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Benign neoplasm of sweat gland

MedGen UID:
146888
•Concept ID:
C0684354
•
Neoplastic Process
Synonyms: Benign Neoplasm of Sweat Gland; benign neoplasm of sweat gland; Benign Neoplasm of the Sweat Gland; benign neoplasm of the sweat gland; Benign Sweat Gland Neoplasm; benign sweat gland neoplasm; Benign sweat gland tumor; Benign Sweat Gland Tumor; benign sweat gland tumor; benign sweat gland tumour; Benign Tumor of Sweat Gland; benign tumor of sweat gland; Benign Tumor of the Sweat Gland; benign tumor of the sweat gland; benign tumour of sweat gland; benign tumour of the sweat gland; sweat gland benign neoplasm; Sweat Gland Neoplasm, Benign; sweat gland neoplasm, benign; Sweat gland tumor, benign
SNOMED CT: Benign sweat gland tumor (81393009); Sweat gland tumor, benign (81393009); Benign neoplasm of sweat gland (92422009)
 
Monarch Initiative: MONDO:0021489

Definition

An epithelial neoplasm that arises from the sweat gland and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

Current Treatment Options for Cutaneous Adnexal Malignancies.
Goto H
Curr Treat Options Oncol 2022 May;23(5):736-748. Epub 2022 Mar 26 doi: 10.1007/s11864-022-00971-3. PMID: 35347560
Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Apocrine and Eccrine Differentiation.
Płachta I, Kleibert M, Czarnecka AM, Spałek M, Szumera-Ciećkiewicz A, Rutkowski P
Int J Mol Sci 2021 May 11;22(10) doi: 10.3390/ijms22105077. PMID: 34064849Free PMC Article
Challenges in diagnosis and management of a spiradenocarcinoma: a comprehensive literature review.
Wagner K, Jassal K, Lee JC, Ban EJ, Cameron R, Serpell J
ANZ J Surg 2021 Oct;91(10):1996-2001. Epub 2021 Feb 1 doi: 10.1111/ans.16626. PMID: 33522696

Recent clinical studies

Etiology

Porocarcinoma: a review.
Joshy J, Mistry K, Levell NJ, van Bodegraven B, Vernon S, Rajan N, Craig P, Venables ZC
Clin Exp Dermatol 2022 Jun;47(6):1030-1035. Epub 2022 Mar 20 doi: 10.1111/ced.15126. PMID: 35149987
Squamoid Eccrine Ductal Carcinoma.
Svoboda SA, Rush PS, Garofola CJ, Grider DJ, Prickett KA, Phillips MA
Cutis 2021 Jun;107(6):E5-E9. doi: 10.12788/cutis.0280. PMID: 34314321
Alternative Clinical Indications of Botulinum Toxin.
Alster TS, Harrison IS
Am J Clin Dermatol 2020 Dec;21(6):855-880. doi: 10.1007/s40257-020-00532-0. PMID: 32651806
Skin Adnexal Tumors in Plain Language: A Practical Approach for the General Surgical Pathologist.
Fulton EH, Kaley JR, Gardner JM
Arch Pathol Lab Med 2019 Jul;143(7):832-851. Epub 2019 Jan 14 doi: 10.5858/arpa.2018-0189-RA. PMID: 30638401
Chondroid Syringoma.
Sundling RA, So E, Logan DB
Foot Ankle Spec 2017 Apr;10(2):167-169. Epub 2016 Sep 20 doi: 10.1177/1938640016666927. PMID: 27587378

Diagnosis

A systematic review of periungual eccrine neoplasms.
Rao EM, Knackstedt TJ
Int J Dermatol 2022 Jul;61(7):812-820. Epub 2021 Sep 8 doi: 10.1111/ijd.15893. PMID: 34494261
Squamoid Eccrine Ductal Carcinoma.
Svoboda SA, Rush PS, Garofola CJ, Grider DJ, Prickett KA, Phillips MA
Cutis 2021 Jun;107(6):E5-E9. doi: 10.12788/cutis.0280. PMID: 34314321
Epibulbar Subconjunctival Apocrine Hidrocystoma.
Charles NC, Raju LV, Kim ET
Ophthalmic Plast Reconstr Surg 2021 Nov-Dec 01;37(6):e208-e209. doi: 10.1097/IOP.0000000000002019. PMID: 34284427
Topics in histopathology of sweat gland and sebaceous neoplasms.
Ansai SI
J Dermatol 2017 Mar;44(3):315-326. doi: 10.1111/1346-8138.13555. PMID: 28256768
Chondroid syringoma.
Satter EK, Graham BS
Cutis 2003 Jan;71(1):49-52, 55. PMID: 12553630

