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Disorder of mediastinum

MedGen UID:
44321
•Concept ID:
C0025061
•
Disease or Syndrome
Synonyms: Disease, Mediastinal; Diseases, Mediastinal; Mediastinal Disease; Mediastinal Diseases
SNOMED CT: Disorder of mediastinum (49483002); Mediastinal disorder (49483002); Mediastinal disease (49483002)

Definition

A non-neoplastic or neoplastic disorder that affects the structures of the mediastinum. Representative examples include mediastinitis, mediastinal lipoma, mediastinal schwannoma, thymoma, and mediastinal lymphoma. [from NCI]

Professional guidelines

PubMed

Updates in the Management of Primary Mediastinal B Cell Lymphoma.
Soueidy C, Kourie HR
Clin Lymphoma Myeloma Leuk 2023 Dec;23(12):866-873. Epub 2023 Aug 21 doi: 10.1016/j.clml.2023.08.014. PMID: 37722943
Lymphomas of the Mediastinum and Their Differential Diagnosis.
Zhang ML, Sohani AR
Semin Diagn Pathol 2020 Jul;37(4):156-165. Epub 2020 May 15 doi: 10.1053/j.semdp.2020.04.005. PMID: 32451144
Managing Incidental Findings on Thoracic CT: Mediastinal and Cardiovascular Findings. A White Paper of the ACR Incidental Findings Committee.
Munden RF, Carter BW, Chiles C, MacMahon H, Black WC, Ko JP, McAdams HP, Rossi SE, Leung AN, Boiselle PM, Kent MS, Brown K, Dyer DS, Hartman TE, Goodman EM, Naidich DP, Kazerooni EA, Berland LL, Pandharipande PV
J Am Coll Radiol 2018 Aug;15(8):1087-1096. Epub 2018 Jun 22 doi: 10.1016/j.jacr.2018.04.029. PMID: 29941240

Recent clinical studies

Etiology

EBUS-guided cryobiopsy in the diagnosis of thoracic disorders.
Poletti V, Petrarulo S, Piciucchi S, Dubini A, De Grauw AJ, Sultani F, Martinello S, Gonunguntla HK, Ravaglia C
Pulmonology 2024 Sep-Oct;30(5):459-465. Epub 2024 Jan 5 doi: 10.1016/j.pulmoe.2023.11.008. PMID: 38182468
Transbronchial needle aspiration combined with cryobiopsy in the diagnosis of mediastinal diseases: a multicentre, open-label, randomised trial.
Fan Y, Zhang AM, Wu XL, Huang ZS, Kontogianni K, Sun K, Fu WL, Wu N, Kuebler WM, Herth FJF
Lancet Respir Med 2023 Mar;11(3):256-264. Epub 2022 Oct 22 doi: 10.1016/S2213-2600(22)00392-7. PMID: 36279880
High risk and low prevalence diseases: Esophageal perforation.
DeVivo A, Sheng AY, Koyfman A, Long B
Am J Emerg Med 2022 Mar;53:29-36. Epub 2021 Dec 18 doi: 10.1016/j.ajem.2021.12.017. PMID: 34971919
Mediastinal amyloidosis.
Urschel JD, Urschel DM
Ann Thorac Surg 2000 Mar;69(3):944-6. doi: 10.1016/s0003-4975(99)01391-0. PMID: 10750796
Mediastinal granuloma.
Strimlan CV, Dines DE, Payne WS
Mayo Clin Proc 1975 Dec;50(12):702-5. PMID: 1195780

