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Sporadic Cylindroma

MedGen UID:
354197
•Concept ID:
C1710164
•
Neoplastic Process

Definition

A cylindroma occurring as a solitary sporadic lesion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSporadic Cylindroma

Recent clinical studies

Etiology

CYLD-mutant cylindroma-like basaloid carcinoma of the anus: a genetically and morphologically distinct class of HPV-related anal carcinoma.
Williams EA, Montesion M, Sharaf R, Corines J, Patel PJ, Gillespie BJ, Pavlick DC, Sokol ES, Alexander BM, Williams KJ, Elvin JA, Ross JS, Ramkissoon SH, Hemmerich AC, Tse JY, Mochel MC
Mod Pathol 2020 Dec;33(12):2614-2625. Epub 2020 May 27 doi: 10.1038/s41379-020-0584-2. PMID: 32461623Free PMC Article
A clinicopathologic and molecular biologic study of patients presenting with few adnexal tumors (two to four) from the morphological spectrum of Brooke-Spiegler syndrome.
Kacerovska D, Vanecek T, Spagnolo DV, Bisceglia M, Zelger B, Michal M, Kazakov DV
Am J Dermatopathol 2013 Feb;35(1):19-24. doi: 10.1097/DAD.0b013e318255dd37. PMID: 22588548
Dysregulated TRK signalling is a therapeutic target in CYLD defective tumours.
Rajan N, Elliott R, Clewes O, Mackay A, Reis-Filho JS, Burn J, Langtry J, Sieber-Blum M, Lord CJ, Ashworth A
Oncogene 2011 Oct 13;30(41):4243-60. Epub 2011 May 9 doi: 10.1038/onc.2011.133. PMID: 21552290Free PMC Article
Beyond triple-negative breast cancer: the need to define new subtypes.
Constantinidou A, Jones RL, Reis-Filho JS
Expert Rev Anticancer Ther 2010 Aug;10(8):1197-213. doi: 10.1586/era.10.50. PMID: 20735307
Expression of p53 and TP53 mutational analysis in malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome.
Kazakov DV, Grossmann P, Spagnolo DV, Vanecek T, Vazmitel M, Kacerovska D, Zelger B, Calonje E, Michal M
Am J Dermatopathol 2010 May;32(3):215-221. doi: 10.1097/DAD.0b013e3181b9678c. PMID: 20075707

Diagnosis

A rare histopathological spiradenocylindroma: a case report.
Facchini V, Colangeli W, Bozza F, Kapitonov A, Becelli R
Clin Ter 2022 Jul-Aug;173(4):292-294. doi: 10.7417/CT.2022.2433. PMID: 35857041
CYLD-mutant cylindroma-like basaloid carcinoma of the anus: a genetically and morphologically distinct class of HPV-related anal carcinoma.
Williams EA, Montesion M, Sharaf R, Corines J, Patel PJ, Gillespie BJ, Pavlick DC, Sokol ES, Alexander BM, Williams KJ, Elvin JA, Ross JS, Ramkissoon SH, Hemmerich AC, Tse JY, Mochel MC
Mod Pathol 2020 Dec;33(12):2614-2625. Epub 2020 May 27 doi: 10.1038/s41379-020-0584-2. PMID: 32461623Free PMC Article
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
Cancer-associated genodermatoses: skin neoplasms as clues to hereditary tumor syndromes.
Ponti G, Pellacani G, Seidenari S, Pollio A, Muscatello U, Tomasi A
Crit Rev Oncol Hematol 2013 Mar;85(3):239-56. Epub 2012 Jul 21 doi: 10.1016/j.critrevonc.2012.07.001. PMID: 22823951
Electron microscopic findings for diagnosis of breast lesions.
Tsuchiya S, Li F
Med Mol Morphol 2005 Dec;38(4):216-24. doi: 10.1007/s00795-005-0300-9. PMID: 16378230

