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Pleomorphic Variant Mantle Cell Lymphoma

MedGen UID:
396466
Concept ID:
C2698836
Neoplastic Process

Definition

An aggressive mantle cell lymphoma characterized by the presence of pleomorphic neoplastic B-lymphocytes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPleomorphic Variant Mantle Cell Lymphoma

Recent clinical studies

Etiology

Gerson JN, Handorf E, Villa D, Gerrie AS, Chapani P, Li S, Medeiros LJ, Wang M, Cohen JB, Churnetski M, Hill BT, Sawalha Y, Hernandez-Ilizaliturri FJ, Kothari S, Vose JM, Bast M, Fenske T, Rao Gari SN, Maddocks KJ, Bond D, Bachanova V, Kolla B, Chavez J, Shah B, Lansigan F, Burns T, Donovan AM, Wagner-Johnston N, Messmer M, Mehta A, Anderson JK, Reddy N, Kovach AE, Landsburg DJ, Glenn M, Inwards DJ, Ristow K, Karmali R, Kaplan JB, Caimi PF, Rajguru S, Evens A, Klein A, Umyarova E, Pulluri B, Amengual JE, Lue JK, Diefenbach C, Fisher RI, Barta SK
Blood Adv 2023 Dec 26;7(24):7393-7401. doi: 10.1182/bloodadvances.2023010757. PMID: 37874912Free PMC Article
Wang Y, Jain P, Locke FL, Maurer MJ, Frank MJ, Munoz JL, Dahiya S, Beitinjaneh AM, Jacobs MT, Mcguirk JP, Vose JM, Goy A, Andreadis C, Hill BT, Dorritie KA, Oluwole OO, Deol A, Paludo J, Shah B, Wang T, Banerjee R, Miklos DB, Rapoport AP, Lekakis L, Ghobadi A, Neelapu SS, Lin Y, Wang ML, Jain MD
J Clin Oncol 2023 May 10;41(14):2594-2606. Epub 2023 Feb 8 doi: 10.1200/JCO.22.01797. PMID: 36753699Free PMC Article
Zhang YH, Gao LM, Xiang XY, Zhang WY, Liu WP
Ann Hematol 2022 Oct;101(10):2271-2279. Epub 2022 Aug 3 doi: 10.1007/s00277-022-04922-8. PMID: 35918462
Jain P, Wang M
Hematol Oncol Clin North Am 2020 Oct;34(5):941-956. Epub 2020 Aug 5 doi: 10.1016/j.hoc.2020.06.009. PMID: 32861288
Miao Y, Lin P, Saksena A, Xu J, Wang M, Romaguera J, Yin CC, Medeiros LJ, Li S
Am J Surg Pathol 2019 Aug;43(8):1052-1060. doi: 10.1097/PAS.0000000000001278. PMID: 31045891

Diagnosis

Gerson JN, Handorf E, Villa D, Gerrie AS, Chapani P, Li S, Medeiros LJ, Wang M, Cohen JB, Churnetski M, Hill BT, Sawalha Y, Hernandez-Ilizaliturri FJ, Kothari S, Vose JM, Bast M, Fenske T, Rao Gari SN, Maddocks KJ, Bond D, Bachanova V, Kolla B, Chavez J, Shah B, Lansigan F, Burns T, Donovan AM, Wagner-Johnston N, Messmer M, Mehta A, Anderson JK, Reddy N, Kovach AE, Landsburg DJ, Glenn M, Inwards DJ, Ristow K, Karmali R, Kaplan JB, Caimi PF, Rajguru S, Evens A, Klein A, Umyarova E, Pulluri B, Amengual JE, Lue JK, Diefenbach C, Fisher RI, Barta SK
Blood Adv 2023 Dec 26;7(24):7393-7401. doi: 10.1182/bloodadvances.2023010757. PMID: 37874912Free PMC Article
Zhang YH, Gao LM, Xiang XY, Zhang WY, Liu WP
Ann Hematol 2022 Oct;101(10):2271-2279. Epub 2022 Aug 3 doi: 10.1007/s00277-022-04922-8. PMID: 35918462
Yamamoto N, Maeshima AM, Taniguchi H, Makita S, Fukuhara S, Munakata W, Suzuki T, Maruyama D, Izutsu K
Hum Pathol 2021 May;111:84-91. Epub 2021 Mar 13 doi: 10.1016/j.humpath.2021.03.005. PMID: 33727166
Jain P, Wang M
Hematol Oncol Clin North Am 2020 Oct;34(5):941-956. Epub 2020 Aug 5 doi: 10.1016/j.hoc.2020.06.009. PMID: 32861288
Dreyling M, Klapper W, Rule S
Blood 2018 Dec 27;132(26):2722-2729. Epub 2018 Nov 1 doi: 10.1182/blood-2017-08-737502. PMID: 30385481

