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Cerebrospinal fluid leakage

MedGen UID:
9695
•Concept ID:
C0023182
•
Pathologic Function
Synonyms: Cerebrospinal Fluid Drainage; Cerebrospinal Fluid Drainages; Cerebrospinal Fluid Leak; Cerebrospinal Fluid Leakage; Cerebrospinal Fluid Leakages; Cerebrospinal Fluid Leaks; Drainage, Cerebrospinal Fluid; Drainages, Cerebrospinal Fluid; Fluid Drainage, Cerebrospinal; Fluid Drainages, Cerebrospinal; Fluid Leak, Cerebrospinal; Fluid Leakage, Cerebrospinal; Fluid Leakages, Cerebrospinal; Fluid Leaks, Cerebrospinal; Leak, Cerebrospinal Fluid; Leakage, Cerebrospinal Fluid; Leakages, Cerebrospinal Fluid; Leaks, Cerebrospinal Fluid; Spinal Cerebrospinal Fluid Leak
SNOMED CT: Cerebrospinal fluid leakage (73965003); Cerebrospinal fluid leak (230744007); CSF - Cerebrospinal fluid leak (230744007)

Definition

The loss of cerebrospinal fluid into the surrounding tissues. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCerebrospinal fluid leakage

Professional guidelines

PubMed

Craniofacial Encephalocele: Updates on Management.
Alberts A, Lucke-Wold B
J Integr Neurosci 2023 May 19;22(3):79. doi: 10.31083/j.jin2203079. PMID: 37258446Free PMC Article
Risk factors and management strategies for cerebrospinal fluid leakage following lumbar posterior surgery.
Tang J, Lu Q, Li Y, Wu C, Li X, Gan X, Xie W
BMC Surg 2022 Jan 29;22(1):30. doi: 10.1186/s12893-021-01442-6. PMID: 35090413Free PMC Article
Intrathecal catheter use after accidental dural puncture in obstetric patients: literature review and clinical management recommendations.
Orbach-Zinger S, Jadon A, Lucas DN, Sia AT, Tsen LC, Van de Velde M, Heesen M
Anaesthesia 2021 Aug;76(8):1111-1121. Epub 2021 Jan 21 doi: 10.1111/anae.15390. PMID: 33476424

Recent clinical studies

Etiology

Advances in Pituitary Surgery.
Byun YH, Kang H, Kim YH
Endocrinol Metab (Seoul) 2022 Aug;37(4):608-616. Epub 2022 Aug 19 doi: 10.3803/EnM.2022.1546. PMID: 35982611Free PMC Article
Cerebrospinal fluid leakage after cranial surgery in the pediatric population-a systematic review and meta-analysis.
Slot EMH, van Baarsen KM, Hoving EW, Zuithoff NPA, van Doormaal TPC
Childs Nerv Syst 2021 May;37(5):1439-1447. Epub 2021 Feb 4 doi: 10.1007/s00381-021-05036-8. PMID: 33538867Free PMC Article
Vestibular Schwannoma: What We Know and Where We are Heading.
Gupta VK, Thakker A, Gupta KK
Head Neck Pathol 2020 Dec;14(4):1058-1066. Epub 2020 Mar 30 doi: 10.1007/s12105-020-01155-x. PMID: 32232723Free PMC Article
Classification and Current Management of Inner Ear Malformations.
Sennaroğlu L, Bajin MD
Balkan Med J 2017 Sep 29;34(5):397-411. Epub 2017 Aug 25 doi: 10.4274/balkanmedj.2017.0367. PMID: 28840850Free PMC Article
Cerebrospinal Fluid Leakage after Thoracic Decompression.
Hu PP, Liu XG, Yu M
Chin Med J (Engl) 2016 Aug 20;129(16):1994-2000. doi: 10.4103/0366-6999.187854. PMID: 27503026Free PMC Article

