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Cerebrospinal fluid leak

MedGen UID:
9695
Concept ID:
C0023182
Pathologic Function
Synonyms: CSF leak; CSF otorrhea; CSF rhinorrhea; Spinal CSF leak
SNOMED CT: Cerebrospinal fluid leakage (73965003); Cerebrospinal fluid leak (230744007); CSF - Cerebrospinal fluid leak (230744007)
 
Monarch Initiative: MONDO:0043327

Definition

The loss of cerebrospinal fluid into the surrounding tissues. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCerebrospinal fluid leak

Professional guidelines

PubMed

Cheema S, Anderson J, Angus-Leppan H, Armstrong P, Butteriss D, Carlton Jones L, Choi D, Chotai A, D'Antona L, Davagnanam I, Davies B, Dorman PJ, Duncan C, Ellis S, Iodice V, Joy C, Lagrata S, Mead S, Morland D, Nissen J, Pople J, Redfern N, Sayal PP, Scoffings D, Secker R, Toma AK, Trevarthen T, Walkden J, Beck J, Kranz PG, Schievink W, Wang SJ, Matharu MS
J Neurol Neurosurg Psychiatry 2023 Oct;94(10):835-843. Epub 2023 May 5 doi: 10.1136/jnnp-2023-331166. PMID: 37147116Free PMC Article
Almalki MH, Ahmad MM, Brema I, Almehthel M, AlDahmani KM, Mahzari M, Beshyah SA
Sultan Qaboos Univ Med J 2021 Aug;21(3):354-364. Epub 2021 Aug 29 doi: 10.18295/squmj.4.2021.010. PMID: 34522399Free PMC Article
Fang Z, Tian R, Jia YT, Xu TT, Liu Y
Chin J Traumatol 2017 Apr;20(2):81-83. Epub 2017 Feb 24 doi: 10.1016/j.cjtee.2016.12.002. PMID: 28336418Free PMC Article

Recent clinical studies

Etiology

Racette S, Tekumalla S, Agarwal A, Curry J, Beahm DD
Otolaryngol Clin North Am 2023 Aug;56(4):727-739. Epub 2023 Jun 1 doi: 10.1016/j.otc.2023.04.015. PMID: 37268516
Byun YH, Kang H, Kim YH
Endocrinol Metab (Seoul) 2022 Aug;37(4):608-616. Epub 2022 Aug 19 doi: 10.3803/EnM.2022.1546. PMID: 35982611Free PMC Article
AlQahtani A, Albathi A, Castelnuovo P, Alfawwaz F
Am J Rhinol Allergy 2021 Mar;35(2):264-271. Epub 2020 Aug 20 doi: 10.1177/1945892420952262. PMID: 32819147
Tam EK, Gilbert AL
Curr Opin Ophthalmol 2019 Nov;30(6):467-471. doi: 10.1097/ICU.0000000000000603. PMID: 31449087
Welch KC
Otolaryngol Clin North Am 2015 Oct;48(5):769-82. Epub 2015 Jul 2 doi: 10.1016/j.otc.2015.05.005. PMID: 26143103

Diagnosis

Dobrocky T, Nicholson P, Häni L, Mordasini P, Krings T, Brinjikji W, Cutsforth-Gregory JK, Schär R, Schankin C, Gralla J, Pereira VM, Raabe A, Farb R, Beck J, Piechowiak EI
Lancet Neurol 2022 Apr;21(4):369-380. Epub 2022 Feb 25 doi: 10.1016/S1474-4422(21)00423-3. PMID: 35227413
Schievink WI
N Engl J Med 2021 Dec 2;385(23):2173-2178. doi: 10.1056/NEJMra2101561. PMID: 34874632
Luetzen N, Dovi-Akue P, Fung C, Beck J, Urbach H
Neuroradiology 2021 Nov;63(11):1765-1772. Epub 2021 Jul 23 doi: 10.1007/s00234-021-02766-z. PMID: 34297176Free PMC Article
Wang SJ
Continuum (Minneap Minn) 2021 Jun 1;27(3):746-766. doi: 10.1212/CON.0000000000000979. PMID: 34048402
Roytman M, Salama G, Robbins MS, Chazen JL
Curr Pain Headache Rep 2021 Jan 21;25(1):5. doi: 10.1007/s11916-020-00921-4. PMID: 33475890

Therapy

Cheema S, Mehta D, Qureshi A, Sayal P, Kamourieh S, Davagnanam I, Matharu M
Pract Neurol 2024 Mar 19;24(2):98-105. doi: 10.1136/pn-2023-003986. PMID: 38135500Free PMC Article
Cheema S, Anderson J, Angus-Leppan H, Armstrong P, Butteriss D, Carlton Jones L, Choi D, Chotai A, D'Antona L, Davagnanam I, Davies B, Dorman PJ, Duncan C, Ellis S, Iodice V, Joy C, Lagrata S, Mead S, Morland D, Nissen J, Pople J, Redfern N, Sayal PP, Scoffings D, Secker R, Toma AK, Trevarthen T, Walkden J, Beck J, Kranz PG, Schievink W, Wang SJ, Matharu MS
J Neurol Neurosurg Psychiatry 2023 Oct;94(10):835-843. Epub 2023 May 5 doi: 10.1136/jnnp-2023-331166. PMID: 37147116Free PMC Article
Byun YH, Kang H, Kim YH
Endocrinol Metab (Seoul) 2022 Aug;37(4):608-616. Epub 2022 Aug 19 doi: 10.3803/EnM.2022.1546. PMID: 35982611Free PMC Article
Jones MR, Shlobin NA, Dahdaleh NS
World Neurosurg 2021 Jun;150:133-139. Epub 2021 Mar 30 doi: 10.1016/j.wneu.2021.03.115. PMID: 33798778
Welch KC
Otolaryngol Clin North Am 2015 Oct;48(5):769-82. Epub 2015 Jul 2 doi: 10.1016/j.otc.2015.05.005. PMID: 26143103

