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Laryngeal Giant Cell Carcinoma

MedGen UID:
384472
•Concept ID:
C2011252
•
Neoplastic Process
Synonyms: Giant cell carcinoma of larynx; Laryngeal Anaplastic Carcinoma
SNOMED CT: Giant cell carcinoma of larynx (1255654002)

Definition

A rare undifferentiated carcinoma that arises from the larynx. It is characterized by the presence of multiple bizarre multinucleated giant cells. The prognosis is poor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLaryngeal Giant Cell Carcinoma

Professional guidelines

PubMed

Acute respiratory failure in goitre patients qualified for operative treatment.
Buła G, Paliga M, Koziołek H, Mucha R, Gawrychowski J
Endokrynol Pol 2013;64(3):215-9. PMID: 23873426
Anaplastic thyroid cancer: prevalence, diagnosis and treatment.
Chiacchio S, Lorenzoni A, Boni G, Rubello D, Elisei R, Mariani G
Minerva Endocrinol 2008 Dec;33(4):341-57. PMID: 18923370

Recent clinical studies

Etiology

Histopathological Analysis of Nodal Disease After Chemoradiation Reveals Viable Tumor Cells as the most Important Prognostic Factor in Head and Neck Squamous Cell Carcinoma.
Golliez A, Morand GB, Broglie MA, Balermpas P, Rupp NJ
Head Neck Pathol 2023 Sep;17(3):599-606. Epub 2023 May 17 doi: 10.1007/s12105-023-01557-7. PMID: 37195519Free PMC Article
The glottic-subglottic laryngectomy: Surgical technique, oncological, and functional outcomes.
Bertolin A, Lionello M, Baldovin M, Ghirardo G, Rizzotto G
J Surg Oncol 2022 Feb;125(2):145-150. Epub 2021 Sep 20 doi: 10.1002/jso.26675. PMID: 34542917
Surgical strategies for glottic carcinoma with a giant thyroid tumor A case report and literature review.
Feng HY, Zhou Y, Zhou SP, Tian FY, Xiao JM, Xiao Y, Mo BY, Xie H, Zhu HP
Ann Ital Chir 2021 Oct 18;10 PMID: 35232898
Differing characteristics of cartilaginous lesions of the larynx.
Ferlito A, Devaney KO, Mäkitie AA
Eur Arch Otorhinolaryngol 2019 Oct;276(10):2635-2647. Epub 2019 Jul 23 doi: 10.1007/s00405-019-05563-w. PMID: 31338576Free PMC Article
Anaplastic thyroid cancer: prevalence, diagnosis and treatment.
Chiacchio S, Lorenzoni A, Boni G, Rubello D, Elisei R, Mariani G
Minerva Endocrinol 2008 Dec;33(4):341-57. PMID: 18923370

Diagnosis

Top Ten Oncocytic Head and Neck Lesions to Contemplate.
Bullock MJ, Jiang XS
Head Neck Pathol 2023 Mar;17(1):53-65. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01520-y. PMID: 36928735Free PMC Article
Differing characteristics of cartilaginous lesions of the larynx.
Ferlito A, Devaney KO, Mäkitie AA
Eur Arch Otorhinolaryngol 2019 Oct;276(10):2635-2647. Epub 2019 Jul 23 doi: 10.1007/s00405-019-05563-w. PMID: 31338576Free PMC Article
Laryngeal sarcomas: A case series of 5 cases.
AbdullGaffar B, Keloth T
Ann Diagn Pathol 2018 Dec;37:35-41. Epub 2018 Sep 14 doi: 10.1016/j.anndiagpath.2018.09.007. PMID: 30241033
AHNAK and inflammatory markers predict poor survival in laryngeal carcinoma.
Dumitru CA, Bankfalvi A, Gu X, Zeidler R, Brandau S, Lang S
PLoS One 2013;8(2):e56420. Epub 2013 Feb 7 doi: 10.1371/journal.pone.0056420. PMID: 23409183Free PMC Article
Laryngeal manifestations of gout.
Guttenplan MD, Hendrix RA, Townsend MJ, Balsara G
Ann Otol Rhinol Laryngol 1991 Nov;100(11):899-902. doi: 10.1177/000348949110001108. PMID: 1746824