Therapy

Gerson JN, Handorf E, Villa D, Gerrie AS, Chapani P, Li S, Medeiros LJ, Wang M, Cohen JB, Churnetski M, Hill BT, Sawalha Y, Hernandez-Ilizaliturri FJ, Kothari S, Vose JM, Bast M, Fenske T, Rao Gari SN, Maddocks KJ, Bond D, Bachanova V, Kolla B, Chavez J, Shah B, Lansigan F, Burns T, Donovan AM, Wagner-Johnston N, Messmer M, Mehta A, Anderson JK, Reddy N, Kovach AE, Landsburg DJ, Glenn M, Inwards DJ, Ristow K, Karmali R, Kaplan JB, Caimi PF, Rajguru S, Evens A, Klein A, Umyarova E, Pulluri B, Amengual JE, Lue JK, Diefenbach C, Fisher RI, Barta SK
Blood Adv 2023 Dec 26;7(24):7393-7401. doi: 10.1182/bloodadvances.2023010757. PMID: 37874912Free PMC Article
Wang Y, Jain P, Locke FL, Maurer MJ, Frank MJ, Munoz JL, Dahiya S, Beitinjaneh AM, Jacobs MT, Mcguirk JP, Vose JM, Goy A, Andreadis C, Hill BT, Dorritie KA, Oluwole OO, Deol A, Paludo J, Shah B, Wang T, Banerjee R, Miklos DB, Rapoport AP, Lekakis L, Ghobadi A, Neelapu SS, Lin Y, Wang ML, Jain MD
J Clin Oncol 2023 May 10;41(14):2594-2606. Epub 2023 Feb 8 doi: 10.1200/JCO.22.01797. PMID: 36753699Free PMC Article
Jain P, Wang M
Hematol Oncol Clin North Am 2020 Oct;34(5):941-956. Epub 2020 Aug 5 doi: 10.1016/j.hoc.2020.06.009. PMID: 32861288
Miao Y, Lin P, Saksena A, Xu J, Wang M, Romaguera J, Yin CC, Medeiros LJ, Li S
Am J Surg Pathol 2019 Aug;43(8):1052-1060. doi: 10.1097/PAS.0000000000001278. PMID: 31045891
Dreyling M, Klapper W, Rule S
Blood 2018 Dec 27;132(26):2722-2729. Epub 2018 Nov 1 doi: 10.1182/blood-2017-08-737502. PMID: 30385481

