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Disorder of mediastinum

MedGen UID:
44321
•Concept ID:
C0025061
•
Disease or Syndrome
Synonyms: Disease, Mediastinal; Diseases, Mediastinal; Mediastinal Disease; Mediastinal Diseases
SNOMED CT: Disorder of mediastinum (49483002); Mediastinal disorder (49483002); Mediastinal disease (49483002)

Definition

A non-neoplastic or neoplastic disorder that affects the structures of the mediastinum. Representative examples include mediastinitis, mediastinal lipoma, mediastinal schwannoma, thymoma, and mediastinal lymphoma. [from NCI]

Professional guidelines

PubMed

Lymphomas of the Mediastinum and Their Differential Diagnosis.
Zhang ML, Sohani AR
Semin Diagn Pathol 2020 Jul;37(4):156-165. Epub 2020 May 15 doi: 10.1053/j.semdp.2020.04.005. PMID: 32451144
Fetal primary pleural effusions: Prenatal diagnosis and management.
Abbasi N, Ryan G
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:66-77. Epub 2019 Jan 12 doi: 10.1016/j.bpobgyn.2019.01.005. PMID: 30737016
Thymoma: Diagnosis and treatment.
Singh G, Rumende CM, Amin Z
Acta Med Indones 2011 Jan;43(1):74-8. PMID: 21339550

Recent clinical studies

Etiology

EBUS-guided cryobiopsy in the diagnosis of thoracic disorders.
Poletti V, Petrarulo S, Piciucchi S, Dubini A, De Grauw AJ, Sultani F, Martinello S, Gonunguntla HK, Ravaglia C
Pulmonology 2024 Sep-Oct;30(5):459-465. Epub 2024 Jan 5 doi: 10.1016/j.pulmoe.2023.11.008. PMID: 38182468
Transbronchial needle aspiration combined with cryobiopsy in the diagnosis of mediastinal diseases: a multicentre, open-label, randomised trial.
Fan Y, Zhang AM, Wu XL, Huang ZS, Kontogianni K, Sun K, Fu WL, Wu N, Kuebler WM, Herth FJF
Lancet Respir Med 2023 Mar;11(3):256-264. Epub 2022 Oct 22 doi: 10.1016/S2213-2600(22)00392-7. PMID: 36279880
High risk and low prevalence diseases: Esophageal perforation.
DeVivo A, Sheng AY, Koyfman A, Long B
Am J Emerg Med 2022 Mar;53:29-36. Epub 2021 Dec 18 doi: 10.1016/j.ajem.2021.12.017. PMID: 34971919
Mediastinal amyloidosis.
Urschel JD, Urschel DM
Ann Thorac Surg 2000 Mar;69(3):944-6. doi: 10.1016/s0003-4975(99)01391-0. PMID: 10750796
Mediastinal granuloma.
Strimlan CV, Dines DE, Payne WS
Mayo Clin Proc 1975 Dec;50(12):702-5. PMID: 1195780

Diagnosis

Mediastinal Lipomatosis.
Datta A, Sivasankar R
J Assoc Physicians India 2024 Jan;72(1):106-107. doi: 10.59556/japi.71.0344. PMID: 38736084
Boerhaave syndrome.
Chew FY, Yang ST
CMAJ 2021 Sep 27;193(38):E1499. doi: 10.1503/cmaj.202893. PMID: 34580144Free PMC Article
Mediastinal lymphadenopathy: a practical approach.
Iyer H, Anand A, Sryma PB, Gupta K, Naranje P, Damle N, Mittal S, Madan NK, Mohan A, Hadda V, Tiwari P, Guleria R, Madan K
Expert Rev Respir Med 2021 Oct;15(10):1317-1334. Epub 2021 May 6 doi: 10.1080/17476348.2021.1920404. PMID: 33888038
Intrapericardial goiter.
Kocaman G, Yenigün BM, Çoruh AG, Koçak EM, Memmedyarow İ, Tural M, Sak SD, Yazıcıoğlu L, Akal RM
Gen Thorac Cardiovasc Surg 2020 Sep;68(9):1051-1054. Epub 2019 Oct 3 doi: 10.1007/s11748-019-01211-6. PMID: 31583517
Mediastinal fibrosis.
Davis AM, Pierson RN, Loyd JE
Semin Respir Infect 2001 Jun;16(2):119-30. doi: 10.1053/srin.2001.24242. PMID: 11521244

Therapy

Transbronchial needle aspiration combined with cryobiopsy in the diagnosis of mediastinal diseases: a multicentre, open-label, randomised trial.
Fan Y, Zhang AM, Wu XL, Huang ZS, Kontogianni K, Sun K, Fu WL, Wu N, Kuebler WM, Herth FJF
Lancet Respir Med 2023 Mar;11(3):256-264. Epub 2022 Oct 22 doi: 10.1016/S2213-2600(22)00392-7. PMID: 36279880
Boerhaave syndrome.
Chew FY, Yang ST
CMAJ 2021 Sep 27;193(38):E1499. doi: 10.1503/cmaj.202893. PMID: 34580144Free PMC Article
Histoplasmosis: Up-to-Date Evidence-Based Approach to Diagnosis and Management.
Hage CA, Azar MM, Bahr N, Loyd J, Wheat LJ
Semin Respir Crit Care Med 2015 Oct;36(5):729-45. Epub 2015 Sep 23 doi: 10.1055/s-0035-1562899. PMID: 26398539
Cervical mediastinoscopy.
Kirschner PA
Chest Surg Clin N Am 1996 Feb;6(1):1-20. PMID: 8646496
Mediastinoscopy.
Tucker HM
Postgrad Med 1972 Jun;51(7):77-80. doi: 10.1080/00325481.1972.11698288. PMID: 5031404

