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Nasal Cavity Keratinizing Squamous Cell Carcinoma

MedGen UID:
318530
•Concept ID:
C1711386
•
Neoplastic Process
Synonym: Keratinizing Nasal Cavity Squamous Cell Carcinoma

Definition

A squamous cell carcinoma that arises from the nasal cavity and is characterized by prominent production of keratin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNasal Cavity Keratinizing Squamous Cell Carcinoma

Professional guidelines

PubMed

Adenosquamous carcinoma of the head and neck: criteria for diagnosis in a study of 12 cases.
Alos L, Castillo M, Nadal A, Caballero M, Mallofre C, Palacin A, Cardesa A
Histopathology 2004 Jun;44(6):570-9. doi: 10.1111/j.1365-2559.2004.01881.x. PMID: 15186272
Epidermoid carcinoma of the nasal vestibule: current treatment evaluation.
Schaefer SD, Hill GC
Laryngoscope 1980 Oct;90(10 Pt 1):1631-5. PMID: 7421375

Recent clinical studies

Etiology

HPV-Related Multiphenotypic Sinonasal Carcinoma: Four Cases that Expand the Morpho-Molecular Spectrum and Include Occupational Data.
Rupp NJ, Camenisch U, Seidl K, Rushing EJ, Anderegg N, Broglie MA, Holzmann D, Morand GB
Head Neck Pathol 2020 Sep;14(3):623-629. Epub 2019 Sep 30 doi: 10.1007/s12105-019-01079-1. PMID: 31571045Free PMC Article
Evaluation of inverted papilloma and squamous cell carcinoma by nasal contact endoscopy.
Prado FA, Weber R, Romano FR, Voegels RL
Am J Rhinol Allergy 2010 May-Jun;24(3):210-4. doi: 10.2500/ajra.2010.24.3467. PMID: 20537289
Undifferentiated malignant neoplasms of the sinonasal tract.
Wenig BM
Arch Pathol Lab Med 2009 May;133(5):699-712. doi: 10.5858/133.5.699. PMID: 19415944
Second primary epithelial malignancy of nasopharynx and nasal cavity after successful curative radiation therapy of nasopharyngeal carcinoma.
Chen CL, Hsu MM
Hum Pathol 2000 Feb;31(2):227-32. doi: 10.1016/s0046-8177(00)80224-5. PMID: 10685638
Squamous carcinoma of the nasal vestibule: an analysis of five cases and literature review.
Taxy JB
Am J Clin Pathol 1997 Jun;107(6):698-703. doi: 10.1093/ajcp/107.6.698. PMID: 9169668

Diagnosis

Sinonasal Small Round Blue Cell Tumors: An Immunohistochemical Approach.
Rooper LM, Bishop JA
Surg Pathol Clin 2017 Mar;10(1):103-123. Epub 2016 Dec 28 doi: 10.1016/j.path.2016.10.005. PMID: 28153129
Sinonasal small round blue cell tumors: An approach to diagnosis.
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346
Evaluation of inverted papilloma and squamous cell carcinoma by nasal contact endoscopy.
Prado FA, Weber R, Romano FR, Voegels RL
Am J Rhinol Allergy 2010 May-Jun;24(3):210-4. doi: 10.2500/ajra.2010.24.3467. PMID: 20537289
Nasopharyngeal carcinoma.
Brennan B
Orphanet J Rare Dis 2006 Jun 26;1:23. doi: 10.1186/1750-1172-1-23. PMID: 16800883Free PMC Article
OLFACTORY NEUROBLASTOMA (ESTHESIONEUROEPITHELIOMA).
FITZ-HUGH GS, ALLEN MS Jr, RUCKER TN, SPRINKLE PM
Arch Otolaryngol 1965 Feb;81:161-8. doi: 10.1001/archotol.1965.00750050168011. PMID: 14233932

