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Refractory Primary Central Nervous System Neoplasm

MedGen UID:
417096
Concept ID:
C2347924
Neoplastic Process
Synonym: Refractory Primary Central Nervous System Tumor

Definition

A primary central nervous system neoplasm that is resistant to treatment. [from NCI]

Professional guidelines

PubMed

Wu SY, Short NJ, Nasr L, Dabaja BS, Fang PQ
Curr Treat Options Oncol 2022 Dec;23(12):1829-1844. Epub 2022 Dec 13 doi: 10.1007/s11864-022-01032-5. PMID: 36510037Free PMC Article
Apra C, Peyre M, Kalamarides M
Expert Rev Neurother 2018 Mar;18(3):241-249. Epub 2018 Jan 22 doi: 10.1080/14737175.2018.1429920. PMID: 29338455
Goldbrunner R, Minniti G, Preusser M, Jenkinson MD, Sallabanda K, Houdart E, von Deimling A, Stavrinou P, Lefranc F, Lund-Johansen M, Moyal EC, Brandsma D, Henriksson R, Soffietti R, Weller M
Lancet Oncol 2016 Sep;17(9):e383-91. Epub 2016 Aug 30 doi: 10.1016/S1470-2045(16)30321-7. PMID: 27599143

Recent clinical studies

Etiology

Kopmar NE, Cassaday RD
Blood 2023 Mar 23;141(12):1379-1388. doi: 10.1182/blood.2022017035. PMID: 36548957Free PMC Article
Wu SY, Short NJ, Nasr L, Dabaja BS, Fang PQ
Curr Treat Options Oncol 2022 Dec;23(12):1829-1844. Epub 2022 Dec 13 doi: 10.1007/s11864-022-01032-5. PMID: 36510037Free PMC Article
Thastrup M, Duguid A, Mirian C, Schmiegelow K, Halsey C
Leukemia 2022 Dec;36(12):2751-2768. Epub 2022 Oct 20 doi: 10.1038/s41375-022-01714-x. PMID: 36266325Free PMC Article
McFaline-Figueroa JR, Lee EQ
Am J Med 2018 Aug;131(8):874-882. Epub 2018 Jan 31 doi: 10.1016/j.amjmed.2017.12.039. PMID: 29371158
Apra C, Peyre M, Kalamarides M
Expert Rev Neurother 2018 Mar;18(3):241-249. Epub 2018 Jan 22 doi: 10.1080/14737175.2018.1429920. PMID: 29338455

Diagnosis

Kopmar NE, Cassaday RD
Blood 2023 Mar 23;141(12):1379-1388. doi: 10.1182/blood.2022017035. PMID: 36548957Free PMC Article
Thastrup M, Duguid A, Mirian C, Schmiegelow K, Halsey C
Leukemia 2022 Dec;36(12):2751-2768. Epub 2022 Oct 20 doi: 10.1038/s41375-022-01714-x. PMID: 36266325Free PMC Article
Schaff LR, Grommes C
Blood 2022 Sep 1;140(9):971-979. doi: 10.1182/blood.2020008377. PMID: 34699590Free PMC Article
McFaline-Figueroa JR, Lee EQ
Am J Med 2018 Aug;131(8):874-882. Epub 2018 Jan 31 doi: 10.1016/j.amjmed.2017.12.039. PMID: 29371158
Grommes C, DeAngelis LM
J Clin Oncol 2017 Jul 20;35(21):2410-2418. Epub 2017 Jun 22 doi: 10.1200/JCO.2017.72.7602. PMID: 28640701Free PMC Article

Therapy

Sait SF, Giantini-Larsen AM, Tringale KR, Souweidane MM, Karajannis MA
Curr Neurol Neurosci Rep 2023 Apr;23(4):185-199. Epub 2023 Mar 7 doi: 10.1007/s11910-023-01257-3. PMID: 36881254Free PMC Article
Wu SY, Short NJ, Nasr L, Dabaja BS, Fang PQ
Curr Treat Options Oncol 2022 Dec;23(12):1829-1844. Epub 2022 Dec 13 doi: 10.1007/s11864-022-01032-5. PMID: 36510037Free PMC Article
Chen T, Liu Y, Wang Y, Chang Q, Wu J, Wang Z, Geng D, Yu JT, Li Y, Li XQ, Chen H, Zhuang D, Li J, Wang B, Jiang T, Lyu L, Song Y, Qiu X, Li W, Lin S, Zhang X, Lu D, Lei J, Chen Y, Mao Y
J Hematol Oncol 2022 Sep 29;15(1):136. doi: 10.1186/s13045-022-01356-7. PMID: 36176002Free PMC Article
Schaff LR, Grommes C
Blood 2022 Sep 1;140(9):971-979. doi: 10.1182/blood.2020008377. PMID: 34699590Free PMC Article
Grommes C, DeAngelis LM
J Clin Oncol 2017 Jul 20;35(21):2410-2418. Epub 2017 Jun 22 doi: 10.1200/JCO.2017.72.7602. PMID: 28640701Free PMC Article

