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add(11q23)

MedGen UID:
415163
•Concept ID:
C2825750
•
Cell or Molecular Dysfunction
Synonym: Gain of Chromosome 11q23

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVadd(11q23)

Professional guidelines

PubMed

Risk of acute myelogenous leukaemia and myelodysplasia following cancer treatment.
van Leeuwen FE
Baillieres Clin Haematol 1996 Mar;9(1):57-85. doi: 10.1016/s0950-3536(96)80037-0. PMID: 8730551

Recent clinical studies

Etiology

MLL/KMT2A translocations in diffuse large B-cell lymphomas.
Gindin T, Murty V, Alobeid B, Bhagat G
Hematol Oncol 2015 Dec;33(4):239-46. Epub 2014 Aug 18 doi: 10.1002/hon.2158. PMID: 25131304
Genomic profiling of advanced-stage oral cancers reveals chromosome 11q alterations as markers of poor clinical outcome.
Ambatipudi S, Gerstung M, Gowda R, Pai P, Borges AM, Schäffer AA, Beerenwinkel N, Mahimkar MB
PLoS One 2011 Feb 28;6(2):e17250. doi: 10.1371/journal.pone.0017250. PMID: 21386901Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene.
Cole KA, Attiyeh EF, Mosse YP, Laquaglia MJ, Diskin SJ, Brodeur GM, Maris JM
Mol Cancer Res 2008 May;6(5):735-42. doi: 10.1158/1541-7786.MCR-07-2102. PMID: 18505919Free PMC Article
Risk of acute myelogenous leukaemia and myelodysplasia following cancer treatment.
van Leeuwen FE
Baillieres Clin Haematol 1996 Mar;9(1):57-85. doi: 10.1016/s0950-3536(96)80037-0. PMID: 8730551

Diagnosis

Genomic profiling of advanced-stage oral cancers reveals chromosome 11q alterations as markers of poor clinical outcome.
Ambatipudi S, Gerstung M, Gowda R, Pai P, Borges AM, Schäffer AA, Beerenwinkel N, Mahimkar MB
PLoS One 2011 Feb 28;6(2):e17250. doi: 10.1371/journal.pone.0017250. PMID: 21386901Free PMC Article
Dic (17;20) (p11;q11) preceded MLL gene amplification in a patient with de novo mixed-lineage leukemia.
Amakawa R, Hiramoto N, Kawano S, Hyo A, Nakamichi N, Tajima K, Ito T, Mori S, Kishimoto Y, Fukuhara S
J Clin Exp Hematop 2010;50(1):51-8. doi: 10.3960/jslrt.50.51. PMID: 20505276
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
The prognostic value of MLL-AF9 detection in patients with t(9;11)(p22;q23)-positive acute myeloid leukemia.
Scholl C, Schlenk RF, Eiwen K, Döhner H, Fröhling S, Döhner K; AML Study Group
Haematologica 2005 Dec;90(12):1626-34. PMID: 16330435
Involvement of 11p15 and 3q21q26 in therapy-related myeloid leukemia (t-ML) in children. Case reports and review of the literature.
Stark B, Jeison M, Shohat M, Goshen Y, Vogel R, Cohen IJ, Yaniv I, Kaplinsky C, Zaizov R
Cancer Genet Cytogenet 1994 Jul 1;75(1):11-22. doi: 10.1016/0165-4608(94)90209-7. PMID: 8039158

Therapy

Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Aberrations in chromosomes associated with lymphoma and therapy-related leukemia in benzene-exposed workers.
Zhang L, Rothman N, Li G, Guo W, Yang W, Hubbard AE, Hayes RB, Yin S, Lu W, Smith MT
Environ Mol Mutagen 2007 Jul;48(6):467-74. doi: 10.1002/em.20306. PMID: 17584886
The prognostic value of MLL-AF9 detection in patients with t(9;11)(p22;q23)-positive acute myeloid leukemia.
Scholl C, Schlenk RF, Eiwen K, Döhner H, Fröhling S, Döhner K; AML Study Group
Haematologica 2005 Dec;90(12):1626-34. PMID: 16330435
Risk of acute myelogenous leukaemia and myelodysplasia following cancer treatment.
van Leeuwen FE
Baillieres Clin Haematol 1996 Mar;9(1):57-85. doi: 10.1016/s0950-3536(96)80037-0. PMID: 8730551
Involvement of 11p15 and 3q21q26 in therapy-related myeloid leukemia (t-ML) in children. Case reports and review of the literature.
Stark B, Jeison M, Shohat M, Goshen Y, Vogel R, Cohen IJ, Yaniv I, Kaplinsky C, Zaizov R
Cancer Genet Cytogenet 1994 Jul 1;75(1):11-22. doi: 10.1016/0165-4608(94)90209-7. PMID: 8039158

Prognosis

Genomic profiling of advanced-stage oral cancers reveals chromosome 11q alterations as markers of poor clinical outcome.
Ambatipudi S, Gerstung M, Gowda R, Pai P, Borges AM, Schäffer AA, Beerenwinkel N, Mahimkar MB
PLoS One 2011 Feb 28;6(2):e17250. doi: 10.1371/journal.pone.0017250. PMID: 21386901Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
The prognostic value of MLL-AF9 detection in patients with t(9;11)(p22;q23)-positive acute myeloid leukemia.
Scholl C, Schlenk RF, Eiwen K, Döhner H, Fröhling S, Döhner K; AML Study Group
Haematologica 2005 Dec;90(12):1626-34. PMID: 16330435
Molecular characterization of acute myeloblastic leukemia according to the new WHO classification: a different distribution in Central-West Spain.
Chillón CM, García-Sanz R, Balanzategui A, Ramos F, Fernández-Calvo J, Rodríguez MJ, Rodríguez-Salazar MI, Corrales A, Calmuntia MJ, Orfão A, González M, San Miguel JF
Haematologica 2001 Feb;86(2):162-6. PMID: 11224485
Risk of acute myelogenous leukaemia and myelodysplasia following cancer treatment.
van Leeuwen FE
Baillieres Clin Haematol 1996 Mar;9(1):57-85. doi: 10.1016/s0950-3536(96)80037-0. PMID: 8730551

Clinical prediction guides

Genomic profiling of advanced-stage oral cancers reveals chromosome 11q alterations as markers of poor clinical outcome.
Ambatipudi S, Gerstung M, Gowda R, Pai P, Borges AM, Schäffer AA, Beerenwinkel N, Mahimkar MB
PLoS One 2011 Feb 28;6(2):e17250. doi: 10.1371/journal.pone.0017250. PMID: 21386901Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Aberrations in chromosomes associated with lymphoma and therapy-related leukemia in benzene-exposed workers.
Zhang L, Rothman N, Li G, Guo W, Yang W, Hubbard AE, Hayes RB, Yin S, Lu W, Smith MT
Environ Mol Mutagen 2007 Jul;48(6):467-74. doi: 10.1002/em.20306. PMID: 17584886
Two new translocations involving the 11q23 region map outside the MLL locus in myeloid leukemias.
Giugliano E, Rege-Cambrin G, Scaravaglio P, Wlodarska I, Emanuel B, Stul M, Serra A, Tonso A, Pini M, Saglio G, Hagemeijer A
Haematologica 2002 Oct;87(10):1014-20. PMID: 12368154
Risk of acute myelogenous leukaemia and myelodysplasia following cancer treatment.
van Leeuwen FE
Baillieres Clin Haematol 1996 Mar;9(1):57-85. doi: 10.1016/s0950-3536(96)80037-0. PMID: 8730551

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