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Pediatric Nodal Marginal Zone Lymphoma

MedGen UID:
397258
•Concept ID:
C2698751
•
Neoplastic Process
Synonyms: Childhood Nodal Marginal Zone Lymphoma; Pediatric nodal marginal zone lymphoma
SNOMED CT: Pediatric nodal marginal zone lymphoma (733860007)

Definition

A nodal marginal zone lymphoma affecting the pediatric population, predominantly males. It presents with asymptomatic and localized (mainly head and neck) disease in the vast majority of cases. Morphologically there is often progressive transformation of the germinal centers. The prognosis is excellent. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPediatric Nodal Marginal Zone Lymphoma

Professional guidelines

PubMed

Diagnosis and management of rare paediatric Non-Hodgkin lymphoma.
Xavier AC, Suzuki R, Attarbaschi A
Best Pract Res Clin Haematol 2023 Mar;36(1):101440. Epub 2023 Jan 15 doi: 10.1016/j.beha.2023.101440. PMID: 36907633
Positron emission tomography/magnetic resonance imaging (PET/MRI) vs. gastroscopy: Can it improve detection of extranodal marginal zone lymphomas of the stomach following H. pylori treatment?
Raderer M, Kiesewetter B, Mayerhoefer ME
Expert Rev Hematol 2022 Jul;15(7):565-571. Epub 2022 Jun 21 doi: 10.1080/17474086.2022.2089110. PMID: 35695746Free PMC Article
Nodal marginal zone lymphoma: Clinical features, diagnosis, management and treatment.
Tadmor T, Polliack A
Best Pract Res Clin Haematol 2017 Mar-Jun;30(1-2):92-98. Epub 2016 Nov 4 doi: 10.1016/j.beha.2016.08.026. PMID: 28288722

Recent clinical studies

Etiology

Pediatric-Type Indolent B-Cell Lymphomas With Overlapping Clinical, Pathologic, and Genetic Features.
Lim S, Lim KY, Koh J, Bae JM, Yun H, Lee C, Kim YA, Paik JH, Jeon YK
Am J Surg Pathol 2022 Oct 1;46(10):1397-1406. Epub 2022 Jul 14 doi: 10.1097/PAS.0000000000001932. PMID: 35834399Free PMC Article

Diagnosis

The many faces of nodal and splenic marginal zone lymphomas. A report of the 2022 EA4HP/SH lymphoma workshop.
Zamò A, van den Brand M, Climent F, de Leval L, Dirnhofer S, Leoncini L, Ng SB, Ondrejka SL, Quintanilla-Martinez L, Soma L, Wotherspoon A
Virchows Arch 2023 Sep;483(3):317-331. Epub 2023 Sep 1 doi: 10.1007/s00428-023-03633-3. PMID: 37656249Free PMC Article
Comparison of histological and molecular features of pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma.
Lee J, Han JH, Lee CH, Park HS, Min SK, Lee H, Cho U, Yoon SE, Kim SJ, Kim WS, Cho J
Virchows Arch 2023 May;482(5):849-858. Epub 2023 Jan 19 doi: 10.1007/s00428-023-03493-x. PMID: 36656392
Rare mature B-cell lymphomas in children and adolescents.
Woessmann W, Quintanilla-Martinez L
Hematol Oncol 2019 Jun;37 Suppl 1:53-61. doi: 10.1002/hon.2585. PMID: 31187530
Pediatric-type Follicular Lymphoma and Pediatric Nodal Marginal Zone Lymphoma: Recent Clinical, Morphologic, Immunophenotypic, and Genetic Insights.
Koo M, Ohgami RS
Adv Anat Pathol 2017 May;24(3):128-135. doi: 10.1097/PAP.0000000000000144. PMID: 28277421
Indolent lymphomas in the pediatric population: follicular lymphoma, IRF4/MUM1+ lymphoma, nodal marginal zone lymphoma and chronic lymphocytic leukemia.
Quintanilla-Martinez L, Sander B, Chan JK, Xerri L, Ott G, Campo E, Swerdlow SH
Virchows Arch 2016 Feb;468(2):141-57. Epub 2015 Sep 28 doi: 10.1007/s00428-015-1855-z. PMID: 26416032

Therapy

Pediatric nodal marginal zone lymphoma may develop in the adult population.
Gitelson E, Al-Saleem T, Robu V, Millenson MM, Smith MR
Leuk Lymphoma 2010 Jan;51(1):89-94. doi: 10.3109/10428190903349670. PMID: 19863176Free PMC Article

Prognosis

Rare mature B-cell lymphomas in children and adolescents.
Woessmann W, Quintanilla-Martinez L
Hematol Oncol 2019 Jun;37 Suppl 1:53-61. doi: 10.1002/hon.2585. PMID: 31187530
Pediatric-type Follicular Lymphoma and Pediatric Nodal Marginal Zone Lymphoma: Recent Clinical, Morphologic, Immunophenotypic, and Genetic Insights.
Koo M, Ohgami RS
Adv Anat Pathol 2017 May;24(3):128-135. doi: 10.1097/PAP.0000000000000144. PMID: 28277421
Pediatric nodal marginal zone lymphoma may develop in the adult population.
Gitelson E, Al-Saleem T, Robu V, Millenson MM, Smith MR
Leuk Lymphoma 2010 Jan;51(1):89-94. doi: 10.3109/10428190903349670. PMID: 19863176Free PMC Article

Clinical prediction guides

Pediatric-Type Indolent B-Cell Lymphomas With Overlapping Clinical, Pathologic, and Genetic Features.
Lim S, Lim KY, Koh J, Bae JM, Yun H, Lee C, Kim YA, Paik JH, Jeon YK
Am J Surg Pathol 2022 Oct 1;46(10):1397-1406. Epub 2022 Jul 14 doi: 10.1097/PAS.0000000000001932. PMID: 35834399Free PMC Article
A study of the mutational landscape of pediatric-type follicular lymphoma and pediatric nodal marginal zone lymphoma.
Ozawa MG, Bhaduri A, Chisholm KM, Baker SA, Ma L, Zehnder JL, Luna-Fineman S, Link MP, Merker JD, Arber DA, Ohgami RS
Mod Pathol 2016 Oct;29(10):1212-20. Epub 2016 Jun 24 doi: 10.1038/modpathol.2016.102. PMID: 27338637Free PMC Article

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