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Allergic conjunctivitis

MedGen UID:
3590
•Concept ID:
C0009766
•
Disease or Syndrome
Synonyms: Allergic Conjunctivitides; Allergic Conjunctivitis; Atopic Conjunctivitides; Atopic Conjunctivitis; Conjunctivitides, Allergic; Conjunctivitides, Atopic; Conjunctivitis, Allergic; Conjunctivitis, Atopic
SNOMED CT: Allergic conjunctivitis (473460002); Atopic conjunctivitis (231854006)
 
HPO: HP:0007879
Monarch Initiative: MONDO:0005642

Definition

Allergic Conjunctivitis is an allergic inflammation of the conjunctiva. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAllergic conjunctivitis

Conditions with this feature

Progeroid short stature with pigmented nevi
MedGen UID:
224702
•Concept ID:
C1261128
•
Disease or Syndrome
Mulvihill-Smith syndrome is characterized by premature aging, multiple pigmented nevi, lack of facial subcutaneous fat, microcephaly, short stature, sensorineural hearing loss, and mental retardation. Immunodeficiency may also be a feature. Adult manifestations include the development of tumors, a sleep disorder with severe insomnia, and cognitive decline (summary by Yagihashi et al., 2009).
See: Condition Record
Progeroid short stature with pigmented nevi

Professional guidelines

PubMed

ICON: Diagnosis and management of allergic conjunctivitis.
Bielory L, Delgado L, Katelaris CH, Leonardi A, Rosario N, Vichyanoud P
Ann Allergy Asthma Immunol 2020 Feb;124(2):118-134. Epub 2019 Nov 21 doi: 10.1016/j.anai.2019.11.014. PMID: 31759180
EAACI Guidelines on Allergen Immunotherapy: Allergic rhinoconjunctivitis.
Roberts G, Pfaar O, Akdis CA, Ansotegui IJ, Durham SR, Gerth van Wijk R, Halken S, Larenas-Linnemann D, Pawankar R, Pitsios C, Sheikh A, Worm M, Arasi S, Calderon MA, Cingi C, Dhami S, Fauquert JL, Hamelmann E, Hellings P, Jacobsen L, Knol EF, Lin SY, Maggina P, Mösges R, Oude Elberink JNG, Pajno GB, Pastorello EA, Penagos M, Rotiroti G, Schmidt-Weber CB, Timmermans F, Tsilochristou O, Varga EM, Wilkinson JN, Williams A, Zhang L, Agache I, Angier E, Fernandez-Rivas M, Jutel M, Lau S, van Ree R, Ryan D, Sturm GJ, Muraro A
Allergy 2018 Apr;73(4):765-798. Epub 2017 Oct 30 doi: 10.1111/all.13317. PMID: 28940458
Conjunctivitis: a systematic review of diagnosis and treatment.
Azari AA, Barney NP
JAMA 2013 Oct 23;310(16):1721-9. doi: 10.1001/jama.2013.280318. PMID: 24150468Free PMC Article

Recent clinical studies

Etiology

ILCs and Allergy.
Kabata H, Motomura Y, Kiniwa T, Kobayashi T, Moro K
Adv Exp Med Biol 2022;1365:75-95. doi: 10.1007/978-981-16-8387-9_6. PMID: 35567742
Allergic Conjunctivitis: An Update.
Mueller A
Handb Exp Pharmacol 2022;268:95-99. doi: 10.1007/164_2021_491. PMID: 34136960
Chemokines in allergic conjunctivitis.
Erdinest N, London N, Solomon A
Curr Opin Allergy Clin Immunol 2020 Oct;20(5):516-527. doi: 10.1097/ACI.0000000000000676. PMID: 32739979
Adult vernal keratoconjunctivitis.
Di Zazzo A, Bonini S, Fernandes M
Curr Opin Allergy Clin Immunol 2020 Oct;20(5):501-506. doi: 10.1097/ACI.0000000000000672. PMID: 32675480
ICON: Diagnosis and management of allergic conjunctivitis.
Bielory L, Delgado L, Katelaris CH, Leonardi A, Rosario N, Vichyanoud P
Ann Allergy Asthma Immunol 2020 Feb;124(2):118-134. Epub 2019 Nov 21 doi: 10.1016/j.anai.2019.11.014. PMID: 31759180

