functioning pituitary adenomas: endocrinological and clinical outcome after transsphenoidal and transcranial surgery.
Wichers-Rother M, Hoven S, Kristof RA, Bliesener N, Stoffel-Wagner B
Exp Clin Endocrinol Diabetes 2004 Jun;112(6):323-7. doi: 10.1055/s-2004-820914. PMID: 15216450

Prognosis

A novel model using leukocytes to differentiating mild autonomous cortisol secretion and non-functioning adrenal adenoma.
Zhao X, Zhou J, Lyu X, Li Y, Ma L, Liu Y, Fan H, Zhang Y
Sci Rep 2024 Oct 9;14(1):23557. doi: 10.1038/s41598-024-74452-y. PMID: 39384846Free PMC Article
Using CT radiomic features based on machine learning models to subtype adrenal adenoma.
Qi S, Zuo Y, Chang R, Huang K, Liu J, Zhang Z
BMC Cancer 2023 Jan 31;23(1):111. doi: 10.1186/s12885-023-10562-6. PMID: 36721273Free PMC Article
Surgical Outcomes of Aldosterone-Producing Adenoma on the Basis of the Histopathological Findings.
Wang H, Wang F, Zhang Y, Wen J, Dong D, Chang X, Sun H, Ma X, Cui Y, Chen S, Lu L, Ren W, Tong A, Li Y
Front Endocrinol (Lausanne) 2021;12:663096. Epub 2021 Sep 6 doi: 10.3389/fendo.2021.663096. PMID: 34552553Free PMC Article
Angiogenesis and Lymphangiogenesis in the Adrenocortical Tumors.
Pereira SS, Costa MM, Guerreiro SG, Monteiro MP, Pignatelli D
Pathol Oncol Res 2018 Jul;24(3):689-693. Epub 2017 Jul 10 doi: 10.1007/s12253-017-0259-6. PMID: 28695321
Adrenal venous sampling for primary aldosteronism: laboratory medicine best practice.
Kline G, Holmes DT
J Clin Pathol 2017 Nov;70(11):911-916. Epub 2017 Sep 11 doi: 10.1136/jclinpath-2017-204423. PMID: 28893861

Clinical prediction guides

High prevalence of frailty in patients with adrenal adenomas and adrenocortical hormone excess: a cross-sectional multi-centre study with prospective enrolment.
Dogra P, Šambula L, Saini J, Thangamuthu K, Athimulam S, Delivanis DA, Baikousi DA, Nathani R, Zhang CD, Genere N, Salman Z, Turcu AF, Ambroziak U, Garcia RG, Achenbach SJ, Atkinson EJ, Singh S, LeBrasseur NK, Kastelan D, Bancos I
Eur J Endocrinol 2023 Sep 1;189(3):318-326. doi: 10.1093/ejendo/lvad113. PMID: 37590964Free PMC Article
Surgical Outcomes of Aldosterone-Producing Adenoma on the Basis of the Histopathological Findings.
Wang H, Wang F, Zhang Y, Wen J, Dong D, Chang X, Sun H, Ma X, Cui Y, Chen S, Lu L, Ren W, Tong A, Li Y
Front Endocrinol (Lausanne) 2021;12:663096. Epub 2021 Sep 6 doi: 10.3389/fendo.2021.663096. PMID: 34552553Free PMC Article
Does IGF-1 play a role in the etiopathogenesis of non-functioning adrenocortical adenoma?
Bahadir CT, Ecemis GC, Atmaca H
J Endocrinol Invest 2018 Nov;41(11):1317-1323. Epub 2018 Mar 14 doi: 10.1007/s40618-018-0869-1. PMID: 29542030
Analysis of circulating extracellular vesicle-associated microRNAs in cortisol-producing adrenocortical tumors.
Perge P, Decmann Á, Pezzani R, Bancos I, Fassina A, Luconi M, Canu L, Tóth M, Boscaro M, Patócs A, Igaz P
Endocrine 2018 Feb;59(2):280-287. Epub 2018 Jan 3 doi: 10.1007/s12020-017-1506-z. PMID: 29299796
Adrenal venous sampling for primary aldosteronism: laboratory medicine best practice.
Kline G, Holmes DT
J Clin Pathol 2017 Nov;70(11):911-916. Epub 2017 Sep 11 doi: 10.1136/jclinpath-2017-204423. PMID: 28893861

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