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Wet macular degeneration

MedGen UID:
389185
•Concept ID:
C2237660
•
Disease or Syndrome
Synonyms: Degeneration, Wet Macular; Degenerations, Wet Macular; Macular Degeneration, Wet; Macular Degenerations, Wet; Wet Macular Degeneration; Wet Macular Degenerations
 
Monarch Initiative: MONDO:0005417

Definition

A form of RETINAL degeneration in which abnormal CHOROIDAL NEOVASCULARIZATION occurs under the RETINA and MACULA LUTEA, causing bleeding and leaking of fluid. This leads to bulging and or lifting of the macula and the distortion or destruction of central vision. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWet macular degeneration

Professional guidelines

PubMed

Patient Preferences in the Management of Wet Age-Related Macular Degeneration: A Conjoint Analysis.
Skelly A, Taylor N, Fasser C, Malkowski JP, Goswami P, Downey L
Adv Ther 2022 Oct;39(10):4808-4820. Epub 2022 Aug 22 doi: 10.1007/s12325-022-02248-5. PMID: 35995894Free PMC Article
Drugs in Phase II clinical trials for the treatment of age-related macular degeneration.
Tolentino MJ, Dennrick A, John E, Tolentino MS
Expert Opin Investig Drugs 2015 Feb;24(2):183-99. Epub 2014 Sep 22 doi: 10.1517/13543784.2015.961601. PMID: 25243494
Macugen treatment for wet age-related macular degeneration.
Tobin KA
Insight 2006 Jan-Mar;31(1):11-4. PMID: 16817567

Recent clinical studies

Etiology

Short-term outcomes of intravitreal faricimab for treatment-naïve neovascular age-related macular degeneration.
Matsumoto H, Hoshino J, Nakamura K, Nagashima T, Akiyama H
Graefes Arch Clin Exp Ophthalmol 2023 Oct;261(10):2945-2952. Epub 2023 May 17 doi: 10.1007/s00417-023-06116-y. PMID: 37195339
Efficacy and Safety of Biosimilar FYB201 Compared with Ranibizumab in Neovascular Age-Related Macular Degeneration.
Holz FG, Oleksy P, Ricci F, Kaiser PK, Kiefer J, Schmitz-Valckenberg S; COLUMBUS-AMD Study Group
Ophthalmology 2022 Jan;129(1):54-63. Epub 2021 May 3 doi: 10.1016/j.ophtha.2021.04.031. PMID: 33957183
Homocysteine and risk of age-related macular degeneration: a systematic review and meta-analysis.
Pinna A, Zaccheddu F, Boscia F, Carru C, Solinas G
Acta Ophthalmol 2018 May;96(3):e269-e276. Epub 2016 Dec 14 doi: 10.1111/aos.13343. PMID: 27966830
Recent developments in age-related macular degeneration: a review.
Al-Zamil WM, Yassin SA
Clin Interv Aging 2017;12:1313-1330. Epub 2017 Aug 22 doi: 10.2147/CIA.S143508. PMID: 28860733Free PMC Article
Guidelines for the management of neovascular age-related macular degeneration by the European Society of Retina Specialists (EURETINA).
Schmidt-Erfurth U, Chong V, Loewenstein A, Larsen M, Souied E, Schlingemann R, Eldem B, Monés J, Richard G, Bandello F; European Society of Retina Specialists
Br J Ophthalmol 2014 Sep;98(9):1144-67. doi: 10.1136/bjophthalmol-2014-305702. PMID: 25136079Free PMC Article

