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Skin adenosquamous carcinoma

MedGen UID:
313707
•Concept ID:
C1710103
•
Neoplastic Process
Synonyms: skin adenosquamous cancer; Skin Adenosquamous Carcinoma; skin adenosquamous carcinoma
 
Monarch Initiative: MONDO:0056818

Definition

An uncommon carcinoma that arises from the skin. It is characterized by the presence of malignant glandular and malignant squamous cellular components. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin adenosquamous carcinoma

Professional guidelines

PubMed

Long-term treatment outcomes/toxicities of definite chemoradiotherapy (intensity-modulated radiation therapy) for early-stage "bulky" cervical cancer and survival impact of histological subtype.
Hsieh HY, Lu CH, Wang L
J Formos Med Assoc 2023 Mar;122(3):221-229. Epub 2022 Nov 12 doi: 10.1016/j.jfma.2022.10.012. PMID: 36379808

Recent clinical studies

Etiology

CDX2 expression in primary skin tumors-case series and review of the literature.
Tekin B, Kundert P, Yang HH, Guo R
Hum Pathol 2022 Nov;129:1-10. Epub 2022 Aug 1 doi: 10.1016/j.humpath.2022.07.013. PMID: 35926811
Survival with Cemiplimab in Recurrent Cervical Cancer.
Tewari KS, Monk BJ, Vergote I, Miller A, de Melo AC, Kim HS, Kim YM, Lisyanskaya A, Samouëlian V, Lorusso D, Damian F, Chang CL, Gotovkin EA, Takahashi S, Ramone D, Pikiel J, Maćkowiak-Matejczyk B, Guerra Alía EM, Colombo N, Makarova Y, Rischin D, Lheureux S, Hasegawa K, Fujiwara K, Li J, Jamil S, Jankovic V, Chen CI, Seebach F, Weinreich DM, Yancopoulos GD, Lowy I, Mathias M, Fury MG, Oaknin A; Investigators for GOG Protocol 3016 and ENGOT Protocol En-Cx9
N Engl J Med 2022 Feb 10;386(6):544-555. doi: 10.1056/NEJMoa2112187. PMID: 35139273
High-risk cutaneous squamous cell carcinoma.
Nuño-González A, Vicente-Martín FJ, Pinedo-Moraleda F, López-Estebaranz JL
Actas Dermosifiliogr 2012 Sep;103(7):567-78. Epub 2012 Jan 17 doi: 10.1016/j.ad.2011.09.005. PMID: 22261673
Squamous cell carcinoma of the skin.
Rudolph R, Zelac DE
Plast Reconstr Surg 2004 Nov;114(6):82e-94e. doi: 10.1097/01.prs.0000138243.45735.8a. PMID: 15509920
Squamous cell cancer: a practical approach.
Goldman GD
Semin Cutan Med Surg 1998 Jun;17(2):80-95. doi: 10.1016/s1085-5629(98)80002-3. PMID: 9669602

Diagnosis

Tumour 63 protein (p63) in breast pathology: biology, immunohistochemistry, diagnostic applications, and pitfalls.
Alkhayyat R, Abbas A, Quinn CM, Rakha EA
Histopathology 2024 Apr;84(5):723-741. Epub 2023 Nov 27 doi: 10.1111/his.15101. PMID: 38012539
CDX2 expression in primary skin tumors-case series and review of the literature.
Tekin B, Kundert P, Yang HH, Guo R
Hum Pathol 2022 Nov;129:1-10. Epub 2022 Aug 1 doi: 10.1016/j.humpath.2022.07.013. PMID: 35926811
Intestinal adenosquamous carcinoma with a synchronous skin metastasis: a immunohistochemical and molecular analysis.
Parente P, Covelli C, Parrella P, Latiano TP, Fiordelisi F, Pellico MT, Maiello E, Graziano P
Int J Colorectal Dis 2020 Feb;35(2):337-341. Epub 2019 Dec 10 doi: 10.1007/s00384-019-03464-2. PMID: 31823050
Squamous cell carcinoma of the skin.
Rudolph R, Zelac DE
Plast Reconstr Surg 2004 Nov;114(6):82e-94e. doi: 10.1097/01.prs.0000138243.45735.8a. PMID: 15509920
Squamous cell cancer: a practical approach.
Goldman GD
Semin Cutan Med Surg 1998 Jun;17(2):80-95. doi: 10.1016/s1085-5629(98)80002-3. PMID: 9669602

