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Undifferentiated pancreatic carcinoma with osteoclast-like giant cells

MedGen UID:
389157
Concept ID:
C2007059
Neoplastic Process
Synonym: Osteoclastic giant cell tumor of pancreas
SNOMED CT: Pancreatic undifferentiated carcinoma with osteoclast-like giant cells (1279841001); OGCT (osteoclastic giant cell tumor) of pancreas (1279841001); Osteoclastic giant cell tumor of pancreas (1279841001); Undifferentiated carcinoma with osteoclast-like giant cells of pancreas (1279841001); Undifferentiated carcinoma of pancreas with osteoclast-like giant cells (1279841001)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0006479
Orphanet: ORPHA424080

Definition

A rare type of pancreatic ductal adenocarcinoma with composition of non-neoplastic osteoclast-like multinucleated giant cells, a mononuclear histiocytic component and the neoplastic cells, which vary from spindle-shaped to epithelioid and can be very large and pleomorphic. Clinical features of pancreatic ductal adenocarcinoma include abdominal pain, nausea, weight loss, jaundice, and new-onset diabetes. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUndifferentiated pancreatic carcinoma with osteoclast-like giant cells

Professional guidelines

PubMed

Imaoka H, Ikeda M, Umemoto K, Sunakawa Y, Ueno M, Ueno H, Ozaka M, Kuwahara T, Okano N, Kanai M, Hisano T, Suzuki Y, Asagi A, Shioji K, Todaka A, Tsuji K, Ikezawa K, Miki I, Komatsu Y, Akutsu N, Yamashita T, Okuyama H, Furuse J, Nagano H
Jpn J Clin Oncol 2023 Aug 30;53(9):764-773. doi: 10.1093/jjco/hyad062. PMID: 37325968Free PMC Article

Recent clinical studies

Etiology

Imaoka H, Ikeda M, Umemoto K, Sunakawa Y, Ueno M, Ueno H, Ozaka M, Kuwahara T, Okano N, Kanai M, Hisano T, Suzuki Y, Asagi A, Shioji K, Todaka A, Tsuji K, Ikezawa K, Miki I, Komatsu Y, Akutsu N, Yamashita T, Okuyama H, Furuse J, Nagano H
Jpn J Clin Oncol 2023 Aug 30;53(9):764-773. doi: 10.1093/jjco/hyad062. PMID: 37325968Free PMC Article
Zhao N, Mei N, Yi Y, Wang H, Wang Y, Yao Y, Li C
Pathol Oncol Res 2023;29:1610983. Epub 2023 Mar 3 doi: 10.3389/pore.2023.1610983. PMID: 36938358Free PMC Article
Mattiolo P, Fiadone G, Paolino G, Chatterjee D, Bernasconi R, Piccoli P, Parolini C, El Aidi M, Sperandio N, Malleo G, Salvia R, Brosens LA, Wood LD, Scarpa A, Lawlor RT, Luchini C
Virchows Arch 2021 Feb;478(2):319-326. Epub 2020 Jul 13 doi: 10.1007/s00428-020-02889-3. PMID: 32661742Free PMC Article
Hrudka J, Lawrie K, Waldauf P, Ciprová V, Moravcová J, Matěj R
Virchows Arch 2020 Nov;477(5):687-696. Epub 2020 May 18 doi: 10.1007/s00428-020-02830-8. PMID: 32424767
Luchini C, Cros J, Pea A, Pilati C, Veronese N, Rusev B, Capelli P, Mafficini A, Nottegar A, Brosens LAA, Noë M, Offerhaus GJA, Chianchiano P, Riva G, Piccoli P, Parolini C, Malleo G, Lawlor RT, Corbo V, Sperandio N, Barbareschi M, Fassan M, Cheng L, Wood LD, Scarpa A
Hum Pathol 2018 Nov;81:157-165. Epub 2018 Jul 18 doi: 10.1016/j.humpath.2018.07.006. PMID: 30031096

Diagnosis

Jain PV, Griffin M, Hunt B, Ward E, Tsai S, Doucette S
Ann Diagn Pathol 2022 Apr;57:151884. Epub 2022 Jan 15 doi: 10.1016/j.anndiagpath.2021.151884. PMID: 35074581
Luchini C, Grillo F, Fassan M, Vanoli A, Capelli P, Paolino G, Ingravallo G, Renzulli G, Doglioni C, D'Amuri A, Mattiolo P, Pecori S, Parente P, Florena AM, Zamboni G, Scarpa A
Pathologica 2020 Sep;112(3):210-226. doi: 10.32074/1591-951X-167. PMID: 33179623Free PMC Article
Schawkat K, Manning MA, Glickman JN, Mortele KJ
Radiographics 2020 Sep-Oct;40(5):1219-1239. Epub 2020 Jul 17 doi: 10.1148/rg.2020190184. PMID: 32678699
Sah SK, Li Y, Li Y
Int J Clin Exp Pathol 2015;8(9):11785-91. Epub 2015 Sep 1 PMID: 26617927Free PMC Article
Molberg KH, Heffess C, Delgado R, Albores-Saavedra J
Cancer 1998 Apr 1;82(7):1279-87. doi: 10.1002/(sici)1097-0142(19980401)82:7<1279::aid-cncr10>3.0.co;2-3. PMID: 9529019

