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Nasal cavity and paranasal sinus squamous cell carcinoma

MedGen UID:
124722
Concept ID:
C0280332
Neoplastic Process
Synonyms: nasal cavity and paranasal sinus squamous cell cancer; Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma; nasal cavity and paranasal sinus squamous cell carcinoma; Sinonasal Squamous Cell Carcinoma
 
Monarch Initiative: MONDO:0044787

Definition

A rare, keratinizing or non-keratinizing squamous cell carcinoma arising from the mucosal epithelium of the nasal cavity or the paranasal sinuses. It affects most often the maxillary sinus. Less frequently, it arises from the nasal cavity, ethmoid sinus, sphenoid sinus, and frontal sinus. Symptoms include nasal fullness, epistaxis, rhinorhea, pain, and paresthesia. Patients with nasal squamous cell carcinoma usually present earlier than patients with maxillary sinus carcinoma and have a better prognosis compared to the latter group. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNasal cavity and paranasal sinus squamous cell carcinoma

Professional guidelines

PubMed

Wang Z, Qu Y, Wang K, Wu R, Zhang Y, Huang X, Zhang S, Xiao J, Yi J, Gao L, Xu G, Luo J
Oral Oncol 2020 Feb;101:104512. Epub 2019 Dec 21 doi: 10.1016/j.oraloncology.2019.104512. PMID: 31869689

Recent clinical studies

Etiology

Bahig H, Ehab HY, Garden AS, Ng SP, Frank SJ, Nguyen T, Gunn GB, Rosenthal DI, Fuller CD, Ferrarotto R, Bell D, Su S, Phan J
Head Neck 2023 Jul;45(7):1692-1703. Epub 2023 May 10 doi: 10.1002/hed.27381. PMID: 37165701
Bussu F, Tagliaferri L, Crescio C, Rizzo D, Gallus R, Parrilla C, Fionda B, Lancellotta V, Mattiucci GC, Galli J
Acta Otolaryngol 2023 Mar;143(3):215-222. Epub 2023 Feb 28 doi: 10.1080/00016489.2023.2179662. PMID: 36855802
Mani N, Shah JP
Adv Otorhinolaryngol 2020;84:124-136. Epub 2020 Jul 30 doi: 10.1159/000457932. PMID: 32731225
Biau J, Lapeyre M, Troussier I, Budach W, Giralt J, Grau C, Kazmierska J, Langendijk JA, Ozsahin M, O'Sullivan B, Bourhis J, Grégoire V
Radiother Oncol 2019 May;134:1-9. Epub 2019 Jan 30 doi: 10.1016/j.radonc.2019.01.018. PMID: 31005201
Faggons CE, Mabedi C, Shores CG, Gopal S
Malawi Med J 2015 Sep;27(3):79-87. doi: 10.4314/mmj.v27i3.2. PMID: 26715951Free PMC Article

Diagnosis

Bussu F, Tagliaferri L, Crescio C, Rizzo D, Gallus R, Parrilla C, Fionda B, Lancellotta V, Mattiucci GC, Galli J
Acta Otolaryngol 2023 Mar;143(3):215-222. Epub 2023 Feb 28 doi: 10.1080/00016489.2023.2179662. PMID: 36855802
Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666Free PMC Article
Homma A, Nakamaru Y, Lund VJ, Hanna EY, Kowalski LP, Toledo RN, Mäkitie AA, Rodrigo JP, Rinaldo A, Snyderman CH, Ferlito A
Auris Nasus Larynx 2021 Feb;48(1):41-49. Epub 2020 Dec 4 doi: 10.1016/j.anl.2020.11.018. PMID: 33280972
Mani N, Shah JP
Adv Otorhinolaryngol 2020;84:124-136. Epub 2020 Jul 30 doi: 10.1159/000457932. PMID: 32731225
Rucci J, Eisinger G, Miranda-Gomez G, Nguyen J
Am J Otolaryngol 2014 May-Jun;35(3):390-5. Epub 2014 Jan 2 doi: 10.1016/j.amjoto.2013.12.013. PMID: 24486126

