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Monoclonal Immunoglobulin Deposition Disease

MedGen UID:
423650
•Concept ID:
C2939462
•
Neoplastic Process
Synonyms: Immunoglobulin deposition disease; Immunoglobulin Deposition Disease; Primary amyloidosis; Systemic light chain disease
SNOMED CT: Systemic light chain disease (128817004); Primary amyloidosis (128817004); Immunoglobulin deposition disease (128817004)

Definition

A plasma cell neoplasm characterized by the deposition of immunoglobulin in tissues, resulting in impaired organ function. It includes the following entities: primary amyloidosis, heavy chain deposition disease, and light chain deposition disease. [from NCI]

Professional guidelines

PubMed

European myeloma network recommendations on diagnosis and management of patients with rare plasma cell dyscrasias.
Gavriatopoulou M, Musto P, Caers J, Merlini G, Kastritis E, van de Donk N, Gay F, Hegenbart U, Hajek R, Zweegman S, Bruno B, Straka C, Dimopoulos MA, Einsele H, Boccadoro M, Sonneveld P, Engelhardt M, Terpos E
Leukemia 2018 Sep;32(9):1883-1898. Epub 2018 Jul 23 doi: 10.1038/s41375-018-0209-7. PMID: 30038381
Hematologic and renal improvement of monoclonal immunoglobulin deposition disease after treatment with bortezomib-based regimens.
Ziogas DC, Kastritis E, Terpos E, Roussou M, Migkou M, Gavriatopoulou M, Spanomichou D, Eleutherakis-Papaiakovou E, Fotiou D, Panagiotidis I, Kafantari E, Psimenou E, Boletis I, Vlahakos DV, Gakiopoulou H, Matsouka C, Dimopoulos MA
Leuk Lymphoma 2017 Aug;58(8):1832-1839. Epub 2016 Dec 14 doi: 10.1080/10428194.2016.1267349. PMID: 27967286

Recent clinical studies

Etiology

Monoclonal gammopathy of renal significance: Spectrum of diseases and approach to a case.
Tewari R, Chatterjee T, Mendonca S, Dogra M, Pramanik SK, Yanamandra U
Saudi J Kidney Dis Transpl 2021 Mar-Apr;32(2):298-306. doi: 10.4103/1319-2442.335440. PMID: 35017322
Randall-type monoclonal immunoglobulin deposition disease: novel insights from a nationwide cohort study.
Joly F, Cohen C, Javaugue V, Bender S, Belmouaz M, Arnulf B, Knebelmann B, Nouvier M, Audard V, Provot F, Gnemmi V, Nochy D, Goujon JM, Jaccard A, Touchard G, Fermand JP, Sirac C, Bridoux F
Blood 2019 Feb 7;133(6):576-587. Epub 2018 Dec 21 doi: 10.1182/blood-2018-09-872028. PMID: 30578255
Renal monoclonal immunoglobulin deposition disease: a report of 64 patients from a single institution.
Nasr SH, Valeri AM, Cornell LD, Fidler ME, Sethi S, D'Agati VD, Leung N
Clin J Am Soc Nephrol 2012 Feb;7(2):231-9. Epub 2011 Dec 8 doi: 10.2215/CJN.08640811. PMID: 22156754
Renal outcome and monoclonal immunoglobulin deposition disease in 289 old patients with blood cell dyscrasias: a single center experience.
Stratta P, Gravellone L, Cena T, Rossi D, Gaidano G, Fenoglio R, Lazzarich E, Quaglia M, Airoldi A, Bozzola C, Monga G, Valente G, Canavese C, Magnani C
Crit Rev Oncol Hematol 2011 Jul;79(1):31-42. Epub 2010 May 31 doi: 10.1016/j.critrevonc.2010.05.001. PMID: 20570173
Nonamyloidotic monoclonal immunoglobulin deposition disease. Light-chain, heavy-chain, and light- and heavy-chain deposition diseases.
Buxbaum J, Gallo G
Hematol Oncol Clin North Am 1999 Dec;13(6):1235-48. doi: 10.1016/s0889-8588(05)70123-4. PMID: 10626147

