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Abnormal left ventricular outflow tract morphology

MedGen UID:
488871
•Concept ID:
C0344916
•
Congenital Abnormality
Synonyms: Abnormality of the left ventricular outflow tract; Left ventricular outflow tract abnormality; LVOT - Left ventricular outflow tract abnormality
SNOMED CT: Left ventricular outflow tract abnormality (253545000); LVOT - Left ventricular outflow tract abnormality (253545000)
 
HPO: HP:0011103

Definition

An abnormality of the outflow tract of the left ventricle. [from HPO]

Professional guidelines

PubMed

Bicuspid Aortic Valve: a Review with Recommendations for Genetic Counseling.
Freeze SL, Landis BJ, Ware SM, Helm BM
J Genet Couns 2016 Dec;25(6):1171-1178. Epub 2016 Aug 22 doi: 10.1007/s10897-016-0002-6. PMID: 27550231Free PMC Article
Management of Interrupted Aortic Arch.
Jonas RA
Semin Thorac Cardiovasc Surg 2015 Summer;27(2):177-88. Epub 2015 Jun 14 doi: 10.1053/j.semtcvs.2015.04.003. PMID: 26686446
Prenatal diagnosis of left atrial isomerism.
Pepes S, Zidere V, Allan LD
Heart 2009 Dec;95(24):1974-7. Epub 2009 Mar 19 doi: 10.1136/hrt.2009.165514. PMID: 19304670

Recent clinical studies

Etiology

Repair for Congenital Mitral Valve Stenosis.
Delmo Walter EM, Hetzer R
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2018 Mar;21:46-57. doi: 10.1053/j.pcsu.2017.11.008. PMID: 29425525
Hypertrophic cardiomyopathy.
Santos Mateo JJ, Sabater Molina M, Gimeno Blanes JR
Med Clin (Barc) 2018 Jun 8;150(11):434-442. Epub 2017 Nov 14 doi: 10.1016/j.medcli.2017.09.013. PMID: 29150126
Arrhythmogenic cardiomyopathy.
Pilichou K, Thiene G, Bauce B, Rigato I, Lazzarini E, Migliore F, Perazzolo Marra M, Rizzo S, Zorzi A, Daliento L, Corrado D, Basso C
Orphanet J Rare Dis 2016 Apr 2;11:33. doi: 10.1186/s13023-016-0407-1. PMID: 27038780Free PMC Article
Outflow tract ventricular arrhythmias: An update.
Lerman BB
Trends Cardiovasc Med 2015 Aug;25(6):550-8. Epub 2015 Jan 28 doi: 10.1016/j.tcm.2015.01.011. PMID: 25846938
Echocardiographic evaluation of congenital left ventricular outflow obstruction.
Aboulhosn J, Child JS
Echocardiography 2015 Jan;32 Suppl 2:S140-7. Epub 2014 May 29 doi: 10.1111/echo.12181. PMID: 24891121

Diagnosis

The mitral valve in hypertrophic cardiomyopathy.
Malcolmson J, Shipolini A, Mohiddin S, Savvatis K
Curr Opin Cardiol 2023 Sep 1;38(5):415-423. Epub 2023 Jul 14 doi: 10.1097/HCO.0000000000001067. PMID: 37477154
Accessory mitral valve tissue: anatomical and clinical perspectives.
Yetkin E, Cuglan B, Turhan H, Yalta K
Cardiovasc Pathol 2021 Jan-Feb;50:107277. Epub 2020 Aug 31 doi: 10.1016/j.carpath.2020.107277. PMID: 32882373
Hypertrophic cardiomyopathy.
Santos Mateo JJ, Sabater Molina M, Gimeno Blanes JR
Med Clin (Barc) 2018 Jun 8;150(11):434-442. Epub 2017 Nov 14 doi: 10.1016/j.medcli.2017.09.013. PMID: 29150126
Arrhythmogenic cardiomyopathy.
Pilichou K, Thiene G, Bauce B, Rigato I, Lazzarini E, Migliore F, Perazzolo Marra M, Rizzo S, Zorzi A, Daliento L, Corrado D, Basso C
Orphanet J Rare Dis 2016 Apr 2;11:33. doi: 10.1186/s13023-016-0407-1. PMID: 27038780Free PMC Article
Management of Interrupted Aortic Arch.
Jonas RA
Semin Thorac Cardiovasc Surg 2015 Summer;27(2):177-88. Epub 2015 Jun 14 doi: 10.1053/j.semtcvs.2015.04.003. PMID: 26686446