Prognosis

Sastry RA, Walek K, Leary OP, Rex N, Shaaya EA, Poggi JA, Cielo D
World Neurosurg 2022 Aug;164:e1094-e1102. Epub 2022 May 28 doi: 10.1016/j.wneu.2022.05.102. PMID: 35640831
AlQahtani A, Albathi A, Castelnuovo P, Alfawwaz F
Am J Rhinol Allergy 2021 Mar;35(2):264-271. Epub 2020 Aug 20 doi: 10.1177/1945892420952262. PMID: 32819147
Andrew TW, Morbia R, Lorenz HP
Clin Plast Surg 2019 Apr;46(2):239-247. Epub 2019 Feb 2 doi: 10.1016/j.cps.2018.11.008. PMID: 30851755
Hu PP, Liu XG, Yu M
Chin Med J (Engl) 2016 Aug 20;129(16):1994-2000. doi: 10.4103/0366-6999.187854. PMID: 27503026Free PMC Article
Bathla G, Moritani T
Semin Ultrasound CT MR 2016 Apr;37(2):143-9. Epub 2015 Dec 10 doi: 10.1053/j.sult.2015.12.002. PMID: 27063664

Clinical prediction guides

Cardinal T, Zada G, Carmichael JD
Best Pract Res Clin Endocrinol Metab 2021 Mar;35(2):101489. Epub 2021 Feb 6 doi: 10.1016/j.beem.2021.101489. PMID: 33814302
Masalha MA, VanKoevering KK, Latif OS, Powell AR, Zhang A, Hod KH, Prevedello DM, Carrau RL
Am J Rhinol Allergy 2021 Nov;35(6):802-808. Epub 2021 Mar 20 doi: 10.1177/19458924211003537. PMID: 33745321
AlQahtani A, Albathi A, Castelnuovo P, Alfawwaz F
Am J Rhinol Allergy 2021 Mar;35(2):264-271. Epub 2020 Aug 20 doi: 10.1177/1945892420952262. PMID: 32819147
Dobrocky T, Grunder L, Breiding PS, Branca M, Limacher A, Mosimann PJ, Mordasini P, Zibold F, Haeni L, Jesse CM, Fung C, Raabe A, Ulrich CT, Gralla J, Beck J, Piechowiak EI
JAMA Neurol 2019 May 1;76(5):580-587. doi: 10.1001/jamaneurol.2018.4921. PMID: 30776059Free PMC Article
Dawes JM, Vincent A
Curr Opin Support Palliat Care 2016 Jun;10(2):137-42. doi: 10.1097/SPC.0000000000000211. PMID: 27100817

Recent systematic reviews

Cheema S, Anderson J, Angus-Leppan H, Armstrong P, Butteriss D, Carlton Jones L, Choi D, Chotai A, D'Antona L, Davagnanam I, Davies B, Dorman PJ, Duncan C, Ellis S, Iodice V, Joy C, Lagrata S, Mead S, Morland D, Nissen J, Pople J, Redfern N, Sayal PP, Scoffings D, Secker R, Toma AK, Trevarthen T, Walkden J, Beck J, Kranz PG, Schievink W, Wang SJ, Matharu MS
J Neurol Neurosurg Psychiatry 2023 Oct;94(10):835-843. Epub 2023 May 5 doi: 10.1136/jnnp-2023-331166. PMID: 37147116Free PMC Article
Xie M, Zhou K, Kachra S, McHugh T, Sommer DD
Am J Rhinol Allergy 2022 May;36(3):397-406. Epub 2021 Nov 30 doi: 10.1177/19458924211060918. PMID: 34846218Free PMC Article
Slot EMH, van Baarsen KM, Hoving EW, Zuithoff NPA, van Doormaal TPC
Childs Nerv Syst 2021 May;37(5):1439-1447. Epub 2021 Feb 4 doi: 10.1007/s00381-021-05036-8. PMID: 33538867Free PMC Article
Shlobin NA, Shah VN, Chin CT, Dillon WP, Tan LA
Neurosurgery 2021 Apr 15;88(5):931-941. doi: 10.1093/neuros/nyaa558. PMID: 33438744
Guan Q, Xing F, Long Y, Xiang Z
J Clin Neurosci 2018 Feb;48:1-6. Epub 2017 Nov 20 doi: 10.1016/j.jocn.2017.10.024. PMID: 29162303

Supplemental Content

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