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B-lymphoblastic leukemia/lymphoma with hypodiploidy

MedGen UID:
437498
•Concept ID:
C2698312
•
Neoplastic Process
Synonyms: B lymphoblastic leukemia lymphoma with hypodiploidy; B Lymphoblastic Leukemia/Lymphoma with Hypodiploidy; B-Lymphoblastic Leukemia/Lymphoma with Hypodiploidy; Hypodiploid ALL; Hypodiploid B Lymphoblastic Leukemia/Lymphoma
SNOMED CT: B lymphoblastic leukemia lymphoma with hypodiploidy (838344002)
 
Monarch Initiative: MONDO:0035944
Orphanet: ORPHA585942

Definition

A precursor lymphoid neoplasm composed of B-lymphoblasts which contain less than 46 chromosomes. It has an unfavorable clinical outcome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • B-lymphoblastic leukemia/lymphoma with hypodiploidy

Recent clinical studies

Etiology

Emerging molecular subtypes and therapies in acute lymphoblastic leukemia.
Davis K, Sheikh T, Aggarwal N
Semin Diagn Pathol 2023 May;40(3):202-215. Epub 2023 Apr 9 doi: 10.1053/j.semdp.2023.04.003. PMID: 37120350
Hematopoietic Stem-Cell Transplantation Does Not Improve the Poor Outcome of Children With Hypodiploid Acute Lymphoblastic Leukemia: A Report From Children's Oncology Group.
McNeer JL, Devidas M, Dai Y, Carroll AJ, Heerema NA, Gastier-Foster JM, Kahwash SB, Borowitz MJ, Wood BL, Larsen E, Maloney KW, Mattano L, Winick NJ, Schultz KR, Hunger SP, Carroll WL, Loh ML, Raetz EA
J Clin Oncol 2019 Apr 1;37(10):780-789. Epub 2019 Feb 11 doi: 10.1200/JCO.18.00884. PMID: 30742559Free PMC Article
Adult Low-Hypodiploid Acute B-Lymphoblastic Leukemia With IKZF3 Deletion and TP53 Mutation: Comparison With Pediatric Patients.
Fang M, Becker PS, Linenberger M, Eaton KD, Appelbaum FR, Dreyer Z, Airewele G, Redell M, Lopez-Terrada D, Patel A, Rabin KR, Lu X
Am J Clin Pathol 2015 Aug;144(2):263-70. doi: 10.1309/AJCPW83OXPYKPEEN. PMID: 26185311
Acute lymphoblastic leukemia with low hypodiploid/near triploid karyotype is a specific clinical entity and exhibits a very high TP53 mutation frequency of 93%.
Mühlbacher V, Zenger M, Schnittger S, Weissmann S, Kunze F, Kohlmann A, Bellos F, Kern W, Haferlach T, Haferlach C
Genes Chromosomes Cancer 2014 Jun;53(6):524-36. Epub 2014 Mar 11 doi: 10.1002/gcc.22163. PMID: 24619868
Adult B lymphoblastic leukaemia/lymphoma with hypodiploidy (-9) and a novel chromosomal translocation t(7;12)(q22;p13) presenting with severe eosinophilia - case report and review of literature.
Bhatti FA, Hussain I, Ali MZ
J Hematol Oncol 2009 Jun 21;2:26. doi: 10.1186/1756-8722-2-26. PMID: 19545391Free PMC Article