Prognosis

Gerson JN, Handorf E, Villa D, Gerrie AS, Chapani P, Li S, Medeiros LJ, Wang M, Cohen JB, Churnetski M, Hill BT, Sawalha Y, Hernandez-Ilizaliturri FJ, Kothari S, Vose JM, Bast M, Fenske T, Rao Gari SN, Maddocks KJ, Bond D, Bachanova V, Kolla B, Chavez J, Shah B, Lansigan F, Burns T, Donovan AM, Wagner-Johnston N, Messmer M, Mehta A, Anderson JK, Reddy N, Kovach AE, Landsburg DJ, Glenn M, Inwards DJ, Ristow K, Karmali R, Kaplan JB, Caimi PF, Rajguru S, Evens A, Klein A, Umyarova E, Pulluri B, Amengual JE, Lue JK, Diefenbach C, Fisher RI, Barta SK
Blood Adv 2023 Dec 26;7(24):7393-7401. doi: 10.1182/bloodadvances.2023010757. PMID: 37874912Free PMC Article
Wang Y, Jain P, Locke FL, Maurer MJ, Frank MJ, Munoz JL, Dahiya S, Beitinjaneh AM, Jacobs MT, Mcguirk JP, Vose JM, Goy A, Andreadis C, Hill BT, Dorritie KA, Oluwole OO, Deol A, Paludo J, Shah B, Wang T, Banerjee R, Miklos DB, Rapoport AP, Lekakis L, Ghobadi A, Neelapu SS, Lin Y, Wang ML, Jain MD
J Clin Oncol 2023 May 10;41(14):2594-2606. Epub 2023 Feb 8 doi: 10.1200/JCO.22.01797. PMID: 36753699Free PMC Article
Zhang YH, Gao LM, Xiang XY, Zhang WY, Liu WP
Ann Hematol 2022 Oct;101(10):2271-2279. Epub 2022 Aug 3 doi: 10.1007/s00277-022-04922-8. PMID: 35918462
Jain P, Wang M
Hematol Oncol Clin North Am 2020 Oct;34(5):941-956. Epub 2020 Aug 5 doi: 10.1016/j.hoc.2020.06.009. PMID: 32861288
Dreyling M, Klapper W, Rule S
Blood 2018 Dec 27;132(26):2722-2729. Epub 2018 Nov 1 doi: 10.1182/blood-2017-08-737502. PMID: 30385481

Clinical prediction guides

Gerson JN, Handorf E, Villa D, Gerrie AS, Chapani P, Li S, Medeiros LJ, Wang M, Cohen JB, Churnetski M, Hill BT, Sawalha Y, Hernandez-Ilizaliturri FJ, Kothari S, Vose JM, Bast M, Fenske T, Rao Gari SN, Maddocks KJ, Bond D, Bachanova V, Kolla B, Chavez J, Shah B, Lansigan F, Burns T, Donovan AM, Wagner-Johnston N, Messmer M, Mehta A, Anderson JK, Reddy N, Kovach AE, Landsburg DJ, Glenn M, Inwards DJ, Ristow K, Karmali R, Kaplan JB, Caimi PF, Rajguru S, Evens A, Klein A, Umyarova E, Pulluri B, Amengual JE, Lue JK, Diefenbach C, Fisher RI, Barta SK
Blood Adv 2023 Dec 26;7(24):7393-7401. doi: 10.1182/bloodadvances.2023010757. PMID: 37874912Free PMC Article
Zhang YH, Gao LM, Xiang XY, Zhang WY, Liu WP
Ann Hematol 2022 Oct;101(10):2271-2279. Epub 2022 Aug 3 doi: 10.1007/s00277-022-04922-8. PMID: 35918462
Yamamoto N, Maeshima AM, Taniguchi H, Makita S, Fukuhara S, Munakata W, Suzuki T, Maruyama D, Izutsu K
Hum Pathol 2021 May;111:84-91. Epub 2021 Mar 13 doi: 10.1016/j.humpath.2021.03.005. PMID: 33727166
Chuang WY, Chang H, Chang GJ, Wang TH, Chang YS, Wang TH, Yeh CJ, Ueng SH, Chien HP, Chang CY, Wan YL, Hsueh C
Histopathology 2017 May;70(6):986-999. Epub 2017 Mar 10 doi: 10.1111/his.13161. PMID: 28032914
Zoldan MC, Inghirami G, Masuda Y, Vandekerckhove F, Raphael B, Amorosi E, Hymes K, Frizzera G
Br J Haematol 1996 May;93(2):475-86. doi: 10.1046/j.1365-2141.1996.5421085.x. PMID: 8639452

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