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Pleural epithelioid mesothelioma

MedGen UID:
318031
•Concept ID:
C1709574
•
Neoplastic Process
Synonyms: malignant epithelioid mesothelioma of pleura; pleura malignant epithelioid mesothelioma; Pleural Epithelioid Mesothelioma; pleural epithelioid mesothelioma
 
Monarch Initiative: MONDO:0006378

Definition

Malignant mesothelioma that arises from the pleura. It is characterized by the presence of cells with epithelioid morphology. The epithelioid cells usually have eosinophilic cytoplasm, bland nuclei, and form tubulopapillary, microglandular, or sheet-like patterns. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPleural epithelioid mesothelioma

Professional guidelines

PubMed

Management of Advanced Pleural Mesothelioma-At the Crossroads.
Nowak AK, Jackson A, Sidhu C
JCO Oncol Pract 2022 Feb;18(2):116-124. Epub 2021 Sep 7 doi: 10.1200/OP.21.00426. PMID: 34491782
Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group.
Husain AN, Colby TV, Ordóñez NG, Allen TC, Attanoos RL, Beasley MB, Butnor KJ, Chirieac LR, Churg AM, Dacic S, Galateau-Sallé F, Gibbs A, Gown AM, Krausz T, Litzky LA, Marchevsky A, Nicholson AG, Roggli VL, Sharma AK, Travis WD, Walts AE, Wick MR
Arch Pathol Lab Med 2018 Jan;142(1):89-108. Epub 2017 Jul 7 doi: 10.5858/arpa.2017-0124-RA. PMID: 28686500
Malignant pleural mesothelioma: an update on diagnosis and treatment options.
Kondola S, Manners D, Nowak AK
Ther Adv Respir Dis 2016 Jun;10(3):275-88. Epub 2016 Feb 12 doi: 10.1177/1753465816628800. PMID: 26873306Free PMC Article

Recent clinical studies

Etiology

Diagnostic Utility of BAP1, EZH2 and Survivin in Differentiating Pleural Epithelioid Mesothelioma and Reactive Mesothelial Hyperplasia: Immunohistochemical Study.
Hakim SA, Abou Gabal HH
Pathol Oncol Res 2021;27:600073. Epub 2021 Apr 9 doi: 10.3389/pore.2021.600073. PMID: 34257556Free PMC Article
High tumor cell platelet-derived growth factor receptor beta expression is associated with shorter survival in malignant pleural epithelioid mesothelioma.
Ollila H, Paajanen J, Wolff H, Ilonen I, Sutinen E, Välimäki K, Östman A, Anttila S, Kettunen E, Räsänen J, Kallioniemi O, Myllärniemi M, Mäyränpää MI, Pellinen T
J Pathol Clin Res 2021 Sep;7(5):482-494. Epub 2021 May 6 doi: 10.1002/cjp2.218. PMID: 33955203Free PMC Article
Myxoid variant epithelioid pleural mesothelioma defines a favourable prognosis group: an analysis of 191 patients with pleural malignant mesothelioma.
Alchami FS, Attanoos RL, Bamber AR
J Clin Pathol 2017 Feb;70(2):179-182. Epub 2016 Oct 18 doi: 10.1136/jclinpath-2016-203993. PMID: 27798081

Diagnosis

Ki-67 Proliferation Index Is Associated With Tumor Grade and Survival in Pleural Epithelioid Mesotheliomas.
Galeano B, Smith CJ, Yi ES, Roden AC, Jenkins S, Capelle J, Kittle-Francis M, Mansfield AS, Aubry MC
Am J Surg Pathol 2024 May 1;48(5):615-622. Epub 2024 Feb 19 doi: 10.1097/PAS.0000000000002196. PMID: 38369761Free PMC Article
Diagnostic Utility of BAP1, EZH2 and Survivin in Differentiating Pleural Epithelioid Mesothelioma and Reactive Mesothelial Hyperplasia: Immunohistochemical Study.
Hakim SA, Abou Gabal HH
Pathol Oncol Res 2021;27:600073. Epub 2021 Apr 9 doi: 10.3389/pore.2021.600073. PMID: 34257556Free PMC Article
High tumor cell platelet-derived growth factor receptor beta expression is associated with shorter survival in malignant pleural epithelioid mesothelioma.
Ollila H, Paajanen J, Wolff H, Ilonen I, Sutinen E, Välimäki K, Östman A, Anttila S, Kettunen E, Räsänen J, Kallioniemi O, Myllärniemi M, Mäyränpää MI, Pellinen T
J Pathol Clin Res 2021 Sep;7(5):482-494. Epub 2021 May 6 doi: 10.1002/cjp2.218. PMID: 33955203Free PMC Article
Value of PAX8, PAX2, napsin A, carbonic anhydrase IX, and claudin-4 immunostaining in distinguishing pleural epithelioid mesothelioma from metastatic renal cell carcinoma.
Ordóñez NG
Mod Pathol 2013 Aug;26(8):1132-43. Epub 2013 Mar 15 doi: 10.1038/modpathol.2013.34. PMID: 23503645
Primary pleural epithelioid mesothelioma of clear cell type: a case report and review of current literature.
Gkogkou C, Samitas K, Foteinou M
Ultrastruct Pathol 2011 Dec;35(6):267-70. Epub 2011 Oct 6 doi: 10.3109/01913123.2011.606965. PMID: 21978187

