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Alopecia areata 2(AA2)

MedGen UID:
343971
Concept ID:
C1853104
Disease or Syndrome
Synonym: AA2
 
Monarch Initiative: MONDO:0012551
OMIM®: 610753

Clinical features

From HPO
Alopecia of scalp
MedGen UID:
658454
Concept ID:
C0574769
Finding
Alopecia totalis
MedGen UID:
75525
Concept ID:
C0263504
Disease or Syndrome
Loss of all scalp hair.
Alopecia universalis
MedGen UID:
120481
Concept ID:
C0263505
Disease or Syndrome
Alopecia areata is a common disorder that causes hair loss. "Alopecia" is a Latin term that means baldness, and "areata" refers to the patchy nature of the hair loss that is typically seen with this condition.\n\nIn most people with alopecia areata, hair falls out in small, round patches, leaving coin-sized areas of bare skin. This patchy hair loss occurs most often on the scalp but can affect other parts of the body as well. Uncommonly, the hair loss involves the entire scalp (in which case the condition is known as alopecia totalis) or the whole body (alopecia universalis). Other rare forms of alopecia areata, which have different patterns of hair loss, have also been reported.\n\nAlopecia areata affects people of all ages, although it most commonly appears in adolescence or early adulthood. Hair loss occurs over a period of weeks. The hair usually grows back after several months, although it may fall out again. In some cases, unpredictable cycles of hair loss followed by regrowth can last for years. In addition to hair loss, some affected individuals have fingernail and toenail abnormalities, such as pits on the surface of the nails.\n\nThe hair loss associated with alopecia areata is not painful or disabling. However, it causes changes in a person's appearance that can profoundly affect quality of life and self-esteem. In some people, the condition can lead to depression, anxiety, and other emotional or psychological issues.
Patchy alopecia
MedGen UID:
350774
Concept ID:
C1862862
Finding
Transient, non-scarring hair loss and preservation of the hair follicle located in in well-defined patches.

Professional guidelines

PubMed

Ramot Y, Rosenberg V, Zhou L, Harbers S
Adv Ther 2024 Jul;41(7):2890-2906. Epub 2024 May 27 doi: 10.1007/s12325-024-02875-0. PMID: 38802636Free PMC Article
Thomas LW, Elsensohn A, Bergheim T, Shiu J, Ganesan A, Secrest A
J Drugs Dermatol 2018 Mar 1;17(3):323-329. PMID: 29537450

Recent clinical studies

Etiology

King B, Zhang X, Harcha WG, Szepietowski JC, Shapiro J, Lynde C, Mesinkovska NA, Zwillich SH, Napatalung L, Wajsbrot D, Fayyad R, Freyman A, Mitra D, Purohit V, Sinclair R, Wolk R
Lancet 2023 May 6;401(10387):1518-1529. Epub 2023 Apr 14 doi: 10.1016/S0140-6736(23)00222-2. PMID: 37062298
Fukuyama M, Ito T, Ohyama M
J Dermatol 2022 Jan;49(1):19-36. Epub 2021 Oct 28 doi: 10.1111/1346-8138.16207. PMID: 34709679
Barton VR, Toussi A, Awasthi S, Kiuru M
J Am Acad Dermatol 2022 Jun;86(6):1318-1334. Epub 2021 Apr 30 doi: 10.1016/j.jaad.2021.04.077. PMID: 33940103Free PMC Article
Zhou C, Li X, Wang C, Zhang J
Clin Rev Allergy Immunol 2021 Dec;61(3):403-423. Epub 2021 Aug 17 doi: 10.1007/s12016-021-08883-0. PMID: 34403083
Afford R, Leung AKC, Lam JM
Curr Pediatr Rev 2021;17(1):45-54. doi: 10.2174/1573396316666200430084825. PMID: 32351186

Diagnosis

Goldberg LJ
J Am Acad Dermatol 2023 Aug;89(2S):S1-S2. doi: 10.1016/j.jaad.2023.05.048. PMID: 37591559
Zhou C, Li X, Wang C, Zhang J
Clin Rev Allergy Immunol 2021 Dec;61(3):403-423. Epub 2021 Aug 17 doi: 10.1007/s12016-021-08883-0. PMID: 34403083
Sterkens A, Lambert J, Bervoets A
Clin Exp Med 2021 May;21(2):215-230. Epub 2021 Jan 1 doi: 10.1007/s10238-020-00673-w. PMID: 33386567
Afford R, Leung AKC, Lam JM
Curr Pediatr Rev 2021;17(1):45-54. doi: 10.2174/1573396316666200430084825. PMID: 32351186
Pratt CH, King LE Jr, Messenger AG, Christiano AM, Sundberg JP
Nat Rev Dis Primers 2017 Mar 16;3:17011. doi: 10.1038/nrdp.2017.11. PMID: 28300084Free PMC Article

