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Lung Squamous Cell Carcinoma, Small Cell Variant

MedGen UID:
354199
Concept ID:
C1710176
Neoplastic Process
Synonym: Squamous Cell Lung Carcinoma, Small Cell Variant

Definition

A poorly differentiated morphologic variant of squamous cell lung carcinoma characterized by the presence of small tumor cells with focal squamous differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Squamous Cell Carcinoma, Small Cell Variant

Professional guidelines

PubMed

Malhotra J, Nguyen D, Tan T, Semeniuk Iii GB
Clin Adv Hematol Oncol 2024 Mar;22(2):67-75. PMID: 38446474
Gałecki S, Gdowicz-Kłosok A, Deja R, Masłyk B, Giglok M, Suwiński R, Butkiewicz D
Cells 2023 Nov 28;12(23) doi: 10.3390/cells12232721. PMID: 38067149Free PMC Article
Kurzrock R, Stewart DJ
Clin Cancer Res 2017 Mar 1;23(5):1137-1148. Epub 2016 Dec 9 doi: 10.1158/1078-0432.CCR-16-1968. PMID: 27940520

Recent clinical studies

Etiology

Zhang S, Liu L, Shi S, He H, Shen Q, Wang H, Qin S, Chang J, Zhong R
J Thorac Oncol 2024 Jan;19(1):80-93. Epub 2023 Sep 12 doi: 10.1016/j.jtho.2023.09.004. PMID: 37703998
Pellini B, Madison RW, Childress MA, Miller ST, Gjoerup O, Cheng J, Huang RSP, Krainock M, Gupta P, Zou W, Shames DS, Moshkevich S, Ballinger M, Liu MC, Young A, Srivastava MK, Oxnard GR, Socinski MA
Clin Cancer Res 2023 Nov 14;29(22):4596-4605. doi: 10.1158/1078-0432.CCR-23-1578. PMID: 37702716Free PMC Article
Chuang TP, Lai WY, Gabre JL, Lind DE, Umapathy G, Bokhari AA, Bergman B, Kristenson L, Thorén FB, Le A, Doebele RC, Van den Eynden J, Palmer RH, Hallberg B
Proc Natl Acad Sci U S A 2023 Feb 21;120(8):e2216479120. Epub 2023 Feb 15 doi: 10.1073/pnas.2216479120. PMID: 36791109Free PMC Article
Ashok Kumar P, Graziano SL, Danziger N, Pavlick D, Severson EA, Ramkissoon SH, Huang RSP, Decker B, Ross JS
Cancer Med 2023 Jan;12(2):1157-1166. Epub 2022 Jun 23 doi: 10.1002/cam4.4971. PMID: 35747993Free PMC Article
Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, Geisinger K, Hirsch FR, Ishikawa Y, Kerr KM, Noguchi M, Pelosi G, Powell CA, Tsao MS, Wistuba I; WHO Panel
J Thorac Oncol 2015 Sep;10(9):1243-1260. doi: 10.1097/JTO.0000000000000630. PMID: 26291008

Diagnosis

Lo YC, Bauer AH, Odintsov I, Siegmund SE, Sholl LM, Dong F
Mod Pathol 2023 May;36(5):100126. Epub 2023 Feb 7 doi: 10.1016/j.modpat.2023.100126. PMID: 36842187
Lantuejoul S, Pissaloux D, Ferretti GR, McLeer A
Semin Diagn Pathol 2021 Sep;38(5):72-82. Epub 2021 Jun 16 doi: 10.1053/j.semdp.2021.06.005. PMID: 34176698
Chang YS, Tu SJ, Chen YC, Liu TY, Lee YT, Yen JC, Fang HY, Chang JG
Respir Res 2021 Jan 6;22(1):3. doi: 10.1186/s12931-020-01608-5. PMID: 33407425Free PMC Article
Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, Geisinger K, Hirsch FR, Ishikawa Y, Kerr KM, Noguchi M, Pelosi G, Powell CA, Tsao MS, Wistuba I; WHO Panel
J Thorac Oncol 2015 Sep;10(9):1243-1260. doi: 10.1097/JTO.0000000000000630. PMID: 26291008
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

