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Thyroid Gland Teratoma

MedGen UID:
328115
•Concept ID:
C1710418
•
Neoplastic Process
Synonym: Primary Thyroid Gland Teratoma

Definition

A teratoma that arises from the thyroid gland. Thyroid gland teratomas with high grade/malignant histological features carry DICER1 gene mutations and have been reclassified as thyroblastomas. They are no longer considered true teratomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Teratoma

Professional guidelines

PubMed

Malignant struma ovarii: surgical, histopathological and survival outcomes for thyroid-type carcinoma of struma ovarii with recommendations for standardising multi-modal management. A retrospective case series sharing the experience of a single institution over 10 years.
Addley S, Mihai R, Alazzam M, Dhar S, Soleymani Majd H
Arch Gynecol Obstet 2021 Apr;303(4):863-870. Epub 2021 Jan 29 doi: 10.1007/s00404-021-05969-0. PMID: 33512594
Thyroid tissue outside the thyroid gland: Differential diagnosis and associated diagnostic challenges.
Barbieri A, Prasad ML, Gilani SM
Ann Diagn Pathol 2020 Oct;48:151584. Epub 2020 Aug 15 doi: 10.1016/j.anndiagpath.2020.151584. PMID: 32871503

Recent clinical studies

Etiology

Benign lesions of the mediastinum.
Gerber TS, Porubsky S
Histopathology 2024 Jan;84(1):183-195. Epub 2023 Nov 21 doi: 10.1111/his.15088. PMID: 37988262
Clinicopathological observation of mature teratoma with malignant transformation, a single center retrospective study.
Yuan Y, Li H, Yang H
Indian J Pathol Microbiol 2022 Apr-Jun;65(2):369-373. doi: 10.4103/IJPM.IJPM_828_20. PMID: 35435373
Malignant struma ovarii: surgical, histopathological and survival outcomes for thyroid-type carcinoma of struma ovarii with recommendations for standardising multi-modal management. A retrospective case series sharing the experience of a single institution over 10 years.
Addley S, Mihai R, Alazzam M, Dhar S, Soleymani Majd H
Arch Gynecol Obstet 2021 Apr;303(4):863-870. Epub 2021 Jan 29 doi: 10.1007/s00404-021-05969-0. PMID: 33512594
Malignant teratomas of the thyroid gland: clinico-radiologic and cytomorphologic features of a rare entity.
Miller DL, Thompson LDR, Bishop JA, Rooper LM, Ali SZ
J Am Soc Cytopathol 2020 Jul-Aug;9(4):221-231. Epub 2020 Apr 28 doi: 10.1016/j.jasc.2020.04.008. PMID: 32448730
Recurrent DICER1 Hotspot Mutations in Malignant Thyroid Gland Teratomas: Molecular Characterization and Proposal for a Separate Classification.
Rooper LM, Bynum JP, Miller KP, Lin MT, Gagan J, Thompson LDR, Bishop JA
Am J Surg Pathol 2020 Jun;44(6):826-833. doi: 10.1097/PAS.0000000000001430. PMID: 31917706

Diagnosis

Benign lesions of the mediastinum.
Gerber TS, Porubsky S
Histopathology 2024 Jan;84(1):183-195. Epub 2023 Nov 21 doi: 10.1111/his.15088. PMID: 37988262
Thyroid teratoma in a newborn.
Roscamp J, Balasubramanian S, Gupta SL
BMJ Case Rep 2022 Jan 21;15(1) doi: 10.1136/bcr-2021-243942. PMID: 35064036Free PMC Article
Thyroid tissue outside the thyroid gland: Differential diagnosis and associated diagnostic challenges.
Barbieri A, Prasad ML, Gilani SM
Ann Diagn Pathol 2020 Oct;48:151584. Epub 2020 Aug 15 doi: 10.1016/j.anndiagpath.2020.151584. PMID: 32871503
Malignant teratomas of the thyroid gland: clinico-radiologic and cytomorphologic features of a rare entity.
Miller DL, Thompson LDR, Bishop JA, Rooper LM, Ali SZ
J Am Soc Cytopathol 2020 Jul-Aug;9(4):221-231. Epub 2020 Apr 28 doi: 10.1016/j.jasc.2020.04.008. PMID: 32448730
Malignant struma ovarii.
Yassa L, Sadow P, Marqusee E
Nat Clin Pract Endocrinol Metab 2008 Aug;4(8):469-72. Epub 2008 Jun 17 doi: 10.1038/ncpendmet0887. PMID: 18560398