Therapy

Imaoka H, Ikeda M, Maehara K, Umemoto K, Ozaka M, Kobayashi S, Terashima T, Inoue H, Sakaguchi C, Tsuji K, Shioji K, Okamura K, Kawamoto Y, Suzuki R, Shirakawa H, Nagano H, Ueno M, Morizane C, Furuse J
BMC Cancer 2020 Oct 1;20(1):946. doi: 10.1186/s12885-020-07462-4. PMID: 33004032Free PMC Article
Hrudka J, Lawrie K, Waldauf P, Ciprová V, Moravcová J, Matěj R
Virchows Arch 2020 Nov;477(5):687-696. Epub 2020 May 18 doi: 10.1007/s00428-020-02830-8. PMID: 32424767
Kašperová B, Jurišová S, Macúch J, Bumberová M, Janega P, Dolinský J, Mego M
Klin Onkol 2018 Winter;31(6):453-456. doi: 10.14735/amko2018453. PMID: 31035768
Chiarelli M, Guttadauro A, Gerosa M, Marando A, Gabrielli F, De Simone M, Cioffi U
BMC Gastroenterol 2015 Nov 18;15:161. doi: 10.1186/s12876-015-0391-2. PMID: 26581412Free PMC Article
Gao HQ, Yang YM, Zhuang Y, Liu P
World J Gastroenterol 2015 Jan 14;21(2):694-8. doi: 10.3748/wjg.v21.i2.694. PMID: 25593500Free PMC Article

Prognosis

Christopher W, Nassoiy S, Marcus R, Keller J, Chang SC, Fischer T, Bilchik A, Goldfarb M
HPB (Oxford) 2022 Oct;24(10):1757-1769. Epub 2022 Jun 17 doi: 10.1016/j.hpb.2022.05.1344. PMID: 35780038
Wang X, Miao J, Wang S, Shen R, Zhang S, Tian Y, Li M, Zhu D, Yao A, Bao W, Zhang Q, Tang X, Wang X, Li J
Mol Cancer 2022 Jun 22;21(1):133. doi: 10.1186/s12943-022-01596-8. PMID: 35733218Free PMC Article
Jain PV, Griffin M, Hunt B, Ward E, Tsai S, Doucette S
Ann Diagn Pathol 2022 Apr;57:151884. Epub 2022 Jan 15 doi: 10.1016/j.anndiagpath.2021.151884. PMID: 35074581
Mattiolo P, Fiadone G, Paolino G, Chatterjee D, Bernasconi R, Piccoli P, Parolini C, El Aidi M, Sperandio N, Malleo G, Salvia R, Brosens LA, Wood LD, Scarpa A, Lawlor RT, Luchini C
Virchows Arch 2021 Feb;478(2):319-326. Epub 2020 Jul 13 doi: 10.1007/s00428-020-02889-3. PMID: 32661742Free PMC Article
Luchini C, Pea A, Lionheart G, Mafficini A, Nottegar A, Veronese N, Chianchiano P, Brosens LA, Noë M, Offerhaus GJA, Yonescu R, Ning Y, Malleo G, Riva G, Piccoli P, Cataldo I, Capelli P, Zamboni G, Scarpa A, Wood LD
J Pathol 2017 Oct;243(2):148-154. Epub 2017 Sep 5 doi: 10.1002/path.4941. PMID: 28722124Free PMC Article

Clinical prediction guides

Hrudka J, Kalinová M, Ciprová V, Moravcová J, Dvořák R, Matěj R
Int J Mol Sci 2024 Mar 14;25(6) doi: 10.3390/ijms25063285. PMID: 38542259Free PMC Article
Christopher W, Nassoiy S, Marcus R, Keller J, Chang SC, Fischer T, Bilchik A, Goldfarb M
HPB (Oxford) 2022 Oct;24(10):1757-1769. Epub 2022 Jun 17 doi: 10.1016/j.hpb.2022.05.1344. PMID: 35780038
Imaoka H, Ikeda M, Maehara K, Umemoto K, Ozaka M, Kobayashi S, Terashima T, Inoue H, Sakaguchi C, Tsuji K, Shioji K, Okamura K, Tsujimoto A, Nakamura I, Shirakawa H, Furukawa M, Ueno M, Morizane C, Furuse J
Pancreatology 2021 Jun;21(4):738-745. Epub 2021 Feb 14 doi: 10.1016/j.pan.2021.02.008. PMID: 33602645
Mattiolo P, Fiadone G, Paolino G, Chatterjee D, Bernasconi R, Piccoli P, Parolini C, El Aidi M, Sperandio N, Malleo G, Salvia R, Brosens LA, Wood LD, Scarpa A, Lawlor RT, Luchini C
Virchows Arch 2021 Feb;478(2):319-326. Epub 2020 Jul 13 doi: 10.1007/s00428-020-02889-3. PMID: 32661742Free PMC Article
Hrudka J, Lawrie K, Waldauf P, Ciprová V, Moravcová J, Matěj R
Virchows Arch 2020 Nov;477(5):687-696. Epub 2020 May 18 doi: 10.1007/s00428-020-02830-8. PMID: 32424767

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