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Benign Squamous Cell Neoplasm

MedGen UID:
141634
•Concept ID:
C0474800
•
Neoplastic Process
Synonyms: Benign Epidermoid Cell Neoplasm; Benign Epidermoid Cell Tumor; Benign squamous cell tumor; Benign Squamous Cell Tumor
SNOMED CT: Benign squamous cell tumor (252994001)

Definition

A non-metastasizing neoplasm composed of squamous cells. The neoplastic cells do not display malignant features. [from NCI]

Professional guidelines

PubMed

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Minimally Invasive Techniques for the Management of Thyroid Nodules.
Baldwin CK, Natter MB, Patel KN, Hodak SP
Endocrinol Metab Clin North Am 2022 Jun;51(2):323-349. doi: 10.1016/j.ecl.2022.01.001. PMID: 35662444
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer.
Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S; American Thyroid Association Guidelines Task Force
Thyroid 2015 Jul;25(7):716-59. doi: 10.1089/thy.2014.0460. PMID: 25900731Free PMC Article

Recent clinical studies

Etiology

Sinonasal Papillomas-An Up-To-Date Review for Practicing Pathologists.
Perry WR, Udager AM
Surg Pathol Clin 2024 Dec;17(4):561-576. doi: 10.1016/j.path.2024.07.012. PMID: 39489549
Conjunctival squamous intraepithelial neoplasia and its differential diagnosis.
Reese A, Margo CE
J Clin Pathol 2022 May;75(5):354-358. Epub 2021 Feb 22 doi: 10.1136/jclinpath-2020-207302. PMID: 33619216
Esophageal Squamous Papilloma in Children: A Single-center Case Series.
Tou AM, Al-Nimr AO
J Pediatr Gastroenterol Nutr 2021 May 1;72(5):690-692. doi: 10.1097/MPG.0000000000003066. PMID: 33847287
Cutaneous Squamous Cell Carcinoma: From Biology to Therapy.
Corchado-Cobos R, García-Sancha N, González-Sarmiento R, Pérez-Losada J, Cañueto J
Int J Mol Sci 2020 Apr 22;21(8) doi: 10.3390/ijms21082956. PMID: 32331425Free PMC Article
Cutaneous squamous cell carcinoma: defining the high-risk variant.
Martorell-Calatayud A, Sanmartín Jimenez O, Cruz Mojarrieta J, Guillén Barona C
Actas Dermosifiliogr 2013 Jun;104(5):367-79. Epub 2013 May 14 doi: 10.1016/j.adengl.2011.12.012. PMID: 23683506

Diagnosis

Magic mushroom: all is not as it seems.
Castro BN, Prata Saraiva R, Afonso João D, Dantas Costa S
Acta Chir Belg 2021 Oct;121(5):370-371. Epub 2021 Aug 29 doi: 10.1080/00015458.2021.1972590. PMID: 34427171
Common benign and malignant oral mucosal disease.
Wong T, Yap T, Wiesenfeld D
Aust J Gen Pract 2020 Sep;49(9):568-573. doi: 10.31128/AJGP-02-20-5250-01. PMID: 32864671
Through the looking glass: Basics and principles of reflectance confocal microscopy.
Que SK, Fraga-Braghiroli N, Grant-Kels JM, Rabinovitz HS, Oliviero M, Scope A
J Am Acad Dermatol 2015 Aug;73(2):276-84. Epub 2015 Jun 4 doi: 10.1016/j.jaad.2015.04.047. PMID: 26051696
Congenital epulis.
Merglová V, Mukensnabl P, Andrle P
BMJ Case Rep 2012 Jul 9;2012 doi: 10.1136/bcr.01.2012.5483. PMID: 22778448Free PMC Article
Inverted follicular keratosis.
Azzopardi JG, Laurini R
J Clin Pathol 1975 Jun;28(6):465-71. doi: 10.1136/jcp.28.6.465. PMID: 1141446Free PMC Article

Therapy

Magic mushroom: all is not as it seems.
Castro BN, Prata Saraiva R, Afonso João D, Dantas Costa S
Acta Chir Belg 2021 Oct;121(5):370-371. Epub 2021 Aug 29 doi: 10.1080/00015458.2021.1972590. PMID: 34427171
Management of inverted papilloma: review.
Attlmayr B, Derbyshire SG, Kasbekar AV, Swift AC
J Laryngol Otol 2017 Apr;131(4):284-289. Epub 2017 Feb 9 doi: 10.1017/S0022215117000172. PMID: 28179032
Keratoacanthoma: a distinct entity?
Gleich T, Chiticariu E, Huber M, Hohl D
Exp Dermatol 2016 Feb;25(2):85-91. Epub 2015 Dec 4 doi: 10.1111/exd.12880. PMID: 26476131
Recurrent respiratory papillomatosis.
Tasca RA, Clarke RW
Arch Dis Child 2006 Aug;91(8):689-91. doi: 10.1136/adc.2005.090514. PMID: 16861486Free PMC Article
Thyroid cancer.
Gimm O
Cancer Lett 2001 Feb 26;163(2):143-56. doi: 10.1016/s0304-3835(00)00697-2. PMID: 11165748