Therapy

Ventricular Tachycardia Due to Triggered Activity: Role of Early and Delayed Afterdepolarizations.
Lerman BB, Markowitz SM, Cheung JW, Thomas G, Ip JE
JACC Clin Electrophysiol 2024 Feb;10(2):379-401. Epub 2023 Dec 20 doi: 10.1016/j.jacep.2023.10.033. PMID: 38127010
The mitral valve in hypertrophic cardiomyopathy.
Malcolmson J, Shipolini A, Mohiddin S, Savvatis K
Curr Opin Cardiol 2023 Sep 1;38(5):415-423. Epub 2023 Jul 14 doi: 10.1097/HCO.0000000000001067. PMID: 37477154
Pharmacotherapy in inherited and acquired ventricular arrhythmia in structurally normal adult hearts.
Ortmans S, Daval C, Aguilar M, Compagno P, Cadrin-Tourigny J, Dyrda K, Rivard L, Tadros R
Expert Opin Pharmacother 2019 Dec;20(17):2101-2114. Epub 2019 Sep 30 doi: 10.1080/14656566.2019.1669561. PMID: 31566420
Hypertrophic cardiomyopathy.
Santos Mateo JJ, Sabater Molina M, Gimeno Blanes JR
Med Clin (Barc) 2018 Jun 8;150(11):434-442. Epub 2017 Nov 14 doi: 10.1016/j.medcli.2017.09.013. PMID: 29150126
Management of Interrupted Aortic Arch.
Jonas RA
Semin Thorac Cardiovasc Surg 2015 Summer;27(2):177-88. Epub 2015 Jun 14 doi: 10.1053/j.semtcvs.2015.04.003. PMID: 26686446

Prognosis

Accessory mitral valve tissue: anatomical and clinical perspectives.
Yetkin E, Cuglan B, Turhan H, Yalta K
Cardiovasc Pathol 2021 Jan-Feb;50:107277. Epub 2020 Aug 31 doi: 10.1016/j.carpath.2020.107277. PMID: 32882373
Repair for Congenital Mitral Valve Stenosis.
Delmo Walter EM, Hetzer R
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2018 Mar;21:46-57. doi: 10.1053/j.pcsu.2017.11.008. PMID: 29425525
Outflow tract ventricular arrhythmias: An update.
Lerman BB
Trends Cardiovasc Med 2015 Aug;25(6):550-8. Epub 2015 Jan 28 doi: 10.1016/j.tcm.2015.01.011. PMID: 25846938
Echocardiographic evaluation of congenital left ventricular outflow obstruction.
Aboulhosn J, Child JS
Echocardiography 2015 Jan;32 Suppl 2:S140-7. Epub 2014 May 29 doi: 10.1111/echo.12181. PMID: 24891121
Complex atrioventricular canal.
Mitchell ME, Litwin SB, Tweddell JS
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2007:32-41. doi: 10.1053/j.pcsu.2007.01.002. PMID: 17433989

Clinical prediction guides

The Fate of the Left Ventricular Outflow Tract Following Interrupted Aortic Arch Repair.
Luo S, Schoof PH, Hickey E, Morgan C, Korsuize NA, Grotenhuis HB, Mertens L, Varenbut J, Deng MX, Haranal M, Border W, Schlosser B, Arsdell GV, Alsoufi B
World J Pediatr Congenit Heart Surg 2024 Sep;15(5):562-570. Epub 2024 Jul 25 doi: 10.1177/21501351241236742. PMID: 39053451
Left ventricular anatomy in obstructive hypertrophic cardiomyopathy: beyond basal septal hypertrophy.
Hermida U, Stojanovski D, Raman B, Ariga R, Young AA, Carapella V, Carr-White G, Lukaschuk E, Piechnik SK, Kramer CM, Desai MY, Weintraub WS, Neubauer S, Watkins H, Lamata P
Eur Heart J Cardiovasc Imaging 2023 May 31;24(6):807-818. doi: 10.1093/ehjci/jeac233. PMID: 36441173Free PMC Article
Accessory mitral valve tissue: anatomical and clinical perspectives.
Yetkin E, Cuglan B, Turhan H, Yalta K
Cardiovasc Pathol 2021 Jan-Feb;50:107277. Epub 2020 Aug 31 doi: 10.1016/j.carpath.2020.107277. PMID: 32882373
How valvular calcification can affect the outcomes of transcatheter aortic valve implantation.
Milhorini Pio S, Bax J, Delgado V
Expert Rev Med Devices 2020 Aug;17(8):773-784. Epub 2020 Jul 13 doi: 10.1080/17434440.2020.1789456. PMID: 32597265
Hypertrophic Cardiomyopathy in Liver Transplantation Patients.
Pai SL, Aniskevich S 3rd, Logvinov II, Matcha GV, Palmer WC, Blackshear JL
Transplant Proc 2018 Jun;50(5):1466-1469. Epub 2018 Mar 10 doi: 10.1016/j.transproceed.2018.02.080. PMID: 29880372

Recent systematic reviews

Pacemaker implantation rate after transcatheter aortic valve implantation with early and new-generation devices: a systematic review.
van Rosendael PJ, Delgado V, Bax JJ
Eur Heart J 2018 Jun 1;39(21):2003-2013. doi: 10.1093/eurheartj/ehx785. PMID: 29420704

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