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Bronchial Squamous Cell Papilloma

MedGen UID:
317852
•Concept ID:
C1708785
•
Neoplastic Process
Synonyms: Lung Squamous Cell Papilloma; Lung Squamous Papilloma

Definition

A papillary neoplasm that arises endobronchially. It is characterized by the presence of a delicate fibrovascular core lined by stratified squamous epithelium. Squamous cell papillomas can be solitary or multiple. Patients usually present with signs and symptoms of bronchial obstruction. Because of the possibility of recurrence and reported cases of squamous cell carcinomas arising at the excision site of squamous cell papillomas, complete excision is indicated. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBronchial Squamous Cell Papilloma

Professional guidelines

PubMed

Treatment of recurrent respiratory papillomatosis.
Kavuru MS, Mehta AC
N Engl J Med 1992 Jan 16;326(3):204-5. PMID: 1727560
Treatment of recurrent respiratory papillomatosis with interferon.
Sessions RB, Dichtel WJ, Goepfert H
Ear Nose Throat J 1984 Oct;63(10):488-93. PMID: 6489206

Recent clinical studies

Etiology

Long-term Outcomes of Juvenile Onset Recurrent Respiratory Papillomatosis with Pulmonary Involvement.
Yang Q, Li Y, Ma L, Xiao Y, Wang H, Ding Y, Hu R, Wang X, Meng L, Wang J, Xu W
Laryngoscope 2021 Jul;131(7):EE2277-E2283. Epub 2021 Jan 7 doi: 10.1002/lary.29376. PMID: 33411979
Laryngotracheobronchial papillomatosis: chest CT findings.
Fortes HR, Ranke FMV, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Irion KL, Souza CA, Marchiori E
J Bras Pneumol 2017 Jul-Aug;43(4):259-263. doi: 10.1590/S1806-37562016000000351. PMID: 29364999Free PMC Article
Genetic instability in epithelial tissues at risk for cancer.
Hittelman WN
Ann N Y Acad Sci 2001 Dec;952:1-12. doi: 10.1111/j.1749-6632.2001.tb02723.x. PMID: 11795428
Solitary pulmonary papillomas in adults: a clinicopathologic and in situ hybridization study of 14 cases combined with 27 cases in the literature.
Flieder DB, Koss MN, Nicholson A, Sesterhenn IA, Petras RE, Travis WD
Am J Surg Pathol 1998 Nov;22(11):1328-42. doi: 10.1097/00000478-199811000-00003. PMID: 9808125
The predictive value of human papilloma virus (HPV) typing in the prognosis of bronchial squamous cell papillomas.
Popper HH, Wirnsberger G, Jüttner-Smolle FM, Pongratz MG, Sommersgutter M
Histopathology 1992 Oct;21(4):323-30. doi: 10.1111/j.1365-2559.1992.tb00402.x. PMID: 1328017

Diagnosis

Treatment of Recurrent Respiratory Papillomatosis: Case Series and Review of Technique.
Manley C, Hutchinson C, Mahajan A, Ibrahim O, Folch E, Kumar R
Surg Technol Int 2021 May 20;38:139-143. doi: 10.52198/21.STI.38.GS1408. PMID: 33844241
Laryngotracheobronchial papillomatosis: chest CT findings.
Fortes HR, Ranke FMV, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Irion KL, Souza CA, Marchiori E
J Bras Pneumol 2017 Jul-Aug;43(4):259-263. doi: 10.1590/S1806-37562016000000351. PMID: 29364999Free PMC Article
Cystic Lung Diseases: Algorithmic Approach.
Raoof S, Bondalapati P, Vydyula R, Ryu JH, Gupta N, Raoof S, Galvin J, Rosen MJ, Lynch D, Travis W, Mehta S, Lazzaro R, Naidich D
Chest 2016 Oct;150(4):945-965. Epub 2016 May 13 doi: 10.1016/j.chest.2016.04.026. PMID: 27180915Free PMC Article
Tumors of the trachea.
McCarthy MJ, Rosado-de-Christenson ML
J Thorac Imaging 1995 Summer;10(3):180-98. doi: 10.1097/00005382-199522000-00004. PMID: 7674431
CT of focal pulmonary masses in childhood.
Shady K, Siegel MJ, Glazer HS
Radiographics 1992 May;12(3):505-14. doi: 10.1148/radiographics.12.3.1609141. PMID: 1609141

