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Discrete subaortic stenosis

MedGen UID:
3867
•Concept ID:
C0012628
•
Disease or Syndrome
Synonyms: Discrete Subaortic Stenoses; Discrete Subaortic Stenosis; Stenoses, Discrete Subaortic; Stenosis, Discrete Subaortic; Subaortic Stenoses, Discrete; Subaortic Stenosis, Discrete
 
Monarch Initiative: MONDO:0006729

Definition

A type of constriction that is caused by the presence of a fibrous ring (discrete type) below the aortic valve, anywhere between the aortic valve and the mitral valve. It is characterized by restricted outflow from the left ventricle into the aorta. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiscrete subaortic stenosis

Professional guidelines

PubMed

Medical management of hypertrophic cardiomyopathy.
Naghi JJ, Siegel RJ
Rev Cardiovasc Med 2010 Fall;11(4):202-17. doi: 10.3909/ricm0546. PMID: 21389910
Infant methylenetetrahydrofolate reductase 677TT genotype is a risk factor for congenital heart disease.
Junker R, Kotthoff S, Vielhaber H, Halimeh S, Kosch A, Koch HG, Kassenböhmer R, Heineking B, Nowak-Göttl U
Cardiovasc Res 2001 Aug 1;51(2):251-4. doi: 10.1016/s0008-6363(01)00286-3. PMID: 11470464
Discrete membranous subaortic stenosis. Report of 31 patients, review of the literature, and delineation of management.
Katz NM, Buckley MJ, Liberthson RR
Circulation 1977 Dec;56(6):1034-8. doi: 10.1161/01.cir.56.6.1034. PMID: 336239

Recent clinical studies

Etiology

Long-Term Functional Results of Patients Operated for Isolated Discrete Subaortic Stenosis.
Şahin V, Demirpence S, Tetik F, Okur FF, Alayunt EA
Heart Surg Forum 2021 Jun 11;24(3):E512-E516. doi: 10.1532/hsf.3821. PMID: 34173743
Computational Assessment of Valvular Dysfunction in Discrete Subaortic Stenosis: A Parametric Study.
Shar JA, Keswani SG, Grande-Allen KJ, Sucosky P
Cardiovasc Eng Technol 2021 Dec;12(6):559-575. Epub 2021 Jan 11 doi: 10.1007/s13239-020-00513-8. PMID: 33432514Free PMC Article
Resection of subaortic membrane for discrete subaortic stenosis.
Talwar S, Anand A, Gupta SK, Ramakrishnan S, Kothari SS, Saxena A, Juneja R, Choudhary SK, Airan B
J Card Surg 2017 Jul;32(7):430-435. Epub 2017 Jun 13 doi: 10.1111/jocs.13160. PMID: 28609808
Fixed subaortic stenosis: a clinical dilemma for clinicians and patients.
Ezon DS
Congenit Heart Dis 2013 Sep-Oct;8(5):450-6. Epub 2013 Aug 15 doi: 10.1111/chd.12127. PMID: 23947905
Discrete subaortic stenosis: long-term prognosis on the progression of the obstruction and of the aortic insufficiency.
Stassano P, Di Tommaso L, Contaldo A, Monaco M, Mottola M, Musumeci A, Coronella G, Spampinato N
Thorac Cardiovasc Surg 2005 Feb;53(1):23-7. doi: 10.1055/s-2004-830388. PMID: 15692914

Diagnosis

Long-Term Functional Results of Patients Operated for Isolated Discrete Subaortic Stenosis.
Şahin V, Demirpence S, Tetik F, Okur FF, Alayunt EA
Heart Surg Forum 2021 Jun 11;24(3):E512-E516. doi: 10.1532/hsf.3821. PMID: 34173743
56-year-old lady with transaortic gradient.
Spina R, Iyer A, Jansz P
Heart 2018 Jun;104(12):1036-1044. Epub 2018 Apr 13 doi: 10.1136/heartjnl-2017-312734. PMID: 29654097
Discrete subvalvular aortic stenosis.
Sharma BD, Mittal S, Kasliwal RR, Trehan N, Kohli V
J Assoc Physicians India 2000 Nov;48(11):1103-6. PMID: 11310391
Discrete subaortic stenosis.
Chaikhouni A, Crawford FA Jr, Sade RM, Taylor AB, Riopel DA, Hohn AR
Clin Cardiol 1984 May;7(5):289-93. doi: 10.1002/clc.4960070507. PMID: 6538823
Discrete subaortic stenosis.
Kelly DT, Wulfsberg E, Rowe RD
Circulation 1972 Aug;46(2):309-22. doi: 10.1161/01.cir.46.2.309. PMID: 5065262

