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Pleomorphic Variant Mantle Cell Lymphoma

MedGen UID:
396466
•Concept ID:
C2698836
•
Neoplastic Process

Definition

An aggressive mantle cell lymphoma characterized by the presence of pleomorphic neoplastic B-lymphocytes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPleomorphic Variant Mantle Cell Lymphoma

Recent clinical studies

Etiology

Brexucabtagene Autoleucel for Relapsed or Refractory Mantle Cell Lymphoma in Standard-of-Care Practice: Results From the US Lymphoma CAR T Consortium.
Wang Y, Jain P, Locke FL, Maurer MJ, Frank MJ, Munoz JL, Dahiya S, Beitinjaneh AM, Jacobs MT, Mcguirk JP, Vose JM, Goy A, Andreadis C, Hill BT, Dorritie KA, Oluwole OO, Deol A, Paludo J, Shah B, Wang T, Banerjee R, Miklos DB, Rapoport AP, Lekakis L, Ghobadi A, Neelapu SS, Lin Y, Wang ML, Jain MD
J Clin Oncol 2023 May 10;41(14):2594-2606. Epub 2023 Feb 8 doi: 10.1200/JCO.22.01797. PMID: 36753699Free PMC Article
Prognostic value and computer image analysis of p53 in mantle cell lymphoma.
Zhang YH, Gao LM, Xiang XY, Zhang WY, Liu WP
Ann Hematol 2022 Oct;101(10):2271-2279. Epub 2022 Aug 3 doi: 10.1007/s00277-022-04922-8. PMID: 35918462
Blastoid Mantle Cell Lymphoma.
Jain P, Wang M
Hematol Oncol Clin North Am 2020 Oct;34(5):941-956. Epub 2020 Aug 5 doi: 10.1016/j.hoc.2020.06.009. PMID: 32861288
Mantle Cell Lymphoma Involving Skin: A Clinicopathologic Study of 37 Cases.
Kim DH, Medeiros LJ, Aung PP, Young KH, Miranda RN, Ok CY
Am J Surg Pathol 2019 Oct;43(10):1421-1428. doi: 10.1097/PAS.0000000000001312. PMID: 31219818
CD5-negative Mantle Cell Lymphoma: Clinicopathologic Correlations and Outcome in 58 Patients.
Miao Y, Lin P, Saksena A, Xu J, Wang M, Romaguera J, Yin CC, Medeiros LJ, Li S
Am J Surg Pathol 2019 Aug;43(8):1052-1060. doi: 10.1097/PAS.0000000000001278. PMID: 31045891

Diagnosis

Prognostic value and computer image analysis of p53 in mantle cell lymphoma.
Zhang YH, Gao LM, Xiang XY, Zhang WY, Liu WP
Ann Hematol 2022 Oct;101(10):2271-2279. Epub 2022 Aug 3 doi: 10.1007/s00277-022-04922-8. PMID: 35918462
CD5-negative blastoid variant mantle cell lymphoma: a diagnostic dilemma.
Yamamoto N, Maeshima AM, Taniguchi H, Makita S, Fukuhara S, Munakata W, Suzuki T, Maruyama D, Izutsu K
Hum Pathol 2021 May;111:84-91. Epub 2021 Mar 13 doi: 10.1016/j.humpath.2021.03.005. PMID: 33727166
Blastoid Mantle Cell Lymphoma.
Jain P, Wang M
Hematol Oncol Clin North Am 2020 Oct;34(5):941-956. Epub 2020 Aug 5 doi: 10.1016/j.hoc.2020.06.009. PMID: 32861288
CD5-negative Mantle Cell Lymphoma: Clinicopathologic Correlations and Outcome in 58 Patients.
Miao Y, Lin P, Saksena A, Xu J, Wang M, Romaguera J, Yin CC, Medeiros LJ, Li S
Am J Surg Pathol 2019 Aug;43(8):1052-1060. doi: 10.1097/PAS.0000000000001278. PMID: 31045891
Blastoid and pleomorphic mantle cell lymphoma: still a diagnostic and therapeutic challenge!
Dreyling M, Klapper W, Rule S
Blood 2018 Dec 27;132(26):2722-2729. Epub 2018 Nov 1 doi: 10.1182/blood-2017-08-737502. PMID: 30385481

