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Benign neoplasm of sweat gland

MedGen UID:
146888
•Concept ID:
C0684354
•
Neoplastic Process
Synonyms: Benign Neoplasm of Sweat Gland; benign neoplasm of sweat gland; Benign Neoplasm of the Sweat Gland; benign neoplasm of the sweat gland; Benign Sweat Gland Neoplasm; benign sweat gland neoplasm; Benign sweat gland tumor; Benign Sweat Gland Tumor; benign sweat gland tumor; benign sweat gland tumour; Benign Tumor of Sweat Gland; benign tumor of sweat gland; Benign Tumor of the Sweat Gland; benign tumor of the sweat gland; benign tumour of sweat gland; benign tumour of the sweat gland; sweat gland benign neoplasm; Sweat Gland Neoplasm, Benign; sweat gland neoplasm, benign; Sweat gland tumor, benign
SNOMED CT: Benign sweat gland tumor (81393009); Sweat gland tumor, benign (81393009); Benign neoplasm of sweat gland (92422009)
 
Monarch Initiative: MONDO:0021489

Definition

A benign neoplasm involving the sweat gland. [from NCI]

Professional guidelines

PubMed

Current Treatment Options for Cutaneous Adnexal Malignancies.
Goto H
Curr Treat Options Oncol 2022 May;23(5):736-748. Epub 2022 Mar 26 doi: 10.1007/s11864-022-00971-3. PMID: 35347560
Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Apocrine and Eccrine Differentiation.
Płachta I, Kleibert M, Czarnecka AM, Spałek M, Szumera-Ciećkiewicz A, Rutkowski P
Int J Mol Sci 2021 May 11;22(10) doi: 10.3390/ijms22105077. PMID: 34064849Free PMC Article
Challenges in diagnosis and management of a spiradenocarcinoma: a comprehensive literature review.
Wagner K, Jassal K, Lee JC, Ban EJ, Cameron R, Serpell J
ANZ J Surg 2021 Oct;91(10):1996-2001. Epub 2021 Feb 1 doi: 10.1111/ans.16626. PMID: 33522696

Recent clinical studies

Etiology

Porocarcinoma: a review.
Joshy J, Mistry K, Levell NJ, van Bodegraven B, Vernon S, Rajan N, Craig P, Venables ZC
Clin Exp Dermatol 2022 Jun;47(6):1030-1035. Epub 2022 Mar 20 doi: 10.1111/ced.15126. PMID: 35149987
Squamoid Eccrine Ductal Carcinoma.
Svoboda SA, Rush PS, Garofola CJ, Grider DJ, Prickett KA, Phillips MA
Cutis 2021 Jun;107(6):E5-E9. doi: 10.12788/cutis.0280. PMID: 34314321
Do not break a sweat: avoiding pitfalls in the diagnosis of sweat gland tumors.
Brenn T
Mod Pathol 2020 Jan;33(Suppl 1):25-41. Epub 2019 Sep 26 doi: 10.1038/s41379-019-0377-7. PMID: 31558783
Skin Adnexal Tumors in Plain Language: A Practical Approach for the General Surgical Pathologist.
Fulton EH, Kaley JR, Gardner JM
Arch Pathol Lab Med 2019 Jul;143(7):832-851. Epub 2019 Jan 14 doi: 10.5858/arpa.2018-0189-RA. PMID: 30638401
Chondroid Syringoma.
Sundling RA, So E, Logan DB
Foot Ankle Spec 2017 Apr;10(2):167-169. Epub 2016 Sep 20 doi: 10.1177/1938640016666927. PMID: 27587378

Diagnosis

A systematic review of periungual eccrine neoplasms.
Rao EM, Knackstedt TJ
Int J Dermatol 2022 Jul;61(7):812-820. Epub 2021 Sep 8 doi: 10.1111/ijd.15893. PMID: 34494261
Syringotropic Melanoma: A Diagnostic Challenge With Prognostic Implications.
Torre-Castro J, Haya-Martínez L, Moya-Martínez C, Núñez-Hipólito L, Mendoza-Cembranos MD, Sabaris MDCF, Eraña-Tomás I, Santonja C, Suárez Massa MD, Cerroni L, Requena L
Am J Dermatopathol 2022 Jan 1;44(1):33-36. doi: 10.1097/DAD.0000000000001853. PMID: 33201009
Squamoid Eccrine Ductal Carcinoma.
Svoboda SA, Rush PS, Garofola CJ, Grider DJ, Prickett KA, Phillips MA
Cutis 2021 Jun;107(6):E5-E9. doi: 10.12788/cutis.0280. PMID: 34314321
Apocrine and eccrine hidrocystomas: a clinicopathological study.
Koumaki D, Papadakis M, Lagoudaki E, Manios GA, Kassotakis D, Doxastaki A, Krasagakis K, Manios A
Acta Dermatovenerol Alp Pannonica Adriat 2021 Jun;30(2):53-56. PMID: 34169699
Topics in histopathology of sweat gland and sebaceous neoplasms.
Ansai SI
J Dermatol 2017 Mar;44(3):315-326. doi: 10.1111/1346-8138.13555. PMID: 28256768

