U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cerebrospinal fluid otorrhea

MedGen UID:
3330
•Concept ID:
C0007814
•
Disease or Syndrome
Synonyms: Cerebrospinal Fluid Otorrhea; Cerebrospinal Fluid Otorrheas; Cerebrospinal Otorrhea; Otorrhea, Cerebrospinal; Otorrhea, Cerebrospinal Fluid
SNOMED CT: Cerebrospinal fluid otorrhea (68382005); CSF - Cerebrospinal otorrhea (68382005); Cerebrospinal otorrhea (68382005); CSF - Cerebrospinal fluid otorrhea (68382005)

Definition

Discharge of cerebrospinal fluid through the ear structures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCerebrospinal fluid otorrhea

Professional guidelines

PubMed

Cerebrospinal fluid otorrhea secondary to congenital inner ear dysplasia: diagnosis and management of 18 cases.
Wang B, Dai WJ, Cheng XT, Liuyang WY, Yuan YS, Dai CF, Shu YL, Chen B
J Zhejiang Univ Sci B 2019 Feb.;20(2):156-163. doi: 10.1631/jzus.B1800224. PMID: 30666849Free PMC Article
Management of spontaneous temporal bone cerebrospinal fluid leak: A 30-year experience.
Cheng E, Grande D, Leonetti J
Am J Otolaryngol 2019 Jan-Feb;40(1):97-100. Epub 2018 Sep 26 doi: 10.1016/j.amjoto.2018.09.018. PMID: 30472121
Management of cerebrospinal fluid leaks involving the temporal bone: report on 92 patients.
Savva A, Taylor MJ, Beatty CW
Laryngoscope 2003 Jan;113(1):50-6. doi: 10.1097/00005537-200301000-00010. PMID: 12514382

Recent clinical studies

Etiology

Cerebrospinal Fluid Gusher in Cochlear Implantation and Its Association with Inner-Ear Malformations.
Dalgic A, Atsal G, Ceylan ME, Aydın E, Adıbelli ZH, Edizer DT, Olgun L
J Int Adv Otol 2022 Nov;18(6):478-481. doi: 10.5152/iao.2022.21441. PMID: 36349668Free PMC Article
Spontaneous middle cranial fossa cerebrospinal fluid otorrhea in adults.
Rao N, Redleaf M
Laryngoscope 2016 Feb;126(2):464-8. Epub 2015 Aug 8 doi: 10.1002/lary.25461. PMID: 26257015
Otorrhoea.
Pankhania M, Judd O, Ward A
BMJ 2011 May 20;342:d2299. doi: 10.1136/bmj.d2299. PMID: 21602234
Temporal bone fractures.
Nageris B, Hansen MC, Lavelle WG, Van Pelt FA
Am J Emerg Med 1995 Mar;13(2):211-4. doi: 10.1016/0735-6757(95)90096-9. PMID: 7893311
Craniotomy infections.
Blomstedt GC
Neurosurg Clin N Am 1992 Apr;3(2):375-85. PMID: 1633466

Diagnosis

Cerebrospinal fluid rhinorrhea and otorrhea: A multimodality imaging approach.
Hiremath SB, Gautam AA, Sasindran V, Therakathu J, Benjamin G
Diagn Interv Imaging 2019 Jan;100(1):3-15. Epub 2018 Jun 15 doi: 10.1016/j.diii.2018.05.003. PMID: 29910174
Imaging of Cerebrospinal Fluid Rhinorrhea and Otorrhea.
Reddy M, Baugnon K
Radiol Clin North Am 2017 Jan;55(1):167-187. doi: 10.1016/j.rcl.2016.08.005. PMID: 27890184
Spontaneous middle cranial fossa cerebrospinal fluid otorrhea in adults.
Rao N, Redleaf M
Laryngoscope 2016 Feb;126(2):464-8. Epub 2015 Aug 8 doi: 10.1002/lary.25461. PMID: 26257015
Diagnostic imaging.
Pappas DG Jr, Curé JK
Otolaryngol Clin North Am 2002 Dec;35(6):1317-63, ix. doi: 10.1016/s0030-6665(02)00097-x. PMID: 12687746
Craniotomy infections.
Blomstedt GC
Neurosurg Clin N Am 1992 Apr;3(2):375-85. PMID: 1633466

Therapy

Cerebrospinal Fluid Gusher in Cochlear Implantation and Its Association with Inner-Ear Malformations.
Dalgic A, Atsal G, Ceylan ME, Aydın E, Adıbelli ZH, Edizer DT, Olgun L
J Int Adv Otol 2022 Nov;18(6):478-481. doi: 10.5152/iao.2022.21441. PMID: 36349668Free PMC Article
Temporal bone meningoencephaloceles and cerebrospinal fluid leaks: experience in a tertiary care hospital.
Gupta A, Sikka K, Irugu DVK, Verma H, Bhalla AS, Thakar A
J Laryngol Otol 2019 Mar;133(3):192-200. Epub 2019 Feb 19 doi: 10.1017/S0022215119000203. PMID: 30777139
Complications in septoplasty.
Rettinger G, Kirsche H
Facial Plast Surg 2006 Nov;22(4):289-97. doi: 10.1055/s-2006-954847. PMID: 17131271
Temporal bone fractures.
Yeakley JW
Curr Probl Diagn Radiol 1999 May-Jun;28(3):65-98. doi: 10.1016/s0363-0188(99)90002-6. PMID: 10327292
Craniotomy infections.
Blomstedt GC
Neurosurg Clin N Am 1992 Apr;3(2):375-85. PMID: 1633466

