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Neurite dystrophy

MedGen UID:
393211
•Concept ID:
C2674684
•
Finding
Synonym: Dystrophic neurites
 
HPO: HP:0025713

Definition

Dystrophic neurites are abnormal neuronal processes characterized microscopically by aberrant sprouting, dystrophic expansion, and accumulation of various cellular organelles and cytoskeletal/signaling proteins. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeurite dystrophy

Professional guidelines

PubMed

Oral nimodipine treatment has no effect on amyloid pathology or neuritic dystrophy in the 5XFAD mouse model of amyloidosis.
Sadleir KR, Popovic J, Khatri A, Vassar R
PLoS One 2022;17(2):e0263332. Epub 2022 Feb 2 doi: 10.1371/journal.pone.0263332. PMID: 35108319Free PMC Article
Pregabalin Treatment does not Affect Amyloid Pathology in 5XFAD Mice.
Sadleir KR, Popovoic J, Zhu W, Reidel CT, Do H, Silverman RB, Vassar R
Curr Alzheimer Res 2021;18(4):283-297. doi: 10.2174/1567205018666210713125333. PMID: 34259145Free PMC Article
Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations.
Lombardo JA, Stern EA, McLellan ME, Kajdasz ST, Hickey GA, Bacskai BJ, Hyman BT
J Neurosci 2003 Nov 26;23(34):10879-83. doi: 10.1523/JNEUROSCI.23-34-10879.2003. PMID: 14645482Free PMC Article

Recent clinical studies

Etiology

Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model.
Wang S, Mustafa M, Yuede CM, Salazar SV, Kong P, Long H, Ward M, Siddiqui O, Paul R, Gilfillan S, Ibrahim A, Rhinn H, Tassi I, Rosenthal A, Schwabe T, Colonna M
J Exp Med 2020 Sep 7;217(9) doi: 10.1084/jem.20200785. PMID: 32579671Free PMC Article

Therapy

Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model.
Wang S, Mustafa M, Yuede CM, Salazar SV, Kong P, Long H, Ward M, Siddiqui O, Paul R, Gilfillan S, Ibrahim A, Rhinn H, Tassi I, Rosenthal A, Schwabe T, Colonna M
J Exp Med 2020 Sep 7;217(9) doi: 10.1084/jem.20200785. PMID: 32579671Free PMC Article
Cocoa powder triggers neuroprotective and preventive effects in a human Alzheimer's disease model by modulating BDNF signaling pathway.
Cimini A, Gentile R, D'Angelo B, Benedetti E, Cristiano L, Avantaggiati ML, Giordano A, Ferri C, Desideri G
J Cell Biochem 2013 Oct;114(10):2209-20. doi: 10.1002/jcb.24548. PMID: 23554028Free PMC Article

Prognosis

Characterization of neurite dystrophy after trauma by high speed structured illumination microscopy and lattice light sheet microscopy.
Phillips JK, Sherman SA, Cotton KY, Heddleston JM, Taylor AB, Finan JD
J Neurosci Methods 2019 Jan 15;312:154-161. Epub 2018 Dec 6 doi: 10.1016/j.jneumeth.2018.12.005. PMID: 30529411Free PMC Article

Clinical prediction guides

3D compartmented model to study the neurite-related toxicity of Aβ aggregates included in collagen gels of adaptable porosity.
Labour MN, Vigier S, Lerner D, Marcilhac A, Belamie E
Acta Biomater 2016 Jun;37:38-49. Epub 2016 Apr 4 doi: 10.1016/j.actbio.2016.04.001. PMID: 27057929

Supplemental Content

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    Clinical resources

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