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Undifferentiated pancreatic carcinoma with osteoclast-like giant cells

MedGen UID:
389157
•Concept ID:
C2007059
•
Neoplastic Process
Synonym: Osteoclastic giant cell tumor of pancreas
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0006479
Orphanet: ORPHA424080

Definition

A rare variant of undifferentiated pancreatic carcinoma characterized by the presence of non-neoplastic osteoclast-like giant cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUndifferentiated pancreatic carcinoma with osteoclast-like giant cells

Recent clinical studies

Etiology

Case report: Pathological and genetic features of pancreatic undifferentiated carcinoma with osteoclast-like giant cells.
Zhao N, Mei N, Yi Y, Wang H, Wang Y, Yao Y, Li C
Pathol Oncol Res 2023;29:1610983. Epub 2023 Mar 3 doi: 10.3389/pore.2023.1610983. PMID: 36938358Free PMC Article
Negative prognostic impact of PD-L1 expression in tumor cells of undifferentiated (anaplastic) carcinoma with osteoclast-like giant cells of the pancreas: study of 13 cases comparing ductal pancreatic carcinoma and review of the literature.
Hrudka J, Lawrie K, Waldauf P, Ciprová V, Moravcová J, Matěj R
Virchows Arch 2020 Nov;477(5):687-696. Epub 2020 May 18 doi: 10.1007/s00428-020-02830-8. PMID: 32424767
The Italian Rare Pancreatic Exocrine Cancer Initiative.
Brunetti O, Luchini C, Argentiero A, Tommasi S, Mangia A, Aprile G, Marchetti P, Vasile E, Casadei Gardini A, Scartozzi M, Barni S, Delfanti S, De Vita F, Di Costanzo F, Milella M, Cella CA, Berardi R, Cataldo I, Santini D, Doglioni C, Maiello E, Lawlor RT, Mazzaferro V, Lonardi S, Giuliante F, Brandi G, Scarpa A, Cascinu S, Silvestris N
Tumori 2019 Aug;105(4):353-358. Epub 2019 Apr 9 doi: 10.1177/0300891619839461. PMID: 30967031
Expression of L1CAM, COX-2, EGFR, c-KIT and Her2/neu in anaplastic pancreatic cancer: putative therapeutic targets?
Bergmann F, Moldenhauer G, Herpel E, Gaida MM, Strobel O, Werner J, Esposito I, Müerköster SS, Schirmacher P, Kern MA
Histopathology 2010 Mar;56(4):440-8. doi: 10.1111/j.1365-2559.2010.03499.x. PMID: 20459551

Diagnosis

Case report: Pathological and genetic features of pancreatic undifferentiated carcinoma with osteoclast-like giant cells.
Zhao N, Mei N, Yi Y, Wang H, Wang Y, Yao Y, Li C
Pathol Oncol Res 2023;29:1610983. Epub 2023 Mar 3 doi: 10.3389/pore.2023.1610983. PMID: 36938358Free PMC Article
Assessment and management of undifferentiated carcinoma with osteoclastic like giant cells of the pancreas: a case report and revision of literature.
Cavalcanti E, Schena N, Serino G, Lantone G, Armentano R
BMC Gastroenterol 2021 Jun 2;21(1):247. doi: 10.1186/s12876-021-01779-5. PMID: 34078293Free PMC Article
Malignant epithelial/exocrine tumors of the pancreas.
Luchini C, Grillo F, Fassan M, Vanoli A, Capelli P, Paolino G, Ingravallo G, Renzulli G, Doglioni C, D'Amuri A, Mattiolo P, Pecori S, Parente P, Florena AM, Zamboni G, Scarpa A
Pathologica 2020 Sep;112(3):210-226. doi: 10.32074/1591-951X-167. PMID: 33179623Free PMC Article
Negative prognostic impact of PD-L1 expression in tumor cells of undifferentiated (anaplastic) carcinoma with osteoclast-like giant cells of the pancreas: study of 13 cases comparing ductal pancreatic carcinoma and review of the literature.
Hrudka J, Lawrie K, Waldauf P, Ciprová V, Moravcová J, Matěj R
Virchows Arch 2020 Nov;477(5):687-696. Epub 2020 May 18 doi: 10.1007/s00428-020-02830-8. PMID: 32424767
Cytologic features and clinical implications of undifferentiated carcinoma with osteoclastic giant cells of the pancreas: An analysis of 15 cases.
Reid MD, Muraki T, HooKim K, Memis B, Graham RP, Allende D, Shi J, Schaeffer DF, Singh R, Basturk O, Adsay V
Cancer Cytopathol 2017 Jul;125(7):563-575. Epub 2017 Apr 3 doi: 10.1002/cncy.21859. PMID: 28371566

Therapy

Negative prognostic impact of PD-L1 expression in tumor cells of undifferentiated (anaplastic) carcinoma with osteoclast-like giant cells of the pancreas: study of 13 cases comparing ductal pancreatic carcinoma and review of the literature.
Hrudka J, Lawrie K, Waldauf P, Ciprová V, Moravcová J, Matěj R
Virchows Arch 2020 Nov;477(5):687-696. Epub 2020 May 18 doi: 10.1007/s00428-020-02830-8. PMID: 32424767
Undifferentiated Carcinoma of the Pancreas - a Case Report.
Kašperová B, Jurišová S, Macúch J, Bumberová M, Janega P, Dolinský J, Mego M
Klin Onkol 2018 Winter;31(6):453-456. doi: 10.14735/amko2018453. PMID: 31035768
Expression of L1CAM, COX-2, EGFR, c-KIT and Her2/neu in anaplastic pancreatic cancer: putative therapeutic targets?
Bergmann F, Moldenhauer G, Herpel E, Gaida MM, Strobel O, Werner J, Esposito I, Müerköster SS, Schirmacher P, Kern MA
Histopathology 2010 Mar;56(4):440-8. doi: 10.1111/j.1365-2559.2010.03499.x. PMID: 20459551