Prognosis

Preoperative evaluation and surgical planning of submandibular gland tumors.
Atula T, Panigrahi J, Tarkkanen J, Mäkitie A, Aro K
Head Neck 2017 Jun;39(6):1071-1077. Epub 2017 Mar 28 doi: 10.1002/hed.24691. PMID: 28370782
Bazex syndrome.
Rodrigues IA Jr, Gresta LT, Cruz RC, Carvalho GG, Moreira MH
An Bras Dermatol 2013 Nov-Dec;88(6 Suppl 1):209-11. doi: 10.1590/abd1806-4841.20132488. PMID: 24346922Free PMC Article
Cutaneous squamous cell carcinoma: defining the high-risk variant.
Martorell-Calatayud A, Sanmartín Jimenez O, Cruz Mojarrieta J, Guillén Barona C
Actas Dermosifiliogr 2013 Jun;104(5):367-79. Epub 2013 May 14 doi: 10.1016/j.adengl.2011.12.012. PMID: 23683506
Verrucous carcinoma of the skin and mucosa.
Schwartz RA
J Am Acad Dermatol 1995 Jan;32(1):1-21; quiz 22-4. doi: 10.1016/0190-9622(95)90177-9. PMID: 7822496
Calcified brain metastasis.
Hwang TL, Valdivieso JG, Yang CH, Wolin MJ
Neurosurgery 1993 Mar;32(3):451-4; discussion 454. doi: 10.1227/00006123-199303000-00018. PMID: 8455771

Clinical prediction guides

Usefulness of dermoscopy to improve the clinical and histopathologic diagnosis of skin cancers.
Yélamos O, Braun RP, Liopyris K, Wolner ZJ, Kerl K, Gerami P, Marghoob AA
J Am Acad Dermatol 2019 Feb;80(2):365-377. Epub 2018 Oct 13 doi: 10.1016/j.jaad.2018.07.072. PMID: 30321580
Skin spiradenocarcinoma - case presentation.
Rebegea LF, Firescu D, Dumitru M, Pătraşcu A
Rom J Morphol Embryol 2016;57(1):327-30. PMID: 27151731
Sarcoid-like reaction mimicking vaginal cancer recurrence.
Mayama M, Yoshihara M, Ukai M, Kondo S, Kishigami Y, Oguchi H
J Obstet Gynaecol Res 2015 Nov;41(11):1855-8. Epub 2015 Sep 30 doi: 10.1111/jog.12829. PMID: 26420533
Imaging findings of papillary breast lesions: a pictorial review.
Kestelman FP, Gomes CF, Fontes FB, Marchiori E
Clin Radiol 2014 Apr;69(4):436-41. Epub 2014 Jan 20 doi: 10.1016/j.crad.2013.11.020. PMID: 24457016
Head and neck cancer: the pursuit of molecular diagnostic markers.
Hasina R, Lingen MW
Semin Oncol 2004 Dec;31(6):718-25. doi: 10.1053/j.seminoncol.2004.09.012. PMID: 15599849

Recent systematic reviews

Genetic alterations landscape in paediatric thyroid tumours and/or differentiated thyroid cancer: Systematic review.
de Sousa MSA, Nunes IN, Christiano YP, Sisdelli L, Cerutti JM
Rev Endocr Metab Disord 2024 Feb;25(1):35-51. Epub 2023 Oct 24 doi: 10.1007/s11154-023-09840-2. PMID: 37874477
The Use of Contrast-Enhanced Sonography for Therapy Monitoring of Metastatic Lymph Nodes: A Systematic Review.
Rink M, Jung EM, Künzel J
Curr Oncol 2023 Jul 16;30(7):6734-6743. doi: 10.3390/curroncol30070494. PMID: 37504354Free PMC Article
Dermoscopy of cutaneous adnexal tumours: a systematic review of the literature.
Lai M, Muscianese M, Piana S, Chester J, Borsari S, Paolino G, Pellacani G, Longo C, Pampena R
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1524-1540. Epub 2022 May 25 doi: 10.1111/jdv.18210. PMID: 35536546Free PMC Article
Management of inverted papilloma: review.
Attlmayr B, Derbyshire SG, Kasbekar AV, Swift AC
J Laryngol Otol 2017 Apr;131(4):284-289. Epub 2017 Feb 9 doi: 10.1017/S0022215117000172. PMID: 28179032
Sphingosine kinase 1 and cancer: a systematic review and meta-analysis.
Zhang Y, Wang Y, Wan Z, Liu S, Cao Y, Zeng Z
PLoS One 2014;9(2):e90362. Epub 2014 Feb 27 doi: 10.1371/journal.pone.0090362. PMID: 24587339Free PMC Article

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