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Pyogenic granuloma

MedGen UID:
39085
•Concept ID:
C0085653
•
Neoplastic Process
Synonyms: Lobular capillary hemangioma; PG
SNOMED CT: PG - Pyogenic granuloma (39629007); Capillary hemangioma of granulation tissue type (17372009); Lobular capillary hemangioma (17372009); Granuloma pyogenicum (17372009); Pyogenic granuloma (17372009); Granuloma telangiectaticum (17372009); Pyogenic granuloma (200722003)
 
Monarch Initiative: MONDO:0022096

Definition

A friable, benign vascular neoplasm with lobular capillary architecture that presents as a raised red skin growth. [from NCI]

Professional guidelines

PubMed

Management of Bleeding Pyogenic Granulomas in Acute Care Settings.
Gaw CE, Treat JR, Friedlaender EY, Del Pizzo J
J Emerg Med 2022 Sep;63(3):339-347. Epub 2022 Oct 6 doi: 10.1016/j.jemermed.2022.04.031. PMID: 36210284
S2k guideline: Laser therapy of the skin.
Paasch U, Zidane M, Baron JM, Bund T, Cappius HJ, Drosner M, Feise K, Fischer T, Gauglitz G, Gerber PA, Grunewald S, Herberger K, Jung A, Karsai S, Kautz G, Philipp C, Schädel D, Seitz AT, Nast A
J Dtsch Dermatol Ges 2022 Sep;20(9):1248-1267. Epub 2022 Sep 13 doi: 10.1111/ddg.14879. PMID: 36098675
Acral melanoma foot lesions. Part 2: clinical presentation, diagnosis, and management.
Desai A, Ugorji R, Khachemoune A
Clin Exp Dermatol 2018 Mar;43(2):117-123. Epub 2017 Dec 13 doi: 10.1111/ced.13323. PMID: 29235153

Recent clinical studies

Etiology

Benign oral mucosal lesions: Clinical and pathological findings.
Maymone MBC, Greer RO, Burdine LK, Dao-Cheng A, Venkatesh S, Sahitya PC, Maymone AC, Kesecker J, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):43-56. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.061. PMID: 30447312
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77. doi: 10.1111/jcpe.12940. PMID: 29926499
Systemic alterations and their oral manifestations in pregnant women.
Silva de Araujo Figueiredo C, Gonçalves Carvalho Rosalem C, Costa Cantanhede AL, Abreu Fonseca Thomaz ÉB, Fontoura Nogueira da Cruz MC
J Obstet Gynaecol Res 2017 Jan;43(1):16-22. doi: 10.1111/jog.13150. PMID: 28074549
Oral health during pregnancy.
Silk H, Douglass AB, Douglass JM, Silk L
Am Fam Physician 2008 Apr 15;77(8):1139-44. PMID: 18481562

Diagnosis

Pyogenic Granuloma.
Komakech D, Ssenkumba B
N Engl J Med 2022 Nov 24;387(21):1979. doi: 10.1056/NEJMicm2204602. PMID: 36416770
Vascular Tumors in Infants: Case Report and Review of Clinical, Histopathologic, and Immunohistochemical Characteristics of Infantile Hemangioma, Pyogenic Granuloma, Noninvoluting Congenital Hemangioma, Tufted Angioma, and Kaposiform Hemangioendothelioma.
Johnson EF, Davis DM, Tollefson MM, Fritchie K, Gibson LE
Am J Dermatopathol 2018 Apr;40(4):231-239. doi: 10.1097/DAD.0000000000000983. PMID: 29561329
Congenital Vascular Tumors.
Goss JA, Greene AK
Otolaryngol Clin North Am 2018 Feb;51(1):89-97. doi: 10.1016/j.otc.2017.09.008. PMID: 29217070
Oral pyogenic granuloma: a review.
Jafarzadeh H, Sanatkhani M, Mohtasham N
J Oral Sci 2006 Dec;48(4):167-75. doi: 10.2334/josnusd.48.167. PMID: 17220613
Pyogenic granuloma.
Lin RL, Janniger CK
Cutis 2004 Oct;74(4):229-33. PMID: 15551715

Therapy

Topical beta-blockers in dermatologic therapy.
Filoni A, Ambrogio F, De Marco A, Pacifico A, Bonamonte D
Dermatol Ther 2021 Jul;34(4):e15016. Epub 2021 Jun 21 doi: 10.1111/dth.15016. PMID: 34075667Free PMC Article
Laryngeal Contact Ulcer.
Barrena BG, Miller TM, Nelson BL
Head Neck Pathol 2020 Dec;14(4):1032-1035. Epub 2020 May 7 doi: 10.1007/s12105-020-01167-7. PMID: 32383044Free PMC Article
Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails.
Lacouture M, Sibaud V
Am J Clin Dermatol 2018 Nov;19(Suppl 1):31-39. doi: 10.1007/s40257-018-0384-3. PMID: 30374901Free PMC Article
Drug-related nail disease.
Piraccini BM, Alessandrini A
Clin Dermatol 2013 Sep-Oct;31(5):618-26. doi: 10.1016/j.clindermatol.2013.06.013. PMID: 24079591
Oral pyogenic granuloma: a review.
Jafarzadeh H, Sanatkhani M, Mohtasham N
J Oral Sci 2006 Dec;48(4):167-75. doi: 10.2334/josnusd.48.167. PMID: 17220613

