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Corneal Endothelial Cell Loss

MedGen UID:
404624
•Concept ID:
C2717756
•
Finding
Synonyms: Corneal Endothelial Cell Damage; Endothelial Cell Loss, Corneal

Definition

A decrease in corneal endothelial cell density. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCorneal Endothelial Cell Loss

Professional guidelines

PubMed

A prospective evaluation of photorefractive intrastromal cross-linking for the treatment of low-grade myopia.
Fredriksson A, Näslund S, Behndig A
Acta Ophthalmol 2020 Mar;98(2):201-206. Epub 2019 Jul 12 doi: 10.1111/aos.14190. PMID: 31301105

Recent clinical studies

Etiology

Corneal endothelial cell damage after scleral fixation of intraocular lens surgery.
Jo YJ, Lee JS, Byon IS, Lee JE, Park SW
Jpn J Ophthalmol 2022 Jan;66(1):68-73. Epub 2021 Nov 9 doi: 10.1007/s10384-021-00884-y. PMID: 34751858
Corneal Endothelial Cell Loss After Endocapsular and Supracapsular Phacoemulsification: The PERCEPOLIS Randomized Clinical Trial.
Perone JM, Ghetemme C, Zevering Y, Zaidi M, Ouamara N, Goetz C, Lhuillier L
Cornea 2022 Jun 1;41(6):714-721. Epub 2021 Nov 2 doi: 10.1097/ICO.0000000000002822. PMID: 34732666
Corneal Endothelial Cell Loss after Baerveldt Glaucoma Implant Surgery.
Hau S, Bunce C, Barton K
Ophthalmol Glaucoma 2021 Jan-Feb;4(1):20-31. Epub 2020 Jul 4 doi: 10.1016/j.ogla.2020.06.012. PMID: 32830103
Long-Term Maintenance of Corneal Endothelial Cell Density After Corneal Transplantation.
Kayukawa K, Kitazawa K, Wakimasu K, Patel SV, Bush J, Sotozono C, Kinoshita S
Cornea 2020 Dec;39(12):1510-1515. doi: 10.1097/ICO.0000000000002386. PMID: 32482965
Corneal endothelial cell loss after pars plana vitrectomy and combined phacoemulsification-vitrectomy surgeries.
Koushan K, Mikhail M, Beattie A, Ahuja N, Liszauer A, Kobetz L, Farrokhyar F, Martin JA
Can J Ophthalmol 2017 Feb;52(1):4-8. Epub 2016 Oct 1 doi: 10.1016/j.jcjo.2016.06.001. PMID: 28237147

Diagnosis

Corneal Endothelial Cell Density Loss after Glaucoma Surgery Alone or in Combination with Cataract Surgery: A Systematic Review and Meta-analysis.
Fang CEH, Mathew RG, Khaw PT, Henein C
Ophthalmology 2022 Aug;129(8):841-855. Epub 2022 Mar 22 doi: 10.1016/j.ophtha.2022.03.015. PMID: 35331751
Corneal endothelial cell damage after scleral fixation of intraocular lens surgery.
Jo YJ, Lee JS, Byon IS, Lee JE, Park SW
Jpn J Ophthalmol 2022 Jan;66(1):68-73. Epub 2021 Nov 9 doi: 10.1007/s10384-021-00884-y. PMID: 34751858
Corneal Endothelial Cell Loss After Endocapsular and Supracapsular Phacoemulsification: The PERCEPOLIS Randomized Clinical Trial.
Perone JM, Ghetemme C, Zevering Y, Zaidi M, Ouamara N, Goetz C, Lhuillier L
Cornea 2022 Jun 1;41(6):714-721. Epub 2021 Nov 2 doi: 10.1097/ICO.0000000000002822. PMID: 34732666
Phase 3, Randomized, 20-Month Study of Bimatoprost Implant in Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 1).
Medeiros FA, Walters TR, Kolko M, Coote M, Bejanian M, Goodkin ML, Guo Q, Zhang J, Robinson MR, Weinreb RN; ARTEMIS 1 Study Group
Ophthalmology 2020 Dec;127(12):1627-1641. Epub 2020 Jun 13 doi: 10.1016/j.ophtha.2020.06.018. PMID: 32544560
Corneal endothelial cell loss after pars plana vitrectomy and combined phacoemulsification-vitrectomy surgeries.
Koushan K, Mikhail M, Beattie A, Ahuja N, Liszauer A, Kobetz L, Farrokhyar F, Martin JA
Can J Ophthalmol 2017 Feb;52(1):4-8. Epub 2016 Oct 1 doi: 10.1016/j.jcjo.2016.06.001. PMID: 28237147