Prognosis

Otitis media prone children with cystic fibrosis: A new normal.
McCoy JL, Kaffenberger TM, Yang TS, Dohar JE
Am J Otolaryngol 2021 Sep-Oct;42(5):103137. Epub 2021 Jun 19 doi: 10.1016/j.amjoto.2021.103137. PMID: 34174638Free PMC Article
Cerebrospinal fluid otorrhea secondary to congenital inner ear dysplasia: diagnosis and management of 18 cases.
Wang B, Dai WJ, Cheng XT, Liuyang WY, Yuan YS, Dai CF, Shu YL, Chen B
J Zhejiang Univ Sci B 2019 Feb.;20(2):156-163. doi: 10.1631/jzus.B1800224. PMID: 30666849Free PMC Article
Spontaneous bilateral and concurrent cerebrospinal fluid otorrhoea: case presentation and literature review.
Tikka T, Opeodu A, Irving R, Murphy J
J Laryngol Otol 2016 Aug;130(8):781-6. Epub 2016 Jul 5 doi: 10.1017/S0022215116008458. PMID: 27377193
Post-tympanostomy tube otorrhea: a meta-analysis.
Hochman J, Blakley B, Abdoh A, Aleid H
Otolaryngol Head Neck Surg 2006 Jul;135(1):8-11. doi: 10.1016/j.otohns.2006.02.019. PMID: 16815174
Otogenic pneumocephalus.
Andrews JC, Canalis RF
Laryngoscope 1986 May;96(5):521-8. doi: 10.1288/00005537-198605000-00010. PMID: 3702568

Clinical prediction guides

Spontaneous cerebrospinal fluid leaks of the temporal bone - clinical features and management outcomes.
Hendriks T, Bala A, Kuthubutheen J
Auris Nasus Larynx 2022 Feb;49(1):26-33. Epub 2021 Apr 6 doi: 10.1016/j.anl.2021.03.019. PMID: 33832812
Cerebrospinal fluid leak during stapes surgery: Gushing leaks and oozing leaks, two different phenomena.
Quesada JL, Cammaroto G, Bonanno L, Galletti F, Quesada P
Ear Nose Throat J 2017 Aug;96(8):302-310. doi: 10.1177/014556131709600817. PMID: 28846785
Spontaneous bilateral and concurrent cerebrospinal fluid otorrhoea: case presentation and literature review.
Tikka T, Opeodu A, Irving R, Murphy J
J Laryngol Otol 2016 Aug;130(8):781-6. Epub 2016 Jul 5 doi: 10.1017/S0022215116008458. PMID: 27377193
Spontaneous middle cranial fossa cerebrospinal fluid otorrhea in adults.
Rao N, Redleaf M
Laryngoscope 2016 Feb;126(2):464-8. Epub 2015 Aug 8 doi: 10.1002/lary.25461. PMID: 26257015
Surgical approaches and complications in the removal of vestibular schwannomas.
Bennett M, Haynes DS
Otolaryngol Clin North Am 2007 Jun;40(3):589-609, ix-x. doi: 10.1016/j.otc.2007.03.007. PMID: 17544697

Recent systematic reviews

Systematic review of errors on beta-2 transferrin gel electrophoresis testing of rhinorrhea and otorrhea.
Eide JG, Mason W, Ray A, Carey J, Cook B, Craig JR
Int Forum Allergy Rhinol 2024 Jun;14(6):1016-1025. Epub 2023 Oct 21 doi: 10.1002/alr.23293. PMID: 37864574
Spontaneous Congenital Perilabyrinthine Cerebrospinal Fluid Fistulas.
Lovin BD, Appelbaum EN, Makoshi L, Whitehead WE, Sweeney AD
Ann Otol Rhinol Laryngol 2021 Dec;130(12):1360-1368. Epub 2021 Apr 9 doi: 10.1177/00034894211007242. PMID: 33834882
Fallopian Canal Meningocele with Spontaneous Cerebrospinal Fluid Otorrhea: Case Report and Systematic Review of the Literature.
Dey JK, Van Gompel JJ, Lane JI, Carlson ML
World Neurosurg 2019 Feb;122:e285-e290. Epub 2018 Oct 13 doi: 10.1016/j.wneu.2018.10.021. PMID: 30321684
WITHDRAWN: Interventions for ear discharge associated with grommets (ventilation tubes).
Vaile L, Williamson T, Waddell A, Taylor GJ
Cochrane Database Syst Rev 2016 Nov 15;11(11):CD001933. doi: 10.1002/14651858.CD001933.pub3. PMID: 27845826Free PMC Article
Interventions for ear discharge associated with grommets (ventilation tubes).
Vaile L, Williamson T, Waddell A, Taylor G
Cochrane Database Syst Rev 2006 Apr 19;(2):CD001933. doi: 10.1002/14651858.CD001933.pub2. PMID: 16625551

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...