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Bilateral tonic-clonic seizure on awakening

MedGen UID:
335621
Concept ID:
C1847165
Disease or Syndrome; Finding
Synonym: Morning generalized tonic-clonic seizures
 
HPO: HP:0007193

Definition

Bilateral tonic-clonic seizure of either generalized or focal onset occurring on or soon after wakening (typically within 90 minutes of waking, regardless of the time of day). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBilateral tonic-clonic seizure on awakening

Conditions with this feature

Epilepsy, idiopathic generalized, susceptibility to, 9
MedGen UID:
413424
Concept ID:
C2750887
Finding
For a general phenotypic description and a discussion of genetic heterogeneity of idiopathic generalized epilepsy, see 600669. Juvenile myoclonic epilepsy is a subtype of idiopathic generalized epilepsy; see 254770 for a general phenotypic description and a discussion of genetic heterogeneity of JME.
Epilepsy, juvenile absence, susceptibility to, 1
MedGen UID:
413426
Concept ID:
C2750892
Finding
Juvenile absence epilepsy is a subtype of idiopathic generalized epilepsy (IGE; see 600669). Manifestations occur around puberty, in contrast to childhood absence epilepsy (CAE; 600131), which begins at age 6 to 7 years. Absence seizures, generalized tonic-clonic seizures (GTCS), GTCS on awakening, and myoclonic seizures are the main features of JAE. (Commission on Classification and Terminology of the International League Against Epilepsy, 1989). Genetic Heterogeneity of Juvenile Absence Epilepsy See also susceptibility to juvenile absence epilepsy-2 (EJA2; see 607628), conferred by variation in the CLCN2 gene (600570) on chromosome 3q26.
Epilepsy, idiopathic generalized, susceptibility to, 11
MedGen UID:
416407
Concept ID:
C2750893
Finding
Both juvenile myoclonic epilepsy and juvenile absence epilepsy are subtypes of idiopathic generalized epilepsy (EIG). For a general phenotypic description and a discussion of genetic heterogeneity of these disorders, see EIG1 (600669), EJM1 (254770), and EJA1 (607631).

Professional guidelines

PubMed

Rossetti AO, Alvarez V
Curr Opin Neurol 2021 Apr 1;34(2):172-181. doi: 10.1097/WCO.0000000000000899. PMID: 33664203
Roberson SW, Patel MB, Dabrowski W, Ely EW, Pakulski C, Kotfis K
Curr Neuropharmacol 2021;19(9):1519-1544. doi: 10.2174/1570159X19666210119153839. PMID: 33463474Free PMC Article
Thakran S, Guin D, Singh P, Singh P, Kukal S, Rawat C, Yadav S, Kushwaha SS, Srivastava AK, Hasija Y, Saso L, Ramachandran S, Kukreti R
Int J Mol Sci 2020 Oct 21;21(20) doi: 10.3390/ijms21207784. PMID: 33096746Free PMC Article

Recent clinical studies

Etiology

Mierlo PV, Braakman H, Vandenbussche N, Schelhaas HJ, Pillen S
Neuropediatrics 2022 Apr;53(2):109-114. Epub 2021 Dec 21 doi: 10.1055/s-0041-1740551. PMID: 34933379
Roberson SW, Patel MB, Dabrowski W, Ely EW, Pakulski C, Kotfis K
Curr Neuropharmacol 2021;19(9):1519-1544. doi: 10.2174/1570159X19666210119153839. PMID: 33463474Free PMC Article
Thakran S, Guin D, Singh P, Singh P, Kukal S, Rawat C, Yadav S, Kushwaha SS, Srivastava AK, Hasija Y, Saso L, Ramachandran S, Kukreti R
Int J Mol Sci 2020 Oct 21;21(20) doi: 10.3390/ijms21207784. PMID: 33096746Free PMC Article
Seger DL
J Toxicol Clin Toxicol 2004;42(2):209-16. doi: 10.1081/clt-120030946. PMID: 15214628
Hoffman EJ, Warren EW
Clin Pharm 1993 Sep;12(9):641-56; quiz 699-701. PMID: 8306565

