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Thymic Typical Carcinoid Tumor

MedGen UID:
318258
•Concept ID:
C1710403
•
Neoplastic Process
Synonyms: Thymic NET G1; Thymic Neuroendocrine Tumor G1

Definition

A primary thymic carcinoid tumor, characterized by the presence of uniform, polygonal neoplastic cells, a low mitotic rate, and absence of necrosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThymic Typical Carcinoid Tumor

Recent clinical studies

Etiology

Pancreatic metastases in patients with neuroendocrine neoplasms: A multi-centre cohort study.
Tsoli M, Daskalakis K, Wedin M, Angelousi A, Povlsen S, Srirajaskanthan R, Giovos G, Weickert MO, Kogut A, Kos-Kudla B, Oleinikov K, Grozinsky-Glasberg S, Kaltsas G
J Neuroendocrinol 2023 Apr;35(4):e13269. doi: 10.1111/jne.13269. PMID: 37102337
Carcinoid tumors outside the abdomen.
Koehler K, Iams WT
Cancer Med 2023 Apr;12(7):7893-7903. Epub 2022 Dec 22 doi: 10.1002/cam4.5564. PMID: 36560885Free PMC Article
Typical and Atypical Carcinoid Tumors of the Mediastinum: A Biomarker Analysis of 27 Cases With Clinical Correlation.
Zaleski M, Kalhor N, Moran CA
Int J Surg Pathol 2021 Jun;29(4):358-367. Epub 2020 Nov 27 doi: 10.1177/1066896920976845. PMID: 33243039
CT and MRI findings of thymic carcinoid.
Shimamoto A, Ashizawa K, Kido Y, Hayashi H, Nagayasu T, Kawakami A, Mukae H, Hayashi T, Ohtsubo M, Shigematsu K, Nakazono T, Yabuuchi H, Uetani M
Br J Radiol 2017 Mar;90(1071):20150341. Epub 2017 Jan 20 doi: 10.1259/bjr.20150341. PMID: 28106503Free PMC Article
Bronchial and Thymic Carcinoid Tumors.
Litvak A, Pietanza MC
Hematol Oncol Clin North Am 2016 Feb;30(1):83-102. doi: 10.1016/j.hoc.2015.09.003. PMID: 26614370

Diagnosis

Pancreatic metastases in patients with neuroendocrine neoplasms: A multi-centre cohort study.
Tsoli M, Daskalakis K, Wedin M, Angelousi A, Povlsen S, Srirajaskanthan R, Giovos G, Weickert MO, Kogut A, Kos-Kudla B, Oleinikov K, Grozinsky-Glasberg S, Kaltsas G
J Neuroendocrinol 2023 Apr;35(4):e13269. doi: 10.1111/jne.13269. PMID: 37102337
Carcinoid tumors outside the abdomen.
Koehler K, Iams WT
Cancer Med 2023 Apr;12(7):7893-7903. Epub 2022 Dec 22 doi: 10.1002/cam4.5564. PMID: 36560885Free PMC Article
Bronchial and Thymic Carcinoid Tumors.
Litvak A, Pietanza MC
Hematol Oncol Clin North Am 2016 Feb;30(1):83-102. doi: 10.1016/j.hoc.2015.09.003. PMID: 26614370
Pathology of the thymus on CT-imaging.
Peters R, Peters O, Braak S, Verschakelen J
JBR-BTR 2012 Sep-Oct;95(5):281-8. doi: 10.5334/jbr-btr.648. PMID: 23198365
Thoracic carcinoids: radiologic-pathologic correlation.
Rosado de Christenson ML, Abbott GF, Kirejczyk WM, Galvin JR, Travis WD
Radiographics 1999 May-Jun;19(3):707-36. doi: 10.1148/radiographics.19.3.g99ma11707. PMID: 10336200

Therapy

Efficacy and safety of long-acting pasireotide or everolimus alone or in combination in patients with advanced carcinoids of the lung and thymus (LUNA): an open-label, multicentre, randomised, phase 2 trial.
Ferolla P, Brizzi MP, Meyer T, Mansoor W, Mazieres J, Do Cao C, Léna H, Berruti A, Damiano V, Buikhuisen W, Grønbæk H, Lombard-Bohas C, Grohé C, Minotti V, Tiseo M, De Castro J, Reed N, Gislimberti G, Singh N, Stankovic M, Öberg K, Baudin E
Lancet Oncol 2017 Dec;18(12):1652-1664. Epub 2017 Oct 23 doi: 10.1016/S1470-2045(17)30681-2. PMID: 29074099
Bronchial and Thymic Carcinoid Tumors.
Litvak A, Pietanza MC
Hematol Oncol Clin North Am 2016 Feb;30(1):83-102. doi: 10.1016/j.hoc.2015.09.003. PMID: 26614370
A misleading cause of pseudo-thymic tumor in ectopic Cushing's syndrome.
Icard P, Heyndrickx M, Galateau-Salle F, Resnik Y
Asian Cardiovasc Thorac Ann 2013 Apr;21(2):224-6. doi: 10.1177/0218492312450290. PMID: 24532629
Pure red-cell aplasia as the presenting feature of the carcionoid tumor of the thymus: case report.
Petakov SM, Suvajdzić N, Petakov DM, Sefer D, Ognjanović S, Macut D, Durović M, Isailović T, Subotić D, Stojsić J, Todorović V, Damjanović S
Med Oncol 2010 Mar;27(1):82-5. Epub 2009 Feb 18 doi: 10.1007/s12032-009-9175-2. PMID: 19224408
Thymic carcinoid responds to neoadjuvant therapy with sunitinib and octreotide: a case report.
Dham A, Truskinovsky AM, Dudek AZ
J Thorac Oncol 2008 Jan;3(1):94-7. doi: 10.1097/JTO.0b013e31815eb7a2. PMID: 18166847