Diagnosis

Boerhaave syndrome.
Hauge T, Abu Hejleh A, Nilsson M, Schröder W
Br J Surg 2024 Aug 30;111(9) doi: 10.1093/bjs/znae216. PMID: 39225330
Mediastinal Lipomatosis.
Datta A, Sivasankar R
J Assoc Physicians India 2024 Jan;72(1):106-107. doi: 10.59556/japi.71.0344. PMID: 38736084
Boerhaave syndrome.
Chew FY, Yang ST
CMAJ 2021 Sep 27;193(38):E1499. doi: 10.1503/cmaj.202893. PMID: 34580144Free PMC Article
Mediastinal lymphadenopathy: a practical approach.
Iyer H, Anand A, Sryma PB, Gupta K, Naranje P, Damle N, Mittal S, Madan NK, Mohan A, Hadda V, Tiwari P, Guleria R, Madan K
Expert Rev Respir Med 2021 Oct;15(10):1317-1334. Epub 2021 May 6 doi: 10.1080/17476348.2021.1920404. PMID: 33888038
Intrapericardial goiter.
Kocaman G, Yenigün BM, Çoruh AG, Koçak EM, Memmedyarow İ, Tural M, Sak SD, Yazıcıoğlu L, Akal RM
Gen Thorac Cardiovasc Surg 2020 Sep;68(9):1051-1054. Epub 2019 Oct 3 doi: 10.1007/s11748-019-01211-6. PMID: 31583517

Therapy

Transbronchial needle aspiration combined with cryobiopsy in the diagnosis of mediastinal diseases: a multicentre, open-label, randomised trial.
Fan Y, Zhang AM, Wu XL, Huang ZS, Kontogianni K, Sun K, Fu WL, Wu N, Kuebler WM, Herth FJF
Lancet Respir Med 2023 Mar;11(3):256-264. Epub 2022 Oct 22 doi: 10.1016/S2213-2600(22)00392-7. PMID: 36279880
Boerhaave syndrome.
Chew FY, Yang ST
CMAJ 2021 Sep 27;193(38):E1499. doi: 10.1503/cmaj.202893. PMID: 34580144Free PMC Article
What lies beneath.
Nundeekasen S, Nunez KJ, Trivedi A, La Hei E
J Paediatr Child Health 2019 May;55(5):604. doi: 10.1111/jpc.1_14417. PMID: 31017362
Cervical mediastinoscopy.
Kirschner PA
Chest Surg Clin N Am 1996 Feb;6(1):1-20. PMID: 8646496
Mediastinoscopy.
Tucker HM
Postgrad Med 1972 Jun;51(7):77-80. doi: 10.1080/00325481.1972.11698288. PMID: 5031404

Prognosis

Cardiothoracic manifestations of Erdheim-Chester disease.
Das JP, Xie L, Riedl CC, Hayes SA, Ginsberg MS, Halpenny DF
Br J Radiol 2019 Dec;92(1104):20190473. Epub 2019 Aug 14 doi: 10.1259/bjr.20190473. PMID: 31386554Free PMC Article
Boerhaave Syndrome.
Vest MT, Dross P
J Am Osteopath Assoc 2018 Nov 1;118(11):764. doi: 10.7556/jaoa.2018.165. PMID: 30398574
Esophageal perforations.
Chirica M, Champault A, Dray X, Sulpice L, Munoz-Bongrand N, Sarfati E, Cattan P
J Visc Surg 2010 Jun;147(3):e117-28. Epub 2010 Sep 15 doi: 10.1016/j.jviscsurg.2010.08.003. PMID: 20833121
Fibrosing mediastinitis.
Rossi SE, McAdams HP, Rosado-de-Christenson ML, Franks TJ, Galvin JR
Radiographics 2001 May-Jun;21(3):737-57. doi: 10.1148/radiographics.21.3.g01ma17737. PMID: 11353121
Mediastinal granuloma.
Strimlan CV, Dines DE, Payne WS
Mayo Clin Proc 1975 Dec;50(12):702-5. PMID: 1195780

Clinical prediction guides

EBUS-guided cryobiopsy in the diagnosis of thoracic disorders.
Poletti V, Petrarulo S, Piciucchi S, Dubini A, De Grauw AJ, Sultani F, Martinello S, Gonunguntla HK, Ravaglia C
Pulmonology 2024 Sep-Oct;30(5):459-465. Epub 2024 Jan 5 doi: 10.1016/j.pulmoe.2023.11.008. PMID: 38182468
Pan-mediastinal neoplasm diagnosis via nationwide federated learning: a multicentre cohort study.
Tang R, Liang H, Guo Y, Li Z, Liu Z, Lin X, Yan Z, Liu J, Xu X, Shao W, Li S, Liang W, Wang W, Cui F, He H, Yang C, Jiang L, Wang H, Chen H, Guo C, Zhang H, Gao Z, He Y, Chen X, Zhao L, Yu H, Hu J, Zhao J, Li B, Yin C, Mao W, Lin W, Xie Y, Liu J, Li X, Wu D, Hou Q, Chen Y, Chen D, Xue Y, Liang Y, Tang W, Wang Q, Li E, Liu H, Wang G, Yu P, Chen C, Zheng B, Chen H, Zhang Z, Wang L, Wang A, Li Z, Fu J, Zhang G, Zhang J, Liu B, Zhao J, Deng B, Han Y, Leng X, Li Z, Zhang M, Liu C, Wang T, Luo Z, Yang C, Guo X, Ma K, Wang L, Jiang W, Han X, Wang Q, Qiao K, Xia Z, Zheng S, Xu C, Peng J, Wu S, Zhang Z, Huang H, Pang D, Liu Q, Li J, Ding X, Liu X, Zhong L, Lu Y, Xu F, Dai Q, He J
Lancet Digit Health 2023 Sep;5(9):e560-e570. doi: 10.1016/S2589-7500(23)00106-1. PMID: 37625894
Anesthesia for children with anterior mediastinal masses.
Tan A, Nolan JA
Paediatr Anaesth 2022 Jan;32(1):4-9. Epub 2021 Nov 14 doi: 10.1111/pan.14319. PMID: 34714957
Esophageal perforations.
Chirica M, Champault A, Dray X, Sulpice L, Munoz-Bongrand N, Sarfati E, Cattan P
J Visc Surg 2010 Jun;147(3):e117-28. Epub 2010 Sep 15 doi: 10.1016/j.jviscsurg.2010.08.003. PMID: 20833121
Mediastinal tumors.
Thomas CR Jr, Bonomi PD
Curr Opin Oncol 1991 Apr;3(2):335-43. doi: 10.1097/00001622-199104000-00015. PMID: 1648973

Recent systematic reviews

Pulmonary manifestations, treatments and outcomes of IgG4-related disease-a systematic literature review.
Dragos C, Joseph C, Elwell H, Dey M, Kouranloo K
Rheumatol Int 2024 Oct;44(10):1875-1886. Epub 2024 May 20 doi: 10.1007/s00296-024-05611-7. PMID: 38769126Free PMC Article
Ten Years of Linear Endobronchial Ultrasound: Evidence of Efficacy, Safety and Cost-effectiveness.
Fernández-Villar A, Mouronte-Roibás C, Botana-Rial M, Ruano-Raviña A
Arch Bronconeumol 2016 Feb;52(2):96-102. Epub 2015 Nov 10 doi: 10.1016/j.arbres.2015.08.007. PMID: 26565072
Technical Aspects of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration: CHEST Guideline and Expert Panel Report.
Wahidi MM, Herth F, Yasufuku K, Shepherd RW, Yarmus L, Chawla M, Lamb C, Casey KR, Patel S, Silvestri GA, Feller-Kopman DJ
Chest 2016 Mar;149(3):816-35. Epub 2016 Jan 12 doi: 10.1378/chest.15-1216. PMID: 26402427
Systematic review of spontaneous pneumomediastinum: a survey of 22 years' data.
Dajer-Fadel WL, Argüero-Sánchez R, Ibarra-Pérez C, Navarro-Reynoso FP
Asian Cardiovasc Thorac Ann 2014 Oct;22(8):997-1002. Epub 2013 Nov 5 doi: 10.1177/0218492313504091. PMID: 24887879
Complication rate of endosonography (endobronchial and endoscopic ultrasound): a systematic review.
von Bartheld MB, van Breda A, Annema JT
Respiration 2014;87(4):343-51. Epub 2014 Jan 16 doi: 10.1159/000357066. PMID: 24434575

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