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Ovarian endometrioid adenocarcinoma with squamous differentiation

MedGen UID:
389178
•Concept ID:
C2212017
•
Neoplastic Process
Synonyms: ovarian adenoacanthoma; Ovarian Adenosquamous Carcinoma; ovarian adenosquamous carcinoma; Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation; ovarian endometrioid adenocarcinoma with squamous differentiation
 
Monarch Initiative: MONDO:0006336

Definition

An endometrioid adenocarcinoma that arises from the ovary and exhibits squamous differentiation. The squamous cell component often has a cytologically benign appearance. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian endometrioid adenocarcinoma with squamous differentiation

Professional guidelines

PubMed

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467
Transitional cell carcinoma of the ovary: a morphologic study of 100 cases with emphasis on differential diagnosis.
Eichhorn JH, Young RH
Am J Surg Pathol 2004 Apr;28(4):453-63. doi: 10.1097/00000478-200404000-00004. PMID: 15087664
Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas.
Shappell HW, Riopel MA, Smith Sehdev AE, Ronnett BM, Kurman RJ
Am J Surg Pathol 2002 Dec;26(12):1529-41. doi: 10.1097/00000478-200212000-00001. PMID: 12459620

Recent clinical studies

Etiology

Trichorhinophalangeal Syndrome Type 1 Immunohistochemical Expression in Carcinomas of Gynecologic Origin.
Ruiz F, Tjendra Y, Millan N, Gomez-Fernandez C, Pinto A
Am J Surg Pathol 2024 May 1;48(5):546-550. Epub 2024 Feb 15 doi: 10.1097/PAS.0000000000002193. PMID: 38357982
Mesonephric-like Differentiation of Ovarian Endometrioid and High-grade Serous Carcinomas: Clinicopathological and Molecular Characteristics Distinct from Those of Mesonephric-like Adenocarcinoma.
Choi KH, Kim H, Bae GE, Lee SH, Woo HY, Kim HS
Anticancer Res 2021 Sep;41(9):4587-4601. doi: 10.21873/anticanres.15272. PMID: 34475087
The Many Uses of p53 Immunohistochemistry in Gynecological Pathology: Proceedings of the ISGyP Companion Society Session at the 2020 USCAP Annual9 Meeting.
Köbel M, Kang EY
Int J Gynecol Pathol 2021 Jan;40(1):32-40. doi: 10.1097/PGP.0000000000000725. PMID: 33290354
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
Malignant lesions of the female genital tract and peritoneum that may be underdiagnosed.
Young RH, Clement PB
Semin Diagn Pathol 1995 Feb;12(1):14-29. PMID: 7770671

Diagnosis

Trichorhinophalangeal Syndrome Type 1 Immunohistochemical Expression in Carcinomas of Gynecologic Origin.
Ruiz F, Tjendra Y, Millan N, Gomez-Fernandez C, Pinto A
Am J Surg Pathol 2024 May 1;48(5):546-550. Epub 2024 Feb 15 doi: 10.1097/PAS.0000000000002193. PMID: 38357982
High-grade Serous Carcinoma can Show Squamoid Morphology Mimicking True Squamous Differentiation.
Tomonobe H, Ohishi Y, Hachisuga K, Yahata H, Kato K, Oda Y
Am J Surg Pathol 2023 Sep 1;47(9):967-976. Epub 2023 Jun 29 doi: 10.1097/PAS.0000000000002089. PMID: 37382102
Low grade endometrial endometrioid adenocarcinoma: A review and update with emphasis on morphologic variants, mimics, immunohistochemical and molecular features.
Lucas E, Carrick KS
Semin Diagn Pathol 2022 May;39(3):159-175. Epub 2022 Feb 11 doi: 10.1053/j.semdp.2022.02.002. PMID: 35397943
The Many Uses of p53 Immunohistochemistry in Gynecological Pathology: Proceedings of the ISGyP Companion Society Session at the 2020 USCAP Annual9 Meeting.
Köbel M, Kang EY
Int J Gynecol Pathol 2021 Jan;40(1):32-40. doi: 10.1097/PGP.0000000000000725. PMID: 33290354
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172

Therapy

Association of Hormone Receptor Expression with Survival in Ovarian Endometrioid Carcinoma: Biological Validation and Clinical Implications.
Rambau P, Kelemen LE, Steed H, Quan ML, Ghatage P, Köbel M
Int J Mol Sci 2017 Feb 27;18(3) doi: 10.3390/ijms18030515. PMID: 28264438Free PMC Article

Prognosis

The Many Uses of p53 Immunohistochemistry in Gynecological Pathology: Proceedings of the ISGyP Companion Society Session at the 2020 USCAP Annual9 Meeting.
Köbel M, Kang EY
Int J Gynecol Pathol 2021 Jan;40(1):32-40. doi: 10.1097/PGP.0000000000000725. PMID: 33290354
Association of Hormone Receptor Expression with Survival in Ovarian Endometrioid Carcinoma: Biological Validation and Clinical Implications.
Rambau P, Kelemen LE, Steed H, Quan ML, Ghatage P, Köbel M
Int J Mol Sci 2017 Feb 27;18(3) doi: 10.3390/ijms18030515. PMID: 28264438Free PMC Article
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
Ovarian carcinomas, including secondary tumors: diagnostically challenging areas.
Prat J
Mod Pathol 2005 Feb;18 Suppl 2:S99-111. doi: 10.1038/modpathol.3800312. PMID: 15492758
Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas.
Shappell HW, Riopel MA, Smith Sehdev AE, Ronnett BM, Kurman RJ
Am J Surg Pathol 2002 Dec;26(12):1529-41. doi: 10.1097/00000478-200212000-00001. PMID: 12459620

Clinical prediction guides

Trichorhinophalangeal Syndrome Type 1 Immunohistochemical Expression in Carcinomas of Gynecologic Origin.
Ruiz F, Tjendra Y, Millan N, Gomez-Fernandez C, Pinto A
Am J Surg Pathol 2024 May 1;48(5):546-550. Epub 2024 Feb 15 doi: 10.1097/PAS.0000000000002193. PMID: 38357982
The Many Uses of p53 Immunohistochemistry in Gynecological Pathology: Proceedings of the ISGyP Companion Society Session at the 2020 USCAP Annual9 Meeting.
Köbel M, Kang EY
Int J Gynecol Pathol 2021 Jan;40(1):32-40. doi: 10.1097/PGP.0000000000000725. PMID: 33290354
Association of Hormone Receptor Expression with Survival in Ovarian Endometrioid Carcinoma: Biological Validation and Clinical Implications.
Rambau P, Kelemen LE, Steed H, Quan ML, Ghatage P, Köbel M
Int J Mol Sci 2017 Feb 27;18(3) doi: 10.3390/ijms18030515. PMID: 28264438Free PMC Article
Morphological and Immunohistochemical Reevaluation of Tumors Initially Diagnosed as Ovarian Endometrioid Carcinoma With Emphasis on High-grade Tumors.
Lim D, Murali R, Murray MP, Veras E, Park KJ, Soslow RA
Am J Surg Pathol 2016 Mar;40(3):302-12. doi: 10.1097/PAS.0000000000000550. PMID: 26551621Free PMC Article
Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826

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