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Thick nasal septum

MedGen UID:
335033
Concept ID:
C1844810
Finding
Synonyms: Broad nasal septum; Broad septum of nose; Thick septum of nose; Wide nasal septum; Wide septum of nose
 
HPO: HP:0009746

Definition

Abnormally increased thickness of the nasal septum. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThick nasal septum

Conditions with this feature

Coffin-Lowry syndrome
MedGen UID:
75556
Concept ID:
C0265252
Disease or Syndrome
Coffin-Lowry syndrome (CLS) is usually characterized by severe-to-profound intellectual disability in males; less severely impaired individuals have been reported. Neuropsychiatric concerns can include behavioral problems, loss of strength, progressive spasticity or paraplegia, sleep apnea, or stroke. Stimulus-induced drop attacks (SIDAs) in which unexpected tactile or auditory stimuli or excitement triggers a brief collapse but no loss of consciousness are present in approximately 20% of affected individuals. Typically SIDAs begin between mid-childhood and the teens. Characteristic facial features may be more apparent with age. Upper-extremity differences may be subtle and include short, soft, fleshy hands with tapered fingers as well as fleshy forearms. Progressive kyphoscoliosis is one of the most difficult aspects of long-term care. Affected females tend to have intellectual disability in the mild-to-moderate range and may also have the typical facial, hand, and skeletal findings noted in males.

Professional guidelines

PubMed

Lee DH, Yoon TM, Lee JK, Joo YE, Kim IY, Jang WY, Moon KS, Jung S, Lim SC
J Craniofac Surg 2012 Jul;23(4):e322-6. doi: 10.1097/SCS.0b013e3182543410. PMID: 22801168
Pivonello R, Faggiano A, Arrichiello P, Di Sarno A, Di Somma C, Ferone D, Lombardi G, Colao A
Clin Endocrinol (Oxf) 2001 Jan;54(1):97-106. doi: 10.1046/j.1365-2265.2001.01207.x. PMID: 11167932

Recent clinical studies

Etiology

Almazov I, Rovira RV, Farhadov V
Aesthetic Plast Surg 2022 Jun;46(3):1342-1350. Epub 2022 Feb 15 doi: 10.1007/s00266-021-02751-0. PMID: 35169916
Yildiz K, Gorgulu T, Yesiloglu N, Kelahmetoglu O, Camli MF, Canter HI
Dermatol Ther 2021 Jan;34(1):e14734. Epub 2021 Jan 11 doi: 10.1111/dth.14734. PMID: 33389778
Eid I, Humphrey C, Jones J, Bhalla V, Kriet JD
Facial Plast Surg Aesthet Med 2021 Jan-Feb;23(1):21-24. Epub 2020 Jun 10 doi: 10.1089/fpsam.2020.0053. PMID: 32522042
Lau J, Elhassan HA, Singh N
J Laryngol Otol 2018 Mar;132(3):198-201. Epub 2018 Jan 30 doi: 10.1017/S0022215118000142. PMID: 29380712
Menick FJ, Salibian A
Plast Reconstr Surg 2014 Nov;134(5):1045-1056. doi: 10.1097/PRS.0000000000000694. PMID: 25347637

Diagnosis

Yan Q, Wang X, Deng Y
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Jan 28;47(1):123-128. doi: 10.11817/j.issn.1672-7347.2022.210359. PMID: 35545372Free PMC Article
Şahin E, Songur MS, Kantekin Y, Bayhan HA, Can IH
J Craniofac Surg 2020 Jul-Aug;31(5):e439-e442. doi: 10.1097/SCS.0000000000006374. PMID: 32224782
Houlton JJ, Donaldson AM, Zimmer L, Seiden A
Int Forum Allergy Rhinol 2012 Mar-Apr;2(2):130-4. Epub 2012 Jan 17 doi: 10.1002/alr.21001. PMID: 22253034
Patel AD, Kridel RW
Facial Plast Surg 2010 May;26(2):131-41. Epub 2010 May 4 doi: 10.1055/s-0030-1253499. PMID: 20446207
Touraine RL, Zeniou M, Hanauer A
Eur J Pediatr 2002 Apr;161(4):179-87. doi: 10.1007/s00431-001-0904-6. PMID: 12014383