Therapy

Survival with Cemiplimab in Recurrent Cervical Cancer.
Tewari KS, Monk BJ, Vergote I, Miller A, de Melo AC, Kim HS, Kim YM, Lisyanskaya A, Samouëlian V, Lorusso D, Damian F, Chang CL, Gotovkin EA, Takahashi S, Ramone D, Pikiel J, Maćkowiak-Matejczyk B, Guerra Alía EM, Colombo N, Makarova Y, Rischin D, Lheureux S, Hasegawa K, Fujiwara K, Li J, Jamil S, Jankovic V, Chen CI, Seebach F, Weinreich DM, Yancopoulos GD, Lowy I, Mathias M, Fury MG, Oaknin A; Investigators for GOG Protocol 3016 and ENGOT Protocol En-Cx9
N Engl J Med 2022 Feb 10;386(6):544-555. doi: 10.1056/NEJMoa2112187. PMID: 35139273
A phase II trial of erlotinib monotherapy in pretreated patients with advanced non-small cell lung cancer who do not possess active EGFR mutations: Okayama Lung Cancer Study Group trial 0705.
Yoshioka H, Hotta K, Kiura K, Takigawa N, Hayashi H, Harita S, Kuyama S, Segawa Y, Kamei H, Umemura S, Bessho A, Tabata M, Tanimoto M; Okayama Lung Cancer Study Group
J Thorac Oncol 2010 Jan;5(1):99-104. doi: 10.1097/JTO.0b013e3181c20063. PMID: 19898258
Squamous cell carcinoma of the skin.
Rudolph R, Zelac DE
Plast Reconstr Surg 2004 Nov;114(6):82e-94e. doi: 10.1097/01.prs.0000138243.45735.8a. PMID: 15509920
Port-site metastasis following laparoscopic lymphadenectomy for adenosquamous carcinoma of the cervix.
Lane G, Tay J
Gynecol Oncol 1999 Jul;74(1):130-3. doi: 10.1006/gyno.1999.5379. PMID: 10385565
Randomised study of immunotherapy with OK-432 in uterine cervical carcinoma.
Kikkawa F, Kawai M, Oguchi H, Kojima M, Ishikawa H, Iwata M, Maeda O, Tomoda Y, Arii Y, Kuzuya K
Eur J Cancer 1993;29A(11):1542-6. doi: 10.1016/0959-8049(93)90291-m. PMID: 8217359

Prognosis

Survival with Cemiplimab in Recurrent Cervical Cancer.
Tewari KS, Monk BJ, Vergote I, Miller A, de Melo AC, Kim HS, Kim YM, Lisyanskaya A, Samouëlian V, Lorusso D, Damian F, Chang CL, Gotovkin EA, Takahashi S, Ramone D, Pikiel J, Maćkowiak-Matejczyk B, Guerra Alía EM, Colombo N, Makarova Y, Rischin D, Lheureux S, Hasegawa K, Fujiwara K, Li J, Jamil S, Jankovic V, Chen CI, Seebach F, Weinreich DM, Yancopoulos GD, Lowy I, Mathias M, Fury MG, Oaknin A; Investigators for GOG Protocol 3016 and ENGOT Protocol En-Cx9
N Engl J Med 2022 Feb 10;386(6):544-555. doi: 10.1056/NEJMoa2112187. PMID: 35139273
Intestinal adenosquamous carcinoma with a synchronous skin metastasis: a immunohistochemical and molecular analysis.
Parente P, Covelli C, Parrella P, Latiano TP, Fiordelisi F, Pellico MT, Maiello E, Graziano P
Int J Colorectal Dis 2020 Feb;35(2):337-341. Epub 2019 Dec 10 doi: 10.1007/s00384-019-03464-2. PMID: 31823050
High-risk cutaneous squamous cell carcinoma.
Nuño-González A, Vicente-Martín FJ, Pinedo-Moraleda F, López-Estebaranz JL
Actas Dermosifiliogr 2012 Sep;103(7):567-78. Epub 2012 Jan 17 doi: 10.1016/j.ad.2011.09.005. PMID: 22261673
Squamous cell carcinoma of the skin.
Rudolph R, Zelac DE
Plast Reconstr Surg 2004 Nov;114(6):82e-94e. doi: 10.1097/01.prs.0000138243.45735.8a. PMID: 15509920
Squamous cell cancer: a practical approach.
Goldman GD
Semin Cutan Med Surg 1998 Jun;17(2):80-95. doi: 10.1016/s1085-5629(98)80002-3. PMID: 9669602

Clinical prediction guides

CDX2 expression in primary skin tumors-case series and review of the literature.
Tekin B, Kundert P, Yang HH, Guo R
Hum Pathol 2022 Nov;129:1-10. Epub 2022 Aug 1 doi: 10.1016/j.humpath.2022.07.013. PMID: 35926811
Intestinal adenosquamous carcinoma with a synchronous skin metastasis: a immunohistochemical and molecular analysis.
Parente P, Covelli C, Parrella P, Latiano TP, Fiordelisi F, Pellico MT, Maiello E, Graziano P
Int J Colorectal Dis 2020 Feb;35(2):337-341. Epub 2019 Dec 10 doi: 10.1007/s00384-019-03464-2. PMID: 31823050
Keloidal-like local recurrence after infiltrating adenosquamous breast carcinoma with stromal-overgrowth mimicking a benign skin lesion.
Stolnicu S, Giurgi A, Naznean A, Podoleanu C, Chiriac A
Pol J Pathol 2018;69(1):93-97. doi: 10.5114/pjp.2018.75343. PMID: 29895133
Adenosquamous carcinoma of the skin: a case series.
Fu JM, McCalmont T, Yu SS
Arch Dermatol 2009 Oct;145(10):1152-8. doi: 10.1001/archdermatol.2009.218. PMID: 19841403
Squamous cell carcinoma of the skin.
Rudolph R, Zelac DE
Plast Reconstr Surg 2004 Nov;114(6):82e-94e. doi: 10.1097/01.prs.0000138243.45735.8a. PMID: 15509920

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