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Refractory Spinal Cord Neoplasm

MedGen UID:
389571
•Concept ID:
C2347926
•
Neoplastic Process
Synonym: Refractory Spinal Cord Tumor

Definition

Spinal cord neoplasm resistant to treatment. [from NCI]

Professional guidelines

PubMed

Neuromodulation techniques for cancer pain management.
Magee DJ, Schutzer-Weissmann J, Pereira EAC, Brown MRD
Curr Opin Support Palliat Care 2021 Jun 1;15(2):77-83. doi: 10.1097/SPC.0000000000000549. PMID: 33843762
Diagnosis and management of primary central nervous system lymphoma.
Han CH, Batchelor TT
Cancer 2017 Nov 15;123(22):4314-4324. Epub 2017 Sep 26 doi: 10.1002/cncr.30965. PMID: 28950405
Biology and treatment of primary central nervous system lymphoma.
Algazi AP, Kadoch C, Rubenstein JL
Neurotherapeutics 2009 Jul;6(3):587-97. doi: 10.1016/j.nurt.2009.04.013. PMID: 19560747Free PMC Article

Recent clinical studies

Etiology

Tumor microenvironment remodeling after neoadjuvant immunotherapy in non-small cell lung cancer revealed by single-cell RNA sequencing.
Hu J, Zhang L, Xia H, Yan Y, Zhu X, Sun F, Sun L, Li S, Li D, Wang J, Han Y, Zhang J, Bian D, Yu H, Chen Y, Fan P, Ma Q, Jiang G, Wang C, Zhang P
Genome Med 2023 Mar 3;15(1):14. doi: 10.1186/s13073-023-01164-9. PMID: 36869384Free PMC Article
Exceptional Cases of Spinal Cord Stimulation for the Treatment of Refractory Cancer-Related Pain.
Bulat E, Chakravarthy V, Crowther J, Rakesh N, Barzilai O, Gulati A
Neuromodulation 2023 Jul;26(5):1051-1058. Epub 2022 Aug 6 doi: 10.1016/j.neurom.2022.06.002. PMID: 35941017
Nivolumab versus chemotherapy in patients with advanced oesophageal squamous cell carcinoma refractory or intolerant to previous chemotherapy (ATTRACTION-3): a multicentre, randomised, open-label, phase 3 trial.
Kato K, Cho BC, Takahashi M, Okada M, Lin CY, Chin K, Kadowaki S, Ahn MJ, Hamamoto Y, Doki Y, Yen CC, Kubota Y, Kim SB, Hsu CH, Holtved E, Xynos I, Kodani M, Kitagawa Y
Lancet Oncol 2019 Nov;20(11):1506-1517. Epub 2019 Sep 30 doi: 10.1016/S1470-2045(19)30626-6. PMID: 31582355
Updates on Primary Central Nervous System Lymphoma.
Schaff LR, Grommes C
Curr Oncol Rep 2018 Feb 28;20(2):11. doi: 10.1007/s11912-018-0666-1. PMID: 29492682Free PMC Article
Long-Term Complications of the Neurogenic Bladder.
Nseyo U, Santiago-Lastra Y
Urol Clin North Am 2017 Aug;44(3):355-366. doi: 10.1016/j.ucl.2017.04.003. PMID: 28716317

Diagnosis

Primary central nervous system lymphoma.
Schaff LR, Grommes C
Blood 2022 Sep 1;140(9):971-979. doi: 10.1182/blood.2020008377. PMID: 34699590Free PMC Article
Central Nervous System Lymphomas.
Grommes C
Continuum (Minneap Minn) 2020 Dec;26(6):1476-1494. doi: 10.1212/CON.0000000000000936. PMID: 33273169
Diagnosis and management of primary central nervous system lymphoma.
Han CH, Batchelor TT
Cancer 2017 Nov 15;123(22):4314-4324. Epub 2017 Sep 26 doi: 10.1002/cncr.30965. PMID: 28950405
Painful boney metastases.
Smith HS, Barkin RL
Am J Ther 2014 Mar-Apr;21(2):106-30. doi: 10.1097/MJT.0b013e3182456dff. PMID: 23344095
Painful osseous metastases.
Smith HS
Pain Physician 2011 Jul-Aug;14(4):E373-403. PMID: 21785487

Therapy

Primary central nervous system lymphoma.
Schaff LR, Grommes C
Blood 2022 Sep 1;140(9):971-979. doi: 10.1182/blood.2020008377. PMID: 34699590Free PMC Article
Central Nervous System Lymphomas.
Grommes C
Continuum (Minneap Minn) 2020 Dec;26(6):1476-1494. doi: 10.1212/CON.0000000000000936. PMID: 33273169
Nivolumab versus chemotherapy in patients with advanced oesophageal squamous cell carcinoma refractory or intolerant to previous chemotherapy (ATTRACTION-3): a multicentre, randomised, open-label, phase 3 trial.
Kato K, Cho BC, Takahashi M, Okada M, Lin CY, Chin K, Kadowaki S, Ahn MJ, Hamamoto Y, Doki Y, Yen CC, Kubota Y, Kim SB, Hsu CH, Holtved E, Xynos I, Kodani M, Kitagawa Y
Lancet Oncol 2019 Nov;20(11):1506-1517. Epub 2019 Sep 30 doi: 10.1016/S1470-2045(19)30626-6. PMID: 31582355
Updates on Primary Central Nervous System Lymphoma.
Schaff LR, Grommes C
Curr Oncol Rep 2018 Feb 28;20(2):11. doi: 10.1007/s11912-018-0666-1. PMID: 29492682Free PMC Article
Painful boney metastases.
Smith HS, Barkin RL
Am J Ther 2014 Mar-Apr;21(2):106-30. doi: 10.1097/MJT.0b013e3182456dff. PMID: 23344095