Diagnosis

Eiser AS
Sleep Med Clin 2024 Mar;19(1):159-167. Epub 2023 Nov 22 doi: 10.1016/j.jsmc.2023.10.003. PMID: 38368062
Mierlo PV, Braakman H, Vandenbussche N, Schelhaas HJ, Pillen S
Neuropediatrics 2022 Apr;53(2):109-114. Epub 2021 Dec 21 doi: 10.1055/s-0041-1740551. PMID: 34933379
Rossetti AO, Alvarez V
Curr Opin Neurol 2021 Apr 1;34(2):172-181. doi: 10.1097/WCO.0000000000000899. PMID: 33664203
Roberson SW, Patel MB, Dabrowski W, Ely EW, Pakulski C, Kotfis K
Curr Neuropharmacol 2021;19(9):1519-1544. doi: 10.2174/1570159X19666210119153839. PMID: 33463474Free PMC Article
Thakran S, Guin D, Singh P, Singh P, Kukal S, Rawat C, Yadav S, Kushwaha SS, Srivastava AK, Hasija Y, Saso L, Ramachandran S, Kukreti R
Int J Mol Sci 2020 Oct 21;21(20) doi: 10.3390/ijms21207784. PMID: 33096746Free PMC Article

Therapy

Rossetti AO, Alvarez V
Curr Opin Neurol 2021 Apr 1;34(2):172-181. doi: 10.1097/WCO.0000000000000899. PMID: 33664203
Roberson SW, Patel MB, Dabrowski W, Ely EW, Pakulski C, Kotfis K
Curr Neuropharmacol 2021;19(9):1519-1544. doi: 10.2174/1570159X19666210119153839. PMID: 33463474Free PMC Article
Genton P, Thomas P, Kasteleijn-Nolst Trenité DG, Medina MT, Salas-Puig J
Epilepsy Behav 2013 Jul;28 Suppl 1:S8-14. doi: 10.1016/j.yebeh.2012.10.034. PMID: 23756488
Armijo JA, Shushtarian M, Valdizan EM, Cuadrado A, de las Cuevas I, Adín J
Curr Pharm Des 2005;11(15):1975-2003. doi: 10.2174/1381612054021006. PMID: 15974971
Clement MJ, Wallace SJ
Arch Dis Child 1988 Sep;63(9):1049-53. doi: 10.1136/adc.63.9.1049. PMID: 3140737Free PMC Article

Prognosis

Rossetti AO, Alvarez V
Curr Opin Neurol 2021 Apr 1;34(2):172-181. doi: 10.1097/WCO.0000000000000899. PMID: 33664203
Thakran S, Guin D, Singh P, Singh P, Kukal S, Rawat C, Yadav S, Kushwaha SS, Srivastava AK, Hasija Y, Saso L, Ramachandran S, Kukreti R
Int J Mol Sci 2020 Oct 21;21(20) doi: 10.3390/ijms21207784. PMID: 33096746Free PMC Article
Friberg H, Cronberg T
Semin Neurol 2016 Dec;36(6):542-549. Epub 2016 Dec 1 doi: 10.1055/s-0036-1592168. PMID: 27907958
Rossetti AO
J Clin Neurophysiol 2015 Dec;32(6):447-8. doi: 10.1097/WNP.0000000000000208. PMID: 26629752
Bernasconi A, Andermann F, Cendes F, Dubeau F, Andermann E, Olivier A
Neurology 1998 Jun;50(6):1772-7. doi: 10.1212/wnl.50.6.1772. PMID: 9633726

Clinical prediction guides

Grigg-Damberger M, Foldvary-Schaefer N
Epilepsy Behav 2021 Mar;116:107735. Epub 2021 Feb 6 doi: 10.1016/j.yebeh.2020.107735. PMID: 33561767
Thakran S, Guin D, Singh P, Singh P, Kukal S, Rawat C, Yadav S, Kushwaha SS, Srivastava AK, Hasija Y, Saso L, Ramachandran S, Kukreti R
Int J Mol Sci 2020 Oct 21;21(20) doi: 10.3390/ijms21207784. PMID: 33096746Free PMC Article
Rossetti AO
J Clin Neurophysiol 2015 Dec;32(6):447-8. doi: 10.1097/WNP.0000000000000208. PMID: 26629752
Schmitt B
Neuropediatrics 2015 Jun;46(3):171-80. Epub 2015 May 12 doi: 10.1055/s-0035-1551574. PMID: 25965811
Plazzi G, Vetrugno R, Provini F, Montagna P
Neurol Sci 2005 Dec;26 Suppl 3:s193-8. doi: 10.1007/s10072-005-0486-6. PMID: 16331395

Recent systematic reviews

Guerrier G, Gianni MA
J Clin Anesth 2019 Dec;58:100-104. Epub 2019 May 28 doi: 10.1016/j.jclinane.2019.05.006. PMID: 31151038

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