Prognosis

Pediatric melanoma update.
Mccormack L, Hawryluk EB
G Ital Dermatol Venereol 2018 Oct;153(5):707-715. Epub 2018 Feb 26 doi: 10.23736/S0392-0488.18.05924-2. PMID: 29485257
Systemic alterations and their oral manifestations in pregnant women.
Silva de Araujo Figueiredo C, Gonçalves Carvalho Rosalem C, Costa Cantanhede AL, Abreu Fonseca Thomaz ÉB, Fontoura Nogueira da Cruz MC
J Obstet Gynaecol Res 2017 Jan;43(1):16-22. doi: 10.1111/jog.13150. PMID: 28074549
Nail tumors.
Richert B, Lecerf P, Caucanas M, André J
Clin Dermatol 2013 Sep-Oct;31(5):602-17. doi: 10.1016/j.clindermatol.2013.06.014. PMID: 24079590
Kaposi sarcoma.
Radu O, Pantanowitz L
Arch Pathol Lab Med 2013 Feb;137(2):289-94. doi: 10.5858/arpa.2012-0101-RS. PMID: 23368874
Pyogenic granuloma.
Lin RL, Janniger CK
Cutis 2004 Oct;74(4):229-33. PMID: 15551715

Clinical prediction guides

World Workshop on Oral Medicine VII: Relative frequency of oral mucosal lesions in children, a scoping review.
Hong CHL, Dean DR, Hull K, Hu SJ, Sim YF, Nadeau C, Gonçalves S, Lodi G, Hodgson TA
Oral Dis 2019 Jun;25 Suppl 1:193-203. doi: 10.1111/odi.13112. PMID: 31034120
Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails.
Lacouture M, Sibaud V
Am J Clin Dermatol 2018 Nov;19(Suppl 1):31-39. doi: 10.1007/s40257-018-0384-3. PMID: 30374901Free PMC Article
Systemic alterations and their oral manifestations in pregnant women.
Silva de Araujo Figueiredo C, Gonçalves Carvalho Rosalem C, Costa Cantanhede AL, Abreu Fonseca Thomaz ÉB, Fontoura Nogueira da Cruz MC
J Obstet Gynaecol Res 2017 Jan;43(1):16-22. doi: 10.1111/jog.13150. PMID: 28074549
Drug-related nail disease.
Piraccini BM, Alessandrini A
Clin Dermatol 2013 Sep-Oct;31(5):618-26. doi: 10.1016/j.clindermatol.2013.06.013. PMID: 24079591
Periungual and subungual pyogenic granuloma.
Piraccini BM, Bellavista S, Misciali C, Tosti A, de Berker D, Richert B
Br J Dermatol 2010 Nov;163(5):941-53. doi: 10.1111/j.1365-2133.2010.09906.x. PMID: 20545691

Recent systematic reviews

Acitretin-induced periungual pyogenic granulomas and review.
Thomas M, Shon W, Truong AK
Dermatol Online J 2021 Jul 15;27(7) doi: 10.5070/D327754369. PMID: 34391333
Beta-Blockers for Pyogenic Granuloma: A Systematic Review of Case Reports, Case Series, and Clinical Trials.
Dany M
J Drugs Dermatol 2019 Oct 1;18(10):1006-1010. PMID: 31584779
Therapeutic approaches to pyogenic granuloma: an updated review.
Plachouri KM, Georgiou S
Int J Dermatol 2019 Jun;58(6):642-648. Epub 2018 Oct 21 doi: 10.1111/ijd.14268. PMID: 30345507
Reactive oral lesions associated with dental implants. A systematic review.
Atarbashi-Moghadam F, Atarbashi-Moghadam S, Namdari M, Shahrabi-Farahani S
J Investig Clin Dent 2018 Nov;9(4):e12342. Epub 2018 May 11 doi: 10.1111/jicd.12342. PMID: 29752778
Conjunctival autograft for pterygium.
Clearfield E, Muthappan V, Wang X, Kuo IC
Cochrane Database Syst Rev 2016 Feb 11;2(2):CD011349. doi: 10.1002/14651858.CD011349.pub2. PMID: 26867004Free PMC Article

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