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Thyroid Gland Mucinous Follicular Adenoma

MedGen UID:
313778
•Concept ID:
C1710415
•
Neoplastic Process

Definition

A thyroid gland adenoma composed of follicles and characterized by the presence of abundant extracellular mucin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Mucinous Follicular Adenoma

Professional guidelines

PubMed

In vivo radioiodide imaging and treatment of breast cancer xenografts after MUC1-driven expression of the sodium iodide symporter.
Dwyer RM, Bergert ER, O'connor MK, Gendler SJ, Morris JC
Clin Cancer Res 2005 Feb 15;11(4):1483-9. doi: 10.1158/1078-0432.CCR-04-1636. PMID: 15746050

Recent clinical studies

Etiology

Clinicopathological observation of mature teratoma with malignant transformation, a single center retrospective study.
Yuan Y, Li H, Yang H
Indian J Pathol Microbiol 2022 Apr-Jun;65(2):369-373. doi: 10.4103/IJPM.IJPM_828_20. PMID: 35435373
Epidemiology of Second Primary Tumors in Women With Ovarian Cancer.
Kanninen TT, Nasioudis D, Sisti G, Holcomb K, Di Tommaso M, Khalil S, Gojayev A, Witkin SS
Int J Gynecol Cancer 2017 May;27(4):659-667. doi: 10.1097/IGC.0000000000000950. PMID: 28441249
Expression of the membrane mucins MUC4 and MUC15, potential markers of malignancy and prognosis, in papillary thyroid carcinoma.
Nam KH, Noh TW, Chung SH, Lee SH, Lee MK, Hong SW, Chung WY, Lee EJ, Park CS
Thyroid 2011 Jul;21(7):745-50. Epub 2011 May 26 doi: 10.1089/thy.2010.0339. PMID: 21615302
New and unusual aspects of ovarian germ cell tumors.
Young RH
Am J Surg Pathol 1993 Dec;17(12):1210-24. doi: 10.1097/00000478-199312000-00002. PMID: 7694512
Solid cell nests of the thyroid.
Harach HR
J Pathol 1988 Jul;155(3):191-200. doi: 10.1002/path.1711550303. PMID: 3045277

Diagnosis

Top 10 Clear Cell Head and Neck Lesions to Contemplate.
Cipriani NA, Kakkar A
Head Neck Pathol 2023 Mar;17(1):33-52. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01518-6. PMID: 36928734Free PMC Article
SOX17: A Highly Sensitive and Specific Immunomarker for Ovarian and Endometrial Carcinomas.
Zhang X, Yao J, Niu N, Li X, Liu Y, Huo L, Euscher ED, Wang H, Bell D, Sood AK, Wang G, Lawson BC, Ramalingam P, Malpica A, Sahin AA, Ding Q, Liu J
Mod Pathol 2023 Feb;36(2):100001. Epub 2023 Jan 9 doi: 10.1016/j.modpat.2022.100001. PMID: 36853778
Identifying SOX17 as a Sensitive and Specific Marker for Ovarian and Endometrial Carcinomas.
Shaker N, Chen W, Sinclair W, Parwani AV, Li Z
Mod Pathol 2023 Jan;36(1):100038. doi: 10.1016/j.modpat.2022.100038. PMID: 36788073
Nonthyroidal metastatic lesion in thyroid: A missed diagnosis and a lesson learnt.
Prameela CG, Ravind R, Sruthi K
J Cancer Res Ther 2019 Jul-Sep;15(3):665-668. doi: 10.4103/jcrt.JCRT_1043_16. PMID: 31169237
Primary lesions that may imitate metastatic tumors histologically: A selective review.
Wick MR
Semin Diagn Pathol 2018 Mar;35(2):123-142. Epub 2017 Nov 17 doi: 10.1053/j.semdp.2017.11.010. PMID: 29174934

