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Cerebrospinal fluid otorrhea

MedGen UID:
3330
•Concept ID:
C0007814
•
Disease or Syndrome
Synonyms: Cerebrospinal Fluid Otorrhea; Cerebrospinal Fluid Otorrheas; Cerebrospinal Otorrhea; Otorrhea, Cerebrospinal; Otorrhea, Cerebrospinal Fluid
SNOMED CT: Cerebrospinal fluid otorrhea (68382005); CSF - Cerebrospinal otorrhea (68382005); Cerebrospinal otorrhea (68382005); CSF - Cerebrospinal fluid otorrhea (68382005)

Definition

Discharge of cerebrospinal fluid through the ear structures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCerebrospinal fluid otorrhea

Professional guidelines

PubMed

Management of spontaneous temporal bone cerebrospinal fluid leak: A 30-year experience.
Cheng E, Grande D, Leonetti J
Am J Otolaryngol 2019 Jan-Feb;40(1):97-100. Epub 2018 Sep 26 doi: 10.1016/j.amjoto.2018.09.018. PMID: 30472121
Transcanal Endoscopic Management of Cerebrospinal Fluid Otorrhea Secondary to Congenital Inner Ear Malformations.
Kou YF, Zhu VF, Kutz JW Jr, Mitchell RB, Isaacson B
Otol Neurotol 2016 Jan;37(1):62-5. doi: 10.1097/MAO.0000000000000898. PMID: 26571412
Management of cerebrospinal fluid leaks involving the temporal bone: report on 92 patients.
Savva A, Taylor MJ, Beatty CW
Laryngoscope 2003 Jan;113(1):50-6. doi: 10.1097/00005537-200301000-00010. PMID: 12514382

Recent clinical studies

Etiology

Cerebrospinal Fluid Gusher in Cochlear Implantation and Its Association with Inner-Ear Malformations.
Dalgic A, Atsal G, Ceylan ME, Aydın E, Adıbelli ZH, Edizer DT, Olgun L
J Int Adv Otol 2022 Nov;18(6):478-481. doi: 10.5152/iao.2022.21441. PMID: 36349668Free PMC Article
Spontaneous cerebrospinal fluid leaks of the temporal bone - clinical features and management outcomes.
Hendriks T, Bala A, Kuthubutheen J
Auris Nasus Larynx 2022 Feb;49(1):26-33. Epub 2021 Apr 6 doi: 10.1016/j.anl.2021.03.019. PMID: 33832812
Idiopathic intracranial hypertension: Contemporary review and implications for the otolaryngologist.
Stevens SM, Rizk HG, Golnik K, Andaluz N, Samy RN, Meyer TA, Lambert PR
Laryngoscope 2018 Jan;128(1):248-256. Epub 2017 Mar 27 doi: 10.1002/lary.26581. PMID: 28349571
Spontaneous middle cranial fossa cerebrospinal fluid otorrhea in adults.
Rao N, Redleaf M
Laryngoscope 2016 Feb;126(2):464-8. Epub 2015 Aug 8 doi: 10.1002/lary.25461. PMID: 26257015
Otorrhoea.
Pankhania M, Judd O, Ward A
BMJ 2011 May 20;342:d2299. doi: 10.1136/bmj.d2299. PMID: 21602234

Diagnosis

Top-cited articles in cerebrospinal fluid leak (rhinorrhea and otorrhea) (1945-2018).
Monjas-Cánovas I, Belinchón-Romero I, Gras-Albert JR, González-Alcaide G, Ramos-Rincón JM
Braz J Otorhinolaryngol 2021 Sep-Oct;87(5):557-571. Epub 2020 Jan 14 doi: 10.1016/j.bjorl.2019.12.002. PMID: 31982378Free PMC Article
Cerebrospinal fluid rhinorrhea and otorrhea: A multimodality imaging approach.
Hiremath SB, Gautam AA, Sasindran V, Therakathu J, Benjamin G
Diagn Interv Imaging 2019 Jan;100(1):3-15. Epub 2018 Jun 15 doi: 10.1016/j.diii.2018.05.003. PMID: 29910174
Imaging of Cerebrospinal Fluid Rhinorrhea and Otorrhea.
Reddy M, Baugnon K
Radiol Clin North Am 2017 Jan;55(1):167-187. doi: 10.1016/j.rcl.2016.08.005. PMID: 27890184
Spontaneous middle cranial fossa cerebrospinal fluid otorrhea in adults.
Rao N, Redleaf M
Laryngoscope 2016 Feb;126(2):464-8. Epub 2015 Aug 8 doi: 10.1002/lary.25461. PMID: 26257015
Temporal bone encephaloceles.
Sdano MT, Pensak ML
Curr Opin Otolaryngol Head Neck Surg 2005 Oct;13(5):287-9. doi: 10.1097/01.moo.0000179247.51476.f5. PMID: 16160522

Therapy

Cerebrospinal Fluid Gusher in Cochlear Implantation and Its Association with Inner-Ear Malformations.
Dalgic A, Atsal G, Ceylan ME, Aydın E, Adıbelli ZH, Edizer DT, Olgun L
J Int Adv Otol 2022 Nov;18(6):478-481. doi: 10.5152/iao.2022.21441. PMID: 36349668Free PMC Article
Cerebrospinal fluid gusher in cochlear implant and its associated factors.
Hashemi SB, Bozorgi H, Kazemi T, Babaei A
Acta Otolaryngol 2020 Aug;140(8):621-625. Epub 2020 Apr 24 doi: 10.1080/00016489.2020.1751276. PMID: 32329639
Temporal bone meningoencephaloceles and cerebrospinal fluid leaks: experience in a tertiary care hospital.
Gupta A, Sikka K, Irugu DVK, Verma H, Bhalla AS, Thakar A
J Laryngol Otol 2019 Mar;133(3):192-200. Epub 2019 Feb 19 doi: 10.1017/S0022215119000203. PMID: 30777139
Complications in septoplasty.
Rettinger G, Kirsche H
Facial Plast Surg 2006 Nov;22(4):289-97. doi: 10.1055/s-2006-954847. PMID: 17131271
Temporal bone fractures.
Yeakley JW
Curr Probl Diagn Radiol 1999 May-Jun;28(3):65-98. doi: 10.1016/s0363-0188(99)90002-6. PMID: 10327292

