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Pallor of dorsal columns of the spinal cord

MedGen UID:
Concept ID:
HPO: HP:0006825


An abnormally pale appearance of the dorsal portion of the gray substance of the spinal cord. This finding can be observed by histological examination. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPallor of dorsal columns of the spinal cord

Conditions with this feature

Amyotrophic lateral sclerosis type 4
MedGen UID:
Concept ID:
Disease or Syndrome
Juvenile amyotrophic lateral sclerosis-4 (ALS4) is an autosomal dominant disorder characterized by distal muscle weakness and atrophy, normal sensation, and pyramidal signs, with onset of symptoms before the age of 25 years, a slow rate of progression, and a normal life span (summary by Chen et al., 2004). For a phenotypic description and a discussion of genetic heterogeneity of amyotrophic lateral sclerosis, see ALS1 (105400).

Recent clinical studies


Wenning GK, Tison F, Ben Shlomo Y, Daniel SE, Quinn NP
Mov Disord 1997 Mar;12(2):133-47. doi: 10.1002/mds.870120203. PMID: 9087971

Clinical prediction guides

Umehara F, Izumo S, Zyounosono M, Osame M
Acta Neuropathol 1990;80(5):563-7. doi: 10.1007/BF00294621. PMID: 2174631

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