Therapy

Carney complex: a clinicopathologic and molecular biological study of a sporadic case, including extracutaneous and cutaneous lesions and a novel mutation of the PRKAR1A gene.
Kacerovska D, Sima R, Michal M, Hes O, Roucka P, Zarybnicka M, Hora M, Chudacek Z, Kazakov DV
J Am Acad Dermatol 2009 Jul;61(1):80-7. doi: 10.1016/j.jaad.2008.11.015. PMID: 19539840
In vivo radioiodide imaging and treatment of breast cancer xenografts after MUC1-driven expression of the sodium iodide symporter.
Dwyer RM, Bergert ER, O'connor MK, Gendler SJ, Morris JC
Clin Cancer Res 2005 Feb 15;11(4):1483-9. doi: 10.1158/1078-0432.CCR-04-1636. PMID: 15746050
Unusual case of metastatic thyroid nodule: nonpalpable breast mass as origin.
Tutal E, Tütüncü NB, Akçaer N, Bilezikçi B, Güvener N, Arican A
Endocr Pract 2001 Sep-Oct;7(5):379-82. doi: 10.4158/EP.7.5.379. PMID: 11585375
Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity.
Nemunaitis J, Cunningham C, Buchanan A, Blackburn A, Edelman G, Maples P, Netto G, Tong A, Randlev B, Olson S, Kirn D
Gene Ther 2001 May;8(10):746-59. doi: 10.1038/sj.gt.3301424. PMID: 11420638
Current therapy of thyroid nodules.
Wright HK, Burrow GN, Spaulding S, Sheahan DG
Surg Clin North Am 1974 Apr;54(2):277-88. doi: 10.1016/s0039-6109(16)40279-3. PMID: 4361604

Prognosis

Mucinous breast carcinoma metastatic to thyroid gland: Report of a case diagnosed by fine-needle aspiration cytology.
Wang M, Liu X, Wei B, Liu N, Li Q, Su X
Diagn Cytopathol 2020 May;48(5):475-478. Epub 2020 Feb 17 doi: 10.1002/dc.24396. PMID: 32065477
Nonthyroidal metastatic lesion in thyroid: A missed diagnosis and a lesson learnt.
Prameela CG, Ravind R, Sruthi K
J Cancer Res Ther 2019 Jul-Sep;15(3):665-668. doi: 10.4103/jcrt.JCRT_1043_16. PMID: 31169237
Epidemiology of Second Primary Tumors in Women With Ovarian Cancer.
Kanninen TT, Nasioudis D, Sisti G, Holcomb K, Di Tommaso M, Khalil S, Gojayev A, Witkin SS
Int J Gynecol Cancer 2017 May;27(4):659-667. doi: 10.1097/IGC.0000000000000950. PMID: 28441249
Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia: a clinicopathologic and molecular analysis of a distinct entity.
Shah AA, La Fortune K, Miller C, Mills SE, Baloch Z, LiVolsi V, Dacic S, Mahaffey AL, Nikiforova M, Nikiforov YE, Seethala RR
Mod Pathol 2017 Mar;30(3):329-339. Epub 2016 Dec 2 doi: 10.1038/modpathol.2016.180. PMID: 27910944Free PMC Article
Primary mucinous carcinoma with rhabdoid cells of the thyroid gland: a case report.
Matsuo M, Tuneyoshi M, Mine M
Diagn Pathol 2016 Jun 10;11(1):48. doi: 10.1186/s13000-016-0500-8. PMID: 27282149Free PMC Article

Clinical prediction guides

Clinicopathological observation of mature teratoma with malignant transformation, a single center retrospective study.
Yuan Y, Li H, Yang H
Indian J Pathol Microbiol 2022 Apr-Jun;65(2):369-373. doi: 10.4103/IJPM.IJPM_828_20. PMID: 35435373
Primary lesions that may imitate metastatic tumors histologically: A selective review.
Wick MR
Semin Diagn Pathol 2018 Mar;35(2):123-142. Epub 2017 Nov 17 doi: 10.1053/j.semdp.2017.11.010. PMID: 29174934
Epidemiology of Second Primary Tumors in Women With Ovarian Cancer.
Kanninen TT, Nasioudis D, Sisti G, Holcomb K, Di Tommaso M, Khalil S, Gojayev A, Witkin SS
Int J Gynecol Cancer 2017 May;27(4):659-667. doi: 10.1097/IGC.0000000000000950. PMID: 28441249
Expression of the membrane mucins MUC4 and MUC15, potential markers of malignancy and prognosis, in papillary thyroid carcinoma.
Nam KH, Noh TW, Chung SH, Lee SH, Lee MK, Hong SW, Chung WY, Lee EJ, Park CS
Thyroid 2011 Jul;21(7):745-50. Epub 2011 May 26 doi: 10.1089/thy.2010.0339. PMID: 21615302
Primary mucoepidermoid carcinoma of the thyroid gland: a report of six cases and a review of the literature of a follicular epithelial-derived tumor.
Wenig BM, Adair CF, Heffess CS
Hum Pathol 1995 Oct;26(10):1099-108. doi: 10.1016/0046-8177(95)90272-4. PMID: 7557943

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