Diagnosis

Allergic Conjunctivitis: An Update.
Mueller A
Handb Exp Pharmacol 2022;268:95-99. doi: 10.1007/164_2021_491. PMID: 34136960
Current Knowledge in Allergic Conjunctivitis.
Villegas BV, Benitez-Del-Castillo JM
Turk J Ophthalmol 2021 Feb 25;51(1):45-54. doi: 10.4274/tjo.galenos.2020.11456. PMID: 33631915Free PMC Article
ICON: Diagnosis and management of allergic conjunctivitis.
Bielory L, Delgado L, Katelaris CH, Leonardi A, Rosario N, Vichyanoud P
Ann Allergy Asthma Immunol 2020 Feb;124(2):118-134. Epub 2019 Nov 21 doi: 10.1016/j.anai.2019.11.014. PMID: 31759180
Conjunctivitis.
Alfonso SA, Fawley JD, Alexa Lu X
Prim Care 2015 Sep;42(3):325-45. Epub 2015 Jul 29 doi: 10.1016/j.pop.2015.05.001. PMID: 26319341
Conjunctivitis: a systematic review of diagnosis and treatment.
Azari AA, Barney NP
JAMA 2013 Oct 23;310(16):1721-9. doi: 10.1001/jama.2013.280318. PMID: 24150468Free PMC Article

Therapy

Conjunctivitis in dupilumab clinical trials.
Akinlade B, Guttman-Yassky E, de Bruin-Weller M, Simpson EL, Blauvelt A, Cork MJ, Prens E, Asbell P, Akpek E, Corren J, Bachert C, Hirano I, Weyne J, Korotzer A, Chen Z, Hultsch T, Zhu X, Davis JD, Mannent L, Hamilton JD, Teper A, Staudinger H, Rizova E, Pirozzi G, Graham NMH, Shumel B, Ardeleanu M, Wollenberg A
Br J Dermatol 2019 Sep;181(3):459-473. Epub 2019 May 7 doi: 10.1111/bjd.17869. PMID: 30851191Free PMC Article
Nasal and ocular challenges.
Pepper AN, Ledford DK
J Allergy Clin Immunol 2018 May;141(5):1570-1577. Epub 2018 Mar 6 doi: 10.1016/j.jaci.2017.11.066. PMID: 29501480
Immunomodulators for conjunctivitis.
Pacharn P, Vichyanond P
Curr Opin Allergy Clin Immunol 2013 Oct;13(5):550-7. doi: 10.1097/ACI.0b013e328364d86a. PMID: 23974685
Allergic conjunctivitis: a comprehensive review of the literature.
La Rosa M, Lionetti E, Reibaldi M, Russo A, Longo A, Leonardi S, Tomarchio S, Avitabile T, Reibaldi A
Ital J Pediatr 2013 Mar 14;39:18. doi: 10.1186/1824-7288-39-18. PMID: 23497516Free PMC Article
Allergic conjunctivitis.
Bielory L, Friedlaender MH
Immunol Allergy Clin North Am 2008 Feb;28(1):43-58, vi. doi: 10.1016/j.iac.2007.12.005. PMID: 18282545

Prognosis

Current Knowledge in Allergic Conjunctivitis.
Villegas BV, Benitez-Del-Castillo JM
Turk J Ophthalmol 2021 Feb 25;51(1):45-54. doi: 10.4274/tjo.galenos.2020.11456. PMID: 33631915Free PMC Article
ICON: Diagnosis and management of allergic conjunctivitis.
Bielory L, Delgado L, Katelaris CH, Leonardi A, Rosario N, Vichyanoud P
Ann Allergy Asthma Immunol 2020 Feb;124(2):118-134. Epub 2019 Nov 21 doi: 10.1016/j.anai.2019.11.014. PMID: 31759180
Conjunctivitis in dupilumab clinical trials.
Akinlade B, Guttman-Yassky E, de Bruin-Weller M, Simpson EL, Blauvelt A, Cork MJ, Prens E, Asbell P, Akpek E, Corren J, Bachert C, Hirano I, Weyne J, Korotzer A, Chen Z, Hultsch T, Zhu X, Davis JD, Mannent L, Hamilton JD, Teper A, Staudinger H, Rizova E, Pirozzi G, Graham NMH, Shumel B, Ardeleanu M, Wollenberg A
Br J Dermatol 2019 Sep;181(3):459-473. Epub 2019 May 7 doi: 10.1111/bjd.17869. PMID: 30851191Free PMC Article
Vernal Keratoconjunctivitis.
Singhal D, Sahay P, Maharana PK, Raj N, Sharma N, Titiyal JS
Surv Ophthalmol 2019 May-Jun;64(3):289-311. Epub 2018 Dec 12 doi: 10.1016/j.survophthal.2018.12.001. PMID: 30550738
Neuropathic Pain and Itch Mechanisms Underlying Allergic Conjunctivitis.
Kuruvilla M, Kalangara J, Lee FEE
J Investig Allergol Clin Immunol 2019;29(5):349-356. Epub 2018 Sep 17 doi: 10.18176/jiaci.0320. PMID: 30222114