Therapy

Current Treatment Options for Cutaneous Adnexal Malignancies.
Goto H
Curr Treat Options Oncol 2022 May;23(5):736-748. Epub 2022 Mar 26 doi: 10.1007/s11864-022-00971-3. PMID: 35347560
Management of Dermatologic Events Associated With the Nectin-4-directed Antibody-Drug Conjugate Enfortumab Vedotin.
Lacouture ME, Patel AB, Rosenberg JE, O'Donnell PH
Oncologist 2022 Mar 11;27(3):e223-e232. doi: 10.1093/oncolo/oyac001. PMID: 35274723Free PMC Article
Alternative Clinical Indications of Botulinum Toxin.
Alster TS, Harrison IS
Am J Clin Dermatol 2020 Dec;21(6):855-880. doi: 10.1007/s40257-020-00532-0. PMID: 32651806
Angioadnexocentric nevus.
Hashimoto K, Amano M, Setoyama M
J Dermatol 2012 Nov;39(11):909-15. Epub 2012 Jul 4 doi: 10.1111/j.1346-8138.2012.01599.x. PMID: 22762690
Eccrine porocarcinoma.
Brown CW Jr, Dy LC
Dermatol Ther 2008 Nov-Dec;21(6):433-8. doi: 10.1111/j.1529-8019.2008.00243.x. PMID: 19076620

Prognosis

Adnexal and Sebaceous Carcinomas.
Seger EW, Neill BC, Tolkachjov SN
Dermatol Clin 2023 Jan;41(1):117-132. Epub 2022 Oct 28 doi: 10.1016/j.det.2022.07.010. PMID: 36410972
Porocarcinoma: a review.
Joshy J, Mistry K, Levell NJ, van Bodegraven B, Vernon S, Rajan N, Craig P, Venables ZC
Clin Exp Dermatol 2022 Jun;47(6):1030-1035. Epub 2022 Mar 20 doi: 10.1111/ced.15126. PMID: 35149987
Sweat Gland Tumor Microenvironment.
Yuda Handaya A, Anwar SL, Fauzi AR, Werdana VAP
Adv Exp Med Biol 2020;1296:259-274. doi: 10.1007/978-3-030-59038-3_16. PMID: 34185298
Topics in histopathology of sweat gland and sebaceous neoplasms.
Ansai SI
J Dermatol 2017 Mar;44(3):315-326. doi: 10.1111/1346-8138.13555. PMID: 28256768
Chondroid Syringoma.
Sundling RA, So E, Logan DB
Foot Ankle Spec 2017 Apr;10(2):167-169. Epub 2016 Sep 20 doi: 10.1177/1938640016666927. PMID: 27587378

Clinical prediction guides

Sweat Gland Tumors Arising on Acral Sites: A Molecular Survey.
Kervarrec T, Tallet A, Macagno N, de la Fouchardière A, Pissaloux D, Tirode F, Bravo IG, Nicolas A, Baulande S, Sohier P, Balme B, Osio A, Jullie ML, Moulonguet I, Bonsang B, Tournier E, Herfs M, Frouin E, Zidan A, Calonje E, Berthon P, Touzé A, Seris A, Mortier L, Jouary T, Cribier B, Battistella M
Am J Surg Pathol 2023 Oct 1;47(10):1096-1107. Epub 2023 Jul 31 doi: 10.1097/PAS.0000000000002098. PMID: 37505808
Molecular pathology of skin adnexal tumours.
Plotzke JM, Adams DJ, Harms PW
Histopathology 2022 Jan;80(1):166-183. doi: 10.1111/his.14441. PMID: 34197659
Characteristic Clinical and Dermoscopic Features of Nonvolar Poroma.
Ha DL, Lee GW, Shin K, Kim HS, Ko HC, Kim BS, Kim MB
J Cutan Med Surg 2021 Mar-Apr;25(2):142-149. Epub 2020 Sep 3 doi: 10.1177/1203475420952432. PMID: 32880198
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article

Recent systematic reviews

Dermoscopy of cutaneous adnexal tumours: a systematic review of the literature.
Lai M, Muscianese M, Piana S, Chester J, Borsari S, Paolino G, Pellacani G, Longo C, Pampena R
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1524-1540. Epub 2022 May 25 doi: 10.1111/jdv.18210. PMID: 35536546Free PMC Article
A systematic review of periungual eccrine neoplasms.
Rao EM, Knackstedt TJ
Int J Dermatol 2022 Jul;61(7):812-820. Epub 2021 Sep 8 doi: 10.1111/ijd.15893. PMID: 34494261
Endocrine mucin-producing sweat gland carcinoma: a systematic review and meta-analysis.
Froehlich MH, Conti KR, Norris II, Allensworth JJ, Ufkes NA, Nguyen SA, Bruner ET, Cook J, Day TA
J Dermatolog Treat 2022 Jun;33(4):2182-2191. Epub 2022 Mar 25 doi: 10.1080/09546634.2021.1937479. PMID: 34057875
Eccrine Porocarcinoma: New Insights and a Systematic Review of the Literature.
Nazemi A, Higgins S, Swift R, In G, Miller K, Wysong A
Dermatol Surg 2018 Oct;44(10):1247-1261. doi: 10.1097/DSS.0000000000001566. PMID: 29894433
Evaluation and management of the patient with multiple syringomas: A systematic review of the literature.
Williams K, Shinkai K
J Am Acad Dermatol 2016 Jun;74(6):1234-1240.e9. Epub 2016 Feb 3 doi: 10.1016/j.jaad.2015.12.006. PMID: 26850654

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