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Ocular sebaceous carcinoma

MedGen UID:
317974
•Concept ID:
C1709308
•
Neoplastic Process
Synonyms: Eye Sebaceous Carcinoma; eye sebaceous carcinoma; Ocular Sebaceous Carcinoma; ocular sebaceous carcinoma
 
Monarch Initiative: MONDO:0006327

Definition

A carcinoma that arises from the sebaceous glands of the ocular adnexa and sebaceous glands of the eyelid and caruncle. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOcular sebaceous carcinoma

Professional guidelines

PubMed

Periocular sebaceous carcinoma: updates in the diagnosis, treatment, staging, and management.
Dini F, Susini P, Nisi G, Cuomo R, Grimaldi L, Massi D, Innocenti A, Doni L, Mazzini C, Santoro N, De Giorgi V
Int J Dermatol 2024 Jun;63(6):726-736. Epub 2024 Feb 13 doi: 10.1111/ijd.17045. PMID: 38351466
Sebaceous carcinoma: evidence-based clinical practice guidelines.
Owen JL, Kibbi N, Worley B, Kelm RC, Wang JV, Barker CA, Behshad R, Bichakjian CK, Bolotin D, Bordeaux JS, Bradshaw SH, Cartee TV, Chandra S, Cho NL, Choi JN, Council ML, Demirci H, Eisen DB, Esmaeli B, Golda N, Huang CC, Ibrahim SF, Jiang SB, Kim J, Kuzel TM, Lai SY, Lawrence N, Lee EH, Leitenberger JJ, Maher IA, Mann MW, Minkis K, Mittal BB, Nehal KS, Neuhaus IM, Ozog DM, Petersen B, Rotemberg V, Samant S, Samie FH, Servaes S, Shields CL, Shin TM, Sobanko JF, Somani AK, Stebbins WG, Thomas JR, Thomas VD, Tse DT, Waldman AH, Wong MK, Xu YG, Yu SS, Zeitouni NC, Ramsay T, Reynolds KA, Poon E, Alam M
Lancet Oncol 2019 Dec;20(12):e699-e714. doi: 10.1016/S1470-2045(19)30673-4. PMID: 31797796
Eyelid and ocular surface carcinoma: diagnosis and management.
Yin VT, Merritt HA, Sniegowski M, Esmaeli B
Clin Dermatol 2015 Mar-Apr;33(2):159-69. doi: 10.1016/j.clindermatol.2014.10.008. PMID: 25704936

Recent clinical studies

Etiology

High-risk human papillomavirus and ZEB1 in ocular adnexal sebaceous carcinoma.
Moore RF, Zhang XR, Allison DB, Rooper LM, Campbell AA, Eberhart CG
J Cutan Pathol 2021 Aug;48(8):1027-1033. Epub 2021 Apr 6 doi: 10.1111/cup.13987. PMID: 33745190
Epidemiology of cutaneous sebaceous carcinoma.
Wu A, Rajak SN, Chiang CJ, Lee WC, Huilgol SC, Selva D
Australas J Dermatol 2021 Feb;62(1):57-59. Epub 2020 Jul 6 doi: 10.1111/ajd.13387. PMID: 32632921
Cytologic Grading of Cutaneous Sebaceous Neoplasms: Does it Help to Differentiate Benign From Malignant?
Tirado M, Metze D, Sahlmann J, Böer-Auer A
Am J Dermatopathol 2019 Oct;41(10):722-732. doi: 10.1097/DAD.0000000000001434. PMID: 31584883
Observational prospective cohort study of patients with newly-diagnosed ocular sebaceous carcinoma.
Muqit MM, Foot B, Walters SJ, Mudhar HS, Roberts F, Rennie IG
Br J Ophthalmol 2013 Jan;97(1):47-51. Epub 2012 Oct 31 doi: 10.1136/bjophthalmol-2012-302443. PMID: 23117971
Early onset sebaceous carcinoma.
Sung D, Kaltreider SA, Gonzalez-Fernandez F
Diagn Pathol 2011 Sep 5;6:81. doi: 10.1186/1746-1596-6-81. PMID: 21892948Free PMC Article