Therapy

Brooke-Spiegler syndrome: report of two cases not associated with a mutation in the CYLD and PTCH tumor-suppressor genes.
Ponti G, Nasti S, Losi L, Pastorino L, Pollio A, Benassi L, Giudice S, Bertazzoni G, Veratti E, Azzoni P, Bianchi Scarrà G, Seidenari S
J Cutan Pathol 2012 Mar;39(3):366-71. Epub 2011 Nov 12 doi: 10.1111/j.1600-0560.2011.01813.x. PMID: 22077640
Beyond triple-negative breast cancer: the need to define new subtypes.
Constantinidou A, Jones RL, Reis-Filho JS
Expert Rev Anticancer Ther 2010 Aug;10(8):1197-213. doi: 10.1586/era.10.50. PMID: 20735307
Expression of p53 and TP53 mutational analysis in malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome.
Kazakov DV, Grossmann P, Spagnolo DV, Vanecek T, Vazmitel M, Kacerovska D, Zelger B, Calonje E, Michal M
Am J Dermatopathol 2010 May;32(3):215-221. doi: 10.1097/DAD.0b013e3181b9678c. PMID: 20075707

Prognosis

Adenoid cystic carcinoma of the breast with late recurrence and high-grade transformation.
Vasudevan G, John AM, D K V, Vallonthaiel AG
BMJ Case Rep 2023 Feb 9;16(2) doi: 10.1136/bcr-2022-252336. PMID: 36759039Free PMC Article
A clinicopathologic and molecular biologic study of patients presenting with few adnexal tumors (two to four) from the morphological spectrum of Brooke-Spiegler syndrome.
Kacerovska D, Vanecek T, Spagnolo DV, Bisceglia M, Zelger B, Michal M, Kazakov DV
Am J Dermatopathol 2013 Feb;35(1):19-24. doi: 10.1097/DAD.0b013e318255dd37. PMID: 22588548
Beyond triple-negative breast cancer: the need to define new subtypes.
Constantinidou A, Jones RL, Reis-Filho JS
Expert Rev Anticancer Ther 2010 Aug;10(8):1197-213. doi: 10.1586/era.10.50. PMID: 20735307
Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on the study of 24 cases, sporadic or occurring in the setting of Brooke-Spiegler syndrome.
Kazakov DV, Zelger B, Rütten A, Vazmitel M, Spagnolo DV, Kacerovska D, Vanecek T, Grossmann P, Sima R, Grayson W, Calonje E, Koren J, Mukensnabl P, Danis D, Michal M
Am J Surg Pathol 2009 May;33(5):705-19. doi: 10.1097/PAS.0b013e3181966762. PMID: 19194280
Benign tumors of the breast with multinucleated stromal giant cells. Immunohistochemical analysis of six cases and review of the literature.
Ryska A, Reynolds C, Keeney GL
Virchows Arch 2001 Dec;439(6):768-75. doi: 10.1007/s004280100470. PMID: 11787849

Clinical prediction guides

SOX11: a potentially useful marker in surgical pathology: a systematic analysis of SOX11 expression in epithelial and non-epithelial tumours.
Xu S, Dong Y, Huo Z, Yu L, Xue J, Wang G, Duan Y
Histopathology 2019 Feb;74(3):391-405. Epub 2018 Dec 2 doi: 10.1111/his.13757. PMID: 30221780
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
A clinicopathologic and molecular biologic study of patients presenting with few adnexal tumors (two to four) from the morphological spectrum of Brooke-Spiegler syndrome.
Kacerovska D, Vanecek T, Spagnolo DV, Bisceglia M, Zelger B, Michal M, Kazakov DV
Am J Dermatopathol 2013 Feb;35(1):19-24. doi: 10.1097/DAD.0b013e318255dd37. PMID: 22588548
The MYB-NFIB gene fusion-a novel genetic link between adenoid cystic carcinoma and dermal cylindroma.
Fehr A, Kovács A, Löning T, Frierson H Jr, van den Oord J, Stenman G
J Pathol 2011 Jul;224(3):322-7. Epub 2011 May 27 doi: 10.1002/path.2909. PMID: 21618541
Identification of the familial cylindromatosis tumour-suppressor gene.
Bignell GR, Warren W, Seal S, Takahashi M, Rapley E, Barfoot R, Green H, Brown C, Biggs PJ, Lakhani SR, Jones C, Hansen J, Blair E, Hofmann B, Siebert R, Turner G, Evans DG, Schrander-Stumpel C, Beemer FA, van Den Ouweland A, Halley D, Delpech B, Cleveland MG, Leigh I, Leisti J, Rasmussen S
Nat Genet 2000 Jun;25(2):160-5. doi: 10.1038/76006. PMID: 10835629

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