Therapy

Primary pleural epithelioid mesothelioma of clear cell type: a case report and review of current literature.
Gkogkou C, Samitas K, Foteinou M
Ultrastruct Pathol 2011 Dec;35(6):267-70. Epub 2011 Oct 6 doi: 10.3109/01913123.2011.606965. PMID: 21978187
Late cutaneous metastases to the face from malignant pleural mesothelioma: a case report and review of the literature.
Elbahaie AM, Kamel DE, Lawrence J, Davidson NG
World J Surg Oncol 2009 Nov 9;7:84. doi: 10.1186/1477-7819-7-84. PMID: 19900274Free PMC Article

Prognosis

Diagnostic Utility of BAP1, EZH2 and Survivin in Differentiating Pleural Epithelioid Mesothelioma and Reactive Mesothelial Hyperplasia: Immunohistochemical Study.
Hakim SA, Abou Gabal HH
Pathol Oncol Res 2021;27:600073. Epub 2021 Apr 9 doi: 10.3389/pore.2021.600073. PMID: 34257556Free PMC Article
High tumor cell platelet-derived growth factor receptor beta expression is associated with shorter survival in malignant pleural epithelioid mesothelioma.
Ollila H, Paajanen J, Wolff H, Ilonen I, Sutinen E, Välimäki K, Östman A, Anttila S, Kettunen E, Räsänen J, Kallioniemi O, Myllärniemi M, Mäyränpää MI, Pellinen T
J Pathol Clin Res 2021 Sep;7(5):482-494. Epub 2021 May 6 doi: 10.1002/cjp2.218. PMID: 33955203Free PMC Article
Malignant pleural epithelioid mesothelioma: A mulberry mayhem.
Mishra P, Sahoo S, Pradhan P, Deosale S, Panigrahi R, Tripathy KP, Rath J
Indian J Pathol Microbiol 2021 Apr-Jun;64(2):415-417. doi: 10.4103/IJPM.IJPM_637_20. PMID: 33851650
Myxoid variant epithelioid pleural mesothelioma defines a favourable prognosis group: an analysis of 191 patients with pleural malignant mesothelioma.
Alchami FS, Attanoos RL, Bamber AR
J Clin Pathol 2017 Feb;70(2):179-182. Epub 2016 Oct 18 doi: 10.1136/jclinpath-2016-203993. PMID: 27798081
Primary pleural epithelioid mesothelioma of clear cell type: a case report and review of current literature.
Gkogkou C, Samitas K, Foteinou M
Ultrastruct Pathol 2011 Dec;35(6):267-70. Epub 2011 Oct 6 doi: 10.3109/01913123.2011.606965. PMID: 21978187

Clinical prediction guides

Ki-67 Proliferation Index Is Associated With Tumor Grade and Survival in Pleural Epithelioid Mesotheliomas.
Galeano B, Smith CJ, Yi ES, Roden AC, Jenkins S, Capelle J, Kittle-Francis M, Mansfield AS, Aubry MC
Am J Surg Pathol 2024 May 1;48(5):615-622. Epub 2024 Feb 19 doi: 10.1097/PAS.0000000000002196. PMID: 38369761Free PMC Article
Myxoid variant epithelioid pleural mesothelioma defines a favourable prognosis group: an analysis of 191 patients with pleural malignant mesothelioma.
Alchami FS, Attanoos RL, Bamber AR
J Clin Pathol 2017 Feb;70(2):179-182. Epub 2016 Oct 18 doi: 10.1136/jclinpath-2016-203993. PMID: 27798081
Primary pleural epithelioid mesothelioma of clear cell type: a case report and review of current literature.
Gkogkou C, Samitas K, Foteinou M
Ultrastruct Pathol 2011 Dec;35(6):267-70. Epub 2011 Oct 6 doi: 10.3109/01913123.2011.606965. PMID: 21978187

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