Therapy

The glottic-subglottic laryngectomy: Surgical technique, oncological, and functional outcomes.
Bertolin A, Lionello M, Baldovin M, Ghirardo G, Rizzotto G
J Surg Oncol 2022 Feb;125(2):145-150. Epub 2021 Sep 20 doi: 10.1002/jso.26675. PMID: 34542917
Successful treatment of locally advanced anaplastic thyroid carcinoma by chemotherapy and hyperfractionated radiotherapy.
Shinohara S, Kikuchi M, Naito Y, Fujiwara K, Hori S, Tona Y, Yamazaki H, Kobayashi H, Ishihara T
Auris Nasus Larynx 2009 Dec;36(6):729-32. Epub 2009 Mar 9 doi: 10.1016/j.anl.2009.02.001. PMID: 19269756
Response of the human larynx to silicone.
Tsuzuki T, Fukuda H, Fujioka T
Am J Otolaryngol 1991 Sep-Oct;12(5):288-91. doi: 10.1016/0196-0709(91)90007-3. PMID: 1811424
On the mechanism of cell internalization of chrysotile fibers: an immunocytochemical and ultrastructural study.
Malorni W, Iosi F, Falchi M, Donelli G
Environ Res 1990 Aug;52(2):164-77. doi: 10.1016/s0013-9351(05)80251-8. PMID: 2168315
Active temporal arteritis as a contraindication to elective surgery with general anesthesia.
McGowan BL
Am J Ophthalmol 1967 Sep;64(3):455-7. PMID: 6036308

Prognosis

Histopathological Analysis of Nodal Disease After Chemoradiation Reveals Viable Tumor Cells as the most Important Prognostic Factor in Head and Neck Squamous Cell Carcinoma.
Golliez A, Morand GB, Broglie MA, Balermpas P, Rupp NJ
Head Neck Pathol 2023 Sep;17(3):599-606. Epub 2023 May 17 doi: 10.1007/s12105-023-01557-7. PMID: 37195519Free PMC Article
Differing characteristics of cartilaginous lesions of the larynx.
Ferlito A, Devaney KO, Mäkitie AA
Eur Arch Otorhinolaryngol 2019 Oct;276(10):2635-2647. Epub 2019 Jul 23 doi: 10.1007/s00405-019-05563-w. PMID: 31338576Free PMC Article
Laryngeal sarcomas: A case series of 5 cases.
AbdullGaffar B, Keloth T
Ann Diagn Pathol 2018 Dec;37:35-41. Epub 2018 Sep 14 doi: 10.1016/j.anndiagpath.2018.09.007. PMID: 30241033
AHNAK and inflammatory markers predict poor survival in laryngeal carcinoma.
Dumitru CA, Bankfalvi A, Gu X, Zeidler R, Brandau S, Lang S
PLoS One 2013;8(2):e56420. Epub 2013 Feb 7 doi: 10.1371/journal.pone.0056420. PMID: 23409183Free PMC Article
Anaplastic thyroid cancer: prevalence, diagnosis and treatment.
Chiacchio S, Lorenzoni A, Boni G, Rubello D, Elisei R, Mariani G
Minerva Endocrinol 2008 Dec;33(4):341-57. PMID: 18923370

Clinical prediction guides

The glottic-subglottic laryngectomy: Surgical technique, oncological, and functional outcomes.
Bertolin A, Lionello M, Baldovin M, Ghirardo G, Rizzotto G
J Surg Oncol 2022 Feb;125(2):145-150. Epub 2021 Sep 20 doi: 10.1002/jso.26675. PMID: 34542917
Acute respiratory failure in goitre patients qualified for operative treatment.
Buła G, Paliga M, Koziołek H, Mucha R, Gawrychowski J
Endokrynol Pol 2013;64(3):215-9. PMID: 23873426
AHNAK and inflammatory markers predict poor survival in laryngeal carcinoma.
Dumitru CA, Bankfalvi A, Gu X, Zeidler R, Brandau S, Lang S
PLoS One 2013;8(2):e56420. Epub 2013 Feb 7 doi: 10.1371/journal.pone.0056420. PMID: 23409183Free PMC Article
Head and neck squamous cell carcinomas in HIV-positive patients: a preliminary investigation of viral associations.
McLemore MS, Haigentz M Jr, Smith RV, Nuovo GJ, Alos L, Cardesa A, Brandwein-Gensler M
Head Neck Pathol 2010 Jun;4(2):97-105. Epub 2010 Mar 24 doi: 10.1007/s12105-010-0171-9. PMID: 20333562Free PMC Article
Anaplastic thyroid cancer: prevalence, diagnosis and treatment.
Chiacchio S, Lorenzoni A, Boni G, Rubello D, Elisei R, Mariani G
Minerva Endocrinol 2008 Dec;33(4):341-57. PMID: 18923370

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