Diagnosis

Long-term efficacy and safety of eladocagene exuparvovec in patients with AADC deficiency.
Tai CH, Lee NC, Chien YH, Byrne BJ, Muramatsu SI, Tseng SH, Hwu WL
Mol Ther 2022 Feb 2;30(2):509-518. Epub 2021 Nov 8 doi: 10.1016/j.ymthe.2021.11.005. PMID: 34763085Free PMC Article
Parasellar Meningiomas.
Graillon T, Regis J, Barlier A, Brue T, Dufour H, Buchfelder M
Neuroendocrinology 2020;110(9-10):780-796. Epub 2020 Jun 3 doi: 10.1159/000509090. PMID: 32492684
Vestibular Schwannoma: What We Know and Where We are Heading.
Gupta VK, Thakker A, Gupta KK
Head Neck Pathol 2020 Dec;14(4):1058-1066. Epub 2020 Mar 30 doi: 10.1007/s12105-020-01155-x. PMID: 32232723Free PMC Article
Delayed Diagnosis and Treatment of Cerebrospinal Fluid Leakage in Current Practice.
Li M, Mao S, Tang R, Lin H, Li D, Ye H, Su K, Chen Z, Zhang W
J Craniofac Surg 2019 Sep;30(6):1657-1661. doi: 10.1097/SCS.0000000000005402. PMID: 30908435
Cerebrospinal Fluid Leakage after Thoracic Decompression.
Hu PP, Liu XG, Yu M
Chin Med J (Engl) 2016 Aug 20;129(16):1994-2000. doi: 10.4103/0366-6999.187854. PMID: 27503026Free PMC Article

Therapy

Advances in Pituitary Surgery.
Byun YH, Kang H, Kim YH
Endocrinol Metab (Seoul) 2022 Aug;37(4):608-616. Epub 2022 Aug 19 doi: 10.3803/EnM.2022.1546. PMID: 35982611Free PMC Article
Long-term efficacy and safety of eladocagene exuparvovec in patients with AADC deficiency.
Tai CH, Lee NC, Chien YH, Byrne BJ, Muramatsu SI, Tseng SH, Hwu WL
Mol Ther 2022 Feb 2;30(2):509-518. Epub 2021 Nov 8 doi: 10.1016/j.ymthe.2021.11.005. PMID: 34763085Free PMC Article
Cerebrospinal fluid leakage after cranial surgery in the pediatric population-a systematic review and meta-analysis.
Slot EMH, van Baarsen KM, Hoving EW, Zuithoff NPA, van Doormaal TPC
Childs Nerv Syst 2021 May;37(5):1439-1447. Epub 2021 Feb 4 doi: 10.1007/s00381-021-05036-8. PMID: 33538867Free PMC Article
Intrathecal catheter use after accidental dural puncture in obstetric patients: literature review and clinical management recommendations.
Orbach-Zinger S, Jadon A, Lucas DN, Sia AT, Tsen LC, Van de Velde M, Heesen M
Anaesthesia 2021 Aug;76(8):1111-1121. Epub 2021 Jan 21 doi: 10.1111/anae.15390. PMID: 33476424
Cerebrospinal Fluid Leakage after Thoracic Decompression.
Hu PP, Liu XG, Yu M
Chin Med J (Engl) 2016 Aug 20;129(16):1994-2000. doi: 10.4103/0366-6999.187854. PMID: 27503026Free PMC Article

Prognosis

Craniofacial Encephalocele: Updates on Management.
Alberts A, Lucke-Wold B
J Integr Neurosci 2023 May 19;22(3):79. doi: 10.31083/j.jin2203079. PMID: 37258446Free PMC Article
The incidence of postoperative cerebrospinal fluid leakage after elective cranial surgery: a systematic review.
Coucke B, Van Gerven L, De Vleeschouwer S, Van Calenbergh F, van Loon J, Theys T
Neurosurg Rev 2022 Jun;45(3):1827-1845. Epub 2021 Sep 9 doi: 10.1007/s10143-021-01641-y. PMID: 34499261
Delayed Diagnosis and Treatment of Cerebrospinal Fluid Leakage in Current Practice.
Li M, Mao S, Tang R, Lin H, Li D, Ye H, Su K, Chen Z, Zhang W
J Craniofac Surg 2019 Sep;30(6):1657-1661. doi: 10.1097/SCS.0000000000005402. PMID: 30908435
Cervical intradural disc herniation: A systematic review.
Guan Q, Xing F, Long Y, Xiang Z
J Clin Neurosci 2018 Feb;48:1-6. Epub 2017 Nov 20 doi: 10.1016/j.jocn.2017.10.024. PMID: 29162303
Cerebrospinal Fluid Leakage after Thoracic Decompression.
Hu PP, Liu XG, Yu M
Chin Med J (Engl) 2016 Aug 20;129(16):1994-2000. doi: 10.4103/0366-6999.187854. PMID: 27503026Free PMC Article