Prognosis

Thastrup M, Duguid A, Mirian C, Schmiegelow K, Halsey C
Leukemia 2022 Dec;36(12):2751-2768. Epub 2022 Oct 20 doi: 10.1038/s41375-022-01714-x. PMID: 36266325Free PMC Article
Schaff LR, Grommes C
Blood 2022 Sep 1;140(9):971-979. doi: 10.1182/blood.2020008377. PMID: 34699590Free PMC Article
McFaline-Figueroa JR, Lee EQ
Am J Med 2018 Aug;131(8):874-882. Epub 2018 Jan 31 doi: 10.1016/j.amjmed.2017.12.039. PMID: 29371158
Apra C, Peyre M, Kalamarides M
Expert Rev Neurother 2018 Mar;18(3):241-249. Epub 2018 Jan 22 doi: 10.1080/14737175.2018.1429920. PMID: 29338455
Grommes C, DeAngelis LM
J Clin Oncol 2017 Jul 20;35(21):2410-2418. Epub 2017 Jun 22 doi: 10.1200/JCO.2017.72.7602. PMID: 28640701Free PMC Article

Clinical prediction guides

Strickler JH, Yoshino T, Graham RP, Siena S, Bekaii-Saab T
JAMA Oncol 2022 May 1;8(5):760-769. doi: 10.1001/jamaoncol.2021.8196. PMID: 35238866
Frigault MJ, Dietrich J, Gallagher K, Roschewski M, Jordan JT, Forst D, Plotkin SR, Cook D, Casey KS, Lindell KA, Depinho GD, Katsis K, Elder EL, Leick MB, Choi B, Horick N, Preffer F, Saylor M, McAfee S, O'Donnell PV, Spitzer TR, Dey B, DeFilipp Z, El-Jawahri A, Batchelor TT, Maus MV, Chen YB
Blood 2022 Apr 14;139(15):2306-2315. doi: 10.1182/blood.2021014738. PMID: 35167655Free PMC Article
Haroche J, Cohen-Aubart F, Amoura Z
Blood 2020 Apr 16;135(16):1311-1318. doi: 10.1182/blood.2019002766. PMID: 32107533
Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590Free PMC Article
Apra C, Peyre M, Kalamarides M
Expert Rev Neurother 2018 Mar;18(3):241-249. Epub 2018 Jan 22 doi: 10.1080/14737175.2018.1429920. PMID: 29338455

Recent systematic reviews

Vellayappan B, Lim-Fat MJ, Kotecha R, De Salles A, Fariselli L, Levivier M, Ma L, Paddick I, Pollock BE, Regis J, Sheehan JP, Suh JH, Yomo S, Sahgal A
Int J Radiat Oncol Biol Phys 2024 Jan 1;118(1):14-28. Epub 2023 Jul 22 doi: 10.1016/j.ijrobp.2023.07.015. PMID: 37482137
Serioli S, Agostini L, Pietrantoni A, Valeri F, Costanza F, Chiloiro S, Buffoli B, Piazza A, Poliani PL, Peris-Celda M, Iavarone F, Gaudino S, Gessi M, Schinzari G, Mattogno PP, Giampietro A, De Marinis L, Pontecorvi A, Fontanella MM, Lauretti L, Rindi G, Olivi A, Bianchi A, Doglietto F
Int J Mol Sci 2023 Oct 29;24(21) doi: 10.3390/ijms242115719. PMID: 37958702Free PMC Article
Häuser W, Welsch P, Radbruch L, Fisher E, Bell RF, Moore RA
Cochrane Database Syst Rev 2023 Jun 5;6(6):CD014915. doi: 10.1002/14651858.CD014915.pub2. PMID: 37283486Free PMC Article
Asghar N, Masood A, Dhaliwal A, Khurana S, Davis J, Hashmi H, Husnain M
Clin Lymphoma Myeloma Leuk 2023 Jan;23(1):15-21. Epub 2022 Oct 7 doi: 10.1016/j.clml.2022.09.008. PMID: 36328891
Cook MR, Dorris CS, Makambi KH, Luo Y, Munshi PN, Donato M, Rowley S, Saad A, Goy A, Dunleavy K, Ali A
Blood Adv 2023 Jan 10;7(1):32-39. doi: 10.1182/bloodadvances.2022008525. PMID: 36260735Free PMC Article

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