Therapy

Owin N, Elsayad K, Rolf D, Haverkamp U, Suwelack D, Tschakert R, Berssenbrugge H, Kleinheinz J, Rudack C, Eich HT
Anticancer Res 2021 Mar;41(3):1587-1592. doi: 10.21873/anticanres.14919. PMID: 33788753
Laskar SG, Pai P, Sinha S, Budrukkar A, Nair D, Swain M, Mummudi N, Gupta T, Murthy V, Agarwal JP, Tiwari N, Thiagrajan S, Chaukar D, Chaturvedi P, Pantvaidya G, Deshmukh A, Nair S, Prabhash K, Joshi A, Noronha V, Patil V, Menon N, Patil A, Bal M, Mittal N, Rane S
Head Neck 2021 Jul;43(7):2045-2057. Epub 2021 Mar 9 doi: 10.1002/hed.26669. PMID: 33687114
Homma A, Nakamaru Y, Lund VJ, Hanna EY, Kowalski LP, Toledo RN, Mäkitie AA, Rodrigo JP, Rinaldo A, Snyderman CH, Ferlito A
Auris Nasus Larynx 2021 Feb;48(1):41-49. Epub 2020 Dec 4 doi: 10.1016/j.anl.2020.11.018. PMID: 33280972
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Rucci J, Eisinger G, Miranda-Gomez G, Nguyen J
Am J Otolaryngol 2014 May-Jun;35(3):390-5. Epub 2014 Jan 2 doi: 10.1016/j.amjoto.2013.12.013. PMID: 24486126

Prognosis

Bahig H, Ehab HY, Garden AS, Ng SP, Frank SJ, Nguyen T, Gunn GB, Rosenthal DI, Fuller CD, Ferrarotto R, Bell D, Su S, Phan J
Head Neck 2023 Jul;45(7):1692-1703. Epub 2023 May 10 doi: 10.1002/hed.27381. PMID: 37165701
Bussu F, Tagliaferri L, Crescio C, Rizzo D, Gallus R, Parrilla C, Fionda B, Lancellotta V, Mattiucci GC, Galli J
Acta Otolaryngol 2023 Mar;143(3):215-222. Epub 2023 Feb 28 doi: 10.1080/00016489.2023.2179662. PMID: 36855802
Rooper LM, Agaimy A, Dickson BC, Dueber JC, Eberhart CG, Gagan J, Hartmann A, Khararjian A, London NR, MacMillan CM, Palsgrove DN, Nix JS, Sandison A, Stoehr R, Truong T, Weinreb I, Bishop JA
Am J Surg Pathol 2021 Dec 1;45(12):1682-1693. doi: 10.1097/PAS.0000000000001741. PMID: 34049316
Mani N, Shah JP
Adv Otorhinolaryngol 2020;84:124-136. Epub 2020 Jul 30 doi: 10.1159/000457932. PMID: 32731225
Faggons CE, Mabedi C, Shores CG, Gopal S
Malawi Med J 2015 Sep;27(3):79-87. doi: 10.4314/mmj.v27i3.2. PMID: 26715951Free PMC Article

Clinical prediction guides

Bahig H, Ehab HY, Garden AS, Ng SP, Frank SJ, Nguyen T, Gunn GB, Rosenthal DI, Fuller CD, Ferrarotto R, Bell D, Su S, Phan J
Head Neck 2023 Jul;45(7):1692-1703. Epub 2023 May 10 doi: 10.1002/hed.27381. PMID: 37165701
Mani N, Shah JP
Adv Otorhinolaryngol 2020;84:124-136. Epub 2020 Jul 30 doi: 10.1159/000457932. PMID: 32731225
Torabi SJ, Spock T, Cardoso B, Chao J, Morse E, Manes RP, Judson BL
Laryngoscope 2020 Jun;130(6):E388-E396. Epub 2019 Nov 22 doi: 10.1002/lary.28315. PMID: 31755988
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346

Recent systematic reviews

Lee JJ, Peterson AM, Embry TW, Wamkpah NS, Kallogjeri D, Doering MM, Schneider JS, Klatt-Cromwell CN, Pipkorn P
JAMA Otolaryngol Head Neck Surg 2021 Apr 1;147(4):350-359. doi: 10.1001/jamaoto.2020.5261. PMID: 33507208Free PMC Article
Re M, Gioacchini FM, Bajraktari A, Tomasetti M, Kaleci S, Rubini C, Bertini A, Magliulo G, Pasquini E
Eur Arch Otorhinolaryngol 2017 Aug;274(8):2991-3000. Epub 2017 Apr 21 doi: 10.1007/s00405-017-4571-2. PMID: 28432463
Rytkönen AE, Hirvikoski PP, Salo TA
Head Neck Pathol 2011 Dec;5(4):327-34. Epub 2011 Jun 23 doi: 10.1007/s12105-011-0278-7. PMID: 21698444Free PMC Article
Dulguerov P, Jacobsen MS, Allal AS, Lehmann W, Calcaterra T
Cancer 2001 Dec 15;92(12):3012-29. doi: 10.1002/1097-0142(20011215)92:12<3012::aid-cncr10131>3.0.co;2-e. PMID: 11753979

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