Clinical prediction guides

Factors Influencing Cerebrospinal Fluid Leaking following Pituitary Adenoma Transsphenoidal Surgery: A Meta-Analysis and Comprehensive Review.
Zhang J, Liu J, Huang L
Biomed Res Int 2022;2022:5213744. Epub 2022 Aug 16 doi: 10.1155/2022/5213744. PMID: 36017392Free PMC Article
Long-term efficacy and safety of eladocagene exuparvovec in patients with AADC deficiency.
Tai CH, Lee NC, Chien YH, Byrne BJ, Muramatsu SI, Tseng SH, Hwu WL
Mol Ther 2022 Feb 2;30(2):509-518. Epub 2021 Nov 8 doi: 10.1016/j.ymthe.2021.11.005. PMID: 34763085Free PMC Article
Parasellar Meningiomas.
Graillon T, Regis J, Barlier A, Brue T, Dufour H, Buchfelder M
Neuroendocrinology 2020;110(9-10):780-796. Epub 2020 Jun 3 doi: 10.1159/000509090. PMID: 32492684
Classification and Current Management of Inner Ear Malformations.
Sennaroğlu L, Bajin MD
Balkan Med J 2017 Sep 29;34(5):397-411. Epub 2017 Aug 25 doi: 10.4274/balkanmedj.2017.0367. PMID: 28840850Free PMC Article
Cerebrospinal fluid leaks in orbital and lacrimal surgery.
Limawararut V, Valenzuela AA, Sullivan TJ, McNab AA, Malhotra R, Davis G, Jones N, Selva D
Surv Ophthalmol 2008 May-Jun;53(3):274-84. doi: 10.1016/j.survophthal.2008.02.009. PMID: 18501271

Recent systematic reviews

The incidence of postoperative cerebrospinal fluid leakage after elective cranial surgery: a systematic review.
Coucke B, Van Gerven L, De Vleeschouwer S, Van Calenbergh F, van Loon J, Theys T
Neurosurg Rev 2022 Jun;45(3):1827-1845. Epub 2021 Sep 9 doi: 10.1007/s10143-021-01641-y. PMID: 34499261
Risk factors for postoperative cerebrospinal fluid leakage after transsphenoidal surgery for pituitary adenoma: a meta-analysis and systematic review.
Zhou Z, Zuo F, Chen X, Zhao Q, Luo M, Jiang X, Duan Y
BMC Neurol 2021 Oct 27;21(1):417. doi: 10.1186/s12883-021-02440-0. PMID: 34706659Free PMC Article
Cerebrospinal fluid leakage after cranial surgery in the pediatric population-a systematic review and meta-analysis.
Slot EMH, van Baarsen KM, Hoving EW, Zuithoff NPA, van Doormaal TPC
Childs Nerv Syst 2021 May;37(5):1439-1447. Epub 2021 Feb 4 doi: 10.1007/s00381-021-05036-8. PMID: 33538867Free PMC Article
Effectiveness of Dural Sealants in Prevention of Cerebrospinal Fluid Leakage After Craniotomy: A Systematic Review.
Kinaci A, Algra A, Heuts S, O'Donnell D, van der Zwan A, van Doormaal T
World Neurosurg 2018 Oct;118:368-376.e1. Epub 2018 Jun 30 doi: 10.1016/j.wneu.2018.06.196. PMID: 29969744
Cervical intradural disc herniation: A systematic review.
Guan Q, Xing F, Long Y, Xiang Z
J Clin Neurosci 2018 Feb;48:1-6. Epub 2017 Nov 20 doi: 10.1016/j.jocn.2017.10.024. PMID: 29162303

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