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Disorder of mediastinum

MedGen UID:
44321
•Concept ID:
C0025061
•
Disease or Syndrome
Synonyms: Disease, Mediastinal; Diseases, Mediastinal; Mediastinal Disease; Mediastinal Diseases
SNOMED CT: Disorder of mediastinum (49483002); Mediastinal disorder (49483002); Mediastinal disease (49483002)

Definition

A non-neoplastic or neoplastic disorder that affects the structures of the mediastinum. Representative examples include mediastinitis, mediastinal lipoma, mediastinal schwannoma, thymoma, and mediastinal lymphoma. [from NCI]

Professional guidelines

PubMed

Updates in the Management of Primary Mediastinal B Cell Lymphoma.
Soueidy C, Kourie HR
Clin Lymphoma Myeloma Leuk 2023 Dec;23(12):866-873. Epub 2023 Aug 21 doi: 10.1016/j.clml.2023.08.014. PMID: 37722943
Lymphomas of the Mediastinum and Their Differential Diagnosis.
Zhang ML, Sohani AR
Semin Diagn Pathol 2020 Jul;37(4):156-165. Epub 2020 May 15 doi: 10.1053/j.semdp.2020.04.005. PMID: 32451144
Managing Incidental Findings on Thoracic CT: Mediastinal and Cardiovascular Findings. A White Paper of the ACR Incidental Findings Committee.
Munden RF, Carter BW, Chiles C, MacMahon H, Black WC, Ko JP, McAdams HP, Rossi SE, Leung AN, Boiselle PM, Kent MS, Brown K, Dyer DS, Hartman TE, Goodman EM, Naidich DP, Kazerooni EA, Berland LL, Pandharipande PV
J Am Coll Radiol 2018 Aug;15(8):1087-1096. Epub 2018 Jun 22 doi: 10.1016/j.jacr.2018.04.029. PMID: 29941240

Recent clinical studies

Etiology

Transbronchial needle aspiration combined with cryobiopsy in the diagnosis of mediastinal diseases: a multicentre, open-label, randomised trial.
Fan Y, Zhang AM, Wu XL, Huang ZS, Kontogianni K, Sun K, Fu WL, Wu N, Kuebler WM, Herth FJF
Lancet Respir Med 2023 Mar;11(3):256-264. Epub 2022 Oct 22 doi: 10.1016/S2213-2600(22)00392-7. PMID: 36279880
High risk and low prevalence diseases: Esophageal perforation.
DeVivo A, Sheng AY, Koyfman A, Long B
Am J Emerg Med 2022 Mar;53:29-36. Epub 2021 Dec 18 doi: 10.1016/j.ajem.2021.12.017. PMID: 34971919
Current status of surgical treatment of Boerhaave's syndrome.
Sohda M, Saeki H, Kuwano H, Sakai M, Sano A, Yokobori T, Miyazaki T, Kakeji Y, Toh Y, Doki Y, Matsubara H
Esophagus 2022 Jan;19(1):175-181. Epub 2021 Jun 11 doi: 10.1007/s10388-021-00858-6. PMID: 34117586
The role of EBUS-TBNA and standard bronchoscopic modalities in the diagnosis of sarcoidosis.
Dziedzic DA, Peryt A, Orlowski T
Clin Respir J 2017 Jan;11(1):58-63. Epub 2015 May 26 doi: 10.1111/crj.12304. PMID: 25919969
Complications of thoracoscopy.
Kaiser LR, Bavaria JE
Ann Thorac Surg 1993 Sep;56(3):796-8. doi: 10.1016/0003-4975(93)90983-o. PMID: 8379796

