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Dacryocystitis

MedGen UID:
3686
Concept ID:
C0010930
Disease or Syndrome
Synonym: Dacryocystitides
SNOMED CT: Dacryocystitis (85777005)
 
HPO: HP:0000620
Monarch Initiative: MONDO:0004926

Definition

Inflammation of the nasolacrimal sac. [from HPO]

Conditions with this feature

Dacryocystitis-osteopoikilosis syndrome
MedGen UID:
318939
Concept ID:
C1833698
Disease or Syndrome
An exceedingly rare autosomal dominant disorder reported in only a few patients to date with characteristics of dacryocystitis due to lacrimal canal stenosis and osteopoikilosis (demonstrated radiologically as discrete spherical osteosclerotic lesions of 2-10 mm in diameter).
Familial congenital nasolacrimal duct obstruction
MedGen UID:
332018
Concept ID:
C1835612
Finding
Congenital nasolacrimal drainage system impatency is relatively common, occurring in approximately 20% of children within the first year of life. Such infants typically manifest persistent epiphora and/or recurrent infections of the lacrimal pathway such as conjunctivitis. The most frequent site of such obstruction occurs at the distal intranasal segment of the nasolacrimal drainage system at the valve of Hasner (summary by Wang and Cunningham, 2011). Congenital dacryocystocele, an uncommon variant of nasolacrimal duct obstruction, characterized by the appearance of a cystic blue mass over the area of the lacrimal duct soon after birth. Dacryocystoceles are thought to result from a persistent membrane at the valve of Hasner and a functional obstruction of the common canaliculus or valve of Rosenmuller. The resulting lacrimal sac distention has been reported to be more common in female and non-Hispanic white patients, and familial cases have been described only sporadically. Common presenting signs include dacryocystitis, facial cellulitis, and respiratory distress; the development of astigmatism in association with dacryocystocele has only rarely been observed (summary by Shekunov et al., 2010).
Ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 1
MedGen UID:
343663
Concept ID:
C1851841
Disease or Syndrome
An EEC syndrome characterized by autosomal dominant inheritance that has material basis in variation in the chromosome region 7q11.2-q21.3.
Ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3
MedGen UID:
347666
Concept ID:
C1858562
Disease or Syndrome
The TP63-related disorders comprise six overlapping phenotypes: Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome (which includes Rapp-Hodgkin syndrome). Acro-dermo-ungual-lacrimal-tooth (ADULT) syndrome. Ectrodactyly, ectodermal dysplasia, cleft lip/palate syndrome 3 (EEC3). Limb-mammary syndrome. Split-hand/foot malformation type 4 (SHFM4). Isolated cleft lip/cleft palate (orofacial cleft 8). Individuals typically have varying combinations of ectodermal dysplasia (hypohidrosis, nail dysplasia, sparse hair, tooth abnormalities), cleft lip/palate, split-hand/foot malformation/syndactyly, lacrimal duct obstruction, hypopigmentation, hypoplastic breasts and/or nipples, and hypospadias. Findings associated with a single phenotype include ankyloblepharon filiforme adnatum (tissue strands that completely or partially fuse the upper and lower eyelids), skin erosions especially on the scalp associated with areas of scarring, and alopecia, trismus, and excessive freckling.
LADD syndrome 1
MedGen UID:
1824096
Concept ID:
C5774323
Disease or Syndrome
Lacrimoauriculodentodigital syndrome-1 (LADD1) is a multiple congenital anomaly disorder mainly affecting lacrimal glands and ducts, salivary glands and ducts, ears, teeth, and distal limb segments (summary by Rohmann et al., 2006). Genetic Heterogeneity of Lacrimoauriculodentodigital Syndrome LADD syndrome-2 (LADD2; 620192) is caused by mutation in the FGFR3 gene (134934) on chromosome 4p16, and LADD syndrome-3 (LADD3; 620193) is caused by mutation in the FGF10 gene, an FGFR ligand, on chromosome 5p12.

