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Lung Squamous Papilloma

MedGen UID:
317852
•Concept ID:
C1708785
•
Neoplastic Process
Synonyms: Bronchial Squamous Cell Papilloma; Lung Squamous Cell Papilloma

Definition

A papillary neoplasm that arises endobronchially. It is characterized by the presence of a delicate fibrovascular core lined by stratified squamous epithelium. Squamous cell papillomas can be solitary or multiple. Patients usually present with signs and symptoms of bronchial obstruction. Because of the possibility of recurrence and reported cases of squamous cell carcinomas arising at the excision site of squamous cell papillomas, complete excision is indicated. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Squamous Papilloma

Professional guidelines

PubMed

Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization.
Gormley M, Dudding T, Kachuri L, Burrows K, Chong AHW, Martin RM, Thomas SJ, Tyrrell J, Ness AR, Brennan P, Munafò MR, Pring M, Boccia S, Olshan AF, Diergaarde B, Hung RJ, Liu G, Tajara EH, Severino P, Toporcov TN, Lacko M, Waterboer T, Brenner N, Smith GD, Vincent EE, Richmond RC
BMC Med 2022 Jan 31;20(1):40. doi: 10.1186/s12916-022-02233-3. PMID: 35094705Free PMC Article
Systemic Bevacizumab Treatment for Recurrent Respiratory Papillomatosis: Long-Term Follow-Up.
Ruiz R, Balamuth N, Javia LR, Zur KB
Laryngoscope 2022 Oct;132(10):2071-2075. Epub 2022 Jan 19 doi: 10.1002/lary.30021. PMID: 35043981
Interferons in the treatment of human cancer.
Kirkwood JM, Ernstoff MS
J Clin Oncol 1984 Apr;2(4):336-52. doi: 10.1200/JCO.1984.2.4.336. PMID: 6323641

Recent clinical studies

Etiology

Predictive factors of distant metastasis in surgically treated HPV-positive tonsil cancer.
Shin HI, Cho KJ, Kim MS, Joo YH
PLoS One 2023;18(3):e0283368. Epub 2023 Mar 21 doi: 10.1371/journal.pone.0283368. PMID: 36943852Free PMC Article
Lung cancer in never smokers: The role of different risk factors other than tobacco smoking.
Corrales L, Rosell R, Cardona AF, Martín C, Zatarain-Barrón ZL, Arrieta O
Crit Rev Oncol Hematol 2020 Apr;148:102895. Epub 2020 Jan 31 doi: 10.1016/j.critrevonc.2020.102895. PMID: 32062313
Identifying patterns of failure and secondary primary malignancies in HPV-related oropharyngeal squamous cell carcinomas.
Holstead R, Rasul R, Golden A, Kamdar D, Ghaly M, Teckie S, Frank D, Fantasia J, Seetharamu N
Future Oncol 2020 Feb;16(6):199-207. Epub 2020 Jan 22 doi: 10.2217/fon-2019-0673. PMID: 31967480
Genetic instability in epithelial tissues at risk for cancer.
Hittelman WN
Ann N Y Acad Sci 2001 Dec;952:1-12. doi: 10.1111/j.1749-6632.2001.tb02723.x. PMID: 11795428
Cimetidine treatment for recurrent respiratory papillomatosis.
Harcourt JP, Worley G, Leighton SE
Int J Pediatr Otorhinolaryngol 1999 Dec 5;51(2):109-13. doi: 10.1016/s0165-5876(99)00279-7. PMID: 10619624

