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Nonarteritic anterior ischemic optic neuropathy

MedGen UID:
338887
•Concept ID:
C1852242
•
Disease or Syndrome
Synonyms: NAION; Nonarteritic Anterior Ischemic Optic Neuropathy
 
HPO: HP:0007634
Monarch Initiative: MONDO:0000499
Orphanet: ORPHA415300

Definition

An acute condition characterized by sudden visual loss (usually discovered in the morning), optic disc edema at onset, optic disc-related visual field defects. Nonarteritic anterior ischemic optic neuropathy can be associated with flame hemorrhages on the swollen disk or nearby neuroretinal layer, and sometimes with nearby cotton-wool exudates. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNonarteritic anterior ischemic optic neuropathy

Conditions with this feature

Nonarteritic anterior ischemic optic neuropathy, susceptibility to
MedGen UID:
338294
•Concept ID:
C1847711
•
Finding
See: Condition Record
Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1
MedGen UID:
1634330
•Concept ID:
C4551768
•
Disease or Syndrome
CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is characterized by mid-adult onset of recurrent ischemic stroke, cognitive decline progressing to dementia, a history of migraine with aura, mood disturbance, apathy, and diffuse white matter lesions and subcortical infarcts on neuroimaging.
See: Condition Record
Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1
Nonarteritic anterior ischemic optic neuropathy, susceptibility to

Professional guidelines

PubMed

Steroid Treatment of Optic Neuropathies.
Stunkel L, Van Stavern GP
Asia Pac J Ophthalmol (Phila) 2018 Jul-Aug;7(4):218-228. Epub 2018 Jul 2 doi: 10.22608/APO.2018127. PMID: 29962119
Is there treatment for nonarteritic anterior ischemic optic neuropathy.
Katz DM, Trobe JD
Curr Opin Ophthalmol 2015 Nov;26(6):458-63. doi: 10.1097/ICU.0000000000000199. PMID: 26367094
Treatment of nonarteritic anterior ischemic optic neuropathy.
Atkins EJ, Bruce BB, Newman NJ, Biousse V
Surv Ophthalmol 2010 Jan-Feb;55(1):47-63. doi: 10.1016/j.survophthal.2009.06.008. PMID: 20006051Free PMC Article

Recent clinical studies

Etiology

Erectile Dysfunction Agents and Nonarteritic Anterior Ischemic Optic Neuropathy.
Pomeranz HD
Neurol Clin 2017 Feb;35(1):17-27. doi: 10.1016/j.ncl.2016.08.007. PMID: 27886893
New Treatments for Nonarteritic Anterior Ischemic Optic Neuropathy.
Foroozan R
Neurol Clin 2017 Feb;35(1):1-15. doi: 10.1016/j.ncl.2016.08.003. PMID: 27886887
Is there treatment for nonarteritic anterior ischemic optic neuropathy.
Katz DM, Trobe JD
Curr Opin Ophthalmol 2015 Nov;26(6):458-63. doi: 10.1097/ICU.0000000000000199. PMID: 26367094
Surgery for nonarteritic anterior ischemic optic neuropathy.
Dickersin K, Li T
Cochrane Database Syst Rev 2015 Mar 12;2015(3):CD001538. doi: 10.1002/14651858.CD001538.pub4. PMID: 25763979Free PMC Article
Ischemic optic neuropathies.
Rucker JC, Biousse V, Newman NJ
Curr Opin Neurol 2004 Feb;17(1):27-35. doi: 10.1097/00019052-200402000-00006. PMID: 15090874

Diagnosis

Vitreoretinal Findings in Nonarteritic Ischemic Optic Neuropathy.
Molaie AM, Pramil V, Hedges TR 3rd, Tomb LC, Vuong LN
J Neuroophthalmol 2022 Mar 1;42(1):e124-e129. Epub 2021 Apr 26 doi: 10.1097/WNO.0000000000001264. PMID: 34001734
Immunoprofiling of Nonarteritic Anterior Ischemic Optic Neuropathy.
Mesentier-Louro LA, Stell L, Yan Y, Montague AA, de Jesus Perez V, Liao YJ
Transl Vis Sci Technol 2021 Jul 1;10(8):17. doi: 10.1167/tvst.10.8.17. PMID: 34264294Free PMC Article
Erectile Dysfunction Agents and Nonarteritic Anterior Ischemic Optic Neuropathy.
Pomeranz HD
Neurol Clin 2017 Feb;35(1):17-27. doi: 10.1016/j.ncl.2016.08.007. PMID: 27886893
New Treatments for Nonarteritic Anterior Ischemic Optic Neuropathy.
Foroozan R
Neurol Clin 2017 Feb;35(1):1-15. doi: 10.1016/j.ncl.2016.08.003. PMID: 27886887
Ischemic optic neuropathies.
Rucker JC, Biousse V, Newman NJ
Curr Opin Neurol 2004 Feb;17(1):27-35. doi: 10.1097/00019052-200402000-00006. PMID: 15090874

Therapy

Efficacy of Treatments in Nonarteritic Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis.
Lantos K, Dömötör ZR, Farkas N, Kiss S, Szakács Z, Garami A, Varga G, Lujber L, Kanaan R, Hegyi P, Fehér G, Gaál V
Int J Environ Res Public Health 2022 Feb 26;19(5) doi: 10.3390/ijerph19052718. PMID: 35270411Free PMC Article
Use of erythropoietin in ophthalmology: a review.
Feizi S, Alemzadeh-Ansari M, Karimian F, Esfandiari H
Surv Ophthalmol 2022 Mar-Apr;67(2):427-439. Epub 2021 Jun 23 doi: 10.1016/j.survophthal.2021.06.002. PMID: 34157346
Erectile Dysfunction Agents and Nonarteritic Anterior Ischemic Optic Neuropathy.
Pomeranz HD
Neurol Clin 2017 Feb;35(1):17-27. doi: 10.1016/j.ncl.2016.08.007. PMID: 27886893
New Treatments for Nonarteritic Anterior Ischemic Optic Neuropathy.
Foroozan R
Neurol Clin 2017 Feb;35(1):1-15. doi: 10.1016/j.ncl.2016.08.003. PMID: 27886887
Ischemic optic neuropathies.
Rucker JC, Biousse V, Newman NJ
Curr Opin Neurol 2004 Feb;17(1):27-35. doi: 10.1097/00019052-200402000-00006. PMID: 15090874