Therapy

Corneal Endothelial Cell Density Loss after Glaucoma Surgery Alone or in Combination with Cataract Surgery: A Systematic Review and Meta-analysis.
Fang CEH, Mathew RG, Khaw PT, Henein C
Ophthalmology 2022 Aug;129(8):841-855. Epub 2022 Mar 22 doi: 10.1016/j.ophtha.2022.03.015. PMID: 35331751
Phase 3, Randomized, 20-Month Study of the Efficacy and Safety of Bimatoprost Implant in Patients with Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 2).
Bacharach J, Tatham A, Ferguson G, Belalcázar S, Thieme H, Goodkin ML, Chen MY, Guo Q, Liu J, Robinson MR, Bejanian M, Wirta DL; ARTEMIS 2 Study Group
Drugs 2021 Nov;81(17):2017-2033. Epub 2021 Nov 1 doi: 10.1007/s40265-021-01624-9. PMID: 34724172Free PMC Article
Cannabis and the Cornea.
Nguyen AX, Wu AY
Ocul Immunol Inflamm 2021 Jul 4;29(5):1023-1028. Epub 2020 Mar 11 doi: 10.1080/09273948.2020.1726969. PMID: 32159404Free PMC Article
Phase 3, Randomized, 20-Month Study of Bimatoprost Implant in Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 1).
Medeiros FA, Walters TR, Kolko M, Coote M, Bejanian M, Goodkin ML, Guo Q, Zhang J, Robinson MR, Weinreb RN; ARTEMIS 1 Study Group
Ophthalmology 2020 Dec;127(12):1627-1641. Epub 2020 Jun 13 doi: 10.1016/j.ophtha.2020.06.018. PMID: 32544560
Progress in corneal wound healing.
Ljubimov AV, Saghizadeh M
Prog Retin Eye Res 2015 Nov;49:17-45. Epub 2015 Jul 18 doi: 10.1016/j.preteyeres.2015.07.002. PMID: 26197361Free PMC Article

Prognosis

Endothelial Keratoplasty Update 2020.
Price MO, Feng MT, Price FW Jr
Cornea 2021 May 1;40(5):541-547. doi: 10.1097/ICO.0000000000002565. PMID: 33252380
Three-Year Findings of the HORIZON Trial: A Schlemm Canal Microstent for Pressure Reduction in Primary Open-Angle Glaucoma and Cataract.
Ahmed IIK, Rhee DJ, Jones J, Singh IP, Radcliffe N, Gazzard G, Samuelson TW, Ong J, Singh K; HORIZON Investigators
Ophthalmology 2021 Jun;128(6):857-865. Epub 2020 Nov 6 doi: 10.1016/j.ophtha.2020.11.004. PMID: 33166551
Corneal Endothelial Cell Loss after Baerveldt Glaucoma Implant Surgery.
Hau S, Bunce C, Barton K
Ophthalmol Glaucoma 2021 Jan-Feb;4(1):20-31. Epub 2020 Jul 4 doi: 10.1016/j.ogla.2020.06.012. PMID: 32830103
Corneal endothelial cell loss after pars plana vitrectomy and combined phacoemulsification-vitrectomy surgeries.
Koushan K, Mikhail M, Beattie A, Ahuja N, Liszauer A, Kobetz L, Farrokhyar F, Martin JA
Can J Ophthalmol 2017 Feb;52(1):4-8. Epub 2016 Oct 1 doi: 10.1016/j.jcjo.2016.06.001. PMID: 28237147
Progress in corneal wound healing.
Ljubimov AV, Saghizadeh M
Prog Retin Eye Res 2015 Nov;49:17-45. Epub 2015 Jul 18 doi: 10.1016/j.preteyeres.2015.07.002. PMID: 26197361Free PMC Article