Diagnosis

Boerhaave syndrome.
Chew FY, Yang ST
CMAJ 2021 Sep 27;193(38):E1499. doi: 10.1503/cmaj.202893. PMID: 34580144Free PMC Article
Mediastinal lymphadenopathy: a practical approach.
Iyer H, Anand A, Sryma PB, Gupta K, Naranje P, Damle N, Mittal S, Madan NK, Mohan A, Hadda V, Tiwari P, Guleria R, Madan K
Expert Rev Respir Med 2021 Oct;15(10):1317-1334. Epub 2021 May 6 doi: 10.1080/17476348.2021.1920404. PMID: 33888038
Intrapericardial goiter.
Kocaman G, Yenigün BM, Çoruh AG, Koçak EM, Memmedyarow İ, Tural M, Sak SD, Yazıcıoğlu L, Akal RM
Gen Thorac Cardiovasc Surg 2020 Sep;68(9):1051-1054. Epub 2019 Oct 3 doi: 10.1007/s11748-019-01211-6. PMID: 31583517
The anterior mediastinum: diseases.
Priola AM, Priola SM, Cardinale L, Cataldi A, Fava C
Radiol Med 2006 Apr;111(3):312-42. Epub 2006 Apr 11 doi: 10.1007/s11547-006-0032-5. PMID: 16683081
Mediastinal fibrosis.
Davis AM, Pierson RN, Loyd JE
Semin Respir Infect 2001 Jun;16(2):119-30. doi: 10.1053/srin.2001.24242. PMID: 11521244

Therapy

Transbronchial needle aspiration combined with cryobiopsy in the diagnosis of mediastinal diseases: a multicentre, open-label, randomised trial.
Fan Y, Zhang AM, Wu XL, Huang ZS, Kontogianni K, Sun K, Fu WL, Wu N, Kuebler WM, Herth FJF
Lancet Respir Med 2023 Mar;11(3):256-264. Epub 2022 Oct 22 doi: 10.1016/S2213-2600(22)00392-7. PMID: 36279880
Boerhaave syndrome.
Chew FY, Yang ST
CMAJ 2021 Sep 27;193(38):E1499. doi: 10.1503/cmaj.202893. PMID: 34580144Free PMC Article
Efficacy and safety of EBUS-TBNA and EUS-B-FNA in children: A systematic review and meta-analysis.
Madan K, Iyer H, Madan NK, Mittal S, Tiwari P, Hadda V, Mohan A, Pandey RM, Kabra SK, Guleria R
Pediatr Pulmonol 2021 Jan;56(1):23-33. Epub 2020 Oct 29 doi: 10.1002/ppul.25124. PMID: 33073498
The role of esophageal stents in the management of esophageal anastomotic leaks and benign esophageal perforations.
Dasari BV, Neely D, Kennedy A, Spence G, Rice P, Mackle E, Epanomeritakis E
Ann Surg 2014 May;259(5):852-60. doi: 10.1097/SLA.0000000000000564. PMID: 24509201
Cervical mediastinoscopy.
Kirschner PA
Chest Surg Clin N Am 1996 Feb;6(1):1-20. PMID: 8646496

Prognosis

Cardiothoracic manifestations of Erdheim-Chester disease.
Das JP, Xie L, Riedl CC, Hayes SA, Ginsberg MS, Halpenny DF
Br J Radiol 2019 Dec;92(1104):20190473. Epub 2019 Aug 14 doi: 10.1259/bjr.20190473. PMID: 31386554Free PMC Article
Esophageal perforations.
Chirica M, Champault A, Dray X, Sulpice L, Munoz-Bongrand N, Sarfati E, Cattan P
J Visc Surg 2010 Jun;147(3):e117-28. Epub 2010 Sep 15 doi: 10.1016/j.jviscsurg.2010.08.003. PMID: 20833121
Fibrosing mediastinitis.
Rossi SE, McAdams HP, Rosado-de-Christenson ML, Franks TJ, Galvin JR
Radiographics 2001 May-Jun;21(3):737-57. doi: 10.1148/radiographics.21.3.g01ma17737. PMID: 11353121
Castleman's disease.
Palestro G, Turrini F, Pagano M, Chiusa L
Adv Clin Path 1999 Jan-Apr;3(1-2):11-22. PMID: 10655569
Complications of thoracoscopy.
Kaiser LR, Bavaria JE
Ann Thorac Surg 1993 Sep;56(3):796-8. doi: 10.1016/0003-4975(93)90983-o. PMID: 8379796