Therapy

Brexucabtagene Autoleucel for Relapsed or Refractory Mantle Cell Lymphoma in Standard-of-Care Practice: Results From the US Lymphoma CAR T Consortium.
Wang Y, Jain P, Locke FL, Maurer MJ, Frank MJ, Munoz JL, Dahiya S, Beitinjaneh AM, Jacobs MT, Mcguirk JP, Vose JM, Goy A, Andreadis C, Hill BT, Dorritie KA, Oluwole OO, Deol A, Paludo J, Shah B, Wang T, Banerjee R, Miklos DB, Rapoport AP, Lekakis L, Ghobadi A, Neelapu SS, Lin Y, Wang ML, Jain MD
J Clin Oncol 2023 May 10;41(14):2594-2606. Epub 2023 Feb 8 doi: 10.1200/JCO.22.01797. PMID: 36753699Free PMC Article
From the archives of MD Anderson Cancer Center: Untreated leukemic non-nodal mantle cell lymphoma with relapse as pleomorphic variant mantle cell lymphoma 21 years later.
Fang H, Medeiros LJ, Tang Z, Wang W, Ok CY, Patel KP, Khoury JD, Thakral B
Ann Diagn Pathol 2021 Feb;50:151649. Epub 2020 Oct 24 doi: 10.1016/j.anndiagpath.2020.151649. PMID: 33189964
Blastoid Mantle Cell Lymphoma.
Jain P, Wang M
Hematol Oncol Clin North Am 2020 Oct;34(5):941-956. Epub 2020 Aug 5 doi: 10.1016/j.hoc.2020.06.009. PMID: 32861288
CD5-negative Mantle Cell Lymphoma: Clinicopathologic Correlations and Outcome in 58 Patients.
Miao Y, Lin P, Saksena A, Xu J, Wang M, Romaguera J, Yin CC, Medeiros LJ, Li S
Am J Surg Pathol 2019 Aug;43(8):1052-1060. doi: 10.1097/PAS.0000000000001278. PMID: 31045891
Blastoid and pleomorphic mantle cell lymphoma: still a diagnostic and therapeutic challenge!
Dreyling M, Klapper W, Rule S
Blood 2018 Dec 27;132(26):2722-2729. Epub 2018 Nov 1 doi: 10.1182/blood-2017-08-737502. PMID: 30385481

Prognosis

Brexucabtagene Autoleucel for Relapsed or Refractory Mantle Cell Lymphoma in Standard-of-Care Practice: Results From the US Lymphoma CAR T Consortium.
Wang Y, Jain P, Locke FL, Maurer MJ, Frank MJ, Munoz JL, Dahiya S, Beitinjaneh AM, Jacobs MT, Mcguirk JP, Vose JM, Goy A, Andreadis C, Hill BT, Dorritie KA, Oluwole OO, Deol A, Paludo J, Shah B, Wang T, Banerjee R, Miklos DB, Rapoport AP, Lekakis L, Ghobadi A, Neelapu SS, Lin Y, Wang ML, Jain MD
J Clin Oncol 2023 May 10;41(14):2594-2606. Epub 2023 Feb 8 doi: 10.1200/JCO.22.01797. PMID: 36753699Free PMC Article
Blastoid Mantle Cell Lymphoma.
Jain P, Wang M
Hematol Oncol Clin North Am 2020 Oct;34(5):941-956. Epub 2020 Aug 5 doi: 10.1016/j.hoc.2020.06.009. PMID: 32861288
Mantle Cell Lymphoma Involving Skin: A Clinicopathologic Study of 37 Cases.
Kim DH, Medeiros LJ, Aung PP, Young KH, Miranda RN, Ok CY
Am J Surg Pathol 2019 Oct;43(10):1421-1428. doi: 10.1097/PAS.0000000000001312. PMID: 31219818
CD5-negative Mantle Cell Lymphoma: Clinicopathologic Correlations and Outcome in 58 Patients.
Miao Y, Lin P, Saksena A, Xu J, Wang M, Romaguera J, Yin CC, Medeiros LJ, Li S
Am J Surg Pathol 2019 Aug;43(8):1052-1060. doi: 10.1097/PAS.0000000000001278. PMID: 31045891
Blastoid and pleomorphic mantle cell lymphoma: still a diagnostic and therapeutic challenge!
Dreyling M, Klapper W, Rule S
Blood 2018 Dec 27;132(26):2722-2729. Epub 2018 Nov 1 doi: 10.1182/blood-2017-08-737502. PMID: 30385481

Clinical prediction guides

Prognostic value and computer image analysis of p53 in mantle cell lymphoma.
Zhang YH, Gao LM, Xiang XY, Zhang WY, Liu WP
Ann Hematol 2022 Oct;101(10):2271-2279. Epub 2022 Aug 3 doi: 10.1007/s00277-022-04922-8. PMID: 35918462
CD5-negative blastoid variant mantle cell lymphoma: a diagnostic dilemma.
Yamamoto N, Maeshima AM, Taniguchi H, Makita S, Fukuhara S, Munakata W, Suzuki T, Maruyama D, Izutsu K
Hum Pathol 2021 May;111:84-91. Epub 2021 Mar 13 doi: 10.1016/j.humpath.2021.03.005. PMID: 33727166
Pleomorphic mantle cell lymphoma morphologically mimicking diffuse large B cell lymphoma: common cyclin D1 negativity and a simple immunohistochemical algorithm to avoid the diagnostic pitfall.
Chuang WY, Chang H, Chang GJ, Wang TH, Chang YS, Wang TH, Yeh CJ, Ueng SH, Chien HP, Chang CY, Wan YL, Hsueh C
Histopathology 2017 May;70(6):986-999. Epub 2017 Mar 10 doi: 10.1111/his.13161. PMID: 28032914
Transformation of indolent mantle cell lymphoma to pleomorphic mantle cell lymphoma: case report and review of clinical and morphologic variants.
Kiel MJ, Smith LB
Arch Pathol Lab Med 2012 Aug;136(8):871-5. doi: 10.5858/arpa.2012-0197-CR. PMID: 22849733
Large-cell variants of mantle cell lymphoma: cytologic characteristics and p53 anomalies may predict poor outcome.
Zoldan MC, Inghirami G, Masuda Y, Vandekerckhove F, Raphael B, Amorosi E, Hymes K, Frizzera G
Br J Haematol 1996 May;93(2):475-86. doi: 10.1046/j.1365-2141.1996.5421085.x. PMID: 8639452

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