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Hemorrhagic fever-renal syndrome

MedGen UID:
Concept ID:
Disease or Syndrome
Synonym: Hemorrhagic fever with renal syndrome
SNOMED CT: Hemorrhagic fever with renal syndrome (716864001); HFRS - hemorrhagic fever with renal syndrome (716864001); Puumala virus nephropathy (364756009)
Modes of inheritance:
Not genetically inherited
MedGen UID:
Concept ID:
Source: Orphanet
clinical entity without genetic inheritance.
Monarch Initiative: MONDO:0018081
Orphanet: ORPHA340


Hemorrhagic fever with renal syndrome (HFRS) is a rodent-borne potentially severe hemorrhagic disease caused by Old World Hantaviruses characterized by high fever, malaise, headache, myalgia, arthralgia, backache, abdominal pain, oliguria/renal failure and systemic hemorrhagic manifestations. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHemorrhagic fever-renal syndrome

Professional guidelines


Masaki Y, Kawabata H, Takai K, Kojima M, Tsukamoto N, Ishigaki Y, Kurose N, Ide M, Murakami J, Nara K, Yamamoto H, Ozawa Y, Takahashi H, Miura K, Miyauchi T, Yoshida S, Momoi A, Awano N, Ikushima S, Ohta Y, Furuta N, Fujimoto S, Kawanami H, Sakai T, Kawanami T, Fujita Y, Fukushima T, Nakamura S, Kinoshita T, Aoki S
Int J Hematol 2016 Jun;103(6):686-92. Epub 2016 Mar 18 doi: 10.1007/s12185-016-1979-1. PMID: 27084250

Recent clinical studies


Guo J, Guo X, Wang Y, Tian F, Luo W, Zou Y
J Med Virol 2017 Jul;89(7):1139-1145. Epub 2017 Feb 10 doi: 10.1002/jmv.24752. PMID: 27943332

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