Clinical prediction guides

Pan-mediastinal neoplasm diagnosis via nationwide federated learning: a multicentre cohort study.
Tang R, Liang H, Guo Y, Li Z, Liu Z, Lin X, Yan Z, Liu J, Xu X, Shao W, Li S, Liang W, Wang W, Cui F, He H, Yang C, Jiang L, Wang H, Chen H, Guo C, Zhang H, Gao Z, He Y, Chen X, Zhao L, Yu H, Hu J, Zhao J, Li B, Yin C, Mao W, Lin W, Xie Y, Liu J, Li X, Wu D, Hou Q, Chen Y, Chen D, Xue Y, Liang Y, Tang W, Wang Q, Li E, Liu H, Wang G, Yu P, Chen C, Zheng B, Chen H, Zhang Z, Wang L, Wang A, Li Z, Fu J, Zhang G, Zhang J, Liu B, Zhao J, Deng B, Han Y, Leng X, Li Z, Zhang M, Liu C, Wang T, Luo Z, Yang C, Guo X, Ma K, Wang L, Jiang W, Han X, Wang Q, Qiao K, Xia Z, Zheng S, Xu C, Peng J, Wu S, Zhang Z, Huang H, Pang D, Liu Q, Li J, Ding X, Liu X, Zhong L, Lu Y, Xu F, Dai Q, He J
Lancet Digit Health 2023 Sep;5(9):e560-e570. doi: 10.1016/S2589-7500(23)00106-1. PMID: 37625894
Anesthesia for children with anterior mediastinal masses.
Tan A, Nolan JA
Paediatr Anaesth 2022 Jan;32(1):4-9. Epub 2021 Nov 14 doi: 10.1111/pan.14319. PMID: 34714957
Esophageal perforations.
Chirica M, Champault A, Dray X, Sulpice L, Munoz-Bongrand N, Sarfati E, Cattan P
J Visc Surg 2010 Jun;147(3):e117-28. Epub 2010 Sep 15 doi: 10.1016/j.jviscsurg.2010.08.003. PMID: 20833121
Clinical course and outcome of cocaine-induced pneumomediastinum.
Alnas M, Altayeh A, Zaman M
Am J Med Sci 2010 Jan;339(1):65-7. doi: 10.1097/MAJ.0b013e3181c371da. PMID: 20057278
Mediastinal tumors.
Thomas CR Jr, Bonomi PD
Curr Opin Oncol 1991 Apr;3(2):335-43. doi: 10.1097/00001622-199104000-00015. PMID: 1648973

Recent systematic reviews

The role of surgical resection in Unicentric Castleman's disease: a systematic review.
Mitsos S, Stamatopoulos A, Patrini D, George RS, Lawrence DR, Panagiotopoulos N
Adv Respir Med 2018;86(1):36-43. doi: 10.5603/ARM.2018.0008. PMID: 29490420
Ten Years of Linear Endobronchial Ultrasound: Evidence of Efficacy, Safety and Cost-effectiveness.
Fernández-Villar A, Mouronte-Roibás C, Botana-Rial M, Ruano-Raviña A
Arch Bronconeumol 2016 Feb;52(2):96-102. Epub 2015 Nov 10 doi: 10.1016/j.arbres.2015.08.007. PMID: 26565072
Technical Aspects of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration: CHEST Guideline and Expert Panel Report.
Wahidi MM, Herth F, Yasufuku K, Shepherd RW, Yarmus L, Chawla M, Lamb C, Casey KR, Patel S, Silvestri GA, Feller-Kopman DJ
Chest 2016 Mar;149(3):816-35. Epub 2016 Jan 12 doi: 10.1378/chest.15-1216. PMID: 26402427
A Meta-Analysis of the Relationship between Testicular Microlithiasis and Incidence of Testicular Cancer.
Wang T, Liu L, Luo J, Liu T, Wei A
Urol J 2015 Apr 29;12(2):2057-64. PMID: 25923148
Complication rate of endosonography (endobronchial and endoscopic ultrasound): a systematic review.
von Bartheld MB, van Breda A, Annema JT
Respiration 2014;87(4):343-51. Epub 2014 Jan 16 doi: 10.1159/000357066. PMID: 24434575

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