Therapy

Rudnicka L, Arenbergerova M, Grimalt R, Ioannides D, Katoulis AC, Lazaridou E, Olszewska M, Ovcharenko YS, Piraccini BM, Prohic A, Rakowska A, Reygagne P, Richard MA, Soares RO, Starace M, Vañó-Galvan S, Waskiel-Burnat A
J Eur Acad Dermatol Venereol 2024 Apr;38(4):687-694. Epub 2024 Jan 2 doi: 10.1111/jdv.19768. PMID: 38169088
King B, Zhang X, Harcha WG, Szepietowski JC, Shapiro J, Lynde C, Mesinkovska NA, Zwillich SH, Napatalung L, Wajsbrot D, Fayyad R, Freyman A, Mitra D, Purohit V, Sinclair R, Wolk R
Lancet 2023 May 6;401(10387):1518-1529. Epub 2023 Apr 14 doi: 10.1016/S0140-6736(23)00222-2. PMID: 37062298
Gupta AK, Talukder M, Venkataraman M, Bamimore MA
J Dermatolog Treat 2022 Jun;33(4):1896-1906. Epub 2021 Jul 20 doi: 10.1080/09546634.2021.1945527. PMID: 34159872
Barton VR, Toussi A, Awasthi S, Kiuru M
J Am Acad Dermatol 2022 Jun;86(6):1318-1334. Epub 2021 Apr 30 doi: 10.1016/j.jaad.2021.04.077. PMID: 33940103Free PMC Article
Pratt CH, King LE Jr, Messenger AG, Christiano AM, Sundberg JP
Nat Rev Dis Primers 2017 Mar 16;3:17011. doi: 10.1038/nrdp.2017.11. PMID: 28300084Free PMC Article

Prognosis

Zhou W, Cai J, Li Z, Lin Y
Front Immunol 2023;14:1132719. Epub 2023 Mar 30 doi: 10.3389/fimmu.2023.1132719. PMID: 37063839Free PMC Article
Kwon O, Senna MM, Sinclair R, Ito T, Dutronc Y, Lin CY, Yu G, Chiasserini C, McCollam J, Wu WS, King B
Am J Clin Dermatol 2023 May;24(3):443-451. Epub 2023 Mar 1 doi: 10.1007/s40257-023-00764-w. PMID: 36855020Free PMC Article
Fukuyama M, Ito T, Ohyama M
J Dermatol 2022 Jan;49(1):19-36. Epub 2021 Oct 28 doi: 10.1111/1346-8138.16207. PMID: 34709679
Sterkens A, Lambert J, Bervoets A
Clin Exp Med 2021 May;21(2):215-230. Epub 2021 Jan 1 doi: 10.1007/s10238-020-00673-w. PMID: 33386567
Afford R, Leung AKC, Lam JM
Curr Pediatr Rev 2021;17(1):45-54. doi: 10.2174/1573396316666200430084825. PMID: 32351186

Clinical prediction guides

Rudnicka L, Arenbergerova M, Grimalt R, Ioannides D, Katoulis AC, Lazaridou E, Olszewska M, Ovcharenko YS, Piraccini BM, Prohic A, Rakowska A, Reygagne P, Richard MA, Soares RO, Starace M, Vañó-Galvan S, Waskiel-Burnat A
J Eur Acad Dermatol Venereol 2024 Apr;38(4):687-694. Epub 2024 Jan 2 doi: 10.1111/jdv.19768. PMID: 38169088
King B, Zhang X, Harcha WG, Szepietowski JC, Shapiro J, Lynde C, Mesinkovska NA, Zwillich SH, Napatalung L, Wajsbrot D, Fayyad R, Freyman A, Mitra D, Purohit V, Sinclair R, Wolk R
Lancet 2023 May 6;401(10387):1518-1529. Epub 2023 Apr 14 doi: 10.1016/S0140-6736(23)00222-2. PMID: 37062298
Agashe RP, Lippman SM, Kurzrock R
Mol Cancer Ther 2022 Dec 2;21(12):1757-1764. doi: 10.1158/1535-7163.MCT-22-0323. PMID: 36252553Free PMC Article
King B, Ohyama M, Kwon O, Zlotogorski A, Ko J, Mesinkovska NA, Hordinsky M, Dutronc Y, Wu WS, McCollam J, Chiasserini C, Yu G, Stanley S, Holzwarth K, DeLozier AM, Sinclair R; BRAVE-AA Investigators
N Engl J Med 2022 May 5;386(18):1687-1699. Epub 2022 Mar 26 doi: 10.1056/NEJMoa2110343. PMID: 35334197
Afford R, Leung AKC, Lam JM
Curr Pediatr Rev 2021;17(1):45-54. doi: 10.2174/1573396316666200430084825. PMID: 32351186

Recent systematic reviews

Ly S, Manjaly P, Kamal K, Shields A, Wafae B, Afzal N, Drake L, Sanchez K, Gregoire S, Zhou G, Mita C, Mostaghimi A
Am J Clin Dermatol 2023 Nov;24(6):875-893. Epub 2023 Jul 18 doi: 10.1007/s40257-023-00805-4. PMID: 37464249
Liu M, Gao Y, Yuan Y, Yang K, Shen C, Wang J, Tian J
JAMA Netw Open 2023 Jun 1;6(6):e2320351. doi: 10.1001/jamanetworkopen.2023.20351. PMID: 37368402Free PMC Article
Olbrich H, Sadik CD, Ludwig RJ, Thaçi D, Boch K
Biomolecules 2023 Mar 31;13(4) doi: 10.3390/biom13040634. PMID: 37189381Free PMC Article
Cruciani M, Masiello F, Pati I, Marano G, Pupella S, De Angelis V
Blood Transfus 2023 Jan;21(1):24-36. Epub 2021 Nov 15 doi: 10.2450/2021.0216-21. PMID: 34967722Free PMC Article
Barton VR, Toussi A, Awasthi S, Kiuru M
J Am Acad Dermatol 2022 Jun;86(6):1318-1334. Epub 2021 Apr 30 doi: 10.1016/j.jaad.2021.04.077. PMID: 33940103Free PMC Article

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