Therapy

Zhang S, Liu L, Shi S, He H, Shen Q, Wang H, Qin S, Chang J, Zhong R
J Thorac Oncol 2024 Jan;19(1):80-93. Epub 2023 Sep 12 doi: 10.1016/j.jtho.2023.09.004. PMID: 37703998
Pellini B, Madison RW, Childress MA, Miller ST, Gjoerup O, Cheng J, Huang RSP, Krainock M, Gupta P, Zou W, Shames DS, Moshkevich S, Ballinger M, Liu MC, Young A, Srivastava MK, Oxnard GR, Socinski MA
Clin Cancer Res 2023 Nov 14;29(22):4596-4605. doi: 10.1158/1078-0432.CCR-23-1578. PMID: 37702716Free PMC Article
Malchers F, Nogova L, van Attekum MH, Maas L, Brägelmann J, Bartenhagen C, Girard L, Bosco G, Dahmen I, Michels S, Weeden CE, Scheel AH, Meder L, Golfmann K, Schuldt P, Siemanowski J, Rehker J, Merkelbach-Bruse S, Menon R, Gautschi O, Heuckmann JM, Brambilla E, Asselin-Labat ML, Persigehl T, Minna JD, Walczak H, Ullrich RT, Fischer M, Reinhardt HC, Wolf J, Büttner R, Peifer M, George J, Thomas RK
J Clin Invest 2023 Nov 1;133(21) doi: 10.1172/JCI170217. PMID: 37606995Free PMC Article
Mehrad M, Roy S, Bittar HT, Dacic S
Arch Pathol Lab Med 2018 Mar;142(3):353-357. Epub 2017 Dec 8 doi: 10.5858/arpa.2017-0046-OA. PMID: 29219616
Kurzrock R, Stewart DJ
Clin Cancer Res 2017 Mar 1;23(5):1137-1148. Epub 2016 Dec 9 doi: 10.1158/1078-0432.CCR-16-1968. PMID: 27940520

Prognosis

Lim TKH, Skoulidis F, Kerr KM, Ahn MJ, Kapp JR, Soares FA, Yatabe Y
Lung Cancer 2023 Oct;184:107293. Epub 2023 Jul 13 doi: 10.1016/j.lungcan.2023.107293. PMID: 37683526
Ashok Kumar P, Graziano SL, Danziger N, Pavlick D, Severson EA, Ramkissoon SH, Huang RSP, Decker B, Ross JS
Cancer Med 2023 Jan;12(2):1157-1166. Epub 2022 Jun 23 doi: 10.1002/cam4.4971. PMID: 35747993Free PMC Article
Judd J, Abdel Karim N, Khan H, Naqash AR, Baca Y, Xiu J, VanderWalde AM, Mamdani H, Raez LE, Nagasaka M, Pai SG, Socinski MA, Nieva JJ, Kim C, Wozniak AJ, Ikpeazu C, de Lima Lopes G Jr, Spira AI, Korn WM, Kim ES, Liu SV, Borghaei H
Mol Cancer Ther 2021 Dec;20(12):2577-2584. Epub 2021 Sep 13 doi: 10.1158/1535-7163.MCT-21-0201. PMID: 34518295Free PMC Article
Lantuejoul S, Pissaloux D, Ferretti GR, McLeer A
Semin Diagn Pathol 2021 Sep;38(5):72-82. Epub 2021 Jun 16 doi: 10.1053/j.semdp.2021.06.005. PMID: 34176698
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

Clinical prediction guides

Zhang S, Liu L, Shi S, He H, Shen Q, Wang H, Qin S, Chang J, Zhong R
J Thorac Oncol 2024 Jan;19(1):80-93. Epub 2023 Sep 12 doi: 10.1016/j.jtho.2023.09.004. PMID: 37703998
Lim TKH, Skoulidis F, Kerr KM, Ahn MJ, Kapp JR, Soares FA, Yatabe Y
Lung Cancer 2023 Oct;184:107293. Epub 2023 Jul 13 doi: 10.1016/j.lungcan.2023.107293. PMID: 37683526
Judd J, Abdel Karim N, Khan H, Naqash AR, Baca Y, Xiu J, VanderWalde AM, Mamdani H, Raez LE, Nagasaka M, Pai SG, Socinski MA, Nieva JJ, Kim C, Wozniak AJ, Ikpeazu C, de Lima Lopes G Jr, Spira AI, Korn WM, Kim ES, Liu SV, Borghaei H
Mol Cancer Ther 2021 Dec;20(12):2577-2584. Epub 2021 Sep 13 doi: 10.1158/1535-7163.MCT-21-0201. PMID: 34518295Free PMC Article
Lantuejoul S, Pissaloux D, Ferretti GR, McLeer A
Semin Diagn Pathol 2021 Sep;38(5):72-82. Epub 2021 Jun 16 doi: 10.1053/j.semdp.2021.06.005. PMID: 34176698
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

Recent systematic reviews

Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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