Therapy

Nasopharyngeal carcinoma.
Brennan B
Orphanet J Rare Dis 2006 Jun 26;1:23. doi: 10.1186/1750-1172-1-23. PMID: 16800883Free PMC Article
Endonasal transsphenoidal transclival removal of prepontine epidermoid tumors: technical note.
Esposito F, Becker DP, Villablanca JP, Kelly DF
Neurosurgery 2005 Apr;56(2 Suppl):E443; discussion E443. doi: 10.1227/01.neu.0000157023.12468.6a. PMID: 15794847
Strong nasal carcinogenicity and genotoxicity of 1-nitroso-4-methylpiperazine after low dose inhalation in rats.
Klein RG, Schmezer P, Hermann R, Waas P, Spiegelhalder B, Bartsch H
Carcinogenesis 1999 Aug;20(8):1629-31. doi: 10.1093/carcin/20.8.1629. PMID: 10426818
Malignant neoplasms of the nasal cavities and paranasal sinuses: (a retrospective study).
Jackson RT, Fitz-Hugh GS, Constable WC
Laryngoscope 1977 May;87(5 Pt 1):726-36. doi: 10.1002/lary.5540870508. PMID: 850451
Appearance of carcinoma following single exposure to a refrigeration ammonia-oil mixture; report of a case and discussion of the role of cocarcinogenesis.
SHIMKIN MB, DE LORIMIER AA, MITCHELL JR, BURROUGHS TP
AMA Arch Ind Hyg Occup Med 1954 Mar;9(3):186-93. PMID: 13137615

Prognosis

DEK-AFF2 Carcinoma of the Sinonasal Region and Skull Base: Detailed Clinicopathologic Characterization of a Distinctive Entity.
Rooper LM, Agaimy A, Dickson BC, Dueber JC, Eberhart CG, Gagan J, Hartmann A, Khararjian A, London NR, MacMillan CM, Palsgrove DN, Nix JS, Sandison A, Stoehr R, Truong T, Weinreb I, Bishop JA
Am J Surg Pathol 2021 Dec 1;45(12):1682-1693. doi: 10.1097/PAS.0000000000001741. PMID: 34049316
Significance of human papillomavirus positivity in sinonasal squamous cell carcinoma.
Kılıç S, Kılıç SS, Kim ES, Baredes S, Mahmoud O, Gray ST, Eloy JA
Int Forum Allergy Rhinol 2017 Oct;7(10):980-989. Epub 2017 Aug 31 doi: 10.1002/alr.21996. PMID: 28859244
Sinonasal small round blue cell tumors: An approach to diagnosis.
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346
Nasopharyngeal carcinoma.
Brennan B
Orphanet J Rare Dis 2006 Jun 26;1:23. doi: 10.1186/1750-1172-1-23. PMID: 16800883Free PMC Article
Carcinoma of the nasal cavity--results of primary and adjuvant radiotherapy.
Hawkins RB, Wynstra JH, Pilepich MV, Fields JN
Int J Radiat Oncol Biol Phys 1988 Nov;15(5):1129-33. doi: 10.1016/0360-3016(88)90194-0. PMID: 2846481

Clinical prediction guides

HPV-Related Multiphenotypic Sinonasal Carcinoma: Four Cases that Expand the Morpho-Molecular Spectrum and Include Occupational Data.
Rupp NJ, Camenisch U, Seidl K, Rushing EJ, Anderegg N, Broglie MA, Holzmann D, Morand GB
Head Neck Pathol 2020 Sep;14(3):623-629. Epub 2019 Sep 30 doi: 10.1007/s12105-019-01079-1. PMID: 31571045Free PMC Article
Significance of human papillomavirus positivity in sinonasal squamous cell carcinoma.
Kılıç S, Kılıç SS, Kim ES, Baredes S, Mahmoud O, Gray ST, Eloy JA
Int Forum Allergy Rhinol 2017 Oct;7(10):980-989. Epub 2017 Aug 31 doi: 10.1002/alr.21996. PMID: 28859244
Sinonasal small round blue cell tumors: An approach to diagnosis.
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346
Second primary epithelial malignancy of nasopharynx and nasal cavity after successful curative radiation therapy of nasopharyngeal carcinoma.
Chen CL, Hsu MM
Hum Pathol 2000 Feb;31(2):227-32. doi: 10.1016/s0046-8177(00)80224-5. PMID: 10685638
Nasal Schneiderian papillomas: a study of 83 cases.
Kristensen S, Vorre P, Elbrønd O, Søgaard H
Clin Otolaryngol Allied Sci 1985 Jun;10(3):125-34. doi: 10.1111/j.1365-2273.1985.tb01181.x. PMID: 4028474

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