Clinical prediction guides

Endothelial Keratoplasty Update 2020.
Price MO, Feng MT, Price FW Jr
Cornea 2021 May 1;40(5):541-547. doi: 10.1097/ICO.0000000000002565. PMID: 33252380
Cannabis and the Cornea.
Nguyen AX, Wu AY
Ocul Immunol Inflamm 2021 Jul 4;29(5):1023-1028. Epub 2020 Mar 11 doi: 10.1080/09273948.2020.1726969. PMID: 32159404Free PMC Article
Long-term (≥10 years) results of corneal endothelial cell loss after cataract surgery.
Choi JY, Han YK
Can J Ophthalmol 2019 Aug;54(4):438-444. Epub 2018 Nov 10 doi: 10.1016/j.jcjo.2018.08.005. PMID: 31358141
Corneal endothelial cell density and pterygium: a cross-sectional study.
Sousa HCC, Silva LNP, Tzelikis PF
Arq Bras Oftalmol 2017 Sep-Oct;80(5):317-320. doi: 10.5935/0004-2749.20170077. PMID: 29160544
Progress in corneal wound healing.
Ljubimov AV, Saghizadeh M
Prog Retin Eye Res 2015 Nov;49:17-45. Epub 2015 Jul 18 doi: 10.1016/j.preteyeres.2015.07.002. PMID: 26197361Free PMC Article

Recent systematic reviews

Corneal Endothelial Cell Density Loss after Glaucoma Surgery Alone or in Combination with Cataract Surgery: A Systematic Review and Meta-analysis.
Fang CEH, Mathew RG, Khaw PT, Henein C
Ophthalmology 2022 Aug;129(8):841-855. Epub 2022 Mar 22 doi: 10.1016/j.ophtha.2022.03.015. PMID: 35331751
Comparison of Three Intraocular Lens Implantation Procedures for Aphakic Eyes With Insufficient Capsular Support: A Network Meta-analysis.
Li X, Ni S, Li S, Zheng Q, Wu J, Liang G, Xu W
Am J Ophthalmol 2018 Aug;192:10-19. Epub 2018 May 8 doi: 10.1016/j.ajo.2018.04.023. PMID: 29750951
Systematic Review and Meta-Analysis of Clinical Outcomes of Descemet Membrane Endothelial Keratoplasty Versus Descemet Stripping Endothelial Keratoplasty/Descemet Stripping Automated Endothelial Keratoplasty.
Singh A, Zarei-Ghanavati M, Avadhanam V, Liu C
Cornea 2017 Nov;36(11):1437-1443. doi: 10.1097/ICO.0000000000001320. PMID: 28834814
Efficacy of Corneal Collagen Cross-Linking for the Treatment of Keratoconus: A Systematic Review and Meta-Analysis.
Meiri Z, Keren S, Rosenblatt A, Sarig T, Shenhav L, Varssano D
Cornea 2016 Mar;35(3):417-28. doi: 10.1097/ICO.0000000000000723. PMID: 26751990
Meta-analysis to Compare the Safety and Efficacy of Manual Small Incision Cataract Surgery and Phacoemulsification.
Gogate P, Optom JJ, Deshpande S, Naidoo K
Middle East Afr J Ophthalmol 2015 Jul-Sep;22(3):362-9. doi: 10.4103/0974-9233.159763. PMID: 26180478Free PMC Article

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