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Wet macular degeneration

MedGen UID:
389185
Concept ID:
C2237660
Disease or Syndrome
Synonyms: Degeneration, Wet Macular; Degenerations, Wet Macular; Macular Degeneration, Wet; Macular Degenerations, Wet; Wet Macular Degeneration; Wet Macular Degenerations
 
Monarch Initiative: MONDO:0005417

Definition

A form of RETINAL degeneration in which abnormal CHOROIDAL NEOVASCULARIZATION occurs under the RETINA and MACULA LUTEA, causing bleeding and leaking of fluid. This leads to bulging and or lifting of the macula and the distortion or destruction of central vision. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWet macular degeneration

Professional guidelines

PubMed

Skelly A, Taylor N, Fasser C, Malkowski JP, Goswami P, Downey L
Adv Ther 2022 Oct;39(10):4808-4820. Epub 2022 Aug 22 doi: 10.1007/s12325-022-02248-5. PMID: 35995894Free PMC Article
Tolentino MJ, Dennrick A, John E, Tolentino MS
Expert Opin Investig Drugs 2015 Feb;24(2):183-99. Epub 2014 Sep 22 doi: 10.1517/13543784.2015.961601. PMID: 25243494
Tobin KA
Insight 2006 Jan-Mar;31(1):11-4. PMID: 16817567

Recent clinical studies

Etiology

Fleckenstein M, Schmitz-Valckenberg S, Chakravarthy U
JAMA 2024 Jan 9;331(2):147-157. doi: 10.1001/jama.2023.26074. PMID: 38193957
Matsumoto H, Hoshino J, Nakamura K, Nagashima T, Akiyama H
Graefes Arch Clin Exp Ophthalmol 2023 Oct;261(10):2945-2952. Epub 2023 May 17 doi: 10.1007/s00417-023-06116-y. PMID: 37195339
Holz FG, Oleksy P, Ricci F, Kaiser PK, Kiefer J, Schmitz-Valckenberg S; COLUMBUS-AMD Study Group
Ophthalmology 2022 Jan;129(1):54-63. Epub 2021 May 3 doi: 10.1016/j.ophtha.2021.04.031. PMID: 33957183
Al-Zamil WM, Yassin SA
Clin Interv Aging 2017;12:1313-1330. Epub 2017 Aug 22 doi: 10.2147/CIA.S143508. PMID: 28860733Free PMC Article
Schmidt-Erfurth U, Chong V, Loewenstein A, Larsen M, Souied E, Schlingemann R, Eldem B, Monés J, Richard G, Bandello F; European Society of Retina Specialists
Br J Ophthalmol 2014 Sep;98(9):1144-67. doi: 10.1136/bjophthalmol-2014-305702. PMID: 25136079Free PMC Article

Diagnosis

Hikichi T
Jpn J Ophthalmol 2023 Nov;67(6):652-656. Epub 2023 Oct 20 doi: 10.1007/s10384-023-01024-4. PMID: 37861941
Matsumoto H, Hoshino J, Nakamura K, Nagashima T, Akiyama H
Graefes Arch Clin Exp Ophthalmol 2023 Oct;261(10):2945-2952. Epub 2023 May 17 doi: 10.1007/s00417-023-06116-y. PMID: 37195339
Holz FG, Oleksy P, Ricci F, Kaiser PK, Kiefer J, Schmitz-Valckenberg S; COLUMBUS-AMD Study Group
Ophthalmology 2022 Jan;129(1):54-63. Epub 2021 May 3 doi: 10.1016/j.ophtha.2021.04.031. PMID: 33957183
Al-Zamil WM, Yassin SA
Clin Interv Aging 2017;12:1313-1330. Epub 2017 Aug 22 doi: 10.2147/CIA.S143508. PMID: 28860733Free PMC Article
Schmidt-Erfurth U, Chong V, Loewenstein A, Larsen M, Souied E, Schlingemann R, Eldem B, Monés J, Richard G, Bandello F; European Society of Retina Specialists
Br J Ophthalmol 2014 Sep;98(9):1144-67. doi: 10.1136/bjophthalmol-2014-305702. PMID: 25136079Free PMC Article

Therapy

Khanani AM, Kotecha A, Chang A, Chen SJ, Chen Y, Guymer R, Heier JS, Holz FG, Iida T, Ives JA, Lim JI, Lin H, Michels S, Quezada Ruiz C, Schmidt-Erfurth U, Silverman D, Singh R, Swaminathan B, Willis JR, Tadayoni R; TENAYA and LUCERNE Investigators
Ophthalmology 2024 Aug;131(8):914-926. Epub 2024 Feb 19 doi: 10.1016/j.ophtha.2024.02.014. PMID: 38382813
Girgis S, Lee LR
Clin Exp Ophthalmol 2023 Nov;51(8):835-852. Epub 2023 Sep 22 doi: 10.1111/ceo.14294. PMID: 37737509
Ammar MJ, Hsu J, Chiang A, Ho AC, Regillo CD
Curr Opin Ophthalmol 2020 May;31(3):215-221. doi: 10.1097/ICU.0000000000000657. PMID: 32205470
Dugel PU, Koh A, Ogura Y, Jaffe GJ, Schmidt-Erfurth U, Brown DM, Gomes AV, Warburton J, Weichselberger A, Holz FG; HAWK and HARRIER Study Investigators
Ophthalmology 2020 Jan;127(1):72-84. Epub 2019 Apr 12 doi: 10.1016/j.ophtha.2019.04.017. PMID: 30986442
Heier JS, Brown DM, Chong V, Korobelnik JF, Kaiser PK, Nguyen QD, Kirchhof B, Ho A, Ogura Y, Yancopoulos GD, Stahl N, Vitti R, Berliner AJ, Soo Y, Anderesi M, Groetzbach G, Sommerauer B, Sandbrink R, Simader C, Schmidt-Erfurth U; VIEW 1 and VIEW 2 Study Groups
Ophthalmology 2012 Dec;119(12):2537-48. Epub 2012 Oct 17 doi: 10.1016/j.ophtha.2012.09.006. PMID: 23084240

Prognosis

Matsumoto H, Hoshino J, Nakamura K, Akiyama H
Jpn J Ophthalmol 2024 Mar;68(2):83-90. Epub 2024 Jan 20 doi: 10.1007/s10384-023-01040-4. PMID: 38244172
Kataoka K, Itagaki K, Hashiya N, Wakugawa S, Tanaka K, Nakayama M, Yamamoto A, Mukai R, Honjyo J, Maruko I, Kawai M, Miyara Y, Terao N, Wakatsuki Y, Onoe H, Mori R, Koizumi H, Sekiryu T, Iida T, Okada AA; for Japan AMD Research Consortium (JARC)
Graefes Arch Clin Exp Ophthalmol 2024 Jan;262(1):43-51. Epub 2023 Sep 5 doi: 10.1007/s00417-023-06222-x. PMID: 37668741
Tamiya R, Hata M, Tanaka A, Tsuchikawa M, Ueda-Arakawa N, Tamura H, Miyata M, Takahashi A, Kido A, Muraoka Y, Miyake M, Ooto S, Tsujikawa A
Sci Rep 2023 Nov 30;13(1):21128. doi: 10.1038/s41598-023-48190-6. PMID: 38036627Free PMC Article
Hikichi T
Jpn J Ophthalmol 2023 Nov;67(6):652-656. Epub 2023 Oct 20 doi: 10.1007/s10384-023-01024-4. PMID: 37861941
Monés J, Srivastava SK, Jaffe GJ, Tadayoni R, Albini TA, Kaiser PK, Holz FG, Korobelnik JF, Kim IK, Pruente C, Murray TG, Heier JS
Ophthalmology 2021 Jul;128(7):1050-1059. Epub 2020 Nov 15 doi: 10.1016/j.ophtha.2020.11.011. PMID: 33207259

Clinical prediction guides

Fleckenstein M, Schmitz-Valckenberg S, Chakravarthy U
JAMA 2024 Jan 9;331(2):147-157. doi: 10.1001/jama.2023.26074. PMID: 38193957
Hikichi T
Jpn J Ophthalmol 2023 Nov;67(6):652-656. Epub 2023 Oct 20 doi: 10.1007/s10384-023-01024-4. PMID: 37861941
Stanga PE, Valentín-Bravo FJ, Stanga SEF, Reinstein UI, Pastor-Idoate S, Downes SM
Eye (Lond) 2023 Oct;37(15):3282-3289. Epub 2023 Mar 23 doi: 10.1038/s41433-023-02505-z. PMID: 36959312Free PMC Article
Al-Zamil WM, Yassin SA
Clin Interv Aging 2017;12:1313-1330. Epub 2017 Aug 22 doi: 10.2147/CIA.S143508. PMID: 28860733Free PMC Article
Lambert NG, ElShelmani H, Singh MK, Mansergh FC, Wride MA, Padilla M, Keegan D, Hogg RE, Ambati BK
Prog Retin Eye Res 2016 Sep;54:64-102. Epub 2016 May 6 doi: 10.1016/j.preteyeres.2016.04.003. PMID: 27156982Free PMC Article

Recent systematic reviews

Wu Y, Xie Y, Yuan Y, Xiong R, Hu Y, Ning K, Ha J, Wang W, Han X, He M
Nutrients 2023 Apr 23;15(9) doi: 10.3390/nu15092043. PMID: 37432187Free PMC Article
Zhang J, Liang Y, Xie J, Li D, Hu Q, Li X, Zheng W, He R
BMC Ophthalmol 2018 Jun 15;18(1):142. doi: 10.1186/s12886-018-0807-1. PMID: 29902977Free PMC Article
Pinna A, Zaccheddu F, Boscia F, Carru C, Solinas G
Acta Ophthalmol 2018 May;96(3):e269-e276. Epub 2016 Dec 14 doi: 10.1111/aos.13343. PMID: 27966830
Gheorghe A, Mahdi L, Musat O
Rom J Ophthalmol 2015 Apr-Jun;59(2):74-7. PMID: 26978865Free PMC Article
Kessel L, Erngaard D, Flesner P, Andresen J, Tendal B, Hjortdal J
Acta Ophthalmol 2015 Nov;93(7):593-600. Epub 2015 Jan 20 doi: 10.1111/aos.12665. PMID: 25601333Free PMC Article

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