Prognosis

Lymphomas of Central Nervous System.
Yokogami K, Azuma M, Takeshima H, Hirai T
Adv Exp Med Biol 2023;1405:527-543. doi: 10.1007/978-3-031-23705-8_20. PMID: 37452952
Tumor microenvironment remodeling after neoadjuvant immunotherapy in non-small cell lung cancer revealed by single-cell RNA sequencing.
Hu J, Zhang L, Xia H, Yan Y, Zhu X, Sun F, Sun L, Li S, Li D, Wang J, Han Y, Zhang J, Bian D, Yu H, Chen Y, Fan P, Ma Q, Jiang G, Wang C, Zhang P
Genome Med 2023 Mar 3;15(1):14. doi: 10.1186/s13073-023-01164-9. PMID: 36869384Free PMC Article
Primary central nervous system lymphoma.
Schaff LR, Grommes C
Blood 2022 Sep 1;140(9):971-979. doi: 10.1182/blood.2020008377. PMID: 34699590Free PMC Article
Neuromodulation techniques for cancer pain management.
Magee DJ, Schutzer-Weissmann J, Pereira EAC, Brown MRD
Curr Opin Support Palliat Care 2021 Jun 1;15(2):77-83. doi: 10.1097/SPC.0000000000000549. PMID: 33843762
Central Nervous System Lymphomas.
Grommes C
Continuum (Minneap Minn) 2020 Dec;26(6):1476-1494. doi: 10.1212/CON.0000000000000936. PMID: 33273169

Clinical prediction guides

Tumor microenvironment remodeling after neoadjuvant immunotherapy in non-small cell lung cancer revealed by single-cell RNA sequencing.
Hu J, Zhang L, Xia H, Yan Y, Zhu X, Sun F, Sun L, Li S, Li D, Wang J, Han Y, Zhang J, Bian D, Yu H, Chen Y, Fan P, Ma Q, Jiang G, Wang C, Zhang P
Genome Med 2023 Mar 3;15(1):14. doi: 10.1186/s13073-023-01164-9. PMID: 36869384Free PMC Article
Exceptional Cases of Spinal Cord Stimulation for the Treatment of Refractory Cancer-Related Pain.
Bulat E, Chakravarthy V, Crowther J, Rakesh N, Barzilai O, Gulati A
Neuromodulation 2023 Jul;26(5):1051-1058. Epub 2022 Aug 6 doi: 10.1016/j.neurom.2022.06.002. PMID: 35941017
Central Nervous System Lymphomas.
Grommes C
Continuum (Minneap Minn) 2020 Dec;26(6):1476-1494. doi: 10.1212/CON.0000000000000936. PMID: 33273169
Surgical Management and Adjuvant Therapy for Patients With Neurological Deficits From Vertebral Hemangiomas: A Meta-Analysis.
Piper K, Zou L, Li D, Underberg D, Towner J, Chowdhry AK, Li YM
Spine (Phila Pa 1976) 2020 Jan 15;45(2):E99-E110. doi: 10.1097/BRS.0000000000003181. PMID: 31365517
Update on Mechanism and Therapeutic Implications of Spinal Cord Stimulation and Cerebral Hemodynamics: A Narrative Review.
Peppucci E, Di Bonaventura R, Esposito V, Zhong J, Iacopino G, Barbagallo G, Visocchi M
Acta Neurochir Suppl 2017;124:27-36. doi: 10.1007/978-3-319-39546-3_5. PMID: 28120049

Recent systematic reviews

What is the effectiveness of radiofrequency ablation in the management of patients with spinal metastases? A systematic review and meta-analysis.
Murali N, Turmezei T, Bhatti S, Patel P, Marshall T, Smith T
J Orthop Surg Res 2021 Nov 6;16(1):659. doi: 10.1186/s13018-021-02775-x. PMID: 34742319Free PMC Article
Spinal cord stimulation for cancer-related pain in adults.
Peng L, Min S, Zejun Z, Wei K, Bennett MI
Cochrane Database Syst Rev 2015 Jun 29;2015(6):CD009389. doi: 10.1002/14651858.CD009389.pub3. PMID: 26121600Free PMC Article
Spinal cord stimulation for cancer-related pain in adults.
Lihua P, Su M, Zejun Z, Ke W, Bennett MI
Cochrane Database Syst Rev 2013 Feb 28;(2):CD009389. doi: 10.1002/14651858.CD009389.pub2. PMID: 23450600
Bisphosphonates for advanced prostate cancer.
Yuen KK, Shelley M, Sze WM, Wilt T, Mason MD
Cochrane Database Syst Rev 2006 Oct 18;(4):CD006250. doi: 10.1002/14651858.CD006250. PMID: 17054286

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