Diagnosis

Monoclonal gammopathy of renal significance: Spectrum of diseases and approach to a case.
Tewari R, Chatterjee T, Mendonca S, Dogra M, Pramanik SK, Yanamandra U
Saudi J Kidney Dis Transpl 2021 Mar-Apr;32(2):298-306. doi: 10.4103/1319-2442.335440. PMID: 35017322
European myeloma network recommendations on diagnosis and management of patients with rare plasma cell dyscrasias.
Gavriatopoulou M, Musto P, Caers J, Merlini G, Kastritis E, van de Donk N, Gay F, Hegenbart U, Hajek R, Zweegman S, Bruno B, Straka C, Dimopoulos MA, Einsele H, Boccadoro M, Sonneveld P, Engelhardt M, Terpos E
Leukemia 2018 Sep;32(9):1883-1898. Epub 2018 Jul 23 doi: 10.1038/s41375-018-0209-7. PMID: 30038381
The wonderful colors of the hematoxylin-eosin stain in diagnostic surgical pathology.
Chan JK
Int J Surg Pathol 2014 Feb;22(1):12-32. Epub 2014 Jan 9 doi: 10.1177/1066896913517939. PMID: 24406626
Renal outcome and monoclonal immunoglobulin deposition disease in 289 old patients with blood cell dyscrasias: a single center experience.
Stratta P, Gravellone L, Cena T, Rossi D, Gaidano G, Fenoglio R, Lazzarich E, Quaglia M, Airoldi A, Bozzola C, Monga G, Valente G, Canavese C, Magnani C
Crit Rev Oncol Hematol 2011 Jul;79(1):31-42. Epub 2010 May 31 doi: 10.1016/j.critrevonc.2010.05.001. PMID: 20570173
Nonamyloidotic monoclonal immunoglobulin deposition disease. Light-chain, heavy-chain, and light- and heavy-chain deposition diseases.
Buxbaum J, Gallo G
Hematol Oncol Clin North Am 1999 Dec;13(6):1235-48. doi: 10.1016/s0889-8588(05)70123-4. PMID: 10626147

Therapy

Bortezomib-induced glomerular microangiopathy complicated with monoclonal immunoglobulin deposition disease.
Mizuno S, Kitayama C, Sanada S, Sato T
CEN Case Rep 2021 Nov;10(4):537-542. Epub 2021 Apr 28 doi: 10.1007/s13730-021-00603-z. PMID: 33909224Free PMC Article
Randall-type monoclonal immunoglobulin deposition disease: novel insights from a nationwide cohort study.
Joly F, Cohen C, Javaugue V, Bender S, Belmouaz M, Arnulf B, Knebelmann B, Nouvier M, Audard V, Provot F, Gnemmi V, Nochy D, Goujon JM, Jaccard A, Touchard G, Fermand JP, Sirac C, Bridoux F
Blood 2019 Feb 7;133(6):576-587. Epub 2018 Dec 21 doi: 10.1182/blood-2018-09-872028. PMID: 30578255
Hematologic and renal improvement of monoclonal immunoglobulin deposition disease after treatment with bortezomib-based regimens.
Ziogas DC, Kastritis E, Terpos E, Roussou M, Migkou M, Gavriatopoulou M, Spanomichou D, Eleutherakis-Papaiakovou E, Fotiou D, Panagiotidis I, Kafantari E, Psimenou E, Boletis I, Vlahakos DV, Gakiopoulou H, Matsouka C, Dimopoulos MA
Leuk Lymphoma 2017 Aug;58(8):1832-1839. Epub 2016 Dec 14 doi: 10.1080/10428194.2016.1267349. PMID: 27967286
Outcomes of patients with renal monoclonal immunoglobulin deposition disease.
Kourelis TV, Nasr SH, Dispenzieri A, Kumar SK, Gertz MA, Fervenza FC, Buadi FK, Lacy MQ, Erickson SB, Cosio FG, Kapoor P, Lust JA, Hayman SR, Rajkumar V, Zeldenrust SR, Russell SJ, Dingli D, Lin Y, Gonsalves W, Lorenz EC, Zand L, Kyle RA, Leung N
Am J Hematol 2016 Nov;91(11):1123-1128. Epub 2016 Aug 29 doi: 10.1002/ajh.24528. PMID: 27501122
Recurrence from primary and secondary glomerulopathy after renal transplant.
Canaud G, Audard V, Kofman T, Lang P, Legendre C, Grimbert P
Transpl Int 2012 Aug;25(8):812-24. Epub 2012 Apr 16 doi: 10.1111/j.1432-2277.2012.01483.x. PMID: 22507183