Prognosis

Steroid Treatment of Optic Neuropathies.
Stunkel L, Van Stavern GP
Asia Pac J Ophthalmol (Phila) 2018 Jul-Aug;7(4):218-228. Epub 2018 Jul 2 doi: 10.22608/APO.2018127. PMID: 29962119
Is there treatment for nonarteritic anterior ischemic optic neuropathy.
Katz DM, Trobe JD
Curr Opin Ophthalmol 2015 Nov;26(6):458-63. doi: 10.1097/ICU.0000000000000199. PMID: 26367094
Surgery for nonarteritic anterior ischemic optic neuropathy.
Dickersin K, Li T
Cochrane Database Syst Rev 2015 Mar 12;2015(3):CD001538. doi: 10.1002/14651858.CD001538.pub4. PMID: 25763979Free PMC Article
Nonarteritic anterior ischemic optic neuropathy (NAION) and its experimental models.
Bernstein SL, Johnson MA, Miller NR
Prog Retin Eye Res 2011 May;30(3):167-87. Epub 2011 Mar 2 doi: 10.1016/j.preteyeres.2011.02.003. PMID: 21376134Free PMC Article
Ischemic optic neuropathies.
Rucker JC, Biousse V, Newman NJ
Curr Opin Neurol 2004 Feb;17(1):27-35. doi: 10.1097/00019052-200402000-00006. PMID: 15090874

Clinical prediction guides

Bilateral Simultaneous Nonarteritic Anterior Ischemic Optic Neuropathy: Demographics, Risk Factors, and Visual Outcomes.
Chung JE, Singaravelu J, Wilson BS, Baykal AP, Lee MS, McClelland CM, Chen JJ, Bhatti MT, Melson AT, Van Stavern GP
J Neuroophthalmol 2023 Mar 1;43(1):86-90. Epub 2022 Jul 8 doi: 10.1097/WNO.0000000000001642. PMID: 36166810
Follow-up of Nonarteritic Anterior Ischemic Optic Neuropathy With Optical Coherence Tomography Angiography.
Aghsaei Fard M, Ghahvechian H, Subramanian PS
J Neuroophthalmol 2021 Dec 1;41(4):e433-e439. doi: 10.1097/WNO.0000000000000997. PMID: 34788242
Transcriptomic Analysis of circRNAs in the Peripheral Blood of Nonarteritic Anterior Ischemic Optic Neuropathy.
Suo J, Xu X, Xu H, Hou N, Zhang J, Han X, Zheng Y, Wang X, Han X
Biomed Res Int 2020;2020:5732124. Epub 2020 Nov 26 doi: 10.1155/2020/5732124. PMID: 33294447Free PMC Article
Optic disk drusen in children.
Chang MY, Pineles SL
Surv Ophthalmol 2016 Nov-Dec;61(6):745-758. Epub 2016 Mar 29 doi: 10.1016/j.survophthal.2016.03.007. PMID: 27033945Free PMC Article
Nonarteritic anterior ischemic optic neuropathy (NAION) and its experimental models.
Bernstein SL, Johnson MA, Miller NR
Prog Retin Eye Res 2011 May;30(3):167-87. Epub 2011 Mar 2 doi: 10.1016/j.preteyeres.2011.02.003. PMID: 21376134Free PMC Article

Recent systematic reviews

Neuroprotective Strategies for Nonarteritic Anterior Ischemic Optic Neuropathy: A Systematic Review.
Budihardja BM, Anggraini E, Pratiwi RW, Nastiti AD, Nusanti S
Korean J Ophthalmol 2023 Aug;37(4):328-339. Epub 2023 Aug 5 doi: 10.3341/kjo.2022.0166. PMID: 37563973Free PMC Article
Nonarteritic Anterior Ischemic Optic Neuropathy After Cataract Surgery: A Systematic Review and Meta-Analysis.
Shew W, Wang MTM, Danesh-Meyer HV
J Neuroophthalmol 2023 Mar 1;43(1):17-28. Epub 2022 Jun 23 doi: 10.1097/WNO.0000000000001625. PMID: 36166807
Efficacy of Treatments in Nonarteritic Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis.
Lantos K, Dömötör ZR, Farkas N, Kiss S, Szakács Z, Garami A, Varga G, Lujber L, Kanaan R, Hegyi P, Fehér G, Gaál V
Int J Environ Res Public Health 2022 Feb 26;19(5) doi: 10.3390/ijerph19052718. PMID: 35270411Free PMC Article
The Association Between Obstructive Sleep Apnea and Nonarteritic Anterior Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis.
Wu Y, Zhou LM, Lou H, Cheng JW, Wei RL
Curr Eye Res 2016 Jul;41(7):987-92. Epub 2015 Oct 7 doi: 10.3109/02713683.2015.1075221. PMID: 26443989
Surgery for nonarteritic anterior ischemic optic neuropathy.
Dickersin K, Li T
Cochrane Database Syst Rev 2015 Mar 12;2015(3):CD001538. doi: 10.1002/14651858.CD001538.pub4. PMID: 25763979Free PMC Article

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