Clinical prediction guides

Biologics for allergy: therapeutic potential for ocular allergic diseases and adverse effects on the eye.
Fukuda K, Kishimoto T, Sumi T, Yamashiro K, Ebihara N
Allergol Int 2023 Apr;72(2):234-244. Epub 2022 Nov 1 doi: 10.1016/j.alit.2022.09.005. PMID: 36333219
Lirentelimab for severe and chronic forms of allergic conjunctivitis.
Anesi SD, Tauber J, Nguyen QD, Chang P, Berdy GJ, Lin CC, Chu DS, Levine HT, Fernandez AD, Roy N, Asbell PA, Kantor AM, Chang AT, Singh B, Youngblood BA, Jeng BH, Jhanji V, Rasmussen HS, Foster CS
J Allergy Clin Immunol 2022 Sep;150(3):631-639. Epub 2022 Apr 4 doi: 10.1016/j.jaci.2022.03.021. PMID: 35390403
The relationship between allergic diseases and tic disorders: A systematic review and meta-analysis.
Huang J, Li R, Li L, Song Y, Jin L
Neurosci Biobehav Rev 2022 Jan;132:362-377. Epub 2021 Dec 6 doi: 10.1016/j.neubiorev.2021.12.004. PMID: 34883165
A Systematic Review of Clinical Practice Guidelines for Infectious and Non-infectious Conjunctivitis.
Chan VF, Yong AC, Azuara-Blanco A, Gordon I, Safi S, Lingham G, Evans J, Keel S
Ophthalmic Epidemiol 2022 Oct;29(5):473-482. Epub 2021 Aug 29 doi: 10.1080/09286586.2021.1971262. PMID: 34459321
Seasonal ocular allergy and pollen counts.
Prince A, Norris MR, Bielory L
Curr Opin Allergy Clin Immunol 2018 Oct;18(5):387-392. doi: 10.1097/ACI.0000000000000475. PMID: 30020257

Recent systematic reviews

Vernal Keratoconjunctivitis: A Systematic Review.
Bruschi G, Ghiglioni DG, Cozzi L, Osnaghi S, Viola F, Marchisio P
Clin Rev Allergy Immunol 2023 Aug;65(2):277-329. Epub 2023 Sep 2 doi: 10.1007/s12016-023-08970-4. PMID: 37658939Free PMC Article
Dupilumab ocular side effects in patients with atopic dermatitis: a systematic review.
Neagu N, Dianzani C, Avallone G, Dell'Aquila C, Morariu SH, Zalaudek I, Conforti C
J Eur Acad Dermatol Venereol 2022 Jun;36(6):820-835. Epub 2022 Feb 17 doi: 10.1111/jdv.17981. PMID: 35122335
The relationship between allergic diseases and tic disorders: A systematic review and meta-analysis.
Huang J, Li R, Li L, Song Y, Jin L
Neurosci Biobehav Rev 2022 Jan;132:362-377. Epub 2021 Dec 6 doi: 10.1016/j.neubiorev.2021.12.004. PMID: 34883165
A Systematic Review of Clinical Practice Guidelines for Infectious and Non-infectious Conjunctivitis.
Chan VF, Yong AC, Azuara-Blanco A, Gordon I, Safi S, Lingham G, Evans J, Keel S
Ophthalmic Epidemiol 2022 Oct;29(5):473-482. Epub 2021 Aug 29 doi: 10.1080/09286586.2021.1971262. PMID: 34459321
Conjunctivitis: a systematic review of diagnosis and treatment.
Azari AA, Barney NP
JAMA 2013 Oct 23;310(16):1721-9. doi: 10.1001/jama.2013.280318. PMID: 24150468Free PMC Article

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