Prognosis

Randall-type monoclonal immunoglobulin deposition disease: novel insights from a nationwide cohort study.
Joly F, Cohen C, Javaugue V, Bender S, Belmouaz M, Arnulf B, Knebelmann B, Nouvier M, Audard V, Provot F, Gnemmi V, Nochy D, Goujon JM, Jaccard A, Touchard G, Fermand JP, Sirac C, Bridoux F
Blood 2019 Feb 7;133(6):576-587. Epub 2018 Dec 21 doi: 10.1182/blood-2018-09-872028. PMID: 30578255
European myeloma network recommendations on diagnosis and management of patients with rare plasma cell dyscrasias.
Gavriatopoulou M, Musto P, Caers J, Merlini G, Kastritis E, van de Donk N, Gay F, Hegenbart U, Hajek R, Zweegman S, Bruno B, Straka C, Dimopoulos MA, Einsele H, Boccadoro M, Sonneveld P, Engelhardt M, Terpos E
Leukemia 2018 Sep;32(9):1883-1898. Epub 2018 Jul 23 doi: 10.1038/s41375-018-0209-7. PMID: 30038381
Renal outcome and monoclonal immunoglobulin deposition disease in 289 old patients with blood cell dyscrasias: a single center experience.
Stratta P, Gravellone L, Cena T, Rossi D, Gaidano G, Fenoglio R, Lazzarich E, Quaglia M, Airoldi A, Bozzola C, Monga G, Valente G, Canavese C, Magnani C
Crit Rev Oncol Hematol 2011 Jul;79(1):31-42. Epub 2010 May 31 doi: 10.1016/j.critrevonc.2010.05.001. PMID: 20570173
Clinicopathological features and prognosis in immunoglobulin light and heavy chain deposition disease.
Masai R, Wakui H, Togashi M, Maki N, Ohtani H, Komatsuda A, Sawada K
Clin Nephrol 2009 Jan;71(1):9-20. doi: 10.5414/cnp71009. PMID: 19203545
Nonamyloidotic monoclonal immunoglobulin deposition disease. Light-chain, heavy-chain, and light- and heavy-chain deposition diseases.
Buxbaum J, Gallo G
Hematol Oncol Clin North Am 1999 Dec;13(6):1235-48. doi: 10.1016/s0889-8588(05)70123-4. PMID: 10626147

Clinical prediction guides

Monoclonal gammopathy of renal significance: Spectrum of diseases and approach to a case.
Tewari R, Chatterjee T, Mendonca S, Dogra M, Pramanik SK, Yanamandra U
Saudi J Kidney Dis Transpl 2021 Mar-Apr;32(2):298-306. doi: 10.4103/1319-2442.335440. PMID: 35017322
Randall-type monoclonal immunoglobulin deposition disease: novel insights from a nationwide cohort study.
Joly F, Cohen C, Javaugue V, Bender S, Belmouaz M, Arnulf B, Knebelmann B, Nouvier M, Audard V, Provot F, Gnemmi V, Nochy D, Goujon JM, Jaccard A, Touchard G, Fermand JP, Sirac C, Bridoux F
Blood 2019 Feb 7;133(6):576-587. Epub 2018 Dec 21 doi: 10.1182/blood-2018-09-872028. PMID: 30578255
Hematologic and renal improvement of monoclonal immunoglobulin deposition disease after treatment with bortezomib-based regimens.
Ziogas DC, Kastritis E, Terpos E, Roussou M, Migkou M, Gavriatopoulou M, Spanomichou D, Eleutherakis-Papaiakovou E, Fotiou D, Panagiotidis I, Kafantari E, Psimenou E, Boletis I, Vlahakos DV, Gakiopoulou H, Matsouka C, Dimopoulos MA
Leuk Lymphoma 2017 Aug;58(8):1832-1839. Epub 2016 Dec 14 doi: 10.1080/10428194.2016.1267349. PMID: 27967286
Outcomes of patients with renal monoclonal immunoglobulin deposition disease.
Kourelis TV, Nasr SH, Dispenzieri A, Kumar SK, Gertz MA, Fervenza FC, Buadi FK, Lacy MQ, Erickson SB, Cosio FG, Kapoor P, Lust JA, Hayman SR, Rajkumar V, Zeldenrust SR, Russell SJ, Dingli D, Lin Y, Gonsalves W, Lorenz EC, Zand L, Kyle RA, Leung N
Am J Hematol 2016 Nov;91(11):1123-1128. Epub 2016 Aug 29 doi: 10.1002/ajh.24528. PMID: 27501122
The wonderful colors of the hematoxylin-eosin stain in diagnostic surgical pathology.
Chan JK
Int J Surg Pathol 2014 Feb;22(1):12-32. Epub 2014 Jan 9 doi: 10.1177/1066896913517939. PMID: 24406626

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