Therapy

Primary Malignant Thyroid Teratoma: An Institutional Experience.
Ting J, Bell D, Ahmed S, Ying A, Waguespack SG, Tu SM, Weber R, Zafereo M
Thyroid 2019 Feb;29(2):229-236. doi: 10.1089/thy.2018.0206. PMID: 30759052
Spindle epithelial tumor with thymus-like elements of the thyroid: a multi-institutional case series and review of the literature.
Grushka JR, Ryckman J, Mueller C, Roessingh Ade B, Walton JM, St Vil D, Laberge JM, Bernard C, Nguyen VH, Puligandla PS
J Pediatr Surg 2009 May;44(5):944-8. doi: 10.1016/j.jpedsurg.2009.01.030. PMID: 19433175
Malignant struma ovarii.
Yassa L, Sadow P, Marqusee E
Nat Clin Pract Endocrinol Metab 2008 Aug;4(8):469-72. Epub 2008 Jun 17 doi: 10.1038/ncpendmet0887. PMID: 18560398
Primary malignant teratoma of the thyroid gland: report and discussion of two cases.
Ueno NT, Amato RJ, Ro JJ, Weber RS
Head Neck 1998 Oct;20(7):649-53. doi: 10.1002/(sici)1097-0347(199810)20:7<649::aid-hed13>3.0.co;2-5. PMID: 9744468
Thyroid disease in pregnancy.
Prout TE
Am J Obstet Gynecol 1975 Jul 1;122(5):669-76. doi: 10.1016/0002-9378(75)90068-x. PMID: 50013

Prognosis

A SEER database study of malignant teratomas in the head and neck region.
Ramsey T, Curran K, Mouzakes J, Gildener-Leapman N, Galati L
Int J Pediatr Otorhinolaryngol 2021 May;144:110672. Epub 2021 Mar 11 doi: 10.1016/j.ijporl.2021.110672. PMID: 33740550
Malignant struma ovarii: surgical, histopathological and survival outcomes for thyroid-type carcinoma of struma ovarii with recommendations for standardising multi-modal management. A retrospective case series sharing the experience of a single institution over 10 years.
Addley S, Mihai R, Alazzam M, Dhar S, Soleymani Majd H
Arch Gynecol Obstet 2021 Apr;303(4):863-870. Epub 2021 Jan 29 doi: 10.1007/s00404-021-05969-0. PMID: 33512594
Recurrent DICER1 Hotspot Mutations in Malignant Thyroid Gland Teratomas: Molecular Characterization and Proposal for a Separate Classification.
Rooper LM, Bynum JP, Miller KP, Lin MT, Gagan J, Thompson LDR, Bishop JA
Am J Surg Pathol 2020 Jun;44(6):826-833. doi: 10.1097/PAS.0000000000001430. PMID: 31917706
A case report of a giant mature teratoma of the thyroid gland in a young girl.
Lv Z, Bai X, Sheng Q, Liu J, Wu Y
Medicine (Baltimore) 2019 Mar;98(9):e14703. doi: 10.1097/MD.0000000000014703. PMID: 30817608Free PMC Article
Primary Malignant Thyroid Teratoma: An Institutional Experience.
Ting J, Bell D, Ahmed S, Ying A, Waguespack SG, Tu SM, Weber R, Zafereo M
Thyroid 2019 Feb;29(2):229-236. doi: 10.1089/thy.2018.0206. PMID: 30759052

Clinical prediction guides

Clinicopathological observation of mature teratoma with malignant transformation, a single center retrospective study.
Yuan Y, Li H, Yang H
Indian J Pathol Microbiol 2022 Apr-Jun;65(2):369-373. doi: 10.4103/IJPM.IJPM_828_20. PMID: 35435373
Mature Cervical Teratoma Extending Into the Anterior Mediastinum of an Adult.
Deng H, Wang Z, Yang Q, Ye J
Ear Nose Throat J 2021 Dec;100(10):698-701. Epub 2020 May 19 doi: 10.1177/0145561320925563. PMID: 32425061
Two Tumors in 1: What Should be the Therapeutic Target? Pediatric Germ Cell Tumor With Somatic Malignant Transformation.
Faure Conter C, Fresneau B, Thebaud E, Bertrand A, Dijoud F, Rome A, Dumesnil C, Castex MP, Ghanem A, Orbach D
J Pediatr Hematol Oncol 2017 Jul;39(5):388-394. doi: 10.1097/MPH.0000000000000823. PMID: 28375941
Malignant struma ovarii: a population-level analysis of a large series of 68 patients.
Goffredo P, Sawka AM, Pura J, Adam MA, Roman SA, Sosa JA
Thyroid 2015 Feb;25(2):211-5. Epub 2014 Dec 5 doi: 10.1089/thy.2014.0328. PMID: 25375817
Mediastinal teratomas in children. Case reports and review of the literature.
Paradies G, Zullino F, Orofino A, Leggio S
Ann Ital Chir 2013 Jul-Aug;84(4):395-403. PMID: 23685310

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