Diagnosis

What's new in benign lung tumours?
Boland JM
Histopathology 2024 Jan;84(1):124-135. Epub 2023 Sep 10 doi: 10.1111/his.15037. PMID: 37691383
SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck.
Nigam N, Bernard B, Sevilla S, Kim S, Dar MS, Tsai D, Robbins Y, Burkitt K, Sievers C, Allen CT, Bennett RL, Tettey TT, Carter B, Rinaldi L, Lingen MW, Sater H, Edmondson EF, Moshiri A, Saeed A, Cheng H, Luo X, Brennan K, Koparde V, Chen C, Das S, Andresson T, Abdelmaksoud A, Murali M, Sakata S, Takeuchi K, Chari R, Nakamura Y, Uppaluri R, Sunwoo JB, Van Waes C, Licht JD, Hager GL, Saloura V
Cell Rep 2023 Jul 25;42(7):112823. Epub 2023 Jul 17 doi: 10.1016/j.celrep.2023.112823. PMID: 37463106Free PMC Article
PD-L1: Can it be a biomarker for the prognosis or a promising therapeutic target in cervical cancer?
Wang R, Zhang Y, Shan F
Int Immunopharmacol 2022 Feb;103:108484. Epub 2021 Dec 23 doi: 10.1016/j.intimp.2021.108484. PMID: 34954558
The oral microbiota and its role in carcinogenesis.
Stasiewicz M, Karpiński TM
Semin Cancer Biol 2022 Nov;86(Pt 3):633-642. Epub 2021 Nov 4 doi: 10.1016/j.semcancer.2021.11.002. PMID: 34743032
Cystic Lung Diseases: Algorithmic Approach.
Raoof S, Bondalapati P, Vydyula R, Ryu JH, Gupta N, Raoof S, Galvin J, Rosen MJ, Lynch D, Travis W, Mehta S, Lazzaro R, Naidich D
Chest 2016 Oct;150(4):945-965. Epub 2016 May 13 doi: 10.1016/j.chest.2016.04.026. PMID: 27180915Free PMC Article

Therapy

Lung cancer in never smokers: The role of different risk factors other than tobacco smoking.
Corrales L, Rosell R, Cardona AF, Martín C, Zatarain-Barrón ZL, Arrieta O
Crit Rev Oncol Hematol 2020 Apr;148:102895. Epub 2020 Jan 31 doi: 10.1016/j.critrevonc.2020.102895. PMID: 32062313
Safety and clinical activity of PD-L1 blockade in patients with aggressive recurrent respiratory papillomatosis.
Allen CT, Lee S, Norberg SM, Kovalovsky D, Ye H, Clavijo PE, Hu-Lieskovan S, Schlegel R, Schlom J, Strauss J, Gulley JL, Trepel J, Hinrichs CS
J Immunother Cancer 2019 May 3;7(1):119. doi: 10.1186/s40425-019-0603-3. PMID: 31053174Free PMC Article
Therapy for recurrent respiratory papillomatosis.
Auborn KJ
Antivir Ther 2002 Mar;7(1):1-9. PMID: 12008782
Recurrent respiratory papillomatosis.
Derkay CS, Rimell FL, Thompson JW
Head Neck 1998 Aug;20(5):418-24. doi: 10.1002/(sici)1097-0347(199808)20:5<418::aid-hed10>3.0.co;2-c. PMID: 9663670
Interferons in the treatment of human cancer.
Kirkwood JM, Ernstoff MS
J Clin Oncol 1984 Apr;2(4):336-52. doi: 10.1200/JCO.1984.2.4.336. PMID: 6323641

Prognosis

Predictive factors of distant metastasis in surgically treated HPV-positive tonsil cancer.
Shin HI, Cho KJ, Kim MS, Joo YH
PLoS One 2023;18(3):e0283368. Epub 2023 Mar 21 doi: 10.1371/journal.pone.0283368. PMID: 36943852Free PMC Article
PD-L1: Can it be a biomarker for the prognosis or a promising therapeutic target in cervical cancer?
Wang R, Zhang Y, Shan F
Int Immunopharmacol 2022 Feb;103:108484. Epub 2021 Dec 23 doi: 10.1016/j.intimp.2021.108484. PMID: 34954558
HPV-Associated Tumor Eradication by Vaccination with Synthetic Short Peptides and Particle-Forming Liposomes.
He X, Zhou S, Quinn B, Jahagirdar D, Ortega J, Abrams SI, Lovell JF
Small 2021 Mar;17(11):e2007165. Epub 2021 Feb 19 doi: 10.1002/smll.202007165. PMID: 33605054Free PMC Article
Identifying patterns of failure and secondary primary malignancies in HPV-related oropharyngeal squamous cell carcinomas.
Holstead R, Rasul R, Golden A, Kamdar D, Ghaly M, Teckie S, Frank D, Fantasia J, Seetharamu N
Future Oncol 2020 Feb;16(6):199-207. Epub 2020 Jan 22 doi: 10.2217/fon-2019-0673. PMID: 31967480
Recurrent respiratory papillomatosis: A state-of-the-art review.
Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E
Respir Med 2017 May;126:116-121. Epub 2017 Apr 1 doi: 10.1016/j.rmed.2017.03.030. PMID: 28427542