Prognosis

Prognostic indicators for undifferentiated carcinoma with/without osteoclast-like giant cells of the pancreas.
Christopher W, Nassoiy S, Marcus R, Keller J, Chang SC, Fischer T, Bilchik A, Goldfarb M
HPB (Oxford) 2022 Oct;24(10):1757-1769. Epub 2022 Jun 17 doi: 10.1016/j.hpb.2022.05.1344. PMID: 35780038
Single-cell RNA-seq reveals the genesis and heterogeneity of tumor microenvironment in pancreatic undifferentiated carcinoma with osteoclast-like giant-cells.
Wang X, Miao J, Wang S, Shen R, Zhang S, Tian Y, Li M, Zhu D, Yao A, Bao W, Zhang Q, Tang X, Wang X, Li J
Mol Cancer 2022 Jun 22;21(1):133. doi: 10.1186/s12943-022-01596-8. PMID: 35733218Free PMC Article
Undifferentiated Pancreatic Carcinoma with Osteoclast-like Giant Cells: a Review and Case Report Analysis.
Kharkhach A, Bouhout T, Serji B, El Harroudi T
J Gastrointest Cancer 2021 Sep;52(3):1106-1113. Epub 2021 Jan 14 doi: 10.1007/s12029-021-00583-4. PMID: 33447945
Negative prognostic impact of PD-L1 expression in tumor cells of undifferentiated (anaplastic) carcinoma with osteoclast-like giant cells of the pancreas: study of 13 cases comparing ductal pancreatic carcinoma and review of the literature.
Hrudka J, Lawrie K, Waldauf P, Ciprová V, Moravcová J, Matěj R
Virchows Arch 2020 Nov;477(5):687-696. Epub 2020 May 18 doi: 10.1007/s00428-020-02830-8. PMID: 32424767
Pancreatic undifferentiated carcinoma with osteoclast-like giant cells is genetically similar to, but clinically distinct from, conventional ductal adenocarcinoma.
Luchini C, Pea A, Lionheart G, Mafficini A, Nottegar A, Veronese N, Chianchiano P, Brosens LA, Noë M, Offerhaus GJA, Yonescu R, Ning Y, Malleo G, Riva G, Piccoli P, Cataldo I, Capelli P, Zamboni G, Scarpa A, Wood LD
J Pathol 2017 Oct;243(2):148-154. Epub 2017 Sep 5 doi: 10.1002/path.4941. PMID: 28722124Free PMC Article

Clinical prediction guides

Prognostic indicators for undifferentiated carcinoma with/without osteoclast-like giant cells of the pancreas.
Christopher W, Nassoiy S, Marcus R, Keller J, Chang SC, Fischer T, Bilchik A, Goldfarb M
HPB (Oxford) 2022 Oct;24(10):1757-1769. Epub 2022 Jun 17 doi: 10.1016/j.hpb.2022.05.1344. PMID: 35780038
Assessment and management of undifferentiated carcinoma with osteoclastic like giant cells of the pancreas: a case report and revision of literature.
Cavalcanti E, Schena N, Serino G, Lantone G, Armentano R
BMC Gastroenterol 2021 Jun 2;21(1):247. doi: 10.1186/s12876-021-01779-5. PMID: 34078293Free PMC Article
Negative prognostic impact of PD-L1 expression in tumor cells of undifferentiated (anaplastic) carcinoma with osteoclast-like giant cells of the pancreas: study of 13 cases comparing ductal pancreatic carcinoma and review of the literature.
Hrudka J, Lawrie K, Waldauf P, Ciprová V, Moravcová J, Matěj R
Virchows Arch 2020 Nov;477(5):687-696. Epub 2020 May 18 doi: 10.1007/s00428-020-02830-8. PMID: 32424767
Pancreatic undifferentiated carcinoma with osteoclast-like giant cells is genetically similar to, but clinically distinct from, conventional ductal adenocarcinoma.
Luchini C, Pea A, Lionheart G, Mafficini A, Nottegar A, Veronese N, Chianchiano P, Brosens LA, Noë M, Offerhaus GJA, Yonescu R, Ning Y, Malleo G, Riva G, Piccoli P, Cataldo I, Capelli P, Zamboni G, Scarpa A, Wood LD
J Pathol 2017 Oct;243(2):148-154. Epub 2017 Sep 5 doi: 10.1002/path.4941. PMID: 28722124Free PMC Article
Cytologic features and clinical implications of undifferentiated carcinoma with osteoclastic giant cells of the pancreas: An analysis of 15 cases.
Reid MD, Muraki T, HooKim K, Memis B, Graham RP, Allende D, Shi J, Schaeffer DF, Singh R, Basturk O, Adsay V
Cancer Cytopathol 2017 Jul;125(7):563-575. Epub 2017 Apr 3 doi: 10.1002/cncy.21859. PMID: 28371566

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