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Thyroid Gland Signet Ring Cell Follicular Adenoma

MedGen UID:
354254
•Concept ID:
C1710417
•
Neoplastic Process
Synonym: Thyroid Gland Signet-Ring Cell Follicular Adenoma

Definition

A thyroid gland adenoma characterized by the presence of signet ring cells that stain positive for thyroglobulin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Signet Ring Cell Follicular Adenoma

Recent clinical studies

Etiology

Cytopathology of follicular tumours of the thyroid with clear cell change.
Harach HR, Virgili E, Soler G, Zusman SB, Saravia Day E
Cytopathology 1991;2(3):125-35. doi: 10.1111/j.1365-2303.1991.tb00397.x. PMID: 1932576
Follicular thyroid adenoma: signet ring cell variant.
Markaki S, Prevedorou D, Kyratsis G, Bouropoulou V
Arch Anat Cytol Pathol 1990;38(3):114-6. PMID: 2363591

Diagnosis

Clear cell change in follicular adenoma of the thyroid. A diagnostic challenge.
Val-Bernal JF, Martino M
Rom J Morphol Embryol 2020;61(1):219-226. doi: 10.47162/RJME.61.1.24. PMID: 32747913Free PMC Article
Signet ring cell variant of follicular thyroid carcinoma: Report of two cases with focus on morphological, expressional and genetic characteristics.
Hysek M, Jatta K, Stenman A, Darai-Ramqvist E, Zedenius J, Höög A, Juhlin CC
Diagn Pathol 2019 Nov 7;14(1):127. doi: 10.1186/s13000-019-0904-3. PMID: 31699114Free PMC Article
Primary Benign and Malignant Thyroid Neoplasms With Signet Ring Cells: Cytologic, Histologic, and Molecular Features.
Farhat NA, Onenerk AM, Krane JF, Dias-Santagata D, Sadow PM, Faquin WC
Am J Clin Pathol 2017 Sep 1;148(3):251-258. doi: 10.1093/ajcp/aqx074. PMID: 28821194
Fine-needle aspiration of mucin-producing thyroid tumors.
Yang GC, Scognamiglio T, Kuhel WI
Acta Cytol 2011;55(6):549-55. Epub 2011 Dec 9 doi: 10.1159/000333228. PMID: 22156465
The utility and limitation of thyroid transcription factor-1 protein in primary and metastatic pulmonary neoplasms.
Chang YL, Lee YC, Liao WY, Wu CT
Lung Cancer 2004 May;44(2):149-57. doi: 10.1016/j.lungcan.2003.10.008. PMID: 15084379

Therapy

Signet ring cell variant of follicular thyroid carcinoma: Report of two cases with focus on morphological, expressional and genetic characteristics.
Hysek M, Jatta K, Stenman A, Darai-Ramqvist E, Zedenius J, Höög A, Juhlin CC
Diagn Pathol 2019 Nov 7;14(1):127. doi: 10.1186/s13000-019-0904-3. PMID: 31699114Free PMC Article
Poorly differentiated adenocarcinoma with signet-ring cells of the Vater's ampulla, without jaundice but with disseminated carcinomatosis.
Nabeshima S, Kishihara Y, Nabeshima A, Yamaga S, Kinjo M, Kashiwagi S, Hayashi J
Fukuoka Igaku Zasshi 2003 Jul;94(7):235-40. PMID: 14509231

Prognosis

Signet ring cell variant of follicular thyroid carcinoma: Report of two cases with focus on morphological, expressional and genetic characteristics.
Hysek M, Jatta K, Stenman A, Darai-Ramqvist E, Zedenius J, Höög A, Juhlin CC
Diagn Pathol 2019 Nov 7;14(1):127. doi: 10.1186/s13000-019-0904-3. PMID: 31699114Free PMC Article
Ultrasound findings of diffuse metastasis of gastric signet-ring-cell carcinoma to the thyroid gland.
Morita K, Sakamoto T, Ota S, Masugi H, Chikuta I, Mashimo Y, Edo N, Tokairin T, Seki N, Ishikawa T
J Med Ultrason (2001) 2017 Jan;44(1):133-139. Epub 2016 Oct 1 doi: 10.1007/s10396-016-0746-5. PMID: 27696013Free PMC Article
Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2.
Chu PG, Schwarz RE, Lau SK, Yen Y, Weiss LM
Am J Surg Pathol 2005 Mar;29(3):359-67. doi: 10.1097/01.pas.0000149708.12335.6a. PMID: 15725805
Poorly differentiated adenocarcinoma with signet-ring cells of the Vater's ampulla, without jaundice but with disseminated carcinomatosis.
Nabeshima S, Kishihara Y, Nabeshima A, Yamaga S, Kinjo M, Kashiwagi S, Hayashi J
Fukuoka Igaku Zasshi 2003 Jul;94(7):235-40. PMID: 14509231
Signet-ring cell lymphoma of the central nervous system. Case report.
Pappas CT, Johnson PC, Sonntag VK
J Neurosurg 1988 Nov;69(5):789-92. doi: 10.3171/jns.1988.69.5.0789. PMID: 3183739

Clinical prediction guides

Clear cell change in follicular adenoma of the thyroid. A diagnostic challenge.
Val-Bernal JF, Martino M
Rom J Morphol Embryol 2020;61(1):219-226. doi: 10.47162/RJME.61.1.24. PMID: 32747913Free PMC Article
Ultrasound findings of diffuse metastasis of gastric signet-ring-cell carcinoma to the thyroid gland.
Morita K, Sakamoto T, Ota S, Masugi H, Chikuta I, Mashimo Y, Edo N, Tokairin T, Seki N, Ishikawa T
J Med Ultrason (2001) 2017 Jan;44(1):133-139. Epub 2016 Oct 1 doi: 10.1007/s10396-016-0746-5. PMID: 27696013Free PMC Article
Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2.
Chu PG, Schwarz RE, Lau SK, Yen Y, Weiss LM
Am J Surg Pathol 2005 Mar;29(3):359-67. doi: 10.1097/01.pas.0000149708.12335.6a. PMID: 15725805
Pulmonary intestinal-type adenocarcinoma does not show enteric differentiation by immunohistochemical study.
Yousem SA
Mod Pathol 2005 Jun;18(6):816-21. doi: 10.1038/modpathol.3800358. PMID: 15605076
Primary mucin-producing adenosquamous carcinoma of the thyroid gland.
Mizukami Y, Matsubara F, Hashimoto T, Terahata S, Noto H, Noguchi M, Michigishi T
Acta Pathol Jpn 1987 Jul;37(7):1157-64. doi: 10.1111/j.1440-1827.1987.tb00433.x. PMID: 2821736

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