Therapy

Yigit E, Rakici IT, Seden N, Manav V, Kaygisiz I, Yigit O
Aesthetic Plast Surg 2022 Aug;46(4):1760-1770. Epub 2021 Nov 24 doi: 10.1007/s00266-021-02663-z. PMID: 34820691
Irvine LE, Nassif PS
Facial Plast Surg 2018 Feb;34(1):9-13. Epub 2018 Feb 6 doi: 10.1055/s-0037-1617420. PMID: 29409098
Zenga J, Chi JJ
Facial Plast Surg 2017 Feb;33(1):67-73. Epub 2017 Feb 22 doi: 10.1055/s-0036-1597988. PMID: 28226372
Houlton JJ, Donaldson AM, Zimmer L, Seiden A
Int Forum Allergy Rhinol 2012 Mar-Apr;2(2):130-4. Epub 2012 Jan 17 doi: 10.1002/alr.21001. PMID: 22253034
Koch CA, Archibald DJ, Friedman O
Facial Plast Surg Clin North Am 2011 Feb;19(1):113-22. doi: 10.1016/j.fsc.2010.10.003. PMID: 21112514

Prognosis

Almazov I, Rovira RV, Farhadov V
Aesthetic Plast Surg 2022 Jun;46(3):1342-1350. Epub 2022 Feb 15 doi: 10.1007/s00266-021-02751-0. PMID: 35169916
Yigit E, Rakici IT, Seden N, Manav V, Kaygisiz I, Yigit O
Aesthetic Plast Surg 2022 Aug;46(4):1760-1770. Epub 2021 Nov 24 doi: 10.1007/s00266-021-02663-z. PMID: 34820691
Riechelmann H, Widmann G, Kofler B, Arminger R, Url C, Giotakis AI
J Oral Maxillofac Surg 2020 Oct;78(10):1833.e1-1833.e9. Epub 2020 May 14 doi: 10.1016/j.joms.2020.05.011. PMID: 32544472
Serifoglu I, Oz İİ, Damar M, Buyukuysal MC, Tosun A, Tokgöz Ö
Head Face Med 2017 Feb 28;13(1):3. doi: 10.1186/s13005-017-0136-2. PMID: 28245851Free PMC Article
Menick FJ, Salibian A
Plast Reconstr Surg 2014 Nov;134(5):1045-1056. doi: 10.1097/PRS.0000000000000694. PMID: 25347637

Clinical prediction guides

Resuli AS, Dilber M, Bayar Muluk N, Cingi C
Eur Rev Med Pharmacol Sci 2023 Mar;27(2 Suppl):8-13. doi: 10.26355/eurrev_202303_31695. PMID: 36971215
Almazov I, Rovira RV, Farhadov V
Aesthetic Plast Surg 2022 Jun;46(3):1342-1350. Epub 2022 Feb 15 doi: 10.1007/s00266-021-02751-0. PMID: 35169916
Yildiz K, Gorgulu T, Yesiloglu N, Kelahmetoglu O, Camli MF, Canter HI
Dermatol Ther 2021 Jan;34(1):e14734. Epub 2021 Jan 11 doi: 10.1111/dth.14734. PMID: 33389778
Eid I, Humphrey C, Jones J, Bhalla V, Kriet JD
Facial Plast Surg Aesthet Med 2021 Jan-Feb;23(1):21-24. Epub 2020 Jun 10 doi: 10.1089/fpsam.2020.0053. PMID: 32522042
Riechelmann H, Widmann G, Kofler B, Arminger R, Url C, Giotakis AI
J Oral Maxillofac Surg 2020 Oct;78(10):1833.e1-1833.e9. Epub 2020 May 14 doi: 10.1016/j.joms.2020.05.011. PMID: 32544472

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