Professional guidelines

PubMed

Frisova V, Kranerova M, Mikulec J
Taiwan J Obstet Gynecol 2024 Sep;63(5):717-721. doi: 10.1016/j.tjog.2024.04.015. PMID: 39266153
Cnaan RB, Abumanhal M, Wengier A, Feldman I, Leibovitch I, Abergel A
Eur Arch Otorhinolaryngol 2022 Jan;279(1):199-203. Epub 2021 Mar 27 doi: 10.1007/s00405-021-06773-x. PMID: 33772319
Thompson CJ
Optometry 2001 Feb;72(2):103-11. PMID: 11243426

Recent clinical studies

Etiology

Nanayakkara U, Khan MA, Hargun DK, Sivagnanam S, Samarawickrama C
Surv Ophthalmol 2023 Jul-Aug;68(4):678-696. Epub 2023 Feb 9 doi: 10.1016/j.survophthal.2023.02.001. PMID: 36764397
Stein M, Bethmann D, Viestenz A, Wickenhauser C, Struck HG, Heichel J
Klin Monbl Augenheilkd 2023 Jan;240(1):44-52. Epub 2023 Jan 27 doi: 10.1055/a-1975-0190. PMID: 36706767
Luo B, Li M, Xiang N, Hu W, Liu R, Yan X
BMC Ophthalmol 2021 Jan 11;21(1):29. doi: 10.1186/s12886-020-01792-4. PMID: 33430825Free PMC Article
Krishna Y, Coupland SE
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):173-178. doi: 10.22608/APO.201713. PMID: 28399337
Ali MJ
Ophthalmic Plast Reconstr Surg 2015 Sep-Oct;31(5):341-7. doi: 10.1097/IOP.0000000000000472. PMID: 25856337

Diagnosis

Stein M, Bethmann D, Viestenz A, Wickenhauser C, Struck HG, Heichel J
Klin Monbl Augenheilkd 2023 Jan;240(1):44-52. Epub 2023 Jan 27 doi: 10.1055/a-1975-0190. PMID: 36706767
Singh S, Selva D
Surv Ophthalmol 2022 Mar-Apr;67(2):353-368. Epub 2021 May 31 doi: 10.1016/j.survophthal.2021.05.011. PMID: 34081929
Flores Balverdi J, Baenas DF, Riscanevo NC, Sánchez AV, Figueroa Rosales R, Alvarellos A
Arch Soc Esp Oftalmol (Engl Ed) 2018 Oct;93(10):494-496. Epub 2018 Jun 1 doi: 10.1016/j.oftal.2018.04.003. PMID: 29866378
Krishna Y, Coupland SE
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):173-178. doi: 10.22608/APO.201713. PMID: 28399337
Ali MJ
Ophthalmic Plast Reconstr Surg 2015 Sep-Oct;31(5):341-7. doi: 10.1097/IOP.0000000000000472. PMID: 25856337

Therapy

Ang T, Chaggar V, Tong JY, Selva D
Surv Ophthalmol 2024 Jul-Aug;69(4):622-631. Epub 2024 Mar 13 doi: 10.1016/j.survophthal.2024.03.003. PMID: 38490453
Nanayakkara U, Khan MA, Hargun DK, Sivagnanam S, Samarawickrama C
Surv Ophthalmol 2023 Jul-Aug;68(4):678-696. Epub 2023 Feb 9 doi: 10.1016/j.survophthal.2023.02.001. PMID: 36764397
Luo B, Li M, Xiang N, Hu W, Liu R, Yan X
BMC Ophthalmol 2021 Jan 11;21(1):29. doi: 10.1186/s12886-020-01792-4. PMID: 33430825Free PMC Article
Bakshi SS
Cleve Clin J Med 2020 Jul 31;87(8):477. doi: 10.3949/ccjm.87a.19121. PMID: 32737045
Williams KJ, Allen RC
Curr Opin Ophthalmol 2019 Sep;30(5):349-355. doi: 10.1097/ICU.0000000000000589. PMID: 31261188

