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Sternal cleft

MedGen UID:
419096
Concept ID:
C2931507
Congenital Abnormality
Synonyms: Bifid sternum; Congenital sternal cleft
SNOMED CT: Bifid sternum (54008006); Sternum bifidum (54008006); Cleft sternum (54008006); Sternoschisis (54008006); Bipartite sternum (54008006)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
HPO: HP:0010309
Monarch Initiative: MONDO:0016066
Orphanet: ORPHA2017

Definition

The sternal cleft is a rare congenital anomaly resulting from a fusion failure of the sternum. [from HPO]

Conditions with this feature

Coffin-Lowry syndrome
MedGen UID:
75556
Concept ID:
C0265252
Disease or Syndrome
Coffin-Lowry syndrome (CLS) is usually characterized by severe-to-profound intellectual disability in males; less severely impaired individuals have been reported. Neuropsychiatric concerns can include behavioral problems, loss of strength, progressive spasticity or paraplegia, sleep apnea, or stroke. Stimulus-induced drop attacks (SIDAs) in which unexpected tactile or auditory stimuli or excitement triggers a brief collapse but no loss of consciousness are present in approximately 20% of affected individuals. Typically SIDAs begin between mid-childhood and the teens. Characteristic facial features may be more apparent with age. Upper-extremity differences may be subtle and include short, soft, fleshy hands with tapered fingers as well as fleshy forearms. Progressive kyphoscoliosis is one of the most difficult aspects of long-term care. Affected females tend to have intellectual disability in the mild-to-moderate range and may also have the typical facial, hand, and skeletal findings noted in males.
Cavernous hemangiomas of face-supraumbilical midline raphe syndrome
MedGen UID:
99171
Concept ID:
C0472694
Neoplastic Process

Professional guidelines

PubMed

Lu J, Tse WT, Law KM, Leung TY
Ultrasound Obstet Gynecol 2022 Feb;59(2):267-268. doi: 10.1002/uog.23687. PMID: 33998075
Benzar IM, Levytskyi AF, Pylypko VM
Wiad Lek 2020;73(6):1267-1271. PMID: 32723967
Solman L, Glover M, Beattie PE, Buckley H, Clark S, Gach JE, Giardini A, Helbling I, Hewitt RJ, Laguda B, Langan SM, Martinez AE, Murphy R, Proudfoot L, Ravenscroft J, Shahidullah H, Shaw L, Syed SB, Wells L, Flohr C
Br J Dermatol 2018 Sep;179(3):582-589. doi: 10.1111/bjd.16779. PMID: 29774538

Recent clinical studies

Therapy

Solman L, Glover M, Beattie PE, Buckley H, Clark S, Gach JE, Giardini A, Helbling I, Hewitt RJ, Laguda B, Langan SM, Martinez AE, Murphy R, Proudfoot L, Ravenscroft J, Shahidullah H, Shaw L, Syed SB, Wells L, Flohr C
Br J Dermatol 2018 Sep;179(3):582-589. doi: 10.1111/bjd.16779. PMID: 29774538
Ateşoğlu S, Deniz M, Uslu AI
Folia Morphol (Warsz) 2018;77(3):489-497. Epub 2018 Jan 18 doi: 10.5603/FM.a2018.0002. PMID: 29345718
Gnarra M, Solman L, Harper J, Batul Syed S
Br J Dermatol 2015 Jul;173(1):242-6. Epub 2015 May 18 doi: 10.1111/bjd.13588. PMID: 25639889
Levin JH, Kaler SG
Clin Genet 2007 Oct;72(4):345-50. doi: 10.1111/j.1399-0004.2007.00851.x. PMID: 17850631

Prognosis

Bharadwaj S, Vicari FA, Backer CL, Eltayeb O
World J Pediatr Congenit Heart Surg 2022 Jan;13(1):94-96. Epub 2021 May 6 doi: 10.1177/2150135120978951. PMID: 33956542
Paraskevas G, Tzika M, Anastasopoulos N, Kitsoulis P, Sofidis G, Natsis K
Surg Radiol Anat 2015 Sep;37(7):845-51. Epub 2015 Jan 1 doi: 10.1007/s00276-014-1412-5. PMID: 25552238
de Campos JR, Das-Neves-Pereira JC, Velhote MC, Jatene FB
Eur J Cardiothorac Surg 2009 Mar;35(3):539-41. Epub 2009 Jan 22 doi: 10.1016/j.ejcts.2008.12.011. PMID: 19167236
Dòmini M, Cupaioli M, Rossi F, Fakhro A, Aquino A, Chiesa PL
Ann Thorac Surg 2000 Jan;69(1):267-9. doi: 10.1016/s0003-4975(99)01206-0. PMID: 10654531
de Campos JR, Filomeno LT, Fernandez A, Ruiz RL, Minamoto H, Werebe Ede C, Jatene FB
Ann Thorac Surg 1998 Oct;66(4):1151-4. doi: 10.1016/s0003-4975(98)00596-7. PMID: 9800797

Clinical prediction guides

Piro L, Lena F, Roggero A, Stagnaro N, Mattioli G, Torre M
Pediatr Surg Int 2024 Apr 11;40(1):105. doi: 10.1007/s00383-024-05686-0. PMID: 38602580
Ngoc Thach P, Tran Ban H, Anh Dung HV, Minh Chieu V, Viet Tanh NT, Truong Nhan V, Thanh Tri T, Tra My TT, Tan Lien Bang M, Minh Duc N
Clin Ter 2021 Nov 22;172(6):495-499. doi: 10.7417/CT.2021.2363. PMID: 34821337
Vatzia K, Fanariotis M, Makridis KG, Vlychou M, Fezoulidis IV, Vassiou K
Eur J Radiol 2021 Sep;142:109828. Epub 2021 Jun 24 doi: 10.1016/j.ejrad.2021.109828. PMID: 34280594
Yang M, Jiang H, Yu X, Chen W, Li Q, Zhang Y, Pan B
J Comput Assist Tomogr 2017 Sep/Oct;41(5):784-791. doi: 10.1097/RCT.0000000000000590. PMID: 28296686
Paraskevas G, Tzika M, Anastasopoulos N, Kitsoulis P, Sofidis G, Natsis K
Surg Radiol Anat 2015 Sep;37(7):845-51. Epub 2015 Jan 1 doi: 10.1007/s00276-014-1412-5. PMID: 25552238

Recent systematic reviews

Hinchcliff KM, Xue Y, Wong GB
Ann Plast Surg 2021 May 1;86(5S Suppl 3):S418-S421. doi: 10.1097/SAP.0000000000002724. PMID: 33470621

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