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Mediastinal T Acute Lymphoblastic Leukemia

MedGen UID:
313961
•Concept ID:
C1711168
•
Neoplastic Process
Synonyms: Mediastinal Precursor T-Lymphoblastic Leukemia; Mediastinal T-Acute Lymphoblastic Leukemia; Mediastinal T-Cell Acute Lymphoblastic Leukemia

Definition

A precursor T-cell lymphoblastic leukemia that involves the mediastinum. It usually affects adolescent and young adult males. It is treated with aggressive chemotherapy and radiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMediastinal T Acute Lymphoblastic Leukemia

Professional guidelines

PubMed

Biology and Treatment Paradigms in T Cell Acute Lymphoblastic Leukemia in Older Adolescents and Adults.
Patel AA, Thomas J, Rojek AE, Stock W
Curr Treat Options Oncol 2020 May 28;21(7):57. doi: 10.1007/s11864-020-00757-5. PMID: 32468488
Adult T-type lymphoblastic lymphoma: Treatment advances and prognostic indicators.
Lepretre S, Graux C, Touzart A, Macintyre E, Boissel N
Exp Hematol 2017 Jul;51:7-16. Epub 2017 Apr 12 doi: 10.1016/j.exphem.2017.04.002. PMID: 28412288
Lymphoblastic lymphoma: an updated review on biology, diagnosis, and treatment.
Bassan R, Maino E, Cortelazzo S
Eur J Haematol 2016 May;96(5):447-60. Epub 2016 Jan 24 doi: 10.1111/ejh.12722. PMID: 26679753

Recent clinical studies

Etiology

Lymphoblastic Lymphoma: a Concise Review.
Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993
Adult T-type lymphoblastic lymphoma: Treatment advances and prognostic indicators.
Lepretre S, Graux C, Touzart A, Macintyre E, Boissel N
Exp Hematol 2017 Jul;51:7-16. Epub 2017 Apr 12 doi: 10.1016/j.exphem.2017.04.002. PMID: 28412288
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870
A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811.
Larson RA, Dodge RK, Burns CP, Lee EJ, Stone RM, Schulman P, Duggan D, Davey FR, Sobol RE, Frankel SR
Blood 1995 Apr 15;85(8):2025-37. PMID: 7718875

Diagnosis

Lymphoblastic Lymphoma: a Concise Review.
Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993
T-Cell Acute Lymphoblastic Leukemia: Biomarkers and Their Clinical Usefulness.
Bardelli V, Arniani S, Pierini V, Di Giacomo D, Pierini T, Gorello P, Mecucci C, La Starza R
Genes (Basel) 2021 Jul 23;12(8) doi: 10.3390/genes12081118. PMID: 34440292Free PMC Article
Lymphoblastic lymphoma in children and adolescents: review of current challenges and future opportunities.
Burkhardt B, Hermiston ML
Br J Haematol 2019 Jun;185(6):1158-1170. Epub 2019 Feb 27 doi: 10.1111/bjh.15793. PMID: 30809797
Lymphoblastic lymphoma.
Cortelazzo S, Ferreri A, Hoelzer D, Ponzoni M
Crit Rev Oncol Hematol 2017 May;113:304-317. Epub 2017 Mar 18 doi: 10.1016/j.critrevonc.2017.03.020. PMID: 28427520
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870

Therapy

Lymphoblastic lymphoma.
Cortelazzo S, Ferreri A, Hoelzer D, Ponzoni M
Crit Rev Oncol Hematol 2017 May;113:304-317. Epub 2017 Mar 18 doi: 10.1016/j.critrevonc.2017.03.020. PMID: 28427520
Adult lymphoblastic lymphoma.
Portell CA, Sweetenham JW
Cancer J 2012 Sep-Oct;18(5):432-8. doi: 10.1097/PPO.0b013e31826b1232. PMID: 23006948
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870
A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811.
Larson RA, Dodge RK, Burns CP, Lee EJ, Stone RM, Schulman P, Duggan D, Davey FR, Sobol RE, Frankel SR
Blood 1995 Apr 15;85(8):2025-37. PMID: 7718875

Prognosis

Lymphoblastic Lymphoma: a Concise Review.
Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993
Lymphoblastic lymphoma in children and adolescents: review of current challenges and future opportunities.
Burkhardt B, Hermiston ML
Br J Haematol 2019 Jun;185(6):1158-1170. Epub 2019 Feb 27 doi: 10.1111/bjh.15793. PMID: 30809797
Lymphoblastic lymphoma.
Cortelazzo S, Ferreri A, Hoelzer D, Ponzoni M
Crit Rev Oncol Hematol 2017 May;113:304-317. Epub 2017 Mar 18 doi: 10.1016/j.critrevonc.2017.03.020. PMID: 28427520
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870
A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811.
Larson RA, Dodge RK, Burns CP, Lee EJ, Stone RM, Schulman P, Duggan D, Davey FR, Sobol RE, Frankel SR
Blood 1995 Apr 15;85(8):2025-37. PMID: 7718875

Clinical prediction guides

Lymphoblastic Lymphoma: a Concise Review.
Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993
Outcomes of children and young adults with T-cell acute lymphoblastic leukemia/lymphoma who present in critical status.
Wayne NJ, Li Y, Chung P, Coffan K, Rheingold SR
Pediatr Blood Cancer 2022 Apr;69(4):e29457. Epub 2022 Jan 8 doi: 10.1002/pbc.29457. PMID: 34997812
T-cell lymphoblastic lymphoma and T-cell acute lymphoblastic leukemia: a separate entity?
Hoelzer D, Gökbuget N
Clin Lymphoma Myeloma 2009;9 Suppl 3:S214-21. doi: 10.3816/CLM.2009.s.015. PMID: 19778844
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870
A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811.
Larson RA, Dodge RK, Burns CP, Lee EJ, Stone RM, Schulman P, Duggan D, Davey FR, Sobol RE, Frankel SR
Blood 1995 Apr 15;85(8):2025-37. PMID: 7718875

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