Prognosis

Cardiothoracic manifestations of Erdheim-Chester disease.
Das JP, Xie L, Riedl CC, Hayes SA, Ginsberg MS, Halpenny DF
Br J Radiol 2019 Dec;92(1104):20190473. Epub 2019 Aug 14 doi: 10.1259/bjr.20190473. PMID: 31386554Free PMC Article
Boerhaave Syndrome.
Vest MT, Dross P
J Am Osteopath Assoc 2018 Nov 1;118(11):764. doi: 10.7556/jaoa.2018.165. PMID: 30398574
Esophageal perforations.
Chirica M, Champault A, Dray X, Sulpice L, Munoz-Bongrand N, Sarfati E, Cattan P
J Visc Surg 2010 Jun;147(3):e117-28. Epub 2010 Sep 15 doi: 10.1016/j.jviscsurg.2010.08.003. PMID: 20833121
Fibrosing mediastinitis.
Rossi SE, McAdams HP, Rosado-de-Christenson ML, Franks TJ, Galvin JR
Radiographics 2001 May-Jun;21(3):737-57. doi: 10.1148/radiographics.21.3.g01ma17737. PMID: 11353121
Mediastinal granuloma.
Strimlan CV, Dines DE, Payne WS
Mayo Clin Proc 1975 Dec;50(12):702-5. PMID: 1195780

Clinical prediction guides

Pan-mediastinal neoplasm diagnosis via nationwide federated learning: a multicentre cohort study.
Tang R, Liang H, Guo Y, Li Z, Liu Z, Lin X, Yan Z, Liu J, Xu X, Shao W, Li S, Liang W, Wang W, Cui F, He H, Yang C, Jiang L, Wang H, Chen H, Guo C, Zhang H, Gao Z, He Y, Chen X, Zhao L, Yu H, Hu J, Zhao J, Li B, Yin C, Mao W, Lin W, Xie Y, Liu J, Li X, Wu D, Hou Q, Chen Y, Chen D, Xue Y, Liang Y, Tang W, Wang Q, Li E, Liu H, Wang G, Yu P, Chen C, Zheng B, Chen H, Zhang Z, Wang L, Wang A, Li Z, Fu J, Zhang G, Zhang J, Liu B, Zhao J, Deng B, Han Y, Leng X, Li Z, Zhang M, Liu C, Wang T, Luo Z, Yang C, Guo X, Ma K, Wang L, Jiang W, Han X, Wang Q, Qiao K, Xia Z, Zheng S, Xu C, Peng J, Wu S, Zhang Z, Huang H, Pang D, Liu Q, Li J, Ding X, Liu X, Zhong L, Lu Y, Xu F, Dai Q, He J
Lancet Digit Health 2023 Sep;5(9):e560-e570. doi: 10.1016/S2589-7500(23)00106-1. PMID: 37625894
Descending mediastinitis.
Vural FS, Girdwood RW, Patel AR, Zigiriadis E
Asian Cardiovasc Thorac Ann 2012 Jun;20(3):304-7. doi: 10.1177/0218492311434088. PMID: 22718719
Esophageal perforations.
Chirica M, Champault A, Dray X, Sulpice L, Munoz-Bongrand N, Sarfati E, Cattan P
J Visc Surg 2010 Jun;147(3):e117-28. Epub 2010 Sep 15 doi: 10.1016/j.jviscsurg.2010.08.003. PMID: 20833121
Diffusion and perfusion MRI of the lung and mediastinum.
Henzler T, Schmid-Bindert G, Schoenberg SO, Fink C
Eur J Radiol 2010 Dec;76(3):329-36. doi: 10.1016/j.ejrad.2010.05.005. PMID: 20627435
Mediastinal tumors.
Thomas CR Jr, Bonomi PD
Curr Opin Oncol 1991 Apr;3(2):335-43. doi: 10.1097/00001622-199104000-00015. PMID: 1648973

Recent systematic reviews

Ectopic air localizations after transanal procedures: A systematic literature review.
Balla A, Quaresima S, Paganini AM
Int J Surg 2018 Aug;56:167-173. Epub 2018 Jun 21 doi: 10.1016/j.ijsu.2018.05.743. PMID: 29936199
Ten Years of Linear Endobronchial Ultrasound: Evidence of Efficacy, Safety and Cost-effectiveness.
Fernández-Villar A, Mouronte-Roibás C, Botana-Rial M, Ruano-Raviña A
Arch Bronconeumol 2016 Feb;52(2):96-102. Epub 2015 Nov 10 doi: 10.1016/j.arbres.2015.08.007. PMID: 26565072
Technical Aspects of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration: CHEST Guideline and Expert Panel Report.
Wahidi MM, Herth F, Yasufuku K, Shepherd RW, Yarmus L, Chawla M, Lamb C, Casey KR, Patel S, Silvestri GA, Feller-Kopman DJ
Chest 2016 Mar;149(3):816-35. Epub 2016 Jan 12 doi: 10.1378/chest.15-1216. PMID: 26402427
A Meta-Analysis of the Relationship between Testicular Microlithiasis and Incidence of Testicular Cancer.
Wang T, Liu L, Luo J, Liu T, Wei A
Urol J 2015 Apr 29;12(2):2057-64. PMID: 25923148
Unusual manifestations of thoracic sarcoidosis.
Rockoff SD, Rohatgi PK
AJR Am J Roentgenol 1985 Mar;144(3):513-28. doi: 10.2214/ajr.144.3.513. PMID: 3155892

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