Diagnosis

Emerging molecular subtypes and therapies in acute lymphoblastic leukemia.
Davis K, Sheikh T, Aggarwal N
Semin Diagn Pathol 2023 May;40(3):202-215. Epub 2023 Apr 9 doi: 10.1053/j.semdp.2023.04.003. PMID: 37120350
A near-haploid clone harboring a BCR/ABL1 gene fusion in an adult patient with newly diagnosed B-lymphoblastic leukemia.
Peterson JF, Ketterling RP, Huang L, Finn LE, Shi M, Hoppman NL, Greipp PT, Baughn LB
Genes Chromosomes Cancer 2019 Sep;58(9):665-668. Epub 2019 Mar 18 doi: 10.1002/gcc.22744. PMID: 30790375
Hematopoietic Stem-Cell Transplantation Does Not Improve the Poor Outcome of Children With Hypodiploid Acute Lymphoblastic Leukemia: A Report From Children's Oncology Group.
McNeer JL, Devidas M, Dai Y, Carroll AJ, Heerema NA, Gastier-Foster JM, Kahwash SB, Borowitz MJ, Wood BL, Larsen E, Maloney KW, Mattano L, Winick NJ, Schultz KR, Hunger SP, Carroll WL, Loh ML, Raetz EA
J Clin Oncol 2019 Apr 1;37(10):780-789. Epub 2019 Feb 11 doi: 10.1200/JCO.18.00884. PMID: 30742559Free PMC Article
Adult B lymphoblastic leukaemia/lymphoma with hypodiploidy (-9) and a novel chromosomal translocation t(7;12)(q22;p13) presenting with severe eosinophilia - case report and review of literature.
Bhatti FA, Hussain I, Ali MZ
J Hematol Oncol 2009 Jun 21;2:26. doi: 10.1186/1756-8722-2-26. PMID: 19545391Free PMC Article

Therapy

Hematopoietic Stem-Cell Transplantation Does Not Improve the Poor Outcome of Children With Hypodiploid Acute Lymphoblastic Leukemia: A Report From Children's Oncology Group.
McNeer JL, Devidas M, Dai Y, Carroll AJ, Heerema NA, Gastier-Foster JM, Kahwash SB, Borowitz MJ, Wood BL, Larsen E, Maloney KW, Mattano L, Winick NJ, Schultz KR, Hunger SP, Carroll WL, Loh ML, Raetz EA
J Clin Oncol 2019 Apr 1;37(10):780-789. Epub 2019 Feb 11 doi: 10.1200/JCO.18.00884. PMID: 30742559Free PMC Article

Prognosis

A near-haploid clone harboring a BCR/ABL1 gene fusion in an adult patient with newly diagnosed B-lymphoblastic leukemia.
Peterson JF, Ketterling RP, Huang L, Finn LE, Shi M, Hoppman NL, Greipp PT, Baughn LB
Genes Chromosomes Cancer 2019 Sep;58(9):665-668. Epub 2019 Mar 18 doi: 10.1002/gcc.22744. PMID: 30790375
Hematopoietic Stem-Cell Transplantation Does Not Improve the Poor Outcome of Children With Hypodiploid Acute Lymphoblastic Leukemia: A Report From Children's Oncology Group.
McNeer JL, Devidas M, Dai Y, Carroll AJ, Heerema NA, Gastier-Foster JM, Kahwash SB, Borowitz MJ, Wood BL, Larsen E, Maloney KW, Mattano L, Winick NJ, Schultz KR, Hunger SP, Carroll WL, Loh ML, Raetz EA
J Clin Oncol 2019 Apr 1;37(10):780-789. Epub 2019 Feb 11 doi: 10.1200/JCO.18.00884. PMID: 30742559Free PMC Article
Adult Low-Hypodiploid Acute B-Lymphoblastic Leukemia With IKZF3 Deletion and TP53 Mutation: Comparison With Pediatric Patients.
Fang M, Becker PS, Linenberger M, Eaton KD, Appelbaum FR, Dreyer Z, Airewele G, Redell M, Lopez-Terrada D, Patel A, Rabin KR, Lu X
Am J Clin Pathol 2015 Aug;144(2):263-70. doi: 10.1309/AJCPW83OXPYKPEEN. PMID: 26185311

Clinical prediction guides

A near-haploid clone harboring a BCR/ABL1 gene fusion in an adult patient with newly diagnosed B-lymphoblastic leukemia.
Peterson JF, Ketterling RP, Huang L, Finn LE, Shi M, Hoppman NL, Greipp PT, Baughn LB
Genes Chromosomes Cancer 2019 Sep;58(9):665-668. Epub 2019 Mar 18 doi: 10.1002/gcc.22744. PMID: 30790375
Acute lymphoblastic leukemia with low hypodiploid/near triploid karyotype is a specific clinical entity and exhibits a very high TP53 mutation frequency of 93%.
Mühlbacher V, Zenger M, Schnittger S, Weissmann S, Kunze F, Kohlmann A, Bellos F, Kern W, Haferlach T, Haferlach C
Genes Chromosomes Cancer 2014 Jun;53(6):524-36. Epub 2014 Mar 11 doi: 10.1002/gcc.22163. PMID: 24619868

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