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Decreased circulating apolipoprotein C-II concentration

MedGen UID:
395336
•Concept ID:
C1859747
•
Finding
Synonym: Decreased plasma apolipoprotein C-II
 
HPO: HP:0033983

Definition

Reduced concentration of apolipoprotein C-II in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating apolipoprotein C-II concentration

Conditions with this feature

Familial apolipoprotein C-II deficiency
MedGen UID:
328375
•Concept ID:
C1720779
•
Disease or Syndrome
Clinically and biochemically, apoC-II deficiency closely simulates lipoprotein lipase deficiency, or hyperlipoproteinemia type I (238600), and is therefore referred to as hyperlipoproteinemia type IB.
See: Condition Record
Familial apolipoprotein C-II deficiency

Recent clinical studies

Etiology

Inverse association between apolipoprotein C-II and cardiovascular mortality: role of lipoprotein lipase activity modulation.
Silbernagel G, Chen YQ, Rief M, Kleber ME, Hoffmann MM, Stojakovic T, Stang A, Sarzynski MA, Bouchard C, März W, Qian YW, Scharnagl H, Konrad RJ
Eur Heart J 2023 Jul 1;44(25):2335-2345. doi: 10.1093/eurheartj/ehad261. PMID: 37155355
Eggs distinctly modulate plasma carotenoid and lipoprotein subclasses in adult men following a carbohydrate-restricted diet.
Mutungi G, Waters D, Ratliff J, Puglisi M, Clark RM, Volek JS, Fernandez ML
J Nutr Biochem 2010 Apr;21(4):261-7. Epub 2009 Apr 14 doi: 10.1016/j.jnutbio.2008.12.011. PMID: 19369056

Diagnosis

The relationship between high density lipoprotein subclass profile and apolipoprotein concentrations.
Tian L, Fu M
J Endocrinol Invest 2011 Jun;34(6):461-72. doi: 10.1007/BF03346714. PMID: 21747218

Therapy

Eggs distinctly modulate plasma carotenoid and lipoprotein subclasses in adult men following a carbohydrate-restricted diet.
Mutungi G, Waters D, Ratliff J, Puglisi M, Clark RM, Volek JS, Fernandez ML
J Nutr Biochem 2010 Apr;21(4):261-7. Epub 2009 Apr 14 doi: 10.1016/j.jnutbio.2008.12.011. PMID: 19369056

Prognosis

Reduction of plasma triglycerides in apolipoprotein C-II transgenic mice overexpressing lipoprotein lipase in muscle.
Pulawa LK, Jensen DR, Coates A, Eckel RH
J Lipid Res 2007 Jan;48(1):145-51. Epub 2006 Oct 3 doi: 10.1194/jlr.M600384-JLR200. PMID: 17018885

Clinical prediction guides

Inverse association between apolipoprotein C-II and cardiovascular mortality: role of lipoprotein lipase activity modulation.
Silbernagel G, Chen YQ, Rief M, Kleber ME, Hoffmann MM, Stojakovic T, Stang A, Sarzynski MA, Bouchard C, März W, Qian YW, Scharnagl H, Konrad RJ
Eur Heart J 2023 Jul 1;44(25):2335-2345. doi: 10.1093/eurheartj/ehad261. PMID: 37155355
The relationship between high density lipoprotein subclass profile and apolipoprotein concentrations.
Tian L, Fu M
J Endocrinol Invest 2011 Jun;34(6):461-72. doi: 10.1007/BF03346714. PMID: 21747218
Eggs distinctly modulate plasma carotenoid and lipoprotein subclasses in adult men following a carbohydrate-restricted diet.
Mutungi G, Waters D, Ratliff J, Puglisi M, Clark RM, Volek JS, Fernandez ML
J Nutr Biochem 2010 Apr;21(4):261-7. Epub 2009 Apr 14 doi: 10.1016/j.jnutbio.2008.12.011. PMID: 19369056
Reduction of plasma triglycerides in apolipoprotein C-II transgenic mice overexpressing lipoprotein lipase in muscle.
Pulawa LK, Jensen DR, Coates A, Eckel RH
J Lipid Res 2007 Jan;48(1):145-51. Epub 2006 Oct 3 doi: 10.1194/jlr.M600384-JLR200. PMID: 17018885

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