Therapy

Exhaled HPV infection in lung cancer: role of MA at 3p.
Carpagnano GE, Lacedonia D, Crisetti E, Palladino GP, Saliani V, Zoppo LD, Antonetti R, Natalicchio I, Foschino-Barbaro MP
Arch Med Res 2014 Jul;45(5):383-7. Epub 2014 Jun 21 doi: 10.1016/j.arcmed.2014.06.006. PMID: 24962429
Genetic instability in epithelial tissues at risk for cancer.
Hittelman WN
Ann N Y Acad Sci 2001 Dec;952:1-12. doi: 10.1111/j.1749-6632.2001.tb02723.x. PMID: 11795428
A solitary bronchial papilloma with malignant changes.
Inoue Y, Oka M, Ishii H, Kimino K, Kishikawa M, Ito M, Ito T, Nakashima M, Kohno S
Intern Med 2001 Jan;40(1):56-60. doi: 10.2169/internalmedicine.40.56. PMID: 11201373
Squamous cell carcinoma of the respiratory tract following laryngeal papillomatosis.
Lie ES, Engh V, Boysen M, Clausen OP, Kvernvold H, Stenersen TC, Winther FO
Acta Otolaryngol 1994 Mar;114(2):209-12. doi: 10.3109/00016489409126044. PMID: 7515551
Sites of predilection in recurrent respiratory papillomatosis.
Kashima H, Mounts P, Leventhal B, Hruban RH
Ann Otol Rhinol Laryngol 1993 Aug;102(8 Pt 1):580-3. doi: 10.1177/000348949310200802. PMID: 8394667

Prognosis

Sialadenoma Papilliferum of the Bronchus: An Unrecognized Bronchial Counterpart of the Salivary Gland Tumor With Frequent BRAF V600E Mutations.
Nakaguro M, Mino-Kenudson M, Urano M, Ogawa I, Honda Y, Hirai H, Tanigawa M, Sukeda A, Kajiwara N, Ohira T, Ikeda N, Mikami Y, Tada Y, Ikeda JI, Matsubayashi J, Faquin WC, Sadow PM, Nagao T
Am J Surg Pathol 2021 May 1;45(5):662-671. doi: 10.1097/PAS.0000000000001657. PMID: 33443864Free PMC Article
Long-term Outcomes of Juvenile Onset Recurrent Respiratory Papillomatosis with Pulmonary Involvement.
Yang Q, Li Y, Ma L, Xiao Y, Wang H, Ding Y, Hu R, Wang X, Meng L, Wang J, Xu W
Laryngoscope 2021 Jul;131(7):EE2277-E2283. Epub 2021 Jan 7 doi: 10.1002/lary.29376. PMID: 33411979
Cytological findings of mixed squamous cell and glandular papilloma in the lung.
Kadota K, Haba R, Katsuki N, Hayashi T, Miyai Y, Bando K, Shibuya S, Kushida Y
Diagn Cytopathol 2010 Dec;38(12):913-7. doi: 10.1002/dc.21334. PMID: 20301213
Solitary pulmonary papillomas in adults: a clinicopathologic and in situ hybridization study of 14 cases combined with 27 cases in the literature.
Flieder DB, Koss MN, Nicholson A, Sesterhenn IA, Petras RE, Travis WD
Am J Surg Pathol 1998 Nov;22(11):1328-42. doi: 10.1097/00000478-199811000-00003. PMID: 9808125
The predictive value of human papilloma virus (HPV) typing in the prognosis of bronchial squamous cell papillomas.
Popper HH, Wirnsberger G, Jüttner-Smolle FM, Pongratz MG, Sommersgutter M
Histopathology 1992 Oct;21(4):323-30. doi: 10.1111/j.1365-2559.1992.tb00402.x. PMID: 1328017

Clinical prediction guides

Sialadenoma Papilliferum of the Bronchus: An Unrecognized Bronchial Counterpart of the Salivary Gland Tumor With Frequent BRAF V600E Mutations.
Nakaguro M, Mino-Kenudson M, Urano M, Ogawa I, Honda Y, Hirai H, Tanigawa M, Sukeda A, Kajiwara N, Ohira T, Ikeda N, Mikami Y, Tada Y, Ikeda JI, Matsubayashi J, Faquin WC, Sadow PM, Nagao T
Am J Surg Pathol 2021 May 1;45(5):662-671. doi: 10.1097/PAS.0000000000001657. PMID: 33443864Free PMC Article
Laryngotracheobronchial papillomatosis: chest CT findings.
Fortes HR, Ranke FMV, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Irion KL, Souza CA, Marchiori E
J Bras Pneumol 2017 Jul-Aug;43(4):259-263. doi: 10.1590/S1806-37562016000000351. PMID: 29364999Free PMC Article
Genetic instability in epithelial tissues at risk for cancer.
Hittelman WN
Ann N Y Acad Sci 2001 Dec;952:1-12. doi: 10.1111/j.1749-6632.2001.tb02723.x. PMID: 11795428
Solitary pulmonary papillomas in adults: a clinicopathologic and in situ hybridization study of 14 cases combined with 27 cases in the literature.
Flieder DB, Koss MN, Nicholson A, Sesterhenn IA, Petras RE, Travis WD
Am J Surg Pathol 1998 Nov;22(11):1328-42. doi: 10.1097/00000478-199811000-00003. PMID: 9808125
Papilloma of the bronchus.
Zimmermann A, Läng HR, Mühlberger F, Bachmann M
Respiration 1980;39(5):286-90. doi: 10.1159/000194230. PMID: 7414109

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