Therapy

Efficacy and safety of lasers in treating syringomas: a review of the literature.
Alsaidan MS
J Dermatolog Treat 2022 Dec;33(8):3127-3135. Epub 2022 Sep 27 doi: 10.1080/09546634.2022.2127307. PMID: 36125344
Current Treatment Options for Cutaneous Adnexal Malignancies.
Goto H
Curr Treat Options Oncol 2022 May;23(5):736-748. Epub 2022 Mar 26 doi: 10.1007/s11864-022-00971-3. PMID: 35347560
Management of Dermatologic Events Associated With the Nectin-4-directed Antibody-Drug Conjugate Enfortumab Vedotin.
Lacouture ME, Patel AB, Rosenberg JE, O'Donnell PH
Oncologist 2022 Mar 11;27(3):e223-e232. doi: 10.1093/oncolo/oyac001. PMID: 35274723Free PMC Article
Alternative Clinical Indications of Botulinum Toxin.
Alster TS, Harrison IS
Am J Clin Dermatol 2020 Dec;21(6):855-880. doi: 10.1007/s40257-020-00532-0. PMID: 32651806
Eccrine porocarcinoma.
Brown CW Jr, Dy LC
Dermatol Ther 2008 Nov-Dec;21(6):433-8. doi: 10.1111/j.1529-8019.2008.00243.x. PMID: 19076620

Prognosis

Porocarcinoma: a review.
Joshy J, Mistry K, Levell NJ, van Bodegraven B, Vernon S, Rajan N, Craig P, Venables ZC
Clin Exp Dermatol 2022 Jun;47(6):1030-1035. Epub 2022 Mar 20 doi: 10.1111/ced.15126. PMID: 35149987
Sweat Gland Tumor Microenvironment.
Yuda Handaya A, Anwar SL, Fauzi AR, Werdana VAP
Adv Exp Med Biol 2020;1296:259-274. doi: 10.1007/978-3-030-59038-3_16. PMID: 34185298
Do not break a sweat: avoiding pitfalls in the diagnosis of sweat gland tumors.
Brenn T
Mod Pathol 2020 Jan;33(Suppl 1):25-41. Epub 2019 Sep 26 doi: 10.1038/s41379-019-0377-7. PMID: 31558783
Topics in histopathology of sweat gland and sebaceous neoplasms.
Ansai SI
J Dermatol 2017 Mar;44(3):315-326. doi: 10.1111/1346-8138.13555. PMID: 28256768
Chondroid Syringoma.
Sundling RA, So E, Logan DB
Foot Ankle Spec 2017 Apr;10(2):167-169. Epub 2016 Sep 20 doi: 10.1177/1938640016666927. PMID: 27587378

Clinical prediction guides

Molecular pathology of skin adnexal tumours.
Plotzke JM, Adams DJ, Harms PW
Histopathology 2022 Jan;80(1):166-183. doi: 10.1111/his.14441. PMID: 34197659
Apocrine and eccrine hidrocystomas: a clinicopathological study.
Koumaki D, Papadakis M, Lagoudaki E, Manios GA, Kassotakis D, Doxastaki A, Krasagakis K, Manios A
Acta Dermatovenerol Alp Pannonica Adriat 2021 Jun;30(2):53-56. PMID: 34169699
Do not break a sweat: avoiding pitfalls in the diagnosis of sweat gland tumors.
Brenn T
Mod Pathol 2020 Jan;33(Suppl 1):25-41. Epub 2019 Sep 26 doi: 10.1038/s41379-019-0377-7. PMID: 31558783
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article

Recent systematic reviews

Dermoscopy of cutaneous adnexal tumours: a systematic review of the literature.
Lai M, Muscianese M, Piana S, Chester J, Borsari S, Paolino G, Pellacani G, Longo C, Pampena R
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1524-1540. Epub 2022 May 25 doi: 10.1111/jdv.18210. PMID: 35536546Free PMC Article
A systematic review of periungual eccrine neoplasms.
Rao EM, Knackstedt TJ
Int J Dermatol 2022 Jul;61(7):812-820. Epub 2021 Sep 8 doi: 10.1111/ijd.15893. PMID: 34494261
Endocrine mucin-producing sweat gland carcinoma: a systematic review and meta-analysis.
Froehlich MH, Conti KR, Norris II, Allensworth JJ, Ufkes NA, Nguyen SA, Bruner ET, Cook J, Day TA
J Dermatolog Treat 2022 Jun;33(4):2182-2191. Epub 2022 Mar 25 doi: 10.1080/09546634.2021.1937479. PMID: 34057875
Eccrine Porocarcinoma: New Insights and a Systematic Review of the Literature.
Nazemi A, Higgins S, Swift R, In G, Miller K, Wysong A
Dermatol Surg 2018 Oct;44(10):1247-1261. doi: 10.1097/DSS.0000000000001566. PMID: 29894433
Evaluation and management of the patient with multiple syringomas: A systematic review of the literature.
Williams K, Shinkai K
J Am Acad Dermatol 2016 Jun;74(6):1234-1240.e9. Epub 2016 Feb 3 doi: 10.1016/j.jaad.2015.12.006. PMID: 26850654

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