Prognosis

Cerebrospinal fluid gusher in cochlear implant and its associated factors.
Hashemi SB, Bozorgi H, Kazemi T, Babaei A
Acta Otolaryngol 2020 Aug;140(8):621-625. Epub 2020 Apr 24 doi: 10.1080/00016489.2020.1751276. PMID: 32329639
Cerebrospinal fluid otorrhea secondary to congenital inner ear dysplasia: diagnosis and management of 18 cases.
Wang B, Dai WJ, Cheng XT, Liuyang WY, Yuan YS, Dai CF, Shu YL, Chen B
J Zhejiang Univ Sci B 2019 Feb.;20(2):156-163. doi: 10.1631/jzus.B1800224. PMID: 30666849Free PMC Article
Spontaneous bilateral and concurrent cerebrospinal fluid otorrhoea: case presentation and literature review.
Tikka T, Opeodu A, Irving R, Murphy J
J Laryngol Otol 2016 Aug;130(8):781-6. Epub 2016 Jul 5 doi: 10.1017/S0022215116008458. PMID: 27377193
The incidence of cerebrospinal fluid leak after vestibular schwannoma surgery.
Selesnick SH, Liu JC, Jen A, Newman J
Otol Neurotol 2004 May;25(3):387-93. doi: 10.1097/00129492-200405000-00030. PMID: 15129122
Factors affecting the development of cerebrospinal fluid leak and meningitis after translabyrinthine acoustic tumor surgery.
Rodgers GK, Luxford WM
Laryngoscope 1993 Sep;103(9):959-62. doi: 10.1288/00005537-199309000-00003. PMID: 8361315

Clinical prediction guides

Spontaneous cerebrospinal fluid leaks of the temporal bone - clinical features and management outcomes.
Hendriks T, Bala A, Kuthubutheen J
Auris Nasus Larynx 2022 Feb;49(1):26-33. Epub 2021 Apr 6 doi: 10.1016/j.anl.2021.03.019. PMID: 33832812
Simultaneous repair of cerebrospinal fluid otorrhea and cochlear implantation in two patients with recurrent meningitis and severe inner ear malformation.
Chen B, Shi Y, Gong Y, Chen J, Li Y
Int J Pediatr Otorhinolaryngol 2019 Sep;124:147-151. Epub 2019 Jun 1 doi: 10.1016/j.ijporl.2019.05.045. PMID: 31195308
Cerebrospinal fluid leak during stapes surgery: Gushing leaks and oozing leaks, two different phenomena.
Quesada JL, Cammaroto G, Bonanno L, Galletti F, Quesada P
Ear Nose Throat J 2017 Aug;96(8):302-310. doi: 10.1177/014556131709600817. PMID: 28846785
Spontaneous bilateral and concurrent cerebrospinal fluid otorrhoea: case presentation and literature review.
Tikka T, Opeodu A, Irving R, Murphy J
J Laryngol Otol 2016 Aug;130(8):781-6. Epub 2016 Jul 5 doi: 10.1017/S0022215116008458. PMID: 27377193
Spontaneous middle cranial fossa cerebrospinal fluid otorrhea in adults.
Rao N, Redleaf M
Laryngoscope 2016 Feb;126(2):464-8. Epub 2015 Aug 8 doi: 10.1002/lary.25461. PMID: 26257015

Recent systematic reviews

Complications After Pediatric Temporal Bone Fractures by Classification System: A Systematic Review and Meta-analysis.
Poupore NS, Britt AF, Nguyen SA, White DR
Otolaryngol Head Neck Surg 2024 Apr;170(4):1009-1019. Epub 2024 Jan 3 doi: 10.1002/ohn.638. PMID: 38168743
Spontaneous Congenital Perilabyrinthine Cerebrospinal Fluid Fistulas.
Lovin BD, Appelbaum EN, Makoshi L, Whitehead WE, Sweeney AD
Ann Otol Rhinol Laryngol 2021 Dec;130(12):1360-1368. Epub 2021 Apr 9 doi: 10.1177/00034894211007242. PMID: 33834882
Fallopian Canal Meningocele with Spontaneous Cerebrospinal Fluid Otorrhea: Case Report and Systematic Review of the Literature.
Dey JK, Van Gompel JJ, Lane JI, Carlson ML
World Neurosurg 2019 Feb;122:e285-e290. Epub 2018 Oct 13 doi: 10.1016/j.wneu.2018.10.021. PMID: 30321684
WITHDRAWN: Interventions for ear discharge associated with grommets (ventilation tubes).
Vaile L, Williamson T, Waddell A, Taylor GJ
Cochrane Database Syst Rev 2016 Nov 15;11(11):CD001933. doi: 10.1002/14651858.CD001933.pub3. PMID: 27845826Free PMC Article
Interventions for ear discharge associated with grommets (ventilation tubes).
Vaile L, Williamson T, Waddell A, Taylor G
Cochrane Database Syst Rev 2006 Apr 19;(2):CD001933. doi: 10.1002/14651858.CD001933.pub2. PMID: 16625551

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