Therapy

Right Mini-Thoracotomy Subaortic Membrane Resection.
Johnson CA Jr, Siordia JA, Robinson DA, Sagebin F, Knight PA
Innovations (Phila) 2018 Nov/Dec;13(6):428-432. doi: 10.1097/IMI.0000000000000564. PMID: 30547896
Outcomes of Subaortic Obstruction Resection in Children.
Donald JS, Naimo PS, d'Udekem Y, Richardson M, Bullock A, Weintraub RG, Brizard CP, Konstantinov IE
Heart Lung Circ 2017 Feb;26(2):179-186. Epub 2016 Jul 19 doi: 10.1016/j.hlc.2016.05.120. PMID: 27522512
Outcomes and questions about discrete subaortic stenosis.
Foker JE
Circulation 2013 Apr 9;127(14):1447-50. doi: 10.1161/CIRCULATIONAHA.113.001619. PMID: 23569118
The dilemma of subaortic stenosis--a single center experience of 15 years with a review of the literature.
Valeske K, Huber C, Mueller M, Böning A, Hijjeh N, Schranz D, Akintuerk H
Thorac Cardiovasc Surg 2011 Aug;59(5):293-7. Epub 2011 May 3 doi: 10.1055/s-0030-1271039. PMID: 21544788
Long-term pediatric outcome of isolated discrete subaortic stenosis.
Drolet C, Miro J, Côté JM, Finley J, Gardin L, Rohlicek CV
Can J Cardiol 2011 May-Jun;27(3):389.e19-24. Epub 2011 Apr 19 doi: 10.1016/j.cjca.2010.12.051. PMID: 21507602

Prognosis

Computational Assessment of Valvular Dysfunction in Discrete Subaortic Stenosis: A Parametric Study.
Shar JA, Keswani SG, Grande-Allen KJ, Sucosky P
Cardiovasc Eng Technol 2021 Dec;12(6):559-575. Epub 2021 Jan 11 doi: 10.1007/s13239-020-00513-8. PMID: 33432514Free PMC Article
Resection of subaortic membrane for discrete subaortic stenosis.
Talwar S, Anand A, Gupta SK, Ramakrishnan S, Kothari SS, Saxena A, Juneja R, Choudhary SK, Airan B
J Card Surg 2017 Jul;32(7):430-435. Epub 2017 Jun 13 doi: 10.1111/jocs.13160. PMID: 28609808
Fixed subaortic stenosis: a clinical dilemma for clinicians and patients.
Ezon DS
Congenit Heart Dis 2013 Sep-Oct;8(5):450-6. Epub 2013 Aug 15 doi: 10.1111/chd.12127. PMID: 23947905
Discrete subaortic stenosis: long-term prognosis on the progression of the obstruction and of the aortic insufficiency.
Stassano P, Di Tommaso L, Contaldo A, Monaco M, Mottola M, Musumeci A, Coronella G, Spampinato N
Thorac Cardiovasc Surg 2005 Feb;53(1):23-7. doi: 10.1055/s-2004-830388. PMID: 15692914
Discrete subvalvular aortic stenosis.
Sharma BD, Mittal S, Kasliwal RR, Trehan N, Kohli V
J Assoc Physicians India 2000 Nov;48(11):1103-6. PMID: 11310391

Clinical prediction guides

Computational Assessment of Valvular Dysfunction in Discrete Subaortic Stenosis: A Parametric Study.
Shar JA, Keswani SG, Grande-Allen KJ, Sucosky P
Cardiovasc Eng Technol 2021 Dec;12(6):559-575. Epub 2021 Jan 11 doi: 10.1007/s13239-020-00513-8. PMID: 33432514Free PMC Article
Preoperative Factors That Predict Recurrence After Repair of Discrete Subaortic Stenosis.
Carlson L, Pickard S, Gauvreau K, Baird C, Geva T, Del Nido P, Nathan M
Ann Thorac Surg 2021 May;111(5):1613-1619. Epub 2020 Jul 23 doi: 10.1016/j.athoracsur.2020.05.140. PMID: 32712099
Echocardiographic predictors of reoperation for subaortic stenosis in children and adults.
Theocharis P, Viola N, Papamichael ND, Kaarne M, Bharucha T
Eur J Cardiothorac Surg 2019 Sep 1;56(3):549-556. doi: 10.1093/ejcts/ezz046. PMID: 30805587
56-year-old lady with transaortic gradient.
Spina R, Iyer A, Jansz P
Heart 2018 Jun;104(12):1036-1044. Epub 2018 Apr 13 doi: 10.1136/heartjnl-2017-312734. PMID: 29654097
Discrete subaortic stenosis.
Khan MM, Varma MP, Cleland J, O'Kane HO, Webb SW, Mulholland HC, Adgey AA
Br Heart J 1981 Oct;46(4):421-31. doi: 10.1136/hrt.46.4.421. PMID: 6457617Free PMC Article

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