B Acute Lymphoblastic Leukemia with t(12;21)(p13.2;q22.1); ETV6-RUNX1

MedGen UID:: 396855
•Concept ID:: C2698305
•: Neoplastic Process

Synonyms:

B Acute Lymphoblastic Leukemia with t(12;21)(p13.2;q22.1); ETV6::RUNX1; B Acute Lymphoblastic Leukemia with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1); B-Acute Lymphoblastic Leukemia with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1); B-Cell Acute Lymphoblastic Leukemia with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1)

Definition

A B-cell acute leukemia characterized by the presence of lymphoblasts that carry a translocation between the TEL gene on chromosome 12 and the AML1 gene on chromosome 21, (p13.2;q22.1). It results in the production of the TEL-AML1 (ETV6-RUNX1) fusion protein. It is commonly seen in children and rarely in adults. It has a favorable clinical outcome. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVB Acute Lymphoblastic Leukemia with t(12;21)(p13.2;q22.1); ETV6-RUNX1

B-cell lymphoma
- B-cell lymphoma
  - B-cell lymphoma
    - B Lymphoblastic Leukemia/Lymphoma
      - B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality
        B lymphoblastic leukemia lymphoma with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1)
        B Acute Lymphoblastic Leukemia with t(12;21)(p13.2;q22.1); ETV6-RUNX1

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B Acute Lymphoblastic Leukemia with t(12;21)(p13.2;q22.1); ETV6-RUNX1

Definition

Term Hierarchy

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