Prognosis

Pancreatic metastases in patients with neuroendocrine neoplasms: A multi-centre cohort study.
Tsoli M, Daskalakis K, Wedin M, Angelousi A, Povlsen S, Srirajaskanthan R, Giovos G, Weickert MO, Kogut A, Kos-Kudla B, Oleinikov K, Grozinsky-Glasberg S, Kaltsas G
J Neuroendocrinol 2023 Apr;35(4):e13269. doi: 10.1111/jne.13269. PMID: 37102337
Carcinoid tumors outside the abdomen.
Koehler K, Iams WT
Cancer Med 2023 Apr;12(7):7893-7903. Epub 2022 Dec 22 doi: 10.1002/cam4.5564. PMID: 36560885Free PMC Article
Molecular Pathology of Well-Differentiated Pulmonary and Thymic Neuroendocrine Tumors: What Do Pathologists Need to Know?
Volante M, Mete O, Pelosi G, Roden AC, Speel EJM, Uccella S
Endocr Pathol 2021 Mar;32(1):154-168. Epub 2021 Feb 27 doi: 10.1007/s12022-021-09668-z. PMID: 33641055Free PMC Article
Bronchial and Thymic Carcinoid Tumors.
Litvak A, Pietanza MC
Hematol Oncol Clin North Am 2016 Feb;30(1):83-102. doi: 10.1016/j.hoc.2015.09.003. PMID: 26614370
Thoracic carcinoids: radiologic-pathologic correlation.
Rosado de Christenson ML, Abbott GF, Kirejczyk WM, Galvin JR, Travis WD
Radiographics 1999 May-Jun;19(3):707-36. doi: 10.1148/radiographics.19.3.g99ma11707. PMID: 10336200

Clinical prediction guides

Typical and Atypical Carcinoid Tumors of the Mediastinum: A Biomarker Analysis of 27 Cases With Clinical Correlation.
Zaleski M, Kalhor N, Moran CA
Int J Surg Pathol 2021 Jun;29(4):358-367. Epub 2020 Nov 27 doi: 10.1177/1066896920976845. PMID: 33243039
PCSK2 expression in neuroendocrine tumors points to a midgut, pulmonary, or pheochromocytoma-paraganglioma origin.
Remes SM, Leijon H, Vesterinen T, Louhimo J, Pulkkinen V, Ezer S, Kere J, Haglund C, Arola J
APMIS 2020 Nov;128(11):563-572. Epub 2020 Sep 28 doi: 10.1111/apm.13071. PMID: 32794589Free PMC Article
Molecular Classification of Neuroendocrine Tumors of the Thymus.
Dinter H, Bohnenberger H, Beck J, Bornemann-Kolatzki K, Schütz E, Küffer S, Klein L, Franks TJ, Roden A, Emmert A, Hinterthaner M, Marino M, Brcic L, Popper H, Weis CA, Pelosi G, Marx A, Ströbel P
J Thorac Oncol 2019 Aug;14(8):1472-1483. Epub 2019 Apr 28 doi: 10.1016/j.jtho.2019.04.015. PMID: 31042566
Clinical outcomes of atypical carcinoid tumors of the lung and thymus: 7-year experience of a rare malignancy at single institute.
Han B, Sun JM, Ahn JS, Park K, Ahn MJ
Med Oncol 2013 Mar;30(1):479. Epub 2013 Feb 3 doi: 10.1007/s12032-013-0479-x. PMID: 23377986
Thymic neuroendocrine tumour (carcinoid): clinicopathological features of four patients with different presentation.
Dutta R, Kumar A, Julka PK, Mathur SR, Kaushal S, Kumar R, Jindal T, Suri V
Interact Cardiovasc Thorac Surg 2010 Dec;11(6):732-6. Epub 2010 Sep 17 doi: 10.1510/icvts.2010.237651. PMID: 20851876

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