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B Acute Lymphoblastic Leukemia with t(12;21)(p13.2;q22.1); ETV6-RUNX1

MedGen UID:
396855
•Concept ID:
C2698305
•
Neoplastic Process
Synonyms: B Acute Lymphoblastic Leukemia with ETV6-RUNX1 Fusion; B Acute Lymphoblastic Leukemia with ETV6::RUNX1 Fusion; B Acute Lymphoblastic Leukemia with t(12;21)(p13.2;q22.1); ETV6::RUNX1; B Acute Lymphoblastic Leukemia with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1); B-Acute Lymphoblastic Leukemia with ETV6-RUNX1 Fusion; B-Acute Lymphoblastic Leukemia with ETV6::RUNX1 Fusion; B-Acute Lymphoblastic Leukemia with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1); B-ALL with t(12;21)(p13.2;q22.1)/ETV6-RUNX1; B-ALL with t(12;21)(p13.2;q22.1); ETV6-RUNX1; B-Cell Acute Lymphoblastic Leukemia with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1)

Definition

A B-cell acute leukemia characterized by the presence of lymphoblasts that carry a translocation between the TEL gene on chromosome 12 and the AML1 gene on chromosome 21, (p13.2;q22.1). It results in the production of the TEL-AML1 (ETV6-RUNX1) fusion protein. It is commonly seen in children and rarely in adults. It has a favorable clinical outcome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVB Acute Lymphoblastic Leukemia with t(12;21)(p13.2;q22.1); ETV6-RUNX1

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