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Lung Basaloid Squamous Cell Carcinoma

MedGen UID:
318198
•Concept ID:
C1710173
•
Neoplastic Process
Synonyms: Basaloid squamous cell carcinoma of lung; Basaloid Squamous Cell Lung Carcinoma; Squamous Cell Lung Carcinoma, Basaloid Variant
SNOMED CT: Basaloid squamous cell carcinoma of lung (1255651005)

Definition

A morphologic variant of squamous cell lung carcinoma characterized by nuclear palisading. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Basaloid Squamous Cell Carcinoma

Professional guidelines

PubMed

Pulmonary squamous cell carcinoma and lymphoepithelial carcinoma - morphology, molecular characteristics and differential diagnosis.
Berezowska S, Maillard M, Keyter M, Bisig B
Histopathology 2024 Jan;84(1):32-49. Epub 2023 Nov 7 doi: 10.1111/his.15076. PMID: 37936498

Recent clinical studies

Etiology

Pulmonary squamous cell carcinoma and lymphoepithelial carcinoma - morphology, molecular characteristics and differential diagnosis.
Berezowska S, Maillard M, Keyter M, Bisig B
Histopathology 2024 Jan;84(1):32-49. Epub 2023 Nov 7 doi: 10.1111/his.15076. PMID: 37936498
Correlation of clinicopathologic features and lung squamous cell carcinoma subtypes according to the 2015 WHO classification.
Chen R, Ding Z, Zhu L, Lu S, Yu Y
Eur J Surg Oncol 2017 Dec;43(12):2308-2314. Epub 2017 Sep 19 doi: 10.1016/j.ejso.2017.09.011. PMID: 28964610
PD-L1 expression in basaloid squamous cell lung carcinoma: Relationship to PD-1(+) and CD8(+) tumor-infiltrating T cells and outcome.
Ilie M, Falk AT, Butori C, Chamorey E, Bonnetaud C, Long E, Lassalle S, Zahaf K, Vénissac N, Mouroux J, Cohen C, Brambilla E, Marquette CH, Hofman V, Hofman P
Mod Pathol 2016 Dec;29(12):1552-1564. Epub 2016 Aug 26 doi: 10.1038/modpathol.2016.149. PMID: 27562497
The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification.
Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, Geisinger K, Hirsch FR, Ishikawa Y, Kerr KM, Noguchi M, Pelosi G, Powell CA, Tsao MS, Wistuba I; WHO Panel
J Thorac Oncol 2015 Sep;10(9):1243-1260. doi: 10.1097/JTO.0000000000000630. PMID: 26291008
Pulmonary preneoplasia--sequential molecular carcinogenetic events.
Lantuéjoul S, Salameire D, Salon C, Brambilla E
Histopathology 2009 Jan;54(1):43-54. doi: 10.1111/j.1365-2559.2008.03182.x. PMID: 19187179

Diagnosis

POU2F3 in SCLC: Clinicopathologic and Genomic Analysis With a Focus on Its Diagnostic Utility in Neuroendocrine-Low SCLC.
Baine MK, Febres-Aldana CA, Chang JC, Jungbluth AA, Sethi S, Antonescu CR, Travis WD, Hsieh MS, Roh MS, Homer RJ, Ladanyi M, Egger JV, Lai WV, Rudin CM, Rekhtman N
J Thorac Oncol 2022 Sep;17(9):1109-1121. Epub 2022 Jun 24 doi: 10.1016/j.jtho.2022.06.004. PMID: 35760287Free PMC Article
Neuroendocrine differentiation distinguishes basaloid variant of lung squamous cell carcinoma.
Keyhanian K, Phillips WJ, Yeung BS, Gomes M, Lo B, Sekhon HS
Diagn Pathol 2022 May 10;17(1):46. doi: 10.1186/s13000-022-01223-6. PMID: 35538551Free PMC Article
NUT carcinoma of the lung.
Lantuejoul S, Pissaloux D, Ferretti GR, McLeer A
Semin Diagn Pathol 2021 Sep;38(5):72-82. Epub 2021 Jun 16 doi: 10.1053/j.semdp.2021.06.005. PMID: 34176698
The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification.
Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, Geisinger K, Hirsch FR, Ishikawa Y, Kerr KM, Noguchi M, Pelosi G, Powell CA, Tsao MS, Wistuba I; WHO Panel
J Thorac Oncol 2015 Sep;10(9):1243-1260. doi: 10.1097/JTO.0000000000000630. PMID: 26291008
Large cell carcinoma of lung: On the verge of extinction?
Weissferdt A
Semin Diagn Pathol 2014 Jul;31(4):278-88. Epub 2014 Jun 12 doi: 10.1053/j.semdp.2014.06.005. PMID: 25023633