Diagnosis

Short-term outcomes of intravitreal faricimab for treatment-naïve neovascular age-related macular degeneration.
Matsumoto H, Hoshino J, Nakamura K, Nagashima T, Akiyama H
Graefes Arch Clin Exp Ophthalmol 2023 Oct;261(10):2945-2952. Epub 2023 May 17 doi: 10.1007/s00417-023-06116-y. PMID: 37195339
Efficacy and Safety of Biosimilar FYB201 Compared with Ranibizumab in Neovascular Age-Related Macular Degeneration.
Holz FG, Oleksy P, Ricci F, Kaiser PK, Kiefer J, Schmitz-Valckenberg S; COLUMBUS-AMD Study Group
Ophthalmology 2022 Jan;129(1):54-63. Epub 2021 May 3 doi: 10.1016/j.ophtha.2021.04.031. PMID: 33957183
Recent developments in age-related macular degeneration: a review.
Al-Zamil WM, Yassin SA
Clin Interv Aging 2017;12:1313-1330. Epub 2017 Aug 22 doi: 10.2147/CIA.S143508. PMID: 28860733Free PMC Article
Microperimetry in age: related macular degeneration.
Midena E, Pilotto E
Eye (Lond) 2017 Jul;31(7):985-994. Epub 2017 Mar 3 doi: 10.1038/eye.2017.34. PMID: 28257134Free PMC Article
Guidelines for the management of neovascular age-related macular degeneration by the European Society of Retina Specialists (EURETINA).
Schmidt-Erfurth U, Chong V, Loewenstein A, Larsen M, Souied E, Schlingemann R, Eldem B, Monés J, Richard G, Bandello F; European Society of Retina Specialists
Br J Ophthalmol 2014 Sep;98(9):1144-67. doi: 10.1136/bjophthalmol-2014-305702. PMID: 25136079Free PMC Article

Therapy

Efficacy, durability, and safety of faricimab up to every 16 weeks in patients with neovascular age-related macular degeneration: 1-year results from the Japan subgroup of the phase 3 TENAYA trial.
Mori R, Honda S, Gomi F, Tsujikawa A, Koizumi H, Ochi H, Ohsawa S, Okada AA; TENAYA and LUCERNE Investigators
Jpn J Ophthalmol 2023 May;67(3):301-310. Epub 2023 Apr 11 doi: 10.1007/s10384-023-00985-w. PMID: 37039948Free PMC Article
Faricimab: an investigational agent targeting the Tie-2/angiopoietin pathway and VEGF-A for the treatment of retinal diseases.
Nicolò M, Ferro Desideri L, Vagge A, Traverso CE
Expert Opin Investig Drugs 2021 Mar;30(3):193-200. Epub 2021 Feb 4 doi: 10.1080/13543784.2021.1879791. PMID: 33471572
Age-related macular degeneration therapy: a review.
Ammar MJ, Hsu J, Chiang A, Ho AC, Regillo CD
Curr Opin Ophthalmol 2020 May;31(3):215-221. doi: 10.1097/ICU.0000000000000657. PMID: 32205470
HAWK and HARRIER: Phase 3, Multicenter, Randomized, Double-Masked Trials of Brolucizumab for Neovascular Age-Related Macular Degeneration.
Dugel PU, Koh A, Ogura Y, Jaffe GJ, Schmidt-Erfurth U, Brown DM, Gomes AV, Warburton J, Weichselberger A, Holz FG; HAWK and HARRIER Study Investigators
Ophthalmology 2020 Jan;127(1):72-84. Epub 2019 Apr 12 doi: 10.1016/j.ophtha.2019.04.017. PMID: 30986442
Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration.
Heier JS, Brown DM, Chong V, Korobelnik JF, Kaiser PK, Nguyen QD, Kirchhof B, Ho A, Ogura Y, Yancopoulos GD, Stahl N, Vitti R, Berliner AJ, Soo Y, Anderesi M, Groetzbach G, Sommerauer B, Sandbrink R, Simader C, Schmidt-Erfurth U; VIEW 1 and VIEW 2 Study Groups
Ophthalmology 2012 Dec;119(12):2537-48. Epub 2012 Oct 17 doi: 10.1016/j.ophtha.2012.09.006. PMID: 23084240

Prognosis

Associations between systemic medications and development of wet age-related macular degeneration.
Loukovaara S, Auvinen A, Haukka J
Acta Ophthalmol 2022 Aug;100(5):572-582. Epub 2021 Nov 14 doi: 10.1111/aos.15056. PMID: 34779110
Effect of cataract surgery on wet age-related macular degeneration activity.
Karesvuo P, Elbaz U, Achiron A, Hecht I, Kaarniranta K, Tuuminen R
Acta Ophthalmol 2022 Feb;100(1):e262-e269. Epub 2021 Apr 10 doi: 10.1111/aos.14864. PMID: 33838002
Risk of Inflammation, Retinal Vasculitis, and Retinal Occlusion-Related Events with Brolucizumab: Post Hoc Review of HAWK and HARRIER.
Monés J, Srivastava SK, Jaffe GJ, Tadayoni R, Albini TA, Kaiser PK, Holz FG, Korobelnik JF, Kim IK, Pruente C, Murray TG, Heier JS
Ophthalmology 2021 Jul;128(7):1050-1059. Epub 2020 Nov 15 doi: 10.1016/j.ophtha.2020.11.011. PMID: 33207259
Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2.
Agrón E, Mares J, Clemons TE, Swaroop A, Chew EY, Keenan TDL; AREDS and AREDS2 Research Groups
Ophthalmology 2021 Mar;128(3):425-442. Epub 2020 Aug 25 doi: 10.1016/j.ophtha.2020.08.018. PMID: 32858063Free PMC Article
Homocysteine and risk of age-related macular degeneration: a systematic review and meta-analysis.
Pinna A, Zaccheddu F, Boscia F, Carru C, Solinas G
Acta Ophthalmol 2018 May;96(3):e269-e276. Epub 2016 Dec 14 doi: 10.1111/aos.13343. PMID: 27966830