Prognosis

Junek ML, Zhao L, Garner S, Cuthbertson D, Pagnoux C, Koening CL, Langford CA, McAlear CA, Monach PA, Moreland LW, Rhee RL, Seo P, Specks U, Sreih AG, Warrington K, Wechsler ME, Merkel PA, Khalidi NA
Rheumatology (Oxford) 2023 Jul 5;62(7):2517-2524. doi: 10.1093/rheumatology/keac663. PMID: 36440847Free PMC Article
Singh S, Selva D
Surv Ophthalmol 2022 Mar-Apr;67(2):353-368. Epub 2021 May 31 doi: 10.1016/j.survophthal.2021.05.011. PMID: 34081929
Williams KJ, Allen RC
Curr Opin Ophthalmol 2019 Sep;30(5):349-355. doi: 10.1097/ICU.0000000000000589. PMID: 31261188
Krishna Y, Coupland SE
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):173-178. doi: 10.22608/APO.201713. PMID: 28399337
Mishra K, Hu KY, Kamal S, Andron A, Della Rocca RC, Ali MJ, Nair AG
Ophthalmic Plast Reconstr Surg 2017 Mar/Apr;33(2):83-89. doi: 10.1097/IOP.0000000000000769. PMID: 27533513

Clinical prediction guides

Mayo-Yáñez M, Viña-Vázquez S, Lechien JR, Chiesa-Estomba CM, Calvo-Henríquez C, González-Torres L
J Voice 2023 Jul;37(4):586-597. Epub 2021 Apr 11 doi: 10.1016/j.jvoice.2021.03.010. PMID: 33849761
Luo B, Li M, Xiang N, Hu W, Liu R, Yan X
BMC Ophthalmol 2021 Jan 11;21(1):29. doi: 10.1186/s12886-020-01792-4. PMID: 33430825Free PMC Article
Williams KJ, Allen RC
Curr Opin Ophthalmol 2019 Sep;30(5):349-355. doi: 10.1097/ICU.0000000000000589. PMID: 31261188
Flores Balverdi J, Baenas DF, Riscanevo NC, Sánchez AV, Figueroa Rosales R, Alvarellos A
Arch Soc Esp Oftalmol (Engl Ed) 2018 Oct;93(10):494-496. Epub 2018 Jun 1 doi: 10.1016/j.oftal.2018.04.003. PMID: 29866378
Pflugfelder SC
Am J Ophthalmol 2004 Feb;137(2):337-42. doi: 10.1016/j.ajo.2003.10.036. PMID: 14962426

Recent systematic reviews

Ang T, Chaggar V, Tong JY, Selva D
Surv Ophthalmol 2024 Jul-Aug;69(4):622-631. Epub 2024 Mar 13 doi: 10.1016/j.survophthal.2024.03.003. PMID: 38490453
Li J, Wang J, Sun C
Am J Rhinol Allergy 2024 May;38(3):185-191. Epub 2024 Mar 5 doi: 10.1177/19458924241237009. PMID: 38444220
Mayo-Yáñez M, Viña-Vázquez S, Lechien JR, Chiesa-Estomba CM, Calvo-Henríquez C, González-Torres L
J Voice 2023 Jul;37(4):586-597. Epub 2021 Apr 11 doi: 10.1016/j.jvoice.2021.03.010. PMID: 33849761
Singh S, Ali MJ
Ophthalmic Plast Reconstr Surg 2019 Nov/Dec;35(6):519-524. doi: 10.1097/IOP.0000000000001404. PMID: 31162301
Petris C, Liu D
Cochrane Database Syst Rev 2017 Jul 12;7(7):CD011109. doi: 10.1002/14651858.CD011109.pub2. PMID: 28700811Free PMC Article

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