Therapy

Diagnostic and Therapeutic Challenges in a Patient with Synchronous Very High-Risk Prostate Adenocarcinoma and Anal Carcinoma.
Wallach J, Youssef I, Leaf A, Schwartz D
Curr Oncol 2022 Jan 15;29(1):377-382. doi: 10.3390/curroncol29010033. PMID: 35049707Free PMC Article
Basaloid Squamous Cell Carcinoma of the Uterine Cervix: Report of a Case With Molecular Analysis.
Munkhdelger J, Shimooka T, Koyama Y, Ikeda S, Mikami Y, Fukuoka J, Hori T, Bychkov A
Int J Surg Pathol 2021 Oct;29(7):770-774. Epub 2021 Apr 1 doi: 10.1177/1066896921997132. PMID: 33792431
HPV-associated neuroendocrine carcinoma of the oropharynx: a rare new entity with potentially aggressive clinical behavior.
Kraft S, Faquin WC, Krane JF
Am J Surg Pathol 2012 Mar;36(3):321-30. doi: 10.1097/PAS.0b013e31823f2f17. PMID: 22301491
Basaloid squamous cell carcinoma of the larynx--A systematic review.
Thankappan K
Auris Nasus Larynx 2012 Aug;39(4):397-401. Epub 2011 Aug 24 doi: 10.1016/j.anl.2011.07.018. PMID: 21868181
Thymic carcinoma: is it a separate entity? From molecular to clinical evidence.
Marx A, Rieker R, Toker A, Länger F, Ströbel P
Thorac Surg Clin 2011 Feb;21(1):25-31. v-vi. doi: 10.1016/j.thorsurg.2010.08.010. PMID: 21070984

Prognosis

NUT carcinoma of the lung.
Lantuejoul S, Pissaloux D, Ferretti GR, McLeer A
Semin Diagn Pathol 2021 Sep;38(5):72-82. Epub 2021 Jun 16 doi: 10.1053/j.semdp.2021.06.005. PMID: 34176698
PD-L1 expression in basaloid squamous cell lung carcinoma: Relationship to PD-1(+) and CD8(+) tumor-infiltrating T cells and outcome.
Ilie M, Falk AT, Butori C, Chamorey E, Bonnetaud C, Long E, Lassalle S, Zahaf K, Vénissac N, Mouroux J, Cohen C, Brambilla E, Marquette CH, Hofman V, Hofman P
Mod Pathol 2016 Dec;29(12):1552-1564. Epub 2016 Aug 26 doi: 10.1038/modpathol.2016.149. PMID: 27562497
Lung squamous cell carcinomas with basaloid histology represent a specific molecular entity.
Brambilla C, Laffaire J, Lantuejoul S, Moro-Sibilot D, Mignotte H, Arbib F, Toffart AC, Petel F, Hainaut P, Rousseaux S, Khochbin S, de Reyniès A, Brambilla E
Clin Cancer Res 2014 Nov 15;20(22):5777-86. Epub 2014 Sep 4 doi: 10.1158/1078-0432.CCR-14-0459. PMID: 25189482
Morphologic and clinicopathologic features of lung squamous cell carcinomas expressing Sox2.
Brcic L, Sherer CK, Shuai Y, Hornick JL, Chirieac LR, Dacic S
Am J Clin Pathol 2012 Nov;138(5):712-8. doi: 10.1309/AJCP05TTWQTWNLTN. PMID: 23086772
Basaloid squamous cell carcinoma of the larynx--A systematic review.
Thankappan K
Auris Nasus Larynx 2012 Aug;39(4):397-401. Epub 2011 Aug 24 doi: 10.1016/j.anl.2011.07.018. PMID: 21868181

Clinical prediction guides

Integrated molecular characterization of esophageal basaloid squamous cell carcinoma: a subtype with distinct RNA expression pattern and immune characteristics, but no specific genetic mutations.
Li Y, Liu L, Pan Y, Fang F, Xie T, Cheng N, Guo C, Xue X, Zeng H, Xue L
J Pathol 2023 Feb;259(2):136-148. Epub 2022 Dec 13 doi: 10.1002/path.6028. PMID: 36371676
NUT carcinoma of the lung.
Lantuejoul S, Pissaloux D, Ferretti GR, McLeer A
Semin Diagn Pathol 2021 Sep;38(5):72-82. Epub 2021 Jun 16 doi: 10.1053/j.semdp.2021.06.005. PMID: 34176698
PD-L1 expression in basaloid squamous cell lung carcinoma: Relationship to PD-1(+) and CD8(+) tumor-infiltrating T cells and outcome.
Ilie M, Falk AT, Butori C, Chamorey E, Bonnetaud C, Long E, Lassalle S, Zahaf K, Vénissac N, Mouroux J, Cohen C, Brambilla E, Marquette CH, Hofman V, Hofman P
Mod Pathol 2016 Dec;29(12):1552-1564. Epub 2016 Aug 26 doi: 10.1038/modpathol.2016.149. PMID: 27562497
Lung squamous cell carcinomas with basaloid histology represent a specific molecular entity.
Brambilla C, Laffaire J, Lantuejoul S, Moro-Sibilot D, Mignotte H, Arbib F, Toffart AC, Petel F, Hainaut P, Rousseaux S, Khochbin S, de Reyniès A, Brambilla E
Clin Cancer Res 2014 Nov 15;20(22):5777-86. Epub 2014 Sep 4 doi: 10.1158/1078-0432.CCR-14-0459. PMID: 25189482
Leser-Trelat sign.
Ceylan C, Alper S, Kilinç I
Int J Dermatol 2002 Oct;41(10):687-8. doi: 10.1046/j.1365-4362.2002.01600.x. PMID: 12390193

Recent systematic reviews

Basaloid squamous cell carcinoma of the larynx--A systematic review.
Thankappan K
Auris Nasus Larynx 2012 Aug;39(4):397-401. Epub 2011 Aug 24 doi: 10.1016/j.anl.2011.07.018. PMID: 21868181

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