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Mediastinal T Acute Lymphoblastic Leukemia

MedGen UID:
313961
•Concept ID:
C1711168
•
Neoplastic Process
Synonyms: Mediastinal Precursor T-Lymphoblastic Leukemia; Mediastinal T-Acute Lymphoblastic Leukemia; Mediastinal T-Cell Acute Lymphoblastic Leukemia

Definition

A precursor T-cell lymphoblastic leukemia that involves the mediastinum. It usually affects adolescent and young adult males. It is treated with aggressive chemotherapy and radiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMediastinal T Acute Lymphoblastic Leukemia

Professional guidelines

PubMed

Diagnosis and management of lymphoblastic lymphoma in children, adolescents and young adults.
Temple WC, Mueller S, Hermiston ML, Burkhardt B
Best Pract Res Clin Haematol 2023 Mar;36(1):101449. Epub 2023 Feb 16 doi: 10.1016/j.beha.2023.101449. PMID: 36907639
Adult T-type lymphoblastic lymphoma: Treatment advances and prognostic indicators.
Lepretre S, Graux C, Touzart A, Macintyre E, Boissel N
Exp Hematol 2017 Jul;51:7-16. Epub 2017 Apr 12 doi: 10.1016/j.exphem.2017.04.002. PMID: 28412288
Lymphoblastic lymphoma: an updated review on biology, diagnosis, and treatment.
Bassan R, Maino E, Cortelazzo S
Eur J Haematol 2016 May;96(5):447-60. Epub 2016 Jan 24 doi: 10.1111/ejh.12722. PMID: 26679753

Recent clinical studies

Etiology

Lymphoblastic Lymphoma: a Concise Review.
Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093
Lymphoblastic lymphoma.
Thomas DA, Kantarjian HM
Hematol Oncol Clin North Am 2001 Feb;15(1):51-95, vi. doi: 10.1016/s0889-8588(05)70200-8. PMID: 11253609
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870
A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811.
Larson RA, Dodge RK, Burns CP, Lee EJ, Stone RM, Schulman P, Duggan D, Davey FR, Sobol RE, Frankel SR
Blood 1995 Apr 15;85(8):2025-37. PMID: 7718875

Diagnosis

Diagnosis and management of lymphoblastic lymphoma in children, adolescents and young adults.
Temple WC, Mueller S, Hermiston ML, Burkhardt B
Best Pract Res Clin Haematol 2023 Mar;36(1):101449. Epub 2023 Feb 16 doi: 10.1016/j.beha.2023.101449. PMID: 36907639
Lymphoblastic Lymphoma: a Concise Review.
Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993
T-Cell Acute Lymphoblastic Leukemia: Biomarkers and Their Clinical Usefulness.
Bardelli V, Arniani S, Pierini V, Di Giacomo D, Pierini T, Gorello P, Mecucci C, La Starza R
Genes (Basel) 2021 Jul 23;12(8) doi: 10.3390/genes12081118. PMID: 34440292Free PMC Article
Lymphoblastic lymphoma.
Thomas DA, Kantarjian HM
Hematol Oncol Clin North Am 2001 Feb;15(1):51-95, vi. doi: 10.1016/s0889-8588(05)70200-8. PMID: 11253609
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870

Therapy

Lymphoblastic lymphoma.
Cortelazzo S, Ferreri A, Hoelzer D, Ponzoni M
Crit Rev Oncol Hematol 2017 May;113:304-317. Epub 2017 Mar 18 doi: 10.1016/j.critrevonc.2017.03.020. PMID: 28427520
Adult lymphoblastic lymphoma.
Portell CA, Sweetenham JW
Cancer J 2012 Sep-Oct;18(5):432-8. doi: 10.1097/PPO.0b013e31826b1232. PMID: 23006948
Lymphoblastic lymphoma.
Thomas DA, Kantarjian HM
Hematol Oncol Clin North Am 2001 Feb;15(1):51-95, vi. doi: 10.1016/s0889-8588(05)70200-8. PMID: 11253609
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870
A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811.
Larson RA, Dodge RK, Burns CP, Lee EJ, Stone RM, Schulman P, Duggan D, Davey FR, Sobol RE, Frankel SR
Blood 1995 Apr 15;85(8):2025-37. PMID: 7718875

Prognosis

Diagnosis and management of lymphoblastic lymphoma in children, adolescents and young adults.
Temple WC, Mueller S, Hermiston ML, Burkhardt B
Best Pract Res Clin Haematol 2023 Mar;36(1):101449. Epub 2023 Feb 16 doi: 10.1016/j.beha.2023.101449. PMID: 36907639
Lymphoblastic Lymphoma: a Concise Review.
Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993
Lymphoblastic lymphoma in children and adolescents: review of current challenges and future opportunities.
Burkhardt B, Hermiston ML
Br J Haematol 2019 Jun;185(6):1158-1170. Epub 2019 Feb 27 doi: 10.1111/bjh.15793. PMID: 30809797
Lymphoblastic lymphoma.
Thomas DA, Kantarjian HM
Hematol Oncol Clin North Am 2001 Feb;15(1):51-95, vi. doi: 10.1016/s0889-8588(05)70200-8. PMID: 11253609
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870

Clinical prediction guides

Clinicopathologic features and outcomes of acute leukemia harboring PICALM::MLLT10 fusion.
Wang J, Zhang W, Xu X, Buglioni A, Li P, Chen X, Liu Y, Xu M, Herrick JL, Horna P, Zhang X, Song J, Jevremovic D, He R, Shi M, Yuan J
Hum Pathol 2024 Sep;151:105626. Epub 2024 Jul 4 doi: 10.1016/j.humpath.2024.07.003. PMID: 38971327
Lymphoblastic Lymphoma: a Concise Review.
Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993
Acute lymphoblastic leukemia and lymphoma in the context of constitutional mismatch repair deficiency syndrome.
Ripperger T, Schlegelberger B
Eur J Med Genet 2016 Mar;59(3):133-42. Epub 2015 Dec 30 doi: 10.1016/j.ejmg.2015.12.014. PMID: 26743104
Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia.
Kantarjian HM, O'Brien S, Smith TL, Cortes J, Giles FJ, Beran M, Pierce S, Huh Y, Andreeff M, Koller C, Ha CS, Keating MJ, Murphy S, Freireich EJ
J Clin Oncol 2000 Feb;18(3):547-61. doi: 10.1200/JCO.2000.18.3.547. PMID: 10653870
A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811.
Larson RA, Dodge RK, Burns CP, Lee EJ, Stone RM, Schulman P, Duggan D, Davey FR, Sobol RE, Frankel SR
Blood 1995 Apr 15;85(8):2025-37. PMID: 7718875

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