Diagnosis

Extra-ocular sebaceous carcinoma - A rare case report.
Sindhura M, Santosh T, Kumar JR, Shankaralingappa A, Pannerselvam NK, Balakrishna P
Indian J Pathol Microbiol 2024 Jan-Mar;67(1):169-171. doi: 10.4103/ijpm.ijpm_860_21. PMID: 38358213
Cytomorphology of sebaceous carcinoma of the eyelid: A short series of three cases with literature review.
Kumar T, Tewari P, Khanna N, Surabhi, Bharti S, Sinha R, Bhadani PP
Diagn Cytopathol 2022 Dec;50(12):E361-E366. Epub 2022 Aug 6 doi: 10.1002/dc.25029. PMID: 35932255
miR-196b-5p and miR-107 Expression Differentiates Ocular Sebaceous Carcinoma from Squamous Cell Carcinoma of the Conjunctiva.
de Keizer ROB, Vriends ALM, Hötte GJ, Paridaens DA, Wiemer EAC, Verdijk RM
Int J Mol Sci 2022 Apr 28;23(9) doi: 10.3390/ijms23094877. PMID: 35563269Free PMC Article
High-risk human papillomavirus and ZEB1 in ocular adnexal sebaceous carcinoma.
Moore RF, Zhang XR, Allison DB, Rooper LM, Campbell AA, Eberhart CG
J Cutan Pathol 2021 Aug;48(8):1027-1033. Epub 2021 Apr 6 doi: 10.1111/cup.13987. PMID: 33745190
A histochemical and immunohistochemical study of extra-ocular sebaceous carcinoma.
Ansai S, Hashimoto H, Aoki T, Hozumi Y, Aso K
Histopathology 1993 Feb;22(2):127-33. doi: 10.1111/j.1365-2559.1993.tb00090.x. PMID: 7681028

Prognosis

miR-196b-5p and miR-107 Expression Differentiates Ocular Sebaceous Carcinoma from Squamous Cell Carcinoma of the Conjunctiva.
de Keizer ROB, Vriends ALM, Hötte GJ, Paridaens DA, Wiemer EAC, Verdijk RM
Int J Mol Sci 2022 Apr 28;23(9) doi: 10.3390/ijms23094877. PMID: 35563269Free PMC Article
High-risk human papillomavirus and ZEB1 in ocular adnexal sebaceous carcinoma.
Moore RF, Zhang XR, Allison DB, Rooper LM, Campbell AA, Eberhart CG
J Cutan Pathol 2021 Aug;48(8):1027-1033. Epub 2021 Apr 6 doi: 10.1111/cup.13987. PMID: 33745190
Twenty-Eight Cases of Extraocular Sebaceous Carcinoma: A Correlative Clinicopathological and Immunohistochemical Analysis of Extraocular Sebaceous Carcinomas and Benign Sebaceous Gland Tumors.
Boecker W, Reusch M, Mielke V, Reusch U, Hallermann C, Loening T, Tiemann M, Buchwalow I
Am J Dermatopathol 2021 Feb 1;43(2):93-102. doi: 10.1097/DAD.0000000000001667. PMID: 32568835
Observational prospective cohort study of patients with newly-diagnosed ocular sebaceous carcinoma.
Muqit MM, Foot B, Walters SJ, Mudhar HS, Roberts F, Rennie IG
Br J Ophthalmol 2013 Jan;97(1):47-51. Epub 2012 Oct 31 doi: 10.1136/bjophthalmol-2012-302443. PMID: 23117971
Immunohistochemical differentiation of extra-ocular sebaceous carcinoma from other skin cancers.
Ansai S, Mitsuhashi Y, Kondo S, Manabe M
J Dermatol 2004 Dec;31(12):998-1008. doi: 10.1111/j.1346-8138.2004.tb00644.x. PMID: 15801265

Clinical prediction guides

miR-196b-5p and miR-107 Expression Differentiates Ocular Sebaceous Carcinoma from Squamous Cell Carcinoma of the Conjunctiva.
de Keizer ROB, Vriends ALM, Hötte GJ, Paridaens DA, Wiemer EAC, Verdijk RM
Int J Mol Sci 2022 Apr 28;23(9) doi: 10.3390/ijms23094877. PMID: 35563269Free PMC Article
High-risk human papillomavirus and ZEB1 in ocular adnexal sebaceous carcinoma.
Moore RF, Zhang XR, Allison DB, Rooper LM, Campbell AA, Eberhart CG
J Cutan Pathol 2021 Aug;48(8):1027-1033. Epub 2021 Apr 6 doi: 10.1111/cup.13987. PMID: 33745190
Twenty-Eight Cases of Extraocular Sebaceous Carcinoma: A Correlative Clinicopathological and Immunohistochemical Analysis of Extraocular Sebaceous Carcinomas and Benign Sebaceous Gland Tumors.
Boecker W, Reusch M, Mielke V, Reusch U, Hallermann C, Loening T, Tiemann M, Buchwalow I
Am J Dermatopathol 2021 Feb 1;43(2):93-102. doi: 10.1097/DAD.0000000000001667. PMID: 32568835
Observational prospective cohort study of patients with newly-diagnosed ocular sebaceous carcinoma.
Muqit MM, Foot B, Walters SJ, Mudhar HS, Roberts F, Rennie IG
Br J Ophthalmol 2013 Jan;97(1):47-51. Epub 2012 Oct 31 doi: 10.1136/bjophthalmol-2012-302443. PMID: 23117971
Immunohistochemical differentiation of extra-ocular sebaceous carcinoma from other skin cancers.
Ansai S, Mitsuhashi Y, Kondo S, Manabe M
J Dermatol 2004 Dec;31(12):998-1008. doi: 10.1111/j.1346-8138.2004.tb00644.x. PMID: 15801265

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