Clinical prediction guides

Predictive factors of distant metastasis in surgically treated HPV-positive tonsil cancer.
Shin HI, Cho KJ, Kim MS, Joo YH
PLoS One 2023;18(3):e0283368. Epub 2023 Mar 21 doi: 10.1371/journal.pone.0283368. PMID: 36943852Free PMC Article
FHIT as tumor suppressor: mechanisms and therapeutic opportunities.
Pekarsky Y, Palamarchuk A, Huebner K, Croce CM
Cancer Biol Ther 2002 May-Jun;1(3):232-6. doi: 10.4161/cbt.73. PMID: 12432269
Genetic instability in epithelial tissues at risk for cancer.
Hittelman WN
Ann N Y Acad Sci 2001 Dec;952:1-12. doi: 10.1111/j.1749-6632.2001.tb02723.x. PMID: 11795428
Systemic cidofovir in papillomatosis.
Van Valckenborgh I, Wellens W, De Boeck K, Snoeck R, De Clercq E, Feenstra L
Clin Infect Dis 2001 Feb 1;32(3):E62-4. Epub 2001 Jan 23 doi: 10.1086/318497. PMID: 11170974
Papilloma of the bronchus.
Zimmermann A, Läng HR, Mühlberger F, Bachmann M
Respiration 1980;39(5):286-90. doi: 10.1159/000194230. PMID: 7414109

Recent systematic reviews

What investigations are needed to optimally monitor for malignancies in SLE?
Tessier-Cloutier B, Clarke AE, Pineau CA, Keeling S, Bissonauth A, Ramsey-Goldman R, Lee J, Bernatsky S
Lupus 2015 Jul;24(8):781-7. Epub 2015 Mar 4 doi: 10.1177/0961203315575587. PMID: 25742688
Human papilloma virus in non-small cell lung cancer in never smokers: a systematic review of the literature.
Hasegawa Y, Ando M, Kubo A, Isa S, Yamamoto S, Tsujino K, Kurata T, Ou SH, Takada M, Kawaguchi T
Lung Cancer 2014 Jan;83(1):8-13. Epub 2013 Oct 31 doi: 10.1016/j.lungcan.2013.10.002. PMID: 24252423
Survival outcomes of squamous cell carcinoma arising from sinonasal inverted papilloma: report of 6 cases with systematic review and pooled analysis.
Tanvetyanon T, Qin D, Padhya T, Kapoor R, McCaffrey J, Trotti A
Am J Otolaryngol 2009 Jan-Feb;30(1):38-43. Epub 2008 Jul 22 doi: 10.1016/j.amjoto.2008.02.005. PMID: 19027511
Lung involvement in juvenile onset recurrent respiratory papillomatosis: a systematic review of the literature.
Gélinas JF, Manoukian J, Côté A
Int J Pediatr Otorhinolaryngol 2008 Apr;72(4):433-52. Epub 2008 Feb 20 doi: 10.1016/j.ijporl.2007.12.003. PMID: 18281102
Transbronchial needle injection: a systematic review of a new diagnostic and therapeutic paradigm.
Seymour CW, Krimsky WS, Sager J, Kruklitis RJ, Lund ME, Musani AI, Sterman DH
Respiration 2006;73(1):78-89. doi: 10.1159/000090994. PMID: 16498271

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