Clinical prediction guides

Associations between systemic medications and development of wet age-related macular degeneration.
Loukovaara S, Auvinen A, Haukka J
Acta Ophthalmol 2022 Aug;100(5):572-582. Epub 2021 Nov 14 doi: 10.1111/aos.15056. PMID: 34779110
Archway Randomized Phase 3 Trial of the Port Delivery System with Ranibizumab for Neovascular Age-Related Macular Degeneration.
Holekamp NM, Campochiaro PA, Chang MA, Miller D, Pieramici D, Adamis AP, Brittain C, Evans E, Kaufman D, Maass KF, Patel S, Ranade S, Singh N, Barteselli G, Regillo C; all Archway Investigators
Ophthalmology 2022 Mar;129(3):295-307. Epub 2021 Sep 29 doi: 10.1016/j.ophtha.2021.09.016. PMID: 34597713
MACULAR ATROPHY AND MACULAR MORPHOLOGY IN AFLIBERCEPT-TREATED NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.
Kuroda Y, Yamashiro K, Ooto S, Tamura H, Oishi A, Nakanishi H, Miyata M, Hata M, Takahashi A, Wakazono T, Yoshimura N, Tsujikawa A
Retina 2018 Sep;38(9):1743-1750. doi: 10.1097/IAE.0000000000001765. PMID: 28691937
Recent developments in age-related macular degeneration: a review.
Al-Zamil WM, Yassin SA
Clin Interv Aging 2017;12:1313-1330. Epub 2017 Aug 22 doi: 10.2147/CIA.S143508. PMID: 28860733Free PMC Article
Risk factors and biomarkers of age-related macular degeneration.
Lambert NG, ElShelmani H, Singh MK, Mansergh FC, Wride MA, Padilla M, Keegan D, Hogg RE, Ambati BK
Prog Retin Eye Res 2016 Sep;54:64-102. Epub 2016 May 6 doi: 10.1016/j.preteyeres.2016.04.003. PMID: 27156982Free PMC Article

Recent systematic reviews

Conbercept for patients with age-related macular degeneration: a systematic review.
Zhang J, Liang Y, Xie J, Li D, Hu Q, Li X, Zheng W, He R
BMC Ophthalmol 2018 Jun 15;18(1):142. doi: 10.1186/s12886-018-0807-1. PMID: 29902977Free PMC Article
Homocysteine and risk of age-related macular degeneration: a systematic review and meta-analysis.
Pinna A, Zaccheddu F, Boscia F, Carru C, Solinas G
Acta Ophthalmol 2018 May;96(3):e269-e276. Epub 2016 Dec 14 doi: 10.1111/aos.13343. PMID: 27966830
AGE-RELATED MACULAR DEGENERATION.
Gheorghe A, Mahdi L, Musat O
Rom J Ophthalmol 2015 Apr-Jun;59(2):74-7. PMID: 26978865Free PMC Article
Intravitreal anti-VEGF injections for treating wet age-related macular degeneration: a systematic review and meta-analysis.
Ba J, Peng RS, Xu D, Li YH, Shi H, Wang Q, Yu J
Drug Des Devel Ther 2015;9:5397-405. Epub 2015 Sep 28 doi: 10.2147/DDDT.S86269. PMID: 26451092Free PMC Article
Cataract surgery and age-related macular degeneration. An evidence-based update.
Kessel L, Erngaard D, Flesner P, Andresen J, Tendal B, Hjortdal J
Acta Ophthalmol 2015 Nov;93(7):593-600. Epub 2015 Jan 20 